Incidental Mutation 'IGL02442:Vmn2r19'
| ID |
293458 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn2r19
|
| Ensembl Gene |
ENSMUSG00000091260 |
| Gene Name |
vomeronasal 2, receptor 19 |
| Synonyms |
EG232358 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.074)
|
| Stock # |
IGL02442
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
6 |
| Chromosomal Location |
123308333-123336537 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 123309662 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Phenylalanine
at position 85
(V85F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000073604
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000073948]
|
| AlphaFold |
G5E8G4 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000073948
AA Change: V85F
PolyPhen 2
Score 0.937 (Sensitivity: 0.80; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000073604
Gene: ENSMUSG00000091260
AA Change: V85F
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
17 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
81 |
476 |
2.9e-35 |
PFAM |
|
Pfam:NCD3G
|
518 |
571 |
8.3e-23 |
PFAM |
|
Pfam:7tm_3
|
603 |
839 |
7.2e-52 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 42 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700006E09Rik |
T |
C |
11: 101,990,826 (GRCm38) |
V116A |
probably benign |
Het |
| Adap2 |
A |
G |
11: 80,177,206 (GRCm38) |
E348G |
probably damaging |
Het |
| Ahnak |
G |
A |
19: 9,004,016 (GRCm38) |
G888D |
probably damaging |
Het |
| Cdc45 |
C |
T |
16: 18,798,729 (GRCm38) |
M200I |
probably benign |
Het |
| Csde1 |
T |
C |
3: 103,054,819 (GRCm38) |
C649R |
probably benign |
Het |
| Cym |
A |
C |
3: 107,214,285 (GRCm38) |
D230E |
probably damaging |
Het |
| Dnah1 |
A |
T |
14: 31,287,878 (GRCm38) |
I1911N |
probably damaging |
Het |
| Fam60a |
A |
T |
6: 148,928,507 (GRCm38) |
|
probably null |
Het |
| Fat1 |
A |
G |
8: 44,950,323 (GRCm38) |
H37R |
probably benign |
Het |
| Ggt6 |
T |
C |
11: 72,436,806 (GRCm38) |
V146A |
possibly damaging |
Het |
| Glud1 |
T |
A |
14: 34,335,438 (GRCm38) |
L54* |
probably null |
Het |
| Grk6 |
A |
G |
13: 55,458,937 (GRCm38) |
|
probably benign |
Het |
| Gsta4 |
G |
A |
9: 78,209,165 (GRCm38) |
V219I |
probably benign |
Het |
| Gucy1a2 |
G |
A |
9: 3,865,385 (GRCm38) |
V620M |
probably damaging |
Het |
| Hspe1 |
T |
C |
1: 55,089,042 (GRCm38) |
|
probably benign |
Het |
| Icmt |
T |
C |
4: 152,298,716 (GRCm38) |
V76A |
possibly damaging |
Het |
| Ifrd1 |
A |
G |
12: 40,216,317 (GRCm38) |
|
probably benign |
Het |
| Lgals12 |
T |
C |
19: 7,606,654 (GRCm38) |
|
probably benign |
Het |
| Lypla1 |
T |
C |
1: 4,832,387 (GRCm38) |
|
probably benign |
Het |
| Map1b |
A |
T |
13: 99,508,198 (GRCm38) |
W66R |
probably damaging |
Het |
| Matn3 |
T |
A |
12: 8,967,678 (GRCm38) |
C443* |
probably null |
Het |
| Mup8 |
T |
A |
4: 60,219,695 (GRCm38) |
R191W |
probably damaging |
Het |
| Mycbp2 |
T |
C |
14: 103,314,375 (GRCm38) |
K140R |
probably benign |
Het |
| Ndfip1 |
C |
T |
18: 38,447,736 (GRCm38) |
S66L |
probably damaging |
Het |
| Neu1 |
A |
G |
17: 34,934,469 (GRCm38) |
I323V |
probably benign |
Het |
| Nup205 |
A |
T |
6: 35,190,068 (GRCm38) |
T341S |
probably benign |
Het |
| Olfr1303 |
G |
A |
2: 111,813,991 (GRCm38) |
T245I |
probably benign |
Het |
| Olfr1466 |
T |
A |
19: 13,342,120 (GRCm38) |
C121S |
probably benign |
Het |
| Olfr1469 |
T |
A |
19: 13,410,987 (GRCm38) |
N139K |
probably benign |
Het |
| Ovch2 |
T |
A |
7: 107,796,548 (GRCm38) |
I88F |
possibly damaging |
Het |
| Pkd1 |
T |
A |
17: 24,565,226 (GRCm38) |
S249T |
probably benign |
Het |
| Plekhg3 |
A |
T |
12: 76,578,353 (GRCm38) |
Q1324L |
probably benign |
Het |
| Ppara |
T |
A |
15: 85,801,143 (GRCm38) |
V431E |
probably benign |
Het |
| Prkaa1 |
T |
G |
15: 5,176,888 (GRCm38) |
H408Q |
probably damaging |
Het |
| Sap25 |
T |
A |
5: 137,641,995 (GRCm38) |
N108K |
probably benign |
Het |
| Setd5 |
A |
C |
6: 113,110,380 (GRCm38) |
I81L |
possibly damaging |
Het |
| Sri |
T |
A |
5: 8,062,411 (GRCm38) |
M78K |
probably damaging |
Het |
| Tyro3 |
A |
G |
2: 119,808,868 (GRCm38) |
N352S |
probably benign |
Het |
| Ubr5 |
T |
A |
15: 38,037,901 (GRCm38) |
E332V |
possibly damaging |
Het |
| Vmn2r53 |
A |
T |
7: 12,581,729 (GRCm38) |
V721D |
probably damaging |
Het |
| Vwa5a |
A |
G |
9: 38,734,784 (GRCm38) |
M483V |
probably benign |
Het |
| Zfp786 |
T |
A |
6: 47,821,367 (GRCm38) |
Q212H |
probably benign |
Het |
|
| Other mutations in Vmn2r19 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01407:Vmn2r19
|
APN |
6 |
123,329,867 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
IGL02294:Vmn2r19
|
APN |
6 |
123,329,978 (GRCm38) |
missense |
probably benign |
0.19 |
|
IGL02871:Vmn2r19
|
APN |
6 |
123,336,083 (GRCm38) |
missense |
probably damaging |
1.00 |
|
H8562:Vmn2r19
|
UTSW |
6 |
123,315,902 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R0025:Vmn2r19
|
UTSW |
6 |
123,331,547 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0389:Vmn2r19
|
UTSW |
6 |
123,335,986 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
R0402:Vmn2r19
|
UTSW |
6 |
123,336,182 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0411:Vmn2r19
|
UTSW |
6 |
123,309,744 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R0554:Vmn2r19
|
UTSW |
6 |
123,336,143 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0578:Vmn2r19
|
UTSW |
6 |
123,335,972 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1102:Vmn2r19
|
UTSW |
6 |
123,336,173 (GRCm38) |
missense |
probably benign |
0.28 |
|
R1652:Vmn2r19
|
UTSW |
6 |
123,315,697 (GRCm38) |
missense |
possibly damaging |
0.68 |
|
R1663:Vmn2r19
|
UTSW |
6 |
123,336,452 (GRCm38) |
missense |
probably benign |
0.11 |
|
R1817:Vmn2r19
|
UTSW |
6 |
123,330,052 (GRCm38) |
missense |
possibly damaging |
0.80 |
|
R1866:Vmn2r19
|
UTSW |
6 |
123,331,638 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1928:Vmn2r19
|
UTSW |
6 |
123,331,630 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1997:Vmn2r19
|
UTSW |
6 |
123,315,921 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R2013:Vmn2r19
|
UTSW |
6 |
123,315,995 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2015:Vmn2r19
|
UTSW |
6 |
123,315,995 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2088:Vmn2r19
|
UTSW |
6 |
123,335,836 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2126:Vmn2r19
|
UTSW |
6 |
123,316,074 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R2128:Vmn2r19
|
UTSW |
6 |
123,308,330 (GRCm38) |
splice site |
probably null |
|
|
R2256:Vmn2r19
|
UTSW |
6 |
123,329,886 (GRCm38) |
missense |
probably benign |
0.20 |
|
R2517:Vmn2r19
|
UTSW |
6 |
123,329,978 (GRCm38) |
missense |
probably benign |
0.19 |
|
R3753:Vmn2r19
|
UTSW |
6 |
123,315,589 (GRCm38) |
missense |
possibly damaging |
0.80 |
|
R3817:Vmn2r19
|
UTSW |
6 |
123,309,642 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3929:Vmn2r19
|
UTSW |
6 |
123,315,628 (GRCm38) |
missense |
probably benign |
0.01 |
|
R3934:Vmn2r19
|
UTSW |
6 |
123,315,669 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4232:Vmn2r19
|
UTSW |
6 |
123,329,912 (GRCm38) |
missense |
probably benign |
|
|
R4574:Vmn2r19
|
UTSW |
6 |
123,315,980 (GRCm38) |
missense |
probably benign |
0.01 |
|
R4886:Vmn2r19
|
UTSW |
6 |
123,309,841 (GRCm38) |
missense |
probably benign |
0.05 |
|
R4995:Vmn2r19
|
UTSW |
6 |
123,329,910 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5107:Vmn2r19
|
UTSW |
6 |
123,309,643 (GRCm38) |
nonsense |
probably null |
|
|
R5232:Vmn2r19
|
UTSW |
6 |
123,335,957 (GRCm38) |
missense |
probably benign |
|
|
R6102:Vmn2r19
|
UTSW |
6 |
123,329,948 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6105:Vmn2r19
|
UTSW |
6 |
123,316,095 (GRCm38) |
missense |
possibly damaging |
0.70 |
|
R6280:Vmn2r19
|
UTSW |
6 |
123,336,253 (GRCm38) |
missense |
probably benign |
|
|
R6393:Vmn2r19
|
UTSW |
6 |
123,316,153 (GRCm38) |
missense |
possibly damaging |
0.80 |
|
R6502:Vmn2r19
|
UTSW |
6 |
123,316,108 (GRCm38) |
missense |
possibly damaging |
0.68 |
|
R6617:Vmn2r19
|
UTSW |
6 |
123,336,535 (GRCm38) |
makesense |
probably null |
|
|
R6742:Vmn2r19
|
UTSW |
6 |
123,329,958 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R7662:Vmn2r19
|
UTSW |
6 |
123,331,562 (GRCm38) |
missense |
probably benign |
0.33 |
|
R8041:Vmn2r19
|
UTSW |
6 |
123,335,791 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R8054:Vmn2r19
|
UTSW |
6 |
123,316,039 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8074:Vmn2r19
|
UTSW |
6 |
123,335,945 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R8267:Vmn2r19
|
UTSW |
6 |
123,336,262 (GRCm38) |
missense |
possibly damaging |
0.50 |
|
R8287:Vmn2r19
|
UTSW |
6 |
123,331,629 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8937:Vmn2r19
|
UTSW |
6 |
123,316,324 (GRCm38) |
critical splice donor site |
probably null |
|
|
R9058:Vmn2r19
|
UTSW |
6 |
123,336,062 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
R9119:Vmn2r19
|
UTSW |
6 |
123,315,568 (GRCm38) |
missense |
possibly damaging |
0.68 |
|
R9384:Vmn2r19
|
UTSW |
6 |
123,315,964 (GRCm38) |
missense |
probably benign |
0.00 |
|
X0058:Vmn2r19
|
UTSW |
6 |
123,308,349 (GRCm38) |
missense |
probably benign |
0.00 |
|
Z1088:Vmn2r19
|
UTSW |
6 |
123,308,339 (GRCm38) |
missense |
probably benign |
0.02 |
|
Z1177:Vmn2r19
|
UTSW |
6 |
123,336,077 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
| Posted On |
2015-04-16 |
Incidental Mutation