Incidental Mutation 'IGL02452:Cyp2g1'
ID 293694
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cyp2g1
Ensembl Gene ENSMUSG00000049685
Gene Name cytochrome P450, family 2, subfamily g, polypeptide 1
Synonyms
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02452
Quality Score
Status
Chromosome 7
Chromosomal Location 26508352-26520622 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 26510871 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 131 (S131T)
Ref Sequence ENSEMBL: ENSMUSP00000047150 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000040944]
AlphaFold Q9WV19
Predicted Effect probably benign
Transcript: ENSMUST00000040944
AA Change: S131T

PolyPhen 2 Score 0.278 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000047150
Gene: ENSMUSG00000049685
AA Change: S131T

DomainStartEndE-ValueType
low complexity region 12 23 N/A INTRINSIC
Pfam:p450 34 491 4e-150 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205273
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for disruptions in this gene display an essentially normal phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acadm C A 3: 153,647,607 (GRCm39) V11F probably damaging Het
Alk A T 17: 72,209,620 (GRCm39) Y941* probably null Het
Blm A T 7: 80,153,125 (GRCm39) probably null Het
Blvrb T C 7: 27,158,765 (GRCm39) V55A possibly damaging Het
Cdh23 T A 10: 60,153,721 (GRCm39) T2288S probably damaging Het
Csnk1g1 T A 9: 65,915,067 (GRCm39) M242K probably damaging Het
Cyp2c29 G A 19: 39,279,291 (GRCm39) G96D possibly damaging Het
Cyp2d26 T A 15: 82,676,827 (GRCm39) H173L probably benign Het
Dusp29 G A 14: 21,752,990 (GRCm39) T52I probably damaging Het
Dzip3 T A 16: 48,758,900 (GRCm39) probably benign Het
Espl1 T C 15: 102,208,274 (GRCm39) S427P probably damaging Het
Fasn A T 11: 120,699,006 (GRCm39) D2424E probably benign Het
Flrt2 G A 12: 95,746,257 (GRCm39) M198I probably benign Het
Gen1 A T 12: 11,292,576 (GRCm39) S404R probably benign Het
Gm11596 A T 11: 99,683,806 (GRCm39) C105S unknown Het
Hdlbp A T 1: 93,345,233 (GRCm39) V714D probably damaging Het
Igkv4-80 A G 6: 68,993,816 (GRCm39) V25A probably benign Het
Igkv8-27 C T 6: 70,148,925 (GRCm39) W76* probably null Het
Ikzf1 T C 11: 11,698,545 (GRCm39) L132P probably damaging Het
Kcna6 C A 6: 126,715,443 (GRCm39) C482F possibly damaging Het
Lhx9 A T 1: 138,769,580 (GRCm39) L47Q probably damaging Het
Lrp4 T A 2: 91,304,347 (GRCm39) D175E probably damaging Het
Lrrtm3 T C 10: 63,923,815 (GRCm39) K451E probably damaging Het
Mcm9 C T 10: 53,417,653 (GRCm39) V17M probably damaging Het
Mios T A 6: 8,222,492 (GRCm39) S475R probably benign Het
Mmp24 C T 2: 155,657,708 (GRCm39) R533C probably damaging Het
Moxd1 C T 10: 24,158,650 (GRCm39) P435S probably damaging Het
Mta2 T A 19: 8,927,670 (GRCm39) I497N probably benign Het
Mtus2 T C 5: 148,014,473 (GRCm39) V422A probably benign Het
Ndufaf1 A T 2: 119,486,907 (GRCm39) F260Y probably damaging Het
Nfasc C T 1: 132,548,662 (GRCm39) probably null Het
Nid1 A T 13: 13,683,305 (GRCm39) T1128S probably benign Het
Odad2 C T 18: 7,129,461 (GRCm39) E906K probably damaging Het
Or51f1d A G 7: 102,701,138 (GRCm39) D211G probably benign Het
Pcdh12 G A 18: 38,414,746 (GRCm39) P793L probably benign Het
Pclo A T 5: 14,726,980 (GRCm39) probably benign Het
Prpf31 T A 7: 3,637,185 (GRCm39) N161K possibly damaging Het
Prpf6 T G 2: 181,290,878 (GRCm39) N656K probably benign Het
Ptprn T A 1: 75,234,813 (GRCm39) H258L probably benign Het
Rab19 A G 6: 39,366,732 (GRCm39) T216A probably benign Het
Ryr3 A C 2: 112,664,335 (GRCm39) L1652W probably damaging Het
Six2 A C 17: 85,992,806 (GRCm39) S232R possibly damaging Het
Spag17 T C 3: 99,934,707 (GRCm39) V663A probably benign Het
Spag5 A G 11: 78,195,449 (GRCm39) N252S probably benign Het
Spata31e4 A T 13: 50,857,113 (GRCm39) H917L probably damaging Het
Sptb C T 12: 76,655,810 (GRCm39) probably null Het
Synj1 A G 16: 90,758,253 (GRCm39) probably benign Het
Tekt2 T C 4: 126,218,645 (GRCm39) H36R possibly damaging Het
Tjp1 A T 7: 64,962,403 (GRCm39) M1258K probably damaging Het
Txnrd3 T C 6: 89,651,777 (GRCm39) *502Q probably null Het
Other mutations in Cyp2g1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01134:Cyp2g1 APN 7 26,509,256 (GRCm39) missense probably benign 0.05
IGL01137:Cyp2g1 APN 7 26,513,684 (GRCm39) missense possibly damaging 0.87
IGL02052:Cyp2g1 APN 7 26,513,719 (GRCm39) splice site probably benign
IGL02338:Cyp2g1 APN 7 26,514,229 (GRCm39) splice site probably benign
IGL02523:Cyp2g1 APN 7 26,518,612 (GRCm39) missense probably damaging 1.00
IGL03165:Cyp2g1 APN 7 26,509,201 (GRCm39) missense possibly damaging 0.94
IGL03230:Cyp2g1 APN 7 26,518,828 (GRCm39) missense probably damaging 1.00
PIT4472001:Cyp2g1 UTSW 7 26,513,619 (GRCm39) missense probably benign 0.28
R0106:Cyp2g1 UTSW 7 26,513,607 (GRCm39) missense probably damaging 1.00
R0106:Cyp2g1 UTSW 7 26,513,607 (GRCm39) missense probably damaging 1.00
R0380:Cyp2g1 UTSW 7 26,513,720 (GRCm39) splice site probably benign
R0697:Cyp2g1 UTSW 7 26,514,152 (GRCm39) nonsense probably null
R0830:Cyp2g1 UTSW 7 26,514,216 (GRCm39) missense probably benign 0.00
R1660:Cyp2g1 UTSW 7 26,509,107 (GRCm39) critical splice acceptor site probably null
R2093:Cyp2g1 UTSW 7 26,518,858 (GRCm39) missense probably benign 0.35
R2131:Cyp2g1 UTSW 7 26,520,135 (GRCm39) missense probably damaging 0.99
R4606:Cyp2g1 UTSW 7 26,513,579 (GRCm39) missense possibly damaging 0.80
R5030:Cyp2g1 UTSW 7 26,520,226 (GRCm39) missense probably benign 0.06
R5574:Cyp2g1 UTSW 7 26,520,165 (GRCm39) missense possibly damaging 0.81
R5877:Cyp2g1 UTSW 7 26,516,065 (GRCm39) missense possibly damaging 0.80
R6745:Cyp2g1 UTSW 7 26,513,604 (GRCm39) missense probably damaging 1.00
R7040:Cyp2g1 UTSW 7 26,520,184 (GRCm39) missense probably damaging 0.99
R7223:Cyp2g1 UTSW 7 26,514,057 (GRCm39) missense probably damaging 0.98
R7934:Cyp2g1 UTSW 7 26,518,618 (GRCm39) missense probably damaging 1.00
R8112:Cyp2g1 UTSW 7 26,518,886 (GRCm39) missense probably benign
R8177:Cyp2g1 UTSW 7 26,518,578 (GRCm39) missense probably damaging 1.00
R8194:Cyp2g1 UTSW 7 26,514,159 (GRCm39) missense possibly damaging 0.89
R9043:Cyp2g1 UTSW 7 26,509,256 (GRCm39) missense probably benign 0.05
R9406:Cyp2g1 UTSW 7 26,518,910 (GRCm39) critical splice donor site probably null
R9441:Cyp2g1 UTSW 7 26,514,060 (GRCm39) missense possibly damaging 0.72
X0067:Cyp2g1 UTSW 7 26,520,187 (GRCm39) missense possibly damaging 0.70
Posted On 2015-04-16