Incidental Mutation 'IGL02442:Olfr1303'
ID293462
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1303
Ensembl Gene ENSMUSG00000093804
Gene Nameolfactory receptor 1303
SynonymsMOR245-7, MOR245-7, Olfr276, GA_x6K02T2N82Q-3465-3764, GA_x6K02T2Q125-72882187-72881249, MOR245-28_p
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.118) question?
Stock #IGL02442
Quality Score
Status
Chromosome2
Chromosomal Location111812247-111820340 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 111813991 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Isoleucine at position 245 (T245I)
Ref Sequence ENSEMBL: ENSMUSP00000149015 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099609] [ENSMUST00000216114]
Predicted Effect probably benign
Transcript: ENSMUST00000099609
AA Change: T245I

PolyPhen 2 Score 0.256 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000097204
Gene: ENSMUSG00000093804
AA Change: T245I

DomainStartEndE-ValueType
Pfam:7tm_4 31 305 2.3e-43 PFAM
Pfam:7TM_GPCR_Srsx 35 302 2.5e-6 PFAM
Pfam:7tm_1 41 287 2.4e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216114
AA Change: T245I

PolyPhen 2 Score 0.256 (Sensitivity: 0.91; Specificity: 0.88)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700006E09Rik T C 11: 101,990,826 V116A probably benign Het
Adap2 A G 11: 80,177,206 E348G probably damaging Het
Ahnak G A 19: 9,004,016 G888D probably damaging Het
Cdc45 C T 16: 18,798,729 M200I probably benign Het
Csde1 T C 3: 103,054,819 C649R probably benign Het
Cym A C 3: 107,214,285 D230E probably damaging Het
Dnah1 A T 14: 31,287,878 I1911N probably damaging Het
Fam60a A T 6: 148,928,507 probably null Het
Fat1 A G 8: 44,950,323 H37R probably benign Het
Ggt6 T C 11: 72,436,806 V146A possibly damaging Het
Glud1 T A 14: 34,335,438 L54* probably null Het
Grk6 A G 13: 55,458,937 probably benign Het
Gsta4 G A 9: 78,209,165 V219I probably benign Het
Gucy1a2 G A 9: 3,865,385 V620M probably damaging Het
Hspe1 T C 1: 55,089,042 probably benign Het
Icmt T C 4: 152,298,716 V76A possibly damaging Het
Ifrd1 A G 12: 40,216,317 probably benign Het
Lgals12 T C 19: 7,606,654 probably benign Het
Lypla1 T C 1: 4,832,387 probably benign Het
Map1b A T 13: 99,508,198 W66R probably damaging Het
Matn3 T A 12: 8,967,678 C443* probably null Het
Mup8 T A 4: 60,219,695 R191W probably damaging Het
Mycbp2 T C 14: 103,314,375 K140R probably benign Het
Ndfip1 C T 18: 38,447,736 S66L probably damaging Het
Neu1 A G 17: 34,934,469 I323V probably benign Het
Nup205 A T 6: 35,190,068 T341S probably benign Het
Olfr1466 T A 19: 13,342,120 C121S probably benign Het
Olfr1469 T A 19: 13,410,987 N139K probably benign Het
Ovch2 T A 7: 107,796,548 I88F possibly damaging Het
Pkd1 T A 17: 24,565,226 S249T probably benign Het
Plekhg3 A T 12: 76,578,353 Q1324L probably benign Het
Ppara T A 15: 85,801,143 V431E probably benign Het
Prkaa1 T G 15: 5,176,888 H408Q probably damaging Het
Sap25 T A 5: 137,641,995 N108K probably benign Het
Setd5 A C 6: 113,110,380 I81L possibly damaging Het
Sri T A 5: 8,062,411 M78K probably damaging Het
Tyro3 A G 2: 119,808,868 N352S probably benign Het
Ubr5 T A 15: 38,037,901 E332V possibly damaging Het
Vmn2r19 G T 6: 123,309,662 V85F possibly damaging Het
Vmn2r53 A T 7: 12,581,729 V721D probably damaging Het
Vwa5a A G 9: 38,734,784 M483V probably benign Het
Zfp786 T A 6: 47,821,367 Q212H probably benign Het
Other mutations in Olfr1303
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00163:Olfr1303 APN 2 111813781 utr 3 prime probably benign
IGL02563:Olfr1303 APN 2 111813817 missense probably benign
IGL03064:Olfr1303 APN 2 111814423 missense possibly damaging 0.86
R0081:Olfr1303 UTSW 2 111813868 missense probably damaging 1.00
R0139:Olfr1303 UTSW 2 111814354 missense possibly damaging 0.54
R0624:Olfr1303 UTSW 2 111814711 missense probably damaging 1.00
R0926:Olfr1303 UTSW 2 111814547 missense probably damaging 1.00
R1436:Olfr1303 UTSW 2 111814561 missense probably damaging 1.00
R2099:Olfr1303 UTSW 2 111813832 missense probably benign 0.18
R5255:Olfr1303 UTSW 2 111814178 missense probably benign 0.02
R6034:Olfr1303 UTSW 2 111814357 missense probably damaging 1.00
R6034:Olfr1303 UTSW 2 111814357 missense probably damaging 1.00
R6101:Olfr1303 UTSW 2 111814253 missense probably benign 0.00
R6385:Olfr1303 UTSW 2 111814619 missense probably benign
R6489:Olfr1303 UTSW 2 111814060 missense probably damaging 1.00
R6978:Olfr1303 UTSW 2 111813810 missense probably benign 0.03
R7410:Olfr1303 UTSW 2 111813926 missense probably benign 0.00
R8507:Olfr1303 UTSW 2 111814706 missense probably benign 0.23
Z1176:Olfr1303 UTSW 2 111814034 missense probably benign 0.22
Posted On2015-04-16