Incidental Mutation 'IGL02439:Lst1'
ID293383
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lst1
Ensembl Gene ENSMUSG00000073412
Gene Nameleukocyte specific transcript 1
SynonymsB144
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02439
Quality Score
Status
Chromosome17
Chromosomal Location35185095-35188439 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 35186982 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Valine at position 32 (I32V)
Ref Sequence ENSEMBL: ENSMUSP00000094949 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000097336]
Predicted Effect probably benign
Transcript: ENSMUST00000097336
AA Change: I32V

PolyPhen 2 Score 0.061 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000094949
Gene: ENSMUSG00000073412
AA Change: I32V

DomainStartEndE-ValueType
Pfam:LST1 22 93 5e-47 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134687
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele are slightly more susceptible to influenza A H1N1 infection. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610042L04Rik A T 14: 4,348,890 Y17F probably benign Het
Ablim2 A C 5: 35,857,862 T507P possibly damaging Het
Arhgef28 T C 13: 97,931,139 Y1426C possibly damaging Het
Armc4 T A 18: 7,268,444 R358S probably benign Het
Cftr T A 6: 18,258,238 Y592* probably null Het
Eogt C T 6: 97,143,973 G93D possibly damaging Het
Exosc9 A G 3: 36,553,031 probably benign Het
Frem1 T C 4: 82,956,345 I1329V probably benign Het
Gal3st1 T C 11: 3,998,110 F106L possibly damaging Het
Gulp1 A T 1: 44,781,004 I216F probably damaging Het
Ints13 A T 6: 146,554,223 probably benign Het
Kars G A 8: 111,997,636 T453I probably benign Het
Kif14 A G 1: 136,490,261 D844G probably damaging Het
Lgals3bp A T 11: 118,398,220 C93S probably damaging Het
Malsu1 T A 6: 49,075,187 Y114N probably damaging Het
Ndufa5 A T 6: 24,519,202 V41E probably damaging Het
Nme6 C A 9: 109,841,931 P80T probably damaging Het
Olfr202 A G 16: 59,284,455 L14P probably damaging Het
Padi4 T C 4: 140,746,221 D635G probably damaging Het
Pcf11 C T 7: 92,661,841 S313N possibly damaging Het
Pdik1l T C 4: 134,278,704 H309R probably benign Het
Pdk2 A T 11: 95,039,497 probably benign Het
Pprc1 A G 19: 46,072,319 S1606G possibly damaging Het
Ptch1 A G 13: 63,545,096 I230T probably damaging Het
Scn10a C T 9: 119,618,848 R1381Q probably benign Het
Sestd1 T C 2: 77,196,830 K479E possibly damaging Het
Sez6l2 C T 7: 126,968,189 S892L probably damaging Het
Slc39a9 G T 12: 80,666,576 A83S probably benign Het
Slc6a6 A G 6: 91,749,827 Y483C probably damaging Het
Srrm1 G A 4: 135,325,104 P658L unknown Het
Tas2r131 A G 6: 132,957,769 S26P probably damaging Het
Timd2 A G 11: 46,678,236 probably benign Het
Tmem126a T C 7: 90,455,433 E27G probably damaging Het
Tns2 G A 15: 102,114,543 G1256E probably damaging Het
Trpv6 T A 6: 41,625,487 I322F probably damaging Het
Tshr G A 12: 91,537,547 V420M probably damaging Het
Ttn C A 2: 76,766,087 A20161S probably damaging Het
Vmn2r66 A T 7: 85,005,247 probably benign Het
Zfp438 T A 18: 5,213,216 S581C probably damaging Het
Other mutations in Lst1
AlleleSourceChrCoordTypePredicted EffectPPH Score
R5822:Lst1 UTSW 17 35188383 missense unknown
R6114:Lst1 UTSW 17 35188360 missense possibly damaging 0.53
R7086:Lst1 UTSW 17 35185286 missense probably damaging 0.98
R7537:Lst1 UTSW 17 35186944 critical splice donor site probably null
Posted On2015-04-16