Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02451:Vmn2r94'

293629

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r94

Ensembl Gene

ENSMUSG00000090417

Gene Name

vomeronasal 2, receptor 94

Synonyms

EG665227

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.123) question?

Stock #

IGL02451

Quality Score

Status

Chromosome

Chromosomal Location

18240994-18277756 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 18258191 bp

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Phenylalanine at position 98 (Y98F)

Ref Sequence

ENSEMBL: ENSMUSP00000126386 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172190] [ENSMUST00000231457] [ENSMUST00000231815]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000172190
AA Change: Y98F

PolyPhen 2 Score 0.955 (Sensitivity: 0.79; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000126386
Gene: ENSMUSG00000090417
AA Change: Y98F

Domain	Start	End	E-Value	Type
Pfam:ANF_receptor	42	425	1.7e-35	PFAM
Pfam:NCD3G	469	522	3.5e-21	PFAM
Pfam:7tm_3	553	790	1.7e-51	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000231457

Predicted Effect

possibly damaging
Transcript: ENSMUST00000231815
AA Change: Y98F

PolyPhen 2 Score 0.646 (Sensitivity: 0.87; Specificity: 0.91)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700123K08Rik	T	G	5: 138,563,547	T126P	probably damaging	Het
Asic2	T	C	11: 80,891,737		probably benign	Het
B430305J03Rik	A	G	3: 61,364,141		probably benign	Het
Bbs7	A	G	3: 36,610,592	F47L	possibly damaging	Het
BC017158	A	G	7: 128,276,410	L257P	probably damaging	Het
Bcl2l14	G	T	6: 134,423,841	G75V	probably benign	Het
Btnl4	T	C	17: 34,475,927	H4R	probably benign	Het
Champ1	C	A	8: 13,878,739	P299Q	probably damaging	Het
Cldnd2	A	G	7: 43,441,658	K5E	probably benign	Het
Ctr9	T	A	7: 111,043,424	L401*	probably null	Het
Cyp2c29	G	A	19: 39,290,847	G96D	possibly damaging	Het
Enpp4	A	T	17: 44,101,424	L298H	probably damaging	Het
Git1	T	C	11: 77,500,687	C222R	possibly damaging	Het
Gpam	T	C	19: 55,088,203	T189A	probably damaging	Het
Hgfac	T	G	5: 35,043,814		probably null	Het
Hivep3	T	A	4: 120,133,965	S2221T	probably damaging	Het
Ifi47	T	C	11: 49,095,777	Y124H	probably damaging	Het
Il1a	T	C	2: 129,306,655	E45G	probably damaging	Het
Itga11	T	A	9: 62,735,353	I186N	probably damaging	Het
Krt16	A	T	11: 100,246,336		probably benign	Het
Mapk13	A	G	17: 28,776,413	T203A	probably damaging	Het
Mrpl37	T	A	4: 107,066,642	I52F	probably damaging	Het
Nr1i2	A	G	16: 38,249,292	F417L	probably benign	Het
Olfr1129	T	A	2: 87,575,232	S49R	probably benign	Het
Olfr811	G	A	10: 129,801,833	Q231*	probably null	Het
Osbpl1a	T	C	18: 12,914,493		probably benign	Het
Parg	C	T	14: 32,242,229	T112M	probably damaging	Het
Pifo	T	A	3: 106,014,504	E34D	probably benign	Het
Pou6f1	T	C	15: 100,579,940	T166A	possibly damaging	Het
Prtg	A	G	9: 72,856,999	I585V	possibly damaging	Het
Ptpru	T	G	4: 131,776,775		probably benign	Het
Rab6a	T	C	7: 100,636,763		probably null	Het
Rnf207	C	T	4: 152,312,412	R425H	probably benign	Het
Skiv2l2	C	T	13: 112,891,347	V660M	probably damaging	Het
Slc27a2	A	G	2: 126,578,992	M468V	probably benign	Het
Slc30a1	A	G	1: 191,907,329	H108R	possibly damaging	Het
Sned1	A	G	1: 93,236,208		probably benign	Het
Sptbn4	A	T	7: 27,365,589	F2095Y	probably null	Het
Sspo	A	T	6: 48,460,303		probably benign	Het
Tbx19	A	G	1: 165,140,171	S336P	probably benign	Het
Tmem101	T	A	11: 102,153,293	D256V	probably damaging	Het
Trbv20	T	G	6: 41,188,276	L2V	unknown	Het
Trpc7	A	G	13: 56,822,461	S382P	probably damaging	Het
Uhmk1	T	C	1: 170,212,526	T91A	possibly damaging	Het
Vmn2r10	T	A	5: 108,995,922	R721*	probably null	Het
Zcchc11	C	A	4: 108,529,276	Y1114*	probably null	Het
Zfp532	A	G	18: 65,623,601	R202G	probably damaging	Het
Zfp827	T	C	8: 79,060,972	S256P	probably damaging	Het
Zzef1	T	C	11: 72,901,388	I2266T	probably damaging	Het

Other mutations in Vmn2r94

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01396:Vmn2r94	APN	17	18257039	missense	probably damaging	1.00
IGL01676:Vmn2r94	APN	17	18257010	missense	probably benign
IGL01687:Vmn2r94	APN	17	18253312	missense	possibly damaging	0.64
IGL02113:Vmn2r94	APN	17	18257675	missense	probably damaging	0.99
IGL02408:Vmn2r94	APN	17	18253261	missense	probably benign	0.01
IGL02755:Vmn2r94	APN	17	18244499	missense	probably benign	0.01
IGL02822:Vmn2r94	APN	17	18243620	missense	probably benign	0.00
IGL02868:Vmn2r94	APN	17	18244054	missense	possibly damaging	0.75
IGL03008:Vmn2r94	APN	17	18257646	missense	probably benign	0.05
R0112:Vmn2r94	UTSW	17	18243604	missense	probably benign
R0371:Vmn2r94	UTSW	17	18257294	missense	probably benign	0.11
R0413:Vmn2r94	UTSW	17	18243818	missense	probably damaging	0.98
R0627:Vmn2r94	UTSW	17	18257165	missense	probably damaging	1.00
R0737:Vmn2r94	UTSW	17	18277433	nonsense	probably null
R0815:Vmn2r94	UTSW	17	18257711	missense	probably damaging	1.00
R0863:Vmn2r94	UTSW	17	18257711	missense	probably damaging	1.00
R1125:Vmn2r94	UTSW	17	18257455	missense	probably damaging	1.00
R1276:Vmn2r94	UTSW	17	18257082	missense	possibly damaging	0.47
R1491:Vmn2r94	UTSW	17	18257703	missense	probably damaging	1.00
R1500:Vmn2r94	UTSW	17	18256980	missense	probably benign	0.07
R1610:Vmn2r94	UTSW	17	18243733	missense	probably damaging	1.00
R1664:Vmn2r94	UTSW	17	18244144	missense	probably damaging	0.99
R1716:Vmn2r94	UTSW	17	18257373	missense	probably benign	0.01
R1843:Vmn2r94	UTSW	17	18244470	missense	probably benign	0.01
R1882:Vmn2r94	UTSW	17	18244214	missense	probably benign	0.07
R1936:Vmn2r94	UTSW	17	18244292	nonsense	probably null
R2273:Vmn2r94	UTSW	17	18257331	missense	probably benign	0.00
R2508:Vmn2r94	UTSW	17	18257474	missense	probably benign	0.32
R3436:Vmn2r94	UTSW	17	18258388	splice site	probably benign
R3917:Vmn2r94	UTSW	17	18244358	missense	probably benign
R3968:Vmn2r94	UTSW	17	18258385	missense	possibly damaging	0.95
R3969:Vmn2r94	UTSW	17	18258385	missense	possibly damaging	0.95
R4257:Vmn2r94	UTSW	17	18244171	missense	probably damaging	1.00
R4271:Vmn2r94	UTSW	17	18243678	missense	probably damaging	1.00
R4349:Vmn2r94	UTSW	17	18244343	missense	probably benign	0.01
R4436:Vmn2r94	UTSW	17	18258383	missense	probably damaging	1.00
R4603:Vmn2r94	UTSW	17	18257385	missense	probably benign	0.33
R4821:Vmn2r94	UTSW	17	18257031	missense	probably benign	0.02
R5288:Vmn2r94	UTSW	17	18244466	missense	probably damaging	1.00
R5725:Vmn2r94	UTSW	17	18256227	missense	possibly damaging	0.88
R5735:Vmn2r94	UTSW	17	18243804	missense	probably damaging	1.00
R6066:Vmn2r94	UTSW	17	18257433	missense	probably damaging	0.99
R6124:Vmn2r94	UTSW	17	18244059	missense	probably benign	0.01
R6189:Vmn2r94	UTSW	17	18257734	missense	probably benign	0.25
R6245:Vmn2r94	UTSW	17	18258123	missense	probably damaging	1.00
R6574:Vmn2r94	UTSW	17	18256159	missense	probably damaging	1.00
R7236:Vmn2r94	UTSW	17	18257549	missense	possibly damaging	0.49
R7317:Vmn2r94	UTSW	17	18243620	missense	probably benign	0.00
R7398:Vmn2r94	UTSW	17	18257341	missense	probably benign	0.00
R7399:Vmn2r94	UTSW	17	18244503	critical splice acceptor site	probably null
R7478:Vmn2r94	UTSW	17	18257505	missense	probably benign
R8099:Vmn2r94	UTSW	17	18257397	missense	probably benign	0.00
R8189:Vmn2r94	UTSW	17	18258356	missense	probably damaging	1.00
R8217:Vmn2r94	UTSW	17	18243724	missense	probably damaging	1.00
R8303:Vmn2r94	UTSW	17	18244171	missense	probably damaging	1.00
R8543:Vmn2r94	UTSW	17	18243722	missense	possibly damaging	0.45
RF014:Vmn2r94	UTSW	17	18253287	nonsense	probably null
X0011:Vmn2r94	UTSW	17	18244448	missense	possibly damaging	0.76
X0028:Vmn2r94	UTSW	17	18243975	missense	probably damaging	1.00

Posted On

2015-04-16