Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02442:Vmn2r19'

293458

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r19

Ensembl Gene

ENSMUSG00000091260

Gene Name

vomeronasal 2, receptor 19

Synonyms

EG232358

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.066) question?

Stock #

IGL02442

Quality Score

Status

Chromosome

Chromosomal Location

123308333-123336537 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 123309662 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Phenylalanine at position 85 (V85F)

Ref Sequence

ENSEMBL: ENSMUSP00000073604 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000073948]

AlphaFold

G5E8G4

Predicted Effect

possibly damaging
Transcript: ENSMUST00000073948
AA Change: V85F

PolyPhen 2 Score 0.937 (Sensitivity: 0.80; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000073604
Gene: ENSMUSG00000091260
AA Change: V85F

Domain	Start	End	E-Value	Type
signal peptide	1	17	N/A	INTRINSIC
Pfam:ANF_receptor	81	476	2.9e-35	PFAM
Pfam:NCD3G	518	571	8.3e-23	PFAM
Pfam:7tm_3	603	839	7.2e-52	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700006E09Rik	T	C	11: 101,990,826	V116A	probably benign	Het
Adap2	A	G	11: 80,177,206	E348G	probably damaging	Het
Ahnak	G	A	19: 9,004,016	G888D	probably damaging	Het
Cdc45	C	T	16: 18,798,729	M200I	probably benign	Het
Csde1	T	C	3: 103,054,819	C649R	probably benign	Het
Cym	A	C	3: 107,214,285	D230E	probably damaging	Het
Dnah1	A	T	14: 31,287,878	I1911N	probably damaging	Het
Fam60a	A	T	6: 148,928,507		probably null	Het
Fat1	A	G	8: 44,950,323	H37R	probably benign	Het
Ggt6	T	C	11: 72,436,806	V146A	possibly damaging	Het
Glud1	T	A	14: 34,335,438	L54*	probably null	Het
Grk6	A	G	13: 55,458,937		probably benign	Het
Gsta4	G	A	9: 78,209,165	V219I	probably benign	Het
Gucy1a2	G	A	9: 3,865,385	V620M	probably damaging	Het
Hspe1	T	C	1: 55,089,042		probably benign	Het
Icmt	T	C	4: 152,298,716	V76A	possibly damaging	Het
Ifrd1	A	G	12: 40,216,317		probably benign	Het
Lgals12	T	C	19: 7,606,654		probably benign	Het
Lypla1	T	C	1: 4,832,387		probably benign	Het
Map1b	A	T	13: 99,508,198	W66R	probably damaging	Het
Matn3	T	A	12: 8,967,678	C443*	probably null	Het
Mup8	T	A	4: 60,219,695	R191W	probably damaging	Het
Mycbp2	T	C	14: 103,314,375	K140R	probably benign	Het
Ndfip1	C	T	18: 38,447,736	S66L	probably damaging	Het
Neu1	A	G	17: 34,934,469	I323V	probably benign	Het
Nup205	A	T	6: 35,190,068	T341S	probably benign	Het
Olfr1303	G	A	2: 111,813,991	T245I	probably benign	Het
Olfr1466	T	A	19: 13,342,120	C121S	probably benign	Het
Olfr1469	T	A	19: 13,410,987	N139K	probably benign	Het
Ovch2	T	A	7: 107,796,548	I88F	possibly damaging	Het
Pkd1	T	A	17: 24,565,226	S249T	probably benign	Het
Plekhg3	A	T	12: 76,578,353	Q1324L	probably benign	Het
Ppara	T	A	15: 85,801,143	V431E	probably benign	Het
Prkaa1	T	G	15: 5,176,888	H408Q	probably damaging	Het
Sap25	T	A	5: 137,641,995	N108K	probably benign	Het
Setd5	A	C	6: 113,110,380	I81L	possibly damaging	Het
Sri	T	A	5: 8,062,411	M78K	probably damaging	Het
Tyro3	A	G	2: 119,808,868	N352S	probably benign	Het
Ubr5	T	A	15: 38,037,901	E332V	possibly damaging	Het
Vmn2r53	A	T	7: 12,581,729	V721D	probably damaging	Het
Vwa5a	A	G	9: 38,734,784	M483V	probably benign	Het
Zfp786	T	A	6: 47,821,367	Q212H	probably benign	Het

Other mutations in Vmn2r19

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01407:Vmn2r19	APN	6	123329867	missense	possibly damaging	0.92
IGL02294:Vmn2r19	APN	6	123329978	missense	probably benign	0.19
IGL02871:Vmn2r19	APN	6	123336083	missense	probably damaging	1.00
H8562:Vmn2r19	UTSW	6	123315902	missense	possibly damaging	0.82
R0025:Vmn2r19	UTSW	6	123331547	missense	probably benign	0.01
R0389:Vmn2r19	UTSW	6	123335986	missense	possibly damaging	0.53
R0402:Vmn2r19	UTSW	6	123336182	missense	probably damaging	1.00
R0411:Vmn2r19	UTSW	6	123309744	missense	probably damaging	0.98
R0554:Vmn2r19	UTSW	6	123336143	missense	probably damaging	0.99
R0578:Vmn2r19	UTSW	6	123335972	missense	probably damaging	1.00
R1102:Vmn2r19	UTSW	6	123336173	missense	probably benign	0.28
R1652:Vmn2r19	UTSW	6	123315697	missense	possibly damaging	0.68
R1663:Vmn2r19	UTSW	6	123336452	missense	probably benign	0.11
R1817:Vmn2r19	UTSW	6	123330052	missense	possibly damaging	0.80
R1866:Vmn2r19	UTSW	6	123331638	critical splice donor site	probably null
R1928:Vmn2r19	UTSW	6	123331630	missense	probably damaging	1.00
R1997:Vmn2r19	UTSW	6	123315921	missense	probably damaging	0.98
R2013:Vmn2r19	UTSW	6	123315995	missense	probably benign	0.01
R2015:Vmn2r19	UTSW	6	123315995	missense	probably benign	0.01
R2088:Vmn2r19	UTSW	6	123335836	missense	probably damaging	1.00
R2126:Vmn2r19	UTSW	6	123316074	missense	possibly damaging	0.82
R2128:Vmn2r19	UTSW	6	123308330	splice site	probably null
R2256:Vmn2r19	UTSW	6	123329886	missense	probably benign	0.20
R2517:Vmn2r19	UTSW	6	123329978	missense	probably benign	0.19
R3753:Vmn2r19	UTSW	6	123315589	missense	possibly damaging	0.80
R3817:Vmn2r19	UTSW	6	123309642	missense	probably damaging	1.00
R3929:Vmn2r19	UTSW	6	123315628	missense	probably benign	0.01
R3934:Vmn2r19	UTSW	6	123315669	missense	probably damaging	1.00
R4232:Vmn2r19	UTSW	6	123329912	missense	probably benign
R4574:Vmn2r19	UTSW	6	123315980	missense	probably benign	0.01
R4886:Vmn2r19	UTSW	6	123309841	missense	probably benign	0.05
R4995:Vmn2r19	UTSW	6	123329910	missense	probably benign	0.00
R5107:Vmn2r19	UTSW	6	123309643	nonsense	probably null
R5232:Vmn2r19	UTSW	6	123335957	missense	probably benign
R6102:Vmn2r19	UTSW	6	123329948	missense	probably damaging	1.00
R6105:Vmn2r19	UTSW	6	123316095	missense	possibly damaging	0.70
R6280:Vmn2r19	UTSW	6	123336253	missense	probably benign
R6393:Vmn2r19	UTSW	6	123316153	missense	possibly damaging	0.80
R6502:Vmn2r19	UTSW	6	123316108	missense	possibly damaging	0.68
R6617:Vmn2r19	UTSW	6	123336535	makesense	probably null
R6742:Vmn2r19	UTSW	6	123329958	missense	possibly damaging	0.90
R7662:Vmn2r19	UTSW	6	123331562	missense	probably benign	0.33
R8041:Vmn2r19	UTSW	6	123335791	missense	possibly damaging	0.94
R8054:Vmn2r19	UTSW	6	123316039	missense	probably damaging	1.00
R8074:Vmn2r19	UTSW	6	123335945	missense	probably damaging	0.96
R8267:Vmn2r19	UTSW	6	123336262	missense	possibly damaging	0.50
R8287:Vmn2r19	UTSW	6	123331629	missense	probably damaging	1.00
R8937:Vmn2r19	UTSW	6	123316324	critical splice donor site	probably null
R9058:Vmn2r19	UTSW	6	123336062	missense	possibly damaging	0.53
R9119:Vmn2r19	UTSW	6	123315568	missense	possibly damaging	0.68
R9384:Vmn2r19	UTSW	6	123315964	missense	probably benign	0.00
X0058:Vmn2r19	UTSW	6	123308349	missense	probably benign	0.00
Z1088:Vmn2r19	UTSW	6	123308339	missense	probably benign	0.02
Z1177:Vmn2r19	UTSW	6	123336077	missense	possibly damaging	0.89

Posted On

2015-04-16