Incidental Mutation 'IGL02440:Olfr457'
ID293437
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr457
Ensembl Gene ENSMUSG00000091983
Gene Nameolfactory receptor 457
SynonymsMOR257-1, GA_x6K02T2P3E9-5088893-5089834
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.167) question?
Stock #IGL02440
Quality Score
Status
Chromosome6
Chromosomal Location42468015-42476335 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 42472166 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glycine at position 4 (D4G)
Ref Sequence ENSEMBL: ENSMUSP00000144914 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000170504] [ENSMUST00000203396] [ENSMUST00000204324]
Predicted Effect probably benign
Transcript: ENSMUST00000170504
AA Change: D4G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000127348
Gene: ENSMUSG00000091983
AA Change: D4G

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 6.4e-53 PFAM
Pfam:7tm_1 41 290 2e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000203396
AA Change: D4G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000145162
Gene: ENSMUSG00000091983
AA Change: D4G

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 6.4e-53 PFAM
Pfam:7tm_1 41 290 2e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000204324
AA Change: D4G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000144914
Gene: ENSMUSG00000091983
AA Change: D4G

DomainStartEndE-ValueType
Pfam:7tm_4 31 125 2.4e-19 PFAM
Pfam:7tm_1 41 125 3.1e-14 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atp8a1 A G 5: 67,667,434 probably benign Het
Bmt2 C T 6: 13,628,610 R358Q probably damaging Het
C2cd6 A G 1: 59,075,100 I182T probably benign Het
Calr3 T C 8: 72,431,432 T100A probably benign Het
Ccdc129 A G 6: 55,884,728 T97A possibly damaging Het
Cln3 T C 7: 126,582,782 K36R probably benign Het
Ddx25 C T 9: 35,557,678 probably benign Het
Dmxl2 A T 9: 54,406,615 V1677E probably damaging Het
Dnah10 A G 5: 124,773,819 E1684G probably damaging Het
Dnah9 A G 11: 65,955,246 S2989P probably damaging Het
F5 A T 1: 164,207,066 T1845S possibly damaging Het
Folh1 G T 7: 86,734,104 N478K probably benign Het
Gpr22 T C 12: 31,709,140 I328V probably damaging Het
Itln1 C T 1: 171,531,529 A128T probably benign Het
Kank1 A G 19: 25,432,908 K1322R probably damaging Het
Klhdc2 A G 12: 69,303,640 Y153C probably damaging Het
Lonp2 T A 8: 86,624,185 M1K probably null Het
Mtor T A 4: 148,546,429 M2281K probably benign Het
Mtor T A 4: 148,491,647 N1378K probably benign Het
Myo1e G A 9: 70,346,740 R557H probably damaging Het
Nedd4l T C 18: 65,163,173 probably null Het
Olfr1504 A T 19: 13,887,859 M117K probably damaging Het
Olfr325 A T 11: 58,581,209 M122L probably damaging Het
Olfr373 T A 8: 72,100,530 F257I probably damaging Het
Pcdh18 T C 3: 49,744,603 probably benign Het
Phldb1 T C 9: 44,715,403 T582A probably damaging Het
Plxna2 A T 1: 194,746,150 E509D probably benign Het
Poln A T 5: 34,129,130 D231E probably damaging Het
Prex2 G A 1: 11,153,657 R735Q possibly damaging Het
Prpf40b T C 15: 99,306,866 S263P probably damaging Het
Sfmbt2 C T 2: 10,568,383 A574V probably damaging Het
Slc12a3 T C 8: 94,331,682 I152T probably damaging Het
Srrm1 G A 4: 135,325,104 P658L unknown Het
Svep1 T C 4: 58,145,293 I391V probably benign Het
Tbx4 A G 11: 85,890,894 E80G probably damaging Het
Vmn2r22 A G 6: 123,637,405 Y409H probably benign Het
Zfp691 T G 4: 119,170,296 R246S probably damaging Het
Zfp846 T C 9: 20,588,500 probably benign Het
Other mutations in Olfr457
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01417:Olfr457 APN 6 42472112 missense probably benign 0.00
IGL01915:Olfr457 APN 6 42471289 missense probably benign 0.01
IGL02006:Olfr457 APN 6 42472091 missense probably benign 0.37
R0024:Olfr457 UTSW 6 42471260 missense probably benign
R0662:Olfr457 UTSW 6 42471774 missense possibly damaging 0.75
R1599:Olfr457 UTSW 6 42471242 missense probably damaging 1.00
R2087:Olfr457 UTSW 6 42472051 missense probably damaging 1.00
R5002:Olfr457 UTSW 6 42471972 missense probably benign 0.18
R5022:Olfr457 UTSW 6 42471287 missense possibly damaging 0.92
R5288:Olfr457 UTSW 6 42471252 missense probably benign
R5342:Olfr457 UTSW 6 42471902 missense probably damaging 1.00
R5823:Olfr457 UTSW 6 42471972 missense probably benign 0.18
R5824:Olfr457 UTSW 6 42471972 missense probably benign 0.18
R6378:Olfr457 UTSW 6 42471753 missense probably benign 0.01
R7384:Olfr457 UTSW 6 42471323 missense possibly damaging 0.89
R7442:Olfr457 UTSW 6 42471500 missense probably benign 0.02
R7631:Olfr457 UTSW 6 42471936 missense probably benign 0.01
R7811:Olfr457 UTSW 6 42471701 missense probably damaging 1.00
R7896:Olfr457 UTSW 6 42472166 missense probably benign 0.22
X0017:Olfr457 UTSW 6 42471818 missense probably damaging 1.00
Posted On2015-04-16