Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00976:Vmn2r118'

29350

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r118

Ensembl Gene

ENSMUSG00000091504

Gene Name

vomeronasal 2, receptor 118

Synonyms

EG383258, Vmn2r119, EG668547

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.125) question?

Stock #

IGL00976

Quality Score

Status

Chromosome

Chromosomal Location

55592341-55624672 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 55593204 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Tyrosine at position 567 (N567Y)

Ref Sequence

ENSEMBL: ENSMUSP00000131128 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168440]

AlphaFold

E9Q1C1

Predicted Effect

probably damaging
Transcript: ENSMUST00000168440
AA Change: N567Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000131128
Gene: ENSMUSG00000091504
AA Change: N567Y

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	142	470	4.6e-27	PFAM
Pfam:NCD3G	513	566	2.6e-20	PFAM
Pfam:7tm_3	599	834	5.9e-55	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930519F16Rik	A	G	X: 103,183,262 (GRCm38)		probably benign	Het
Aldob	C	A	4: 49,541,220 (GRCm38)	V151L	probably damaging	Het
Cacna1i	G	A	15: 80,355,645 (GRCm38)	M298I	probably benign	Het
Capn3	A	G	2: 120,491,901 (GRCm38)	N414S	possibly damaging	Het
Ccdc186	G	A	19: 56,797,500 (GRCm38)	T701M	probably damaging	Het
Ccdc190	A	T	1: 169,933,740 (GRCm38)	H137L	probably benign	Het
Clhc1	G	A	11: 29,561,389 (GRCm38)	D278N	probably benign	Het
Cntnap3	T	C	13: 64,794,352 (GRCm38)	Y188C	probably damaging	Het
Dnah1	A	C	14: 31,278,138 (GRCm38)	V2466G	probably damaging	Het
Dnah8	A	G	17: 30,851,710 (GRCm38)	T4457A	probably damaging	Het
Gm13078	T	A	4: 143,727,015 (GRCm38)	M231K	probably damaging	Het
Hectd4	A	G	5: 121,349,106 (GRCm38)	Q3388R	probably benign	Het
Hecw1	T	A	13: 14,318,972 (GRCm38)	D316V	probably damaging	Het
Il1rap	T	C	16: 26,698,839 (GRCm38)	V263A	probably benign	Het
Il6	G	A	5: 30,014,841 (GRCm38)	G72S	probably benign	Het
Katnal2	T	C	18: 77,017,493 (GRCm38)	Y86C	probably damaging	Het
Kdm7a	G	T	6: 39,144,398 (GRCm38)	S874R	possibly damaging	Het
Mybpc2	T	C	7: 44,522,317 (GRCm38)		probably null	Het
Nphs1	T	G	7: 30,460,685 (GRCm38)	S130A	possibly damaging	Het
Ntrk3	C	T	7: 78,450,953 (GRCm38)	V444I	probably benign	Het
Numbl	T	C	7: 27,268,810 (GRCm38)	V144A	possibly damaging	Het
Olfr952	T	A	9: 39,426,657 (GRCm38)	Y138F	probably benign	Het
P2rx1	T	C	11: 73,013,000 (GRCm38)		probably null	Het
Pcdhb3	G	A	18: 37,302,948 (GRCm38)	V656I	probably benign	Het
Pole	A	G	5: 110,323,572 (GRCm38)	Y1394C	probably benign	Het
Rbm47	A	G	5: 66,026,738 (GRCm38)	V174A	possibly damaging	Het
Rhox4f	T	C	X: 37,604,395 (GRCm38)		probably benign	Het
Serpina12	T	C	12: 104,032,528 (GRCm38)	Y317C	probably damaging	Het
Slc12a5	T	A	2: 164,979,304 (GRCm38)	I236N	probably damaging	Het
Slc4a4	G	A	5: 88,954,798 (GRCm38)	G32R	probably damaging	Het
Slco1a4	T	C	6: 141,807,182 (GRCm38)		probably null	Het
Sorcs3	A	T	19: 48,767,103 (GRCm38)	N894I	probably damaging	Het
Stk38l	A	G	6: 146,775,402 (GRCm38)	E393G	probably benign	Het
Synpo	A	G	18: 60,603,419 (GRCm38)	I485T	possibly damaging	Het
Tenm3	T	A	8: 48,256,841 (GRCm38)	M1687L	probably benign	Het
Ttc39c	T	C	18: 12,684,895 (GRCm38)		probably benign	Het
Unc13d	T	C	11: 116,070,467 (GRCm38)	E378G	probably damaging	Het

Other mutations in Vmn2r118

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00091:Vmn2r118	APN	17	55,592,708 (GRCm38)	missense	probably damaging	1.00
IGL01419:Vmn2r118	APN	17	55,593,000 (GRCm38)	missense	probably benign	0.01
IGL01796:Vmn2r118	APN	17	55,608,585 (GRCm38)	missense	probably benign	0.30
IGL01799:Vmn2r118	APN	17	55,592,990 (GRCm38)	missense	probably damaging	1.00
IGL02002:Vmn2r118	APN	17	55,592,619 (GRCm38)	missense	probably damaging	1.00
IGL02075:Vmn2r118	APN	17	55,610,517 (GRCm38)	missense	probably benign	0.18
IGL02172:Vmn2r118	APN	17	55,624,598 (GRCm38)	missense	probably benign	0.00
IGL02529:Vmn2r118	APN	17	55,610,870 (GRCm38)	missense	possibly damaging	0.58
IGL02712:Vmn2r118	APN	17	55,592,655 (GRCm38)	missense	probably benign	0.21
IGL03096:Vmn2r118	APN	17	55,607,996 (GRCm38)	missense	probably damaging	1.00
R0306:Vmn2r118	UTSW	17	55,608,616 (GRCm38)	missense	possibly damaging	0.89
R0329:Vmn2r118	UTSW	17	55,610,717 (GRCm38)	missense	probably damaging	1.00
R0330:Vmn2r118	UTSW	17	55,610,717 (GRCm38)	missense	probably damaging	1.00
R0396:Vmn2r118	UTSW	17	55,608,643 (GRCm38)	missense	probably benign	0.00
R0411:Vmn2r118	UTSW	17	55,611,021 (GRCm38)	splice site	probably benign
R0513:Vmn2r118	UTSW	17	55,610,970 (GRCm38)	nonsense	probably null
R0627:Vmn2r118	UTSW	17	55,610,772 (GRCm38)	missense	probably benign	0.01
R0638:Vmn2r118	UTSW	17	55,608,466 (GRCm38)	missense	probably benign	0.03
R1328:Vmn2r118	UTSW	17	55,608,620 (GRCm38)	missense	probably benign	0.01
R1366:Vmn2r118	UTSW	17	55,593,237 (GRCm38)	nonsense	probably null
R1465:Vmn2r118	UTSW	17	55,610,935 (GRCm38)	missense	probably benign	0.33
R1465:Vmn2r118	UTSW	17	55,610,935 (GRCm38)	missense	probably benign	0.33
R1511:Vmn2r118	UTSW	17	55,608,496 (GRCm38)	nonsense	probably null
R1515:Vmn2r118	UTSW	17	55,610,643 (GRCm38)	missense	probably benign	0.25
R1550:Vmn2r118	UTSW	17	55,608,083 (GRCm38)	missense	probably damaging	1.00
R1779:Vmn2r118	UTSW	17	55,611,530 (GRCm38)	missense	probably benign	0.03
R1834:Vmn2r118	UTSW	17	55,592,456 (GRCm38)	missense	probably damaging	1.00
R1840:Vmn2r118	UTSW	17	55,610,406 (GRCm38)	nonsense	probably null
R1854:Vmn2r118	UTSW	17	55,611,556 (GRCm38)	missense	possibly damaging	0.57
R1967:Vmn2r118	UTSW	17	55,592,882 (GRCm38)	missense	probably damaging	1.00
R1976:Vmn2r118	UTSW	17	55,592,925 (GRCm38)	missense	probably damaging	1.00
R2308:Vmn2r118	UTSW	17	55,624,650 (GRCm38)	missense	probably benign	0.33
R3700:Vmn2r118	UTSW	17	55,608,421 (GRCm38)	missense	possibly damaging	0.68
R4334:Vmn2r118	UTSW	17	55,610,347 (GRCm38)	missense	possibly damaging	0.58
R4647:Vmn2r118	UTSW	17	55,610,665 (GRCm38)	missense	probably damaging	1.00
R4709:Vmn2r118	UTSW	17	55,610,860 (GRCm38)	missense	probably damaging	1.00
R4805:Vmn2r118	UTSW	17	55,592,581 (GRCm38)	missense	probably damaging	1.00
R4858:Vmn2r118	UTSW	17	55,592,894 (GRCm38)	missense	probably damaging	0.98
R5384:Vmn2r118	UTSW	17	55,611,565 (GRCm38)	missense	probably benign	0.00
R5385:Vmn2r118	UTSW	17	55,611,565 (GRCm38)	missense	probably benign	0.00
R5664:Vmn2r118	UTSW	17	55,592,765 (GRCm38)	missense	possibly damaging	0.46
R5740:Vmn2r118	UTSW	17	55,593,103 (GRCm38)	missense	probably benign	0.00
R5927:Vmn2r118	UTSW	17	55,624,494 (GRCm38)	missense	probably benign	0.04
R6143:Vmn2r118	UTSW	17	55,592,871 (GRCm38)	missense	possibly damaging	0.92
R6513:Vmn2r118	UTSW	17	55,608,093 (GRCm38)	missense	probably damaging	1.00
R6573:Vmn2r118	UTSW	17	55,592,996 (GRCm38)	missense	probably damaging	1.00
R6760:Vmn2r118	UTSW	17	55,592,714 (GRCm38)	missense	possibly damaging	0.92
R6794:Vmn2r118	UTSW	17	55,592,348 (GRCm38)	missense	possibly damaging	0.48
R6929:Vmn2r118	UTSW	17	55,610,440 (GRCm38)	missense	probably benign	0.01
R7201:Vmn2r118	UTSW	17	55,608,496 (GRCm38)	nonsense	probably null
R7539:Vmn2r118	UTSW	17	55,592,853 (GRCm38)	missense	probably damaging	0.98
R7836:Vmn2r118	UTSW	17	55,593,242 (GRCm38)	missense	probably damaging	0.99
R8179:Vmn2r118	UTSW	17	55,608,484 (GRCm38)	missense	probably benign	0.36
R8248:Vmn2r118	UTSW	17	55,610,936 (GRCm38)	missense	probably benign	0.18
R8347:Vmn2r118	UTSW	17	55,610,423 (GRCm38)	missense	possibly damaging	0.94
R8415:Vmn2r118	UTSW	17	55,608,057 (GRCm38)	missense	probably benign	0.08
R8428:Vmn2r118	UTSW	17	55,608,642 (GRCm38)	missense	probably benign	0.33
R8917:Vmn2r118	UTSW	17	55,610,216 (GRCm38)	missense	possibly damaging	0.82
R8993:Vmn2r118	UTSW	17	55,610,835 (GRCm38)	missense	possibly damaging	0.72
R9038:Vmn2r118	UTSW	17	55,611,649 (GRCm38)	missense	probably damaging	1.00
R9155:Vmn2r118	UTSW	17	55,610,207 (GRCm38)	missense	probably null	0.83
R9603:Vmn2r118	UTSW	17	55,592,837 (GRCm38)	missense	probably damaging	1.00
R9742:Vmn2r118	UTSW	17	55,611,009 (GRCm38)	missense	probably damaging	0.98
R9749:Vmn2r118	UTSW	17	55,608,415 (GRCm38)	critical splice donor site	probably null
R9792:Vmn2r118	UTSW	17	55,592,496 (GRCm38)	missense	probably damaging	0.99
R9793:Vmn2r118	UTSW	17	55,592,496 (GRCm38)	missense	probably damaging	0.99
R9795:Vmn2r118	UTSW	17	55,592,496 (GRCm38)	missense	probably damaging	0.99
X0022:Vmn2r118	UTSW	17	55,593,218 (GRCm38)	missense	probably damaging	1.00
Z1176:Vmn2r118	UTSW	17	55,610,655 (GRCm38)	nonsense	probably null

Posted On

2013-04-17