Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02448:Zdhhc25'

293600

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zdhhc25

Ensembl Gene

ENSMUSG00000054117

Gene Name

zinc finger, DHHC domain containing 25

Synonyms

1700030J15Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.079) question?

Stock #

IGL02448

Quality Score

Status

Chromosome

Chromosomal Location

88484505-88485872 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 88485045 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Methionine at position 127 (V127M)

Ref Sequence

ENSEMBL: ENSMUSP00000136289 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000066949]

AlphaFold

Q810M4

Predicted Effect

probably damaging
Transcript: ENSMUST00000066949
AA Change: V127M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000136289
Gene: ENSMUSG00000054117
AA Change: V127M

Domain	Start	End	E-Value	Type
transmembrane domain	35	55	N/A	INTRINSIC
transmembrane domain	65	87	N/A	INTRINSIC
Pfam:zf-DHHC	105	235	2.4e-32	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Angptl6	T	A	9: 20,786,866 (GRCm39)	I286F	probably damaging	Het
Arhgap5	A	G	12: 52,609,123 (GRCm39)	E1366G	probably damaging	Het
Blzf1	T	A	1: 164,123,350 (GRCm39)	I326F	possibly damaging	Het
Cc2d2a	A	C	5: 43,840,547 (GRCm39)		probably benign	Het
Cdc37	T	C	9: 21,051,147 (GRCm39)	E366G	possibly damaging	Het
Cdh17	T	C	4: 11,784,680 (GRCm39)	S279P	probably benign	Het
Cdh18	T	C	15: 23,173,875 (GRCm39)	S30P	probably benign	Het
Cep192	A	G	18: 68,002,518 (GRCm39)	T2238A	probably benign	Het
Cpped1	C	T	16: 11,623,253 (GRCm39)	E289K	probably benign	Het
Ctsq	A	T	13: 61,184,044 (GRCm39)	Y293N	probably damaging	Het
Epb41l2	A	G	10: 25,369,493 (GRCm39)	N20S	possibly damaging	Het
Gcc2	T	A	10: 58,128,393 (GRCm39)	C1304*	probably null	Het
Hsd3b5	C	T	3: 98,529,447 (GRCm39)	G61E	probably damaging	Het
Igfals	A	T	17: 25,099,161 (GRCm39)	N84I	probably damaging	Het
Irs2	A	T	8: 11,057,862 (GRCm39)	V190D	probably benign	Het
Kank1	T	A	19: 25,388,739 (GRCm39)	L804Q	probably damaging	Het
Kcnj2	G	T	11: 110,963,108 (GRCm39)	V167L	probably benign	Het
Kif20a	T	C	18: 34,761,507 (GRCm39)	V300A	possibly damaging	Het
Kmt2d	T	C	15: 98,741,991 (GRCm39)		probably benign	Het
Moxd1	T	C	10: 24,158,617 (GRCm39)	F424L	probably damaging	Het
Mpeg1	A	C	19: 12,439,973 (GRCm39)	D477A	probably benign	Het
Mtmr10	A	T	7: 63,957,898 (GRCm39)	Y166F	probably damaging	Het
Muc5b	T	G	7: 141,422,226 (GRCm39)	I4454S	possibly damaging	Het
Ntng1	G	A	3: 109,841,875 (GRCm39)		probably benign	Het
Or52r1b	T	C	7: 102,691,604 (GRCm39)	I306T	possibly damaging	Het
Or7e175	T	A	9: 20,048,937 (GRCm39)	L175*	probably null	Het
Pex11a	A	T	7: 79,387,208 (GRCm39)		probably null	Het
Plcg2	A	G	8: 118,333,960 (GRCm39)	D911G	probably benign	Het
Rc3h2	T	C	2: 37,279,817 (GRCm39)	T471A	probably benign	Het
Rif1	T	A	2: 52,006,708 (GRCm39)	L2214Q	probably damaging	Het
Rtel1	T	A	2: 180,977,830 (GRCm39)	S120T	probably benign	Het
Ryr1	A	G	7: 28,804,491 (GRCm39)		probably benign	Het
Sh3yl1	G	T	12: 30,989,666 (GRCm39)	A129S	probably damaging	Het
Slc25a10	A	G	11: 120,387,879 (GRCm39)	T191A	probably benign	Het
Slc8b1	T	C	5: 120,663,856 (GRCm39)	S359P	probably damaging	Het
Srf	T	C	17: 46,866,349 (GRCm39)	T136A	possibly damaging	Het
Stx1a	G	T	5: 135,052,473 (GRCm39)		probably benign	Het
Taf1d	T	A	9: 15,221,690 (GRCm39)	C224*	probably null	Het
Tnik	A	G	3: 28,675,226 (GRCm39)	S700G	probably null	Het
Ttn	T	C	2: 76,773,331 (GRCm39)	H2357R	probably benign	Het
Ttn	T	C	2: 76,566,458 (GRCm39)	E28145G	probably damaging	Het
Ush1c	C	A	7: 45,858,561 (GRCm39)	V576F	possibly damaging	Het
Xpc	T	C	6: 91,492,726 (GRCm39)	E19G	probably benign	Het

Other mutations in Zdhhc25

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01999:Zdhhc25	APN	15	88,485,217 (GRCm39)	missense	probably damaging	0.98
IGL02576:Zdhhc25	APN	15	88,485,472 (GRCm39)	missense	probably benign	0.01
R0001:Zdhhc25	UTSW	15	88,485,112 (GRCm39)	missense	probably benign	0.00
R0394:Zdhhc25	UTSW	15	88,485,123 (GRCm39)	missense	probably damaging	0.96
R0622:Zdhhc25	UTSW	15	88,485,310 (GRCm39)	missense	probably damaging	0.98
R1116:Zdhhc25	UTSW	15	88,484,823 (GRCm39)	missense	probably benign	0.25
R1132:Zdhhc25	UTSW	15	88,484,926 (GRCm39)	missense	probably damaging	1.00
R1854:Zdhhc25	UTSW	15	88,484,689 (GRCm39)	missense	probably benign
R1994:Zdhhc25	UTSW	15	88,485,027 (GRCm39)	missense	probably benign	0.00
R2102:Zdhhc25	UTSW	15	88,484,962 (GRCm39)	missense	probably benign	0.10
R3749:Zdhhc25	UTSW	15	88,485,226 (GRCm39)	missense	probably benign	0.00
R5144:Zdhhc25	UTSW	15	88,485,259 (GRCm39)	missense	probably damaging	0.98
R5220:Zdhhc25	UTSW	15	88,485,365 (GRCm39)	nonsense	probably null
R9573:Zdhhc25	UTSW	15	88,485,307 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16