Incidental Mutation 'IGL02451:Zfp827'
ID 293651
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp827
Ensembl Gene ENSMUSG00000071064
Gene Name zinc finger protein 827
Synonyms D630040G17Rik, 2810449M09Rik
Accession Numbers
Essential gene? Probably essential (E-score: 0.920) question?
Stock # IGL02451
Quality Score
Status
Chromosome 8
Chromosomal Location 79755066-79920395 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 79787601 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 256 (S256P)
Ref Sequence ENSEMBL: ENSMUSP00000113199 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087927] [ENSMUST00000098614] [ENSMUST00000119254]
AlphaFold Q505G8
Predicted Effect probably damaging
Transcript: ENSMUST00000087927
AA Change: S256P

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000085238
Gene: ENSMUSG00000071064
AA Change: S256P

DomainStartEndE-ValueType
low complexity region 102 128 N/A INTRINSIC
low complexity region 226 256 N/A INTRINSIC
low complexity region 271 298 N/A INTRINSIC
low complexity region 306 342 N/A INTRINSIC
low complexity region 343 348 N/A INTRINSIC
ZnF_C2H2 371 393 6.78e-3 SMART
ZnF_C2H2 399 422 5.59e-4 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000098614
AA Change: S256P

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000096214
Gene: ENSMUSG00000071064
AA Change: S256P

DomainStartEndE-ValueType
low complexity region 102 128 N/A INTRINSIC
low complexity region 226 256 N/A INTRINSIC
low complexity region 271 298 N/A INTRINSIC
low complexity region 306 342 N/A INTRINSIC
low complexity region 343 348 N/A INTRINSIC
ZnF_C2H2 371 393 6.78e-3 SMART
ZnF_C2H2 399 421 2.99e-4 SMART
ZnF_C2H2 430 452 5.42e-2 SMART
internal_repeat_2 561 585 3.31e-7 PROSPERO
low complexity region 613 627 N/A INTRINSIC
internal_repeat_2 719 743 3.31e-7 PROSPERO
ZnF_C2H2 814 836 2.4e-3 SMART
ZnF_C2H2 842 864 4.72e-2 SMART
ZnF_C2H2 894 916 1.64e-1 SMART
ZnF_C2H2 926 949 7.89e0 SMART
low complexity region 956 974 N/A INTRINSIC
ZnF_C2H2 1016 1038 1.26e-2 SMART
ZnF_C2H2 1044 1066 3.07e-1 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000119254
AA Change: S256P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000113199
Gene: ENSMUSG00000071064
AA Change: S256P

DomainStartEndE-ValueType
low complexity region 102 128 N/A INTRINSIC
low complexity region 226 256 N/A INTRINSIC
low complexity region 271 298 N/A INTRINSIC
low complexity region 306 342 N/A INTRINSIC
low complexity region 343 348 N/A INTRINSIC
ZnF_C2H2 371 393 6.78e-3 SMART
ZnF_C2H2 399 421 2.99e-4 SMART
ZnF_C2H2 430 452 5.42e-2 SMART
internal_repeat_2 561 585 3.25e-7 PROSPERO
low complexity region 613 627 N/A INTRINSIC
internal_repeat_2 719 743 3.25e-7 PROSPERO
ZnF_C2H2 814 836 2.4e-3 SMART
ZnF_C2H2 842 864 4.72e-2 SMART
ZnF_C2H2 894 916 1.64e-1 SMART
ZnF_C2H2 926 949 7.89e0 SMART
low complexity region 956 974 N/A INTRINSIC
ZnF_C2H2 1016 1038 1.26e-2 SMART
ZnF_C2H2 1044 1066 3.07e-1 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700123K08Rik T G 5: 138,561,809 (GRCm39) T126P probably damaging Het
Asic2 T C 11: 80,782,563 (GRCm39) probably benign Het
B430305J03Rik A G 3: 61,271,562 (GRCm39) probably benign Het
Bbs7 A G 3: 36,664,741 (GRCm39) F47L possibly damaging Het
Bcl2l14 G T 6: 134,400,804 (GRCm39) G75V probably benign Het
Btnl4 T C 17: 34,694,901 (GRCm39) H4R probably benign Het
Champ1 C A 8: 13,928,739 (GRCm39) P299Q probably damaging Het
Cimap3 T A 3: 105,921,820 (GRCm39) E34D probably benign Het
Cldnd2 A G 7: 43,091,082 (GRCm39) K5E probably benign Het
Ctr9 T A 7: 110,642,631 (GRCm39) L401* probably null Het
Cyp2c29 G A 19: 39,279,291 (GRCm39) G96D possibly damaging Het
Enpp4 A T 17: 44,412,315 (GRCm39) L298H probably damaging Het
Git1 T C 11: 77,391,513 (GRCm39) C222R possibly damaging Het
Gpam T C 19: 55,076,635 (GRCm39) T189A probably damaging Het
Hgfac T G 5: 35,201,158 (GRCm39) probably null Het
Hivep3 T A 4: 119,991,162 (GRCm39) S2221T probably damaging Het
Ifi47 T C 11: 48,986,604 (GRCm39) Y124H probably damaging Het
Il1a T C 2: 129,148,575 (GRCm39) E45G probably damaging Het
Itga11 T A 9: 62,642,635 (GRCm39) I186N probably damaging Het
Krt16 A T 11: 100,137,162 (GRCm39) probably benign Het
Mapk13 A G 17: 28,995,387 (GRCm39) T203A probably damaging Het
Mrpl37 T A 4: 106,923,839 (GRCm39) I52F probably damaging Het
Mtrex C T 13: 113,027,881 (GRCm39) V660M probably damaging Het
Nr1i2 A G 16: 38,069,654 (GRCm39) F417L probably benign Het
Or10ag59 T A 2: 87,405,576 (GRCm39) S49R probably benign Het
Or6c215 G A 10: 129,637,702 (GRCm39) Q231* probably null Het
Osbpl1a T C 18: 13,047,550 (GRCm39) probably benign Het
Parg C T 14: 31,964,186 (GRCm39) T112M probably damaging Het
Pou6f1 T C 15: 100,477,821 (GRCm39) T166A possibly damaging Het
Prtg A G 9: 72,764,281 (GRCm39) I585V possibly damaging Het
Ptpru T G 4: 131,504,086 (GRCm39) probably benign Het
Rab6a T C 7: 100,285,970 (GRCm39) probably null Het
Rnf207 C T 4: 152,396,869 (GRCm39) R425H probably benign Het
Rusf1 A G 7: 127,875,582 (GRCm39) L257P probably damaging Het
Slc27a2 A G 2: 126,420,912 (GRCm39) M468V probably benign Het
Slc30a1 A G 1: 191,639,441 (GRCm39) H108R possibly damaging Het
Sned1 A G 1: 93,163,930 (GRCm39) probably benign Het
Sptbn4 A T 7: 27,065,014 (GRCm39) F2095Y probably null Het
Sspo A T 6: 48,437,237 (GRCm39) probably benign Het
Tbx19 A G 1: 164,967,740 (GRCm39) S336P probably benign Het
Tmem101 T A 11: 102,044,119 (GRCm39) D256V probably damaging Het
Trbv20 T G 6: 41,165,210 (GRCm39) L2V unknown Het
Trpc7 A G 13: 56,970,274 (GRCm39) S382P probably damaging Het
Tut4 C A 4: 108,386,473 (GRCm39) Y1114* probably null Het
Uhmk1 T C 1: 170,040,095 (GRCm39) T91A possibly damaging Het
Vmn2r10 T A 5: 109,143,788 (GRCm39) R721* probably null Het
Vmn2r94 T A 17: 18,478,453 (GRCm39) Y98F possibly damaging Het
Zfp532 A G 18: 65,756,672 (GRCm39) R202G probably damaging Het
Zzef1 T C 11: 72,792,214 (GRCm39) I2266T probably damaging Het
Other mutations in Zfp827
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01448:Zfp827 APN 8 79,787,362 (GRCm39) missense possibly damaging 0.82
IGL01545:Zfp827 APN 8 79,797,063 (GRCm39) missense probably damaging 1.00
IGL01552:Zfp827 APN 8 79,802,820 (GRCm39) missense probably damaging 1.00
IGL02261:Zfp827 APN 8 79,906,708 (GRCm39) missense probably damaging 0.97
IGL03130:Zfp827 APN 8 79,787,586 (GRCm39) missense probably damaging 1.00
IGL03411:Zfp827 APN 8 79,803,116 (GRCm39) missense probably damaging 0.99
E0354:Zfp827 UTSW 8 79,863,206 (GRCm39) missense probably damaging 1.00
R0502:Zfp827 UTSW 8 79,905,706 (GRCm39) splice site probably null
R0547:Zfp827 UTSW 8 79,786,939 (GRCm39) missense probably damaging 1.00
R0926:Zfp827 UTSW 8 79,844,821 (GRCm39) missense probably benign 0.00
R0975:Zfp827 UTSW 8 79,787,814 (GRCm39) missense probably benign 0.00
R1305:Zfp827 UTSW 8 79,787,523 (GRCm39) missense possibly damaging 0.95
R1462:Zfp827 UTSW 8 79,803,108 (GRCm39) missense probably benign
R1462:Zfp827 UTSW 8 79,803,108 (GRCm39) missense probably benign
R1638:Zfp827 UTSW 8 79,802,975 (GRCm39) missense possibly damaging 0.94
R1714:Zfp827 UTSW 8 79,787,202 (GRCm39) missense probably damaging 1.00
R2044:Zfp827 UTSW 8 79,802,865 (GRCm39) missense probably benign
R2132:Zfp827 UTSW 8 79,912,350 (GRCm39) missense possibly damaging 0.53
R3844:Zfp827 UTSW 8 79,863,248 (GRCm39) missense probably damaging 0.99
R4329:Zfp827 UTSW 8 79,916,463 (GRCm39) utr 3 prime probably benign
R4629:Zfp827 UTSW 8 79,787,011 (GRCm39) missense probably damaging 0.99
R4873:Zfp827 UTSW 8 79,787,403 (GRCm39) missense probably damaging 1.00
R4875:Zfp827 UTSW 8 79,787,403 (GRCm39) missense probably damaging 1.00
R4936:Zfp827 UTSW 8 79,787,812 (GRCm39) missense probably benign
R4965:Zfp827 UTSW 8 79,787,910 (GRCm39) missense probably benign
R5103:Zfp827 UTSW 8 79,797,032 (GRCm39) missense probably damaging 1.00
R5366:Zfp827 UTSW 8 79,912,333 (GRCm39) missense possibly damaging 0.94
R5794:Zfp827 UTSW 8 79,797,071 (GRCm39) missense probably damaging 1.00
R5825:Zfp827 UTSW 8 79,905,645 (GRCm39) missense probably damaging 1.00
R6118:Zfp827 UTSW 8 79,803,067 (GRCm39) missense possibly damaging 0.75
R6236:Zfp827 UTSW 8 79,797,105 (GRCm39) missense probably damaging 1.00
R6263:Zfp827 UTSW 8 79,905,702 (GRCm39) missense probably damaging 1.00
R6306:Zfp827 UTSW 8 79,787,324 (GRCm39) missense probably damaging 1.00
R6490:Zfp827 UTSW 8 79,916,606 (GRCm39) utr 3 prime probably benign
R6497:Zfp827 UTSW 8 79,906,757 (GRCm39) missense probably damaging 1.00
R7250:Zfp827 UTSW 8 79,916,721 (GRCm39) missense
R7290:Zfp827 UTSW 8 79,916,442 (GRCm39) missense possibly damaging 0.86
R7443:Zfp827 UTSW 8 79,917,047 (GRCm39) missense
R7708:Zfp827 UTSW 8 79,902,591 (GRCm39) missense probably damaging 1.00
R7754:Zfp827 UTSW 8 79,916,958 (GRCm39) missense
R7836:Zfp827 UTSW 8 79,912,979 (GRCm39) missense probably damaging 1.00
R7995:Zfp827 UTSW 8 79,844,887 (GRCm39) missense possibly damaging 0.86
R8162:Zfp827 UTSW 8 79,787,206 (GRCm39) nonsense probably null
R8747:Zfp827 UTSW 8 79,755,316 (GRCm39) start codon destroyed probably null
R8798:Zfp827 UTSW 8 79,916,463 (GRCm39) utr 3 prime probably benign
R8980:Zfp827 UTSW 8 79,803,092 (GRCm39) missense probably benign 0.00
R9099:Zfp827 UTSW 8 79,917,107 (GRCm39) missense
R9178:Zfp827 UTSW 8 79,818,564 (GRCm39) missense probably damaging 1.00
R9246:Zfp827 UTSW 8 79,803,132 (GRCm39) missense possibly damaging 0.75
R9277:Zfp827 UTSW 8 79,787,029 (GRCm39) missense probably damaging 0.97
R9318:Zfp827 UTSW 8 79,844,982 (GRCm39) missense possibly damaging 0.75
R9339:Zfp827 UTSW 8 79,844,887 (GRCm39) missense probably benign 0.00
R9425:Zfp827 UTSW 8 79,905,588 (GRCm39) missense probably damaging 1.00
R9499:Zfp827 UTSW 8 79,787,403 (GRCm39) missense probably damaging 1.00
R9544:Zfp827 UTSW 8 79,905,604 (GRCm39) missense probably damaging 1.00
R9551:Zfp827 UTSW 8 79,787,403 (GRCm39) missense probably damaging 1.00
R9552:Zfp827 UTSW 8 79,787,403 (GRCm39) missense probably damaging 1.00
R9588:Zfp827 UTSW 8 79,905,604 (GRCm39) missense probably damaging 1.00
R9665:Zfp827 UTSW 8 79,906,756 (GRCm39) missense possibly damaging 0.89
Posted On 2015-04-16