Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00974:Vmn2r102'

29346

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r102

Ensembl Gene

ENSMUSG00000095961

Gene Name

vomeronasal 2, receptor 102

Synonyms

EG224572

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL00974

Quality Score

Status

Chromosome

Chromosomal Location

19660399-19694748 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 19677509 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tryptophan to Leucine at position 262 (W262L)

Ref Sequence

ENSEMBL: ENSMUSP00000126559 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000171741]

AlphaFold

L7N279

Predicted Effect

possibly damaging
Transcript: ENSMUST00000171741
AA Change: W262L

PolyPhen 2 Score 0.930 (Sensitivity: 0.81; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000126559
Gene: ENSMUSG00000095961
AA Change: W262L

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	448	5.2e-38	PFAM
Pfam:NCD3G	509	562	1.1e-21	PFAM
Pfam:7tm_3	595	830	1.8e-53	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 21 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Brwd1	T	A	16: 96,043,026	K776M	probably damaging	Het
Crisp4	T	C	1: 18,128,647	T188A	probably damaging	Het
E130311K13Rik	T	A	3: 63,920,363		probably null	Het
Fyb	A	G	15: 6,642,585		probably benign	Het
Gcn1l1	G	A	5: 115,613,793	V2076M	possibly damaging	Het
Grik5	A	T	7: 25,013,885	I766N	probably damaging	Het
Grk3	A	G	5: 112,985,819	Y46H	probably damaging	Het
Gtf2a1l	A	G	17: 88,714,949	D456G	probably damaging	Het
Kcna10	A	G	3: 107,195,331	D426G	probably damaging	Het
Luzp2	A	T	7: 55,075,026	I112F	probably damaging	Het
Med12l	G	T	3: 59,083,014	R519M	probably damaging	Het
Mrpl39	G	A	16: 84,723,852	P300S	probably damaging	Het
Polr3a	A	T	14: 24,479,424	I328N	probably benign	Het
Slc22a8	A	G	19: 8,609,926	N450S	probably damaging	Het
Slc38a4	T	C	15: 96,999,516	T473A	probably benign	Het
Slc4a7	C	T	14: 14,760,292	P576S	probably benign	Het
Tecta	A	G	9: 42,331,374	I2057T	probably benign	Het
Tnks1bp1	C	T	2: 85,062,882	T389I	possibly damaging	Het
Tnxb	T	C	17: 34,718,733		probably null	Het
Tsc22d1	A	G	14: 76,506,442	Y10C	probably damaging	Het
Vmn1r34	T	C	6: 66,637,655	H33R	possibly damaging	Het

Other mutations in Vmn2r102

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00944:Vmn2r102	APN	17	19678892	missense	probably damaging	1.00
IGL00978:Vmn2r102	APN	17	19678923	splice site	probably null
IGL01589:Vmn2r102	APN	17	19678804	missense	probably benign
IGL01738:Vmn2r102	APN	17	19677758	missense	probably damaging	1.00
IGL01994:Vmn2r102	APN	17	19660469	missense	probably benign	0.00
IGL02066:Vmn2r102	APN	17	19693929	missense	probably benign	0.01
IGL02525:Vmn2r102	APN	17	19681185	missense	probably benign
IGL02589:Vmn2r102	APN	17	19681218	missense	probably damaging	1.00
IGL02814:Vmn2r102	APN	17	19677908	missense	probably damaging	1.00
IGL03028:Vmn2r102	APN	17	19694066	missense	possibly damaging	0.92
IGL03162:Vmn2r102	APN	17	19694024	missense	probably damaging	1.00
PIT4431001:Vmn2r102	UTSW	17	19676696	missense	possibly damaging	0.68
R0042:Vmn2r102	UTSW	17	19660589	missense	probably damaging	0.98
R0131:Vmn2r102	UTSW	17	19678763	missense	probably benign	0.42
R0131:Vmn2r102	UTSW	17	19678763	missense	probably benign	0.42
R0132:Vmn2r102	UTSW	17	19678763	missense	probably benign	0.42
R0268:Vmn2r102	UTSW	17	19677850	missense	probably benign	0.00
R0441:Vmn2r102	UTSW	17	19694368	missense	probably damaging	1.00
R0583:Vmn2r102	UTSW	17	19676781	missense	probably benign	0.01
R0600:Vmn2r102	UTSW	17	19678015	missense	probably benign	0.00
R0606:Vmn2r102	UTSW	17	19678844	missense	possibly damaging	0.93
R0674:Vmn2r102	UTSW	17	19677867	missense	probably benign	0.00
R0709:Vmn2r102	UTSW	17	19677619	missense	probably benign	0.01
R0879:Vmn2r102	UTSW	17	19694192	missense	probably damaging	1.00
R1349:Vmn2r102	UTSW	17	19660625	splice site	probably benign
R1473:Vmn2r102	UTSW	17	19694581	missense	probably benign	0.00
R1630:Vmn2r102	UTSW	17	19678770	missense	possibly damaging	0.60
R1727:Vmn2r102	UTSW	17	19677508	missense	probably damaging	0.99
R1759:Vmn2r102	UTSW	17	19694493	missense	probably damaging	1.00
R1809:Vmn2r102	UTSW	17	19677619	missense	probably benign	0.01
R2013:Vmn2r102	UTSW	17	19676744	missense	probably benign	0.03
R2086:Vmn2r102	UTSW	17	19676687	missense	probably damaging	1.00
R2241:Vmn2r102	UTSW	17	19676741	missense	probably benign	0.00
R2378:Vmn2r102	UTSW	17	19694668	missense	probably damaging	1.00
R3814:Vmn2r102	UTSW	17	19678831	missense	probably damaging	0.98
R3827:Vmn2r102	UTSW	17	19694525	missense	probably damaging	1.00
R4159:Vmn2r102	UTSW	17	19677826	missense	probably damaging	1.00
R4505:Vmn2r102	UTSW	17	19660583	missense	probably benign	0.00
R4515:Vmn2r102	UTSW	17	19681213	missense	probably damaging	1.00
R4517:Vmn2r102	UTSW	17	19681213	missense	probably damaging	1.00
R4534:Vmn2r102	UTSW	17	19694713	missense	probably benign
R4535:Vmn2r102	UTSW	17	19694713	missense	probably benign
R4662:Vmn2r102	UTSW	17	19681162	missense	probably damaging	1.00
R4708:Vmn2r102	UTSW	17	19694314	missense	probably benign	0.00
R4734:Vmn2r102	UTSW	17	19677533	missense	probably damaging	1.00
R4834:Vmn2r102	UTSW	17	19677941	missense	probably damaging	0.99
R4927:Vmn2r102	UTSW	17	19660399	start codon destroyed	probably benign	0.00
R5077:Vmn2r102	UTSW	17	19677572	missense	probably benign	0.20
R5181:Vmn2r102	UTSW	17	19676741	missense	probably benign	0.00
R5277:Vmn2r102	UTSW	17	19694131	missense	possibly damaging	0.49
R5418:Vmn2r102	UTSW	17	19694153	missense	probably damaging	1.00
R5810:Vmn2r102	UTSW	17	19677542	missense	probably benign	0.20
R5864:Vmn2r102	UTSW	17	19694681	missense	possibly damaging	0.55
R6168:Vmn2r102	UTSW	17	19694140	missense	possibly damaging	0.83
R6266:Vmn2r102	UTSW	17	19678745	missense	probably benign
R6432:Vmn2r102	UTSW	17	19681221	missense	possibly damaging	0.61
R6487:Vmn2r102	UTSW	17	19677907	missense	probably damaging	1.00
R6597:Vmn2r102	UTSW	17	19694188	missense	probably damaging	0.99
R6797:Vmn2r102	UTSW	17	19660432	nonsense	probably null
R7009:Vmn2r102	UTSW	17	19694194	missense	probably damaging	0.99
R7098:Vmn2r102	UTSW	17	19694408	missense	probably damaging	1.00
R7134:Vmn2r102	UTSW	17	19677487	missense	probably benign	0.01
R7463:Vmn2r102	UTSW	17	19676624	missense	probably damaging	1.00
R7511:Vmn2r102	UTSW	17	19681143	missense	probably damaging	1.00
R7512:Vmn2r102	UTSW	17	19694101	missense	probably damaging	1.00
R7556:Vmn2r102	UTSW	17	19677831	missense	probably benign
R8126:Vmn2r102	UTSW	17	19660450	missense	probably benign	0.02
R8385:Vmn2r102	UTSW	17	19693826	missense	possibly damaging	0.89
R8410:Vmn2r102	UTSW	17	19677934	missense	possibly damaging	0.85
R9045:Vmn2r102	UTSW	17	19660579	missense	probably benign	0.00
R9267:Vmn2r102	UTSW	17	19676666	missense	probably damaging	1.00
R9325:Vmn2r102	UTSW	17	19677296	missense	probably damaging	1.00
R9363:Vmn2r102	UTSW	17	19677352	missense	probably benign	0.04
R9524:Vmn2r102	UTSW	17	19677302	missense	possibly damaging	0.74
R9747:Vmn2r102	UTSW	17	19677867	missense	probably benign	0.00
Z1176:Vmn2r102	UTSW	17	19694043	nonsense	probably null

Posted On

2013-04-17