Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02455:Or5w17'

293799

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or5w17

Ensembl Gene

ENSMUSG00000075148

Gene Name

olfactory receptor family 5 subfamily W member 17, pseudogene 1

Synonyms

Olfr1141, GA_x6K02T2Q125-49257818-49256883, MOR177-10

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.112) question?

Stock #

IGL02455

Quality Score

Status

Chromosome

Chromosomal Location

87583400-87584335 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 87583927 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Threonine at position 137 (S137T)

Ref Sequence

ENSEMBL: ENSMUSP00000097433 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099846]

AlphaFold

Q8VFQ7

Predicted Effect

possibly damaging
Transcript: ENSMUST00000099846
AA Change: S137T

PolyPhen 2 Score 0.949 (Sensitivity: 0.79; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000097433
Gene: ENSMUSG00000075148
AA Change: S137T

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	307	2.8e-28	PFAM
Pfam:7tm_1	41	290	1.5e-6	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcf1	A	G	17: 36,271,021 (GRCm39)	V479A	probably damaging	Het
Adam18	T	C	8: 25,141,864 (GRCm39)	D235G	probably damaging	Het
Cdh22	T	C	2: 164,984,175 (GRCm39)	N359S	possibly damaging	Het
Cebpz	G	T	17: 79,242,465 (GRCm39)	N396K	probably benign	Het
Celsr3	T	A	9: 108,720,092 (GRCm39)	W2493R	probably benign	Het
Clca3a2	C	T	3: 144,787,172 (GRCm39)	V500M	probably benign	Het
Clec4a4	A	C	6: 122,990,739 (GRCm39)	N160H	possibly damaging	Het
Crb2	T	C	2: 37,684,576 (GRCm39)	S1139P	possibly damaging	Het
Dnah8	T	C	17: 30,891,308 (GRCm39)	I771T	probably damaging	Het
Etfbkmt	C	T	6: 149,048,724 (GRCm39)	A121V	probably damaging	Het
Fat4	T	A	3: 39,005,280 (GRCm39)	L1893Q	possibly damaging	Het
Fbxw13	A	T	9: 109,012,255 (GRCm39)	S188T	probably benign	Het
Fign	T	C	2: 63,810,841 (GRCm39)	D143G	probably benign	Het
Foxj3	C	A	4: 119,477,434 (GRCm39)	H381N	unknown	Het
Gpr158	A	T	2: 21,373,511 (GRCm39)	T149S	probably benign	Het
Ift74	C	T	4: 94,524,068 (GRCm39)	Q195*	probably null	Het
Kif2c	C	A	4: 117,029,551 (GRCm39)	M143I	probably benign	Het
Kmt2b	A	G	7: 30,278,303 (GRCm39)		probably null	Het
Krt84	C	T	15: 101,434,170 (GRCm39)	R599H	unknown	Het
Ly6g6f	C	T	17: 35,301,866 (GRCm39)	R196H	possibly damaging	Het
Map4	C	A	9: 109,828,901 (GRCm39)	N95K	probably benign	Het
Mrgprx3-ps	T	A	7: 46,959,263 (GRCm39)		noncoding transcript	Het
Mroh9	T	C	1: 162,903,149 (GRCm39)	M85V	probably benign	Het
Npffr2	T	C	5: 89,715,994 (GRCm39)	I107T	probably damaging	Het
Nrcam	T	C	12: 44,617,313 (GRCm39)	V737A	probably damaging	Het
Oprm1	A	G	10: 6,780,219 (GRCm39)	T294A	probably damaging	Het
Or10d5j	T	C	9: 39,868,198 (GRCm39)	E11G	probably damaging	Het
Or7g32	C	T	9: 19,408,559 (GRCm39)	Q172*	probably null	Het
Parvg	A	G	15: 84,214,283 (GRCm39)	R156G	possibly damaging	Het
Pclo	T	C	5: 14,590,189 (GRCm39)	S830P	unknown	Het
Pde11a	T	C	2: 75,988,737 (GRCm39)	D468G	possibly damaging	Het
Peak1	A	T	9: 56,134,757 (GRCm39)	S195T	possibly damaging	Het
Pkhd1	A	G	1: 20,434,425 (GRCm39)	Y2338H	probably damaging	Het
Ppp1r1b	A	T	11: 98,241,395 (GRCm39)	I28F	probably damaging	Het
Prpf8	A	G	11: 75,400,084 (GRCm39)	Y2326C	probably benign	Het
Psmd1	T	A	1: 86,006,302 (GRCm39)	L223I	probably damaging	Het
Runx3	T	A	4: 134,902,841 (GRCm39)	Y310N	probably damaging	Het
Secisbp2l	C	T	2: 125,615,398 (GRCm39)	D76N	possibly damaging	Het
Slfn4	A	T	11: 83,077,584 (GRCm39)	N124I	probably damaging	Het
Spata13	G	A	14: 60,944,163 (GRCm39)	V519I	probably benign	Het
Ssh3	C	T	19: 4,314,460 (GRCm39)	E365K	probably damaging	Het
Strc	A	G	2: 121,206,272 (GRCm39)		probably benign	Het
Tdp2	T	A	13: 25,025,245 (GRCm39)	I338N	probably damaging	Het
Vmn1r13	A	T	6: 57,187,457 (GRCm39)	R205S	probably damaging	Het
Wdr19	G	T	5: 65,382,102 (GRCm39)	A441S	probably benign	Het
Ylpm1	A	G	12: 85,077,037 (GRCm39)	D796G	probably damaging	Het
Zbtb11	T	C	16: 55,821,038 (GRCm39)	S712P	probably damaging	Het
Zcchc14	A	G	8: 122,333,009 (GRCm39)		probably benign	Het
Zfp608	T	G	18: 55,032,405 (GRCm39)	S512R	probably damaging	Het

Other mutations in Or5w17

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01143:Or5w17	APN	2	87,584,278 (GRCm39)	missense	probably benign	0.00
IGL01412:Or5w17	APN	2	87,583,461 (GRCm39)	missense	probably damaging	1.00
IGL01533:Or5w17	APN	2	87,583,412 (GRCm39)	missense	probably benign	0.01
IGL02698:Or5w17	APN	2	87,584,188 (GRCm39)	nonsense	probably null
PIT4480001:Or5w17	UTSW	2	87,584,127 (GRCm39)	missense	possibly damaging	0.95
R0543:Or5w17	UTSW	2	87,583,994 (GRCm39)	missense	probably damaging	1.00
R1542:Or5w17	UTSW	2	87,583,662 (GRCm39)	missense	probably damaging	0.99
R1750:Or5w17	UTSW	2	87,583,530 (GRCm39)	missense	probably damaging	0.97
R1844:Or5w17	UTSW	2	87,584,334 (GRCm39)	start codon destroyed	probably null	1.00
R2248:Or5w17	UTSW	2	87,584,287 (GRCm39)	missense	probably null	0.05
R4064:Or5w17	UTSW	2	87,584,133 (GRCm39)	missense	probably damaging	1.00
R5193:Or5w17	UTSW	2	87,583,448 (GRCm39)	missense	possibly damaging	0.59
R5861:Or5w17	UTSW	2	87,583,922 (GRCm39)	missense	probably benign	0.01
R6146:Or5w17	UTSW	2	87,583,602 (GRCm39)	missense	probably damaging	1.00
R6197:Or5w17	UTSW	2	87,583,696 (GRCm39)	missense	probably benign	0.15
R6481:Or5w17	UTSW	2	87,583,812 (GRCm39)	missense	probably damaging	1.00
R6857:Or5w17	UTSW	2	87,583,831 (GRCm39)	missense	probably damaging	1.00
R6904:Or5w17	UTSW	2	87,584,223 (GRCm39)	missense	probably benign	0.00
R6962:Or5w17	UTSW	2	87,584,071 (GRCm39)	missense	probably benign
R7014:Or5w17	UTSW	2	87,584,215 (GRCm39)	missense	probably benign	0.00
R8229:Or5w17	UTSW	2	87,583,408 (GRCm39)	missense	probably benign	0.00
R8723:Or5w17	UTSW	2	87,583,501 (GRCm39)	missense	possibly damaging	0.69
R8883:Or5w17	UTSW	2	87,583,838 (GRCm39)	missense	probably damaging	1.00
R9129:Or5w17	UTSW	2	87,584,048 (GRCm39)	missense	probably benign	0.00
R9587:Or5w17	UTSW	2	87,584,184 (GRCm39)	missense	possibly damaging	0.79
R9665:Or5w17	UTSW	2	87,583,671 (GRCm39)	missense	probably damaging	0.97
T0722:Or5w17	UTSW	2	87,583,467 (GRCm39)	missense	probably damaging	1.00
Z1177:Or5w17	UTSW	2	87,583,534 (GRCm39)	missense	possibly damaging	0.95

Posted On

2015-04-16