Incidental Mutation 'IGL02442:Lypla1'
ID 293483
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lypla1
Ensembl Gene ENSMUSG00000025903
Gene Name lysophospholipase 1
Synonyms Pla1a
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02442
Quality Score
Chromosome 1
Chromosomal Location 4807788-4848410 bp(+) (GRCm38)
Type of Mutation splice site
DNA Base Change (assembly) T to C at 4832387 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000136108 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027036] [ENSMUST00000115529] [ENSMUST00000119612] [ENSMUST00000131119] [ENSMUST00000134384] [ENSMUST00000137887] [ENSMUST00000150971] [ENSMUST00000155020]
AlphaFold P97823
Predicted Effect probably benign
Transcript: ENSMUST00000027036
SMART Domains Protein: ENSMUSP00000027036
Gene: ENSMUSG00000025903

Pfam:Abhydrolase_2 8 226 2.5e-92 PFAM
Pfam:Abhydrolase_5 23 209 4.3e-14 PFAM
Pfam:Abhydrolase_3 82 170 2.6e-7 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000115529
SMART Domains Protein: ENSMUSP00000111191
Gene: ENSMUSG00000025903

Pfam:Abhydrolase_2 8 125 1.5e-49 PFAM
Pfam:Abhydrolase_2 122 192 2.2e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000119612
SMART Domains Protein: ENSMUSP00000137647
Gene: ENSMUSG00000025903

Pfam:Abhydrolase_2 8 92 1.1e-33 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000131119
SMART Domains Protein: ENSMUSP00000118453
Gene: ENSMUSG00000025903

Pfam:Abhydrolase_2 1 142 8.1e-56 PFAM
Pfam:Abhydrolase_5 10 141 7.8e-11 PFAM
Pfam:Abhydrolase_6 11 139 9.2e-8 PFAM
Pfam:Abhydrolase_3 20 139 4e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000134384
SMART Domains Protein: ENSMUSP00000137104
Gene: ENSMUSG00000025903

Pfam:Abhydrolase_2 8 224 5.6e-85 PFAM
Pfam:Abhydrolase_5 23 209 4e-14 PFAM
Pfam:Abhydrolase_6 24 160 2.5e-10 PFAM
Pfam:Abhydrolase_3 85 195 2.4e-7 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000137887
SMART Domains Protein: ENSMUSP00000119456
Gene: ENSMUSG00000025903

Pfam:Abhydrolase_2 8 142 5.6e-48 PFAM
Pfam:Abhydrolase_5 23 141 9.3e-10 PFAM
Pfam:Abhydrolase_6 24 141 7.2e-12 PFAM
Pfam:Abhydrolase_3 62 140 2.1e-7 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141278
Predicted Effect probably benign
Transcript: ENSMUST00000150971
SMART Domains Protein: ENSMUSP00000137248
Gene: ENSMUSG00000025903

Pfam:Abhydrolase_2 8 215 1.3e-84 PFAM
Pfam:Abhydrolase_5 23 209 4.4e-14 PFAM
Pfam:Abhydrolase_6 24 160 3.6e-10 PFAM
Pfam:Abhydrolase_3 85 195 1.1e-7 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000155020
SMART Domains Protein: ENSMUSP00000136108
Gene: ENSMUSG00000104217

low complexity region 8 24 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the alpha/beta hydrolase superfamily. The encoded protein functions as a homodimer, exhibiting both depalmitoylating as well as lysophospholipase activity, and may be involved in Ras localization and signaling. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 4, 6, and 7. [provided by RefSeq, Jul 2013]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700006E09Rik T C 11: 101,990,826 V116A probably benign Het
Adap2 A G 11: 80,177,206 E348G probably damaging Het
Ahnak G A 19: 9,004,016 G888D probably damaging Het
Cdc45 C T 16: 18,798,729 M200I probably benign Het
Csde1 T C 3: 103,054,819 C649R probably benign Het
Cym A C 3: 107,214,285 D230E probably damaging Het
Dnah1 A T 14: 31,287,878 I1911N probably damaging Het
Fam60a A T 6: 148,928,507 probably null Het
Fat1 A G 8: 44,950,323 H37R probably benign Het
Ggt6 T C 11: 72,436,806 V146A possibly damaging Het
Glud1 T A 14: 34,335,438 L54* probably null Het
Grk6 A G 13: 55,458,937 probably benign Het
Gsta4 G A 9: 78,209,165 V219I probably benign Het
Gucy1a2 G A 9: 3,865,385 V620M probably damaging Het
Hspe1 T C 1: 55,089,042 probably benign Het
Icmt T C 4: 152,298,716 V76A possibly damaging Het
Ifrd1 A G 12: 40,216,317 probably benign Het
Lgals12 T C 19: 7,606,654 probably benign Het
Map1b A T 13: 99,508,198 W66R probably damaging Het
Matn3 T A 12: 8,967,678 C443* probably null Het
Mup8 T A 4: 60,219,695 R191W probably damaging Het
Mycbp2 T C 14: 103,314,375 K140R probably benign Het
Ndfip1 C T 18: 38,447,736 S66L probably damaging Het
Neu1 A G 17: 34,934,469 I323V probably benign Het
Nup205 A T 6: 35,190,068 T341S probably benign Het
Olfr1303 G A 2: 111,813,991 T245I probably benign Het
Olfr1466 T A 19: 13,342,120 C121S probably benign Het
Olfr1469 T A 19: 13,410,987 N139K probably benign Het
Ovch2 T A 7: 107,796,548 I88F possibly damaging Het
Pkd1 T A 17: 24,565,226 S249T probably benign Het
Plekhg3 A T 12: 76,578,353 Q1324L probably benign Het
Ppara T A 15: 85,801,143 V431E probably benign Het
Prkaa1 T G 15: 5,176,888 H408Q probably damaging Het
Sap25 T A 5: 137,641,995 N108K probably benign Het
Setd5 A C 6: 113,110,380 I81L possibly damaging Het
Sri T A 5: 8,062,411 M78K probably damaging Het
Tyro3 A G 2: 119,808,868 N352S probably benign Het
Ubr5 T A 15: 38,037,901 E332V possibly damaging Het
Vmn2r19 G T 6: 123,309,662 V85F possibly damaging Het
Vmn2r53 A T 7: 12,581,729 V721D probably damaging Het
Vwa5a A G 9: 38,734,784 M483V probably benign Het
Zfp786 T A 6: 47,821,367 Q212H probably benign Het
Other mutations in Lypla1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00501:Lypla1 APN 1 4828587 missense probably damaging 1.00
IGL01571:Lypla1 APN 1 4844988 missense probably benign 0.15
IGL01592:Lypla1 APN 1 4828651 critical splice donor site probably null
IGL01865:Lypla1 APN 1 4837036 missense probably damaging 0.96
IGL03005:Lypla1 APN 1 4832390 splice site probably benign
R0095:Lypla1 UTSW 1 4830327 splice site probably benign
R2278:Lypla1 UTSW 1 4841098 splice site probably null
R3766:Lypla1 UTSW 1 4840978 missense probably benign 0.04
R5805:Lypla1 UTSW 1 4830294 missense possibly damaging 0.54
R6014:Lypla1 UTSW 1 4808371 splice site probably null
R6027:Lypla1 UTSW 1 4837076 critical splice donor site probably null
R6842:Lypla1 UTSW 1 4832340 missense probably benign 0.14
R7285:Lypla1 UTSW 1 4841098 missense probably benign
R7564:Lypla1 UTSW 1 4808367 critical splice donor site probably null
R9105:Lypla1 UTSW 1 4841059 missense probably damaging 1.00
R9496:Lypla1 UTSW 1 4828590 start gained probably benign
R9582:Lypla1 UTSW 1 4841025 missense probably benign 0.43
Posted On 2015-04-16