Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02451:Tmem101'

293657

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tmem101

Ensembl Gene

ENSMUSG00000020921

Gene Name

transmembrane protein 101

Synonyms

2610511E22Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.198) question?

Stock #

IGL02451

Quality Score

Status

Chromosome

Chromosomal Location

102043372-102047230 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 102044119 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Valine at position 256 (D256V)

Ref Sequence

ENSEMBL: ENSMUSP00000021296 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000021296] [ENSMUST00000055409]

AlphaFold

Q91VP7

Predicted Effect

probably damaging
Transcript: ENSMUST00000021296
AA Change: D256V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000021296
Gene: ENSMUSG00000020921
AA Change: D256V

Domain	Start	End	E-Value	Type
Pfam:TMEM101	8	256	9.9e-122	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000055409

SMART Domains

Protein: ENSMUSP00000050258
Gene: ENSMUSG00000048217

Domain	Start	End	E-Value	Type
low complexity region	9	48	N/A	INTRINSIC
low complexity region	77	90	N/A	INTRINSIC
Pfam:NAT	349	514	3.5e-50	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000129799

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000136434

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000143986

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000147252

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700123K08Rik	T	G	5: 138,561,809 (GRCm39)	T126P	probably damaging	Het
Asic2	T	C	11: 80,782,563 (GRCm39)		probably benign	Het
B430305J03Rik	A	G	3: 61,271,562 (GRCm39)		probably benign	Het
Bbs7	A	G	3: 36,664,741 (GRCm39)	F47L	possibly damaging	Het
Bcl2l14	G	T	6: 134,400,804 (GRCm39)	G75V	probably benign	Het
Btnl4	T	C	17: 34,694,901 (GRCm39)	H4R	probably benign	Het
Champ1	C	A	8: 13,928,739 (GRCm39)	P299Q	probably damaging	Het
Cimap3	T	A	3: 105,921,820 (GRCm39)	E34D	probably benign	Het
Cldnd2	A	G	7: 43,091,082 (GRCm39)	K5E	probably benign	Het
Ctr9	T	A	7: 110,642,631 (GRCm39)	L401*	probably null	Het
Cyp2c29	G	A	19: 39,279,291 (GRCm39)	G96D	possibly damaging	Het
Enpp4	A	T	17: 44,412,315 (GRCm39)	L298H	probably damaging	Het
Git1	T	C	11: 77,391,513 (GRCm39)	C222R	possibly damaging	Het
Gpam	T	C	19: 55,076,635 (GRCm39)	T189A	probably damaging	Het
Hgfac	T	G	5: 35,201,158 (GRCm39)		probably null	Het
Hivep3	T	A	4: 119,991,162 (GRCm39)	S2221T	probably damaging	Het
Ifi47	T	C	11: 48,986,604 (GRCm39)	Y124H	probably damaging	Het
Il1a	T	C	2: 129,148,575 (GRCm39)	E45G	probably damaging	Het
Itga11	T	A	9: 62,642,635 (GRCm39)	I186N	probably damaging	Het
Krt16	A	T	11: 100,137,162 (GRCm39)		probably benign	Het
Mapk13	A	G	17: 28,995,387 (GRCm39)	T203A	probably damaging	Het
Mrpl37	T	A	4: 106,923,839 (GRCm39)	I52F	probably damaging	Het
Mtrex	C	T	13: 113,027,881 (GRCm39)	V660M	probably damaging	Het
Nr1i2	A	G	16: 38,069,654 (GRCm39)	F417L	probably benign	Het
Or10ag59	T	A	2: 87,405,576 (GRCm39)	S49R	probably benign	Het
Or6c215	G	A	10: 129,637,702 (GRCm39)	Q231*	probably null	Het
Osbpl1a	T	C	18: 13,047,550 (GRCm39)		probably benign	Het
Parg	C	T	14: 31,964,186 (GRCm39)	T112M	probably damaging	Het
Pou6f1	T	C	15: 100,477,821 (GRCm39)	T166A	possibly damaging	Het
Prtg	A	G	9: 72,764,281 (GRCm39)	I585V	possibly damaging	Het
Ptpru	T	G	4: 131,504,086 (GRCm39)		probably benign	Het
Rab6a	T	C	7: 100,285,970 (GRCm39)		probably null	Het
Rnf207	C	T	4: 152,396,869 (GRCm39)	R425H	probably benign	Het
Rusf1	A	G	7: 127,875,582 (GRCm39)	L257P	probably damaging	Het
Slc27a2	A	G	2: 126,420,912 (GRCm39)	M468V	probably benign	Het
Slc30a1	A	G	1: 191,639,441 (GRCm39)	H108R	possibly damaging	Het
Sned1	A	G	1: 93,163,930 (GRCm39)		probably benign	Het
Sptbn4	A	T	7: 27,065,014 (GRCm39)	F2095Y	probably null	Het
Sspo	A	T	6: 48,437,237 (GRCm39)		probably benign	Het
Tbx19	A	G	1: 164,967,740 (GRCm39)	S336P	probably benign	Het
Trbv20	T	G	6: 41,165,210 (GRCm39)	L2V	unknown	Het
Trpc7	A	G	13: 56,970,274 (GRCm39)	S382P	probably damaging	Het
Tut4	C	A	4: 108,386,473 (GRCm39)	Y1114*	probably null	Het
Uhmk1	T	C	1: 170,040,095 (GRCm39)	T91A	possibly damaging	Het
Vmn2r10	T	A	5: 109,143,788 (GRCm39)	R721*	probably null	Het
Vmn2r94	T	A	17: 18,478,453 (GRCm39)	Y98F	possibly damaging	Het
Zfp532	A	G	18: 65,756,672 (GRCm39)	R202G	probably damaging	Het
Zfp827	T	C	8: 79,787,601 (GRCm39)	S256P	probably damaging	Het
Zzef1	T	C	11: 72,792,214 (GRCm39)	I2266T	probably damaging	Het

Other mutations in Tmem101

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01085:Tmem101	APN	11	102,045,486 (GRCm39)	missense	probably damaging	0.99
IGL01096:Tmem101	APN	11	102,045,378 (GRCm39)	splice site	probably null
IGL01593:Tmem101	APN	11	102,046,704 (GRCm39)	missense	probably damaging	1.00
IGL01814:Tmem101	APN	11	102,044,284 (GRCm39)	missense	possibly damaging	0.58
IGL03238:Tmem101	APN	11	102,046,611 (GRCm39)	missense	probably damaging	1.00
R0462:Tmem101	UTSW	11	102,046,693 (GRCm39)	missense	probably benign	0.08
R0848:Tmem101	UTSW	11	102,046,692 (GRCm39)	missense	possibly damaging	0.65
R1465:Tmem101	UTSW	11	102,044,155 (GRCm39)	missense	probably damaging	0.97
R1465:Tmem101	UTSW	11	102,044,155 (GRCm39)	missense	probably damaging	0.97
R1722:Tmem101	UTSW	11	102,045,519 (GRCm39)	missense	probably damaging	1.00
R1928:Tmem101	UTSW	11	102,044,222 (GRCm39)	missense	probably benign
R2082:Tmem101	UTSW	11	102,044,203 (GRCm39)	missense	probably benign	0.17
R4577:Tmem101	UTSW	11	102,046,663 (GRCm39)	missense	possibly damaging	0.48
R4724:Tmem101	UTSW	11	102,044,269 (GRCm39)	missense	probably benign	0.32
R4729:Tmem101	UTSW	11	102,047,155 (GRCm39)	missense	probably benign	0.25
R5146:Tmem101	UTSW	11	102,045,450 (GRCm39)	missense	probably benign
R5184:Tmem101	UTSW	11	102,047,059 (GRCm39)	missense	possibly damaging	0.78
R7381:Tmem101	UTSW	11	102,044,176 (GRCm39)	missense	possibly damaging	0.91
R8799:Tmem101	UTSW	11	102,044,336 (GRCm39)	missense	probably benign	0.08
R9612:Tmem101	UTSW	11	102,044,194 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16