Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02455:Gpr158'

293813

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gpr158

Ensembl Gene

ENSMUSG00000045967

Gene Name

G protein-coupled receptor 158

Synonyms

5330427M13Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02455

Quality Score

Status

Chromosome

Chromosomal Location

21372378-21835355 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 21373511 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Serine at position 149 (T149S)

Ref Sequence

ENSEMBL: ENSMUSP00000049708 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000055946]

AlphaFold

Q8C419

Predicted Effect

probably benign
Transcript: ENSMUST00000055946
AA Change: T149S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000049708
Gene: ENSMUSG00000045967
AA Change: T149S

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
low complexity region	110	125	N/A	INTRINSIC
SCOP:d1edmb_	313	359	5e-4	SMART
Blast:EGF	318	365	2e-27	BLAST
Pfam:7tm_3	426	669	1.2e-35	PFAM
low complexity region	840	863	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000133391

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000155760

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcf1	A	G	17: 36,271,021 (GRCm39)	V479A	probably damaging	Het
Adam18	T	C	8: 25,141,864 (GRCm39)	D235G	probably damaging	Het
Cdh22	T	C	2: 164,984,175 (GRCm39)	N359S	possibly damaging	Het
Cebpz	G	T	17: 79,242,465 (GRCm39)	N396K	probably benign	Het
Celsr3	T	A	9: 108,720,092 (GRCm39)	W2493R	probably benign	Het
Clca3a2	C	T	3: 144,787,172 (GRCm39)	V500M	probably benign	Het
Clec4a4	A	C	6: 122,990,739 (GRCm39)	N160H	possibly damaging	Het
Crb2	T	C	2: 37,684,576 (GRCm39)	S1139P	possibly damaging	Het
Dnah8	T	C	17: 30,891,308 (GRCm39)	I771T	probably damaging	Het
Etfbkmt	C	T	6: 149,048,724 (GRCm39)	A121V	probably damaging	Het
Fat4	T	A	3: 39,005,280 (GRCm39)	L1893Q	possibly damaging	Het
Fbxw13	A	T	9: 109,012,255 (GRCm39)	S188T	probably benign	Het
Fign	T	C	2: 63,810,841 (GRCm39)	D143G	probably benign	Het
Foxj3	C	A	4: 119,477,434 (GRCm39)	H381N	unknown	Het
Ift74	C	T	4: 94,524,068 (GRCm39)	Q195*	probably null	Het
Kif2c	C	A	4: 117,029,551 (GRCm39)	M143I	probably benign	Het
Kmt2b	A	G	7: 30,278,303 (GRCm39)		probably null	Het
Krt84	C	T	15: 101,434,170 (GRCm39)	R599H	unknown	Het
Ly6g6f	C	T	17: 35,301,866 (GRCm39)	R196H	possibly damaging	Het
Map4	C	A	9: 109,828,901 (GRCm39)	N95K	probably benign	Het
Mrgprx3-ps	T	A	7: 46,959,263 (GRCm39)		noncoding transcript	Het
Mroh9	T	C	1: 162,903,149 (GRCm39)	M85V	probably benign	Het
Npffr2	T	C	5: 89,715,994 (GRCm39)	I107T	probably damaging	Het
Nrcam	T	C	12: 44,617,313 (GRCm39)	V737A	probably damaging	Het
Oprm1	A	G	10: 6,780,219 (GRCm39)	T294A	probably damaging	Het
Or10d5j	T	C	9: 39,868,198 (GRCm39)	E11G	probably damaging	Het
Or5w17	A	T	2: 87,583,927 (GRCm39)	S137T	possibly damaging	Het
Or7g32	C	T	9: 19,408,559 (GRCm39)	Q172*	probably null	Het
Parvg	A	G	15: 84,214,283 (GRCm39)	R156G	possibly damaging	Het
Pclo	T	C	5: 14,590,189 (GRCm39)	S830P	unknown	Het
Pde11a	T	C	2: 75,988,737 (GRCm39)	D468G	possibly damaging	Het
Peak1	A	T	9: 56,134,757 (GRCm39)	S195T	possibly damaging	Het
Pkhd1	A	G	1: 20,434,425 (GRCm39)	Y2338H	probably damaging	Het
Ppp1r1b	A	T	11: 98,241,395 (GRCm39)	I28F	probably damaging	Het
Prpf8	A	G	11: 75,400,084 (GRCm39)	Y2326C	probably benign	Het
Psmd1	T	A	1: 86,006,302 (GRCm39)	L223I	probably damaging	Het
Runx3	T	A	4: 134,902,841 (GRCm39)	Y310N	probably damaging	Het
Secisbp2l	C	T	2: 125,615,398 (GRCm39)	D76N	possibly damaging	Het
Slfn4	A	T	11: 83,077,584 (GRCm39)	N124I	probably damaging	Het
Spata13	G	A	14: 60,944,163 (GRCm39)	V519I	probably benign	Het
Ssh3	C	T	19: 4,314,460 (GRCm39)	E365K	probably damaging	Het
Strc	A	G	2: 121,206,272 (GRCm39)		probably benign	Het
Tdp2	T	A	13: 25,025,245 (GRCm39)	I338N	probably damaging	Het
Vmn1r13	A	T	6: 57,187,457 (GRCm39)	R205S	probably damaging	Het
Wdr19	G	T	5: 65,382,102 (GRCm39)	A441S	probably benign	Het
Ylpm1	A	G	12: 85,077,037 (GRCm39)	D796G	probably damaging	Het
Zbtb11	T	C	16: 55,821,038 (GRCm39)	S712P	probably damaging	Het
Zcchc14	A	G	8: 122,333,009 (GRCm39)		probably benign	Het
Zfp608	T	G	18: 55,032,405 (GRCm39)	S512R	probably damaging	Het

Other mutations in Gpr158

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00340:Gpr158	APN	2	21,373,494 (GRCm39)	missense	probably damaging	1.00
IGL00469:Gpr158	APN	2	21,751,606 (GRCm39)	splice site	probably benign
IGL00706:Gpr158	APN	2	21,751,584 (GRCm39)	missense	probably damaging	1.00
IGL00780:Gpr158	APN	2	21,831,629 (GRCm39)	nonsense	probably null
IGL00885:Gpr158	APN	2	21,653,832 (GRCm39)	missense	probably damaging	1.00
IGL01339:Gpr158	APN	2	21,373,842 (GRCm39)	missense	possibly damaging	0.73
IGL01368:Gpr158	APN	2	21,831,909 (GRCm39)	missense	probably damaging	1.00
IGL02141:Gpr158	APN	2	21,788,101 (GRCm39)	missense	probably damaging	0.99
IGL02554:Gpr158	APN	2	21,831,407 (GRCm39)	missense	probably benign
IGL02681:Gpr158	APN	2	21,820,441 (GRCm39)	missense	probably damaging	1.00
IGL02752:Gpr158	APN	2	21,831,638 (GRCm39)	missense	possibly damaging	0.95
IGL02756:Gpr158	APN	2	21,831,890 (GRCm39)	missense	possibly damaging	0.47
IGL03181:Gpr158	APN	2	21,787,972 (GRCm39)	missense	probably benign	0.02
IGL03258:Gpr158	APN	2	21,830,085 (GRCm39)	missense	probably damaging	1.00
IGL03386:Gpr158	APN	2	21,831,057 (GRCm39)	missense	probably damaging	1.00
PIT4810001:Gpr158	UTSW	2	21,831,682 (GRCm39)	missense	probably benign	0.01
R0071:Gpr158	UTSW	2	21,815,479 (GRCm39)	missense	probably benign	0.08
R0081:Gpr158	UTSW	2	21,831,528 (GRCm39)	missense	probably damaging	1.00
R0528:Gpr158	UTSW	2	21,830,019 (GRCm39)	missense	probably damaging	1.00
R0560:Gpr158	UTSW	2	21,830,085 (GRCm39)	missense	probably damaging	1.00
R0603:Gpr158	UTSW	2	21,820,480 (GRCm39)	missense	possibly damaging	0.67
R1560:Gpr158	UTSW	2	21,831,125 (GRCm39)	missense	probably damaging	1.00
R1561:Gpr158	UTSW	2	21,820,505 (GRCm39)	splice site	probably null
R1609:Gpr158	UTSW	2	21,788,104 (GRCm39)	missense	possibly damaging	0.61
R1741:Gpr158	UTSW	2	21,832,359 (GRCm39)	missense	probably benign	0.00
R1827:Gpr158	UTSW	2	21,832,129 (GRCm39)	missense	probably benign
R1854:Gpr158	UTSW	2	21,373,935 (GRCm39)	missense	probably damaging	1.00
R1871:Gpr158	UTSW	2	21,820,426 (GRCm39)	missense	probably damaging	1.00
R2151:Gpr158	UTSW	2	21,832,325 (GRCm39)	missense	possibly damaging	0.82
R2273:Gpr158	UTSW	2	21,831,674 (GRCm39)	missense	probably benign
R2275:Gpr158	UTSW	2	21,831,674 (GRCm39)	missense	probably benign
R3004:Gpr158	UTSW	2	21,831,810 (GRCm39)	missense	probably damaging	0.99
R3151:Gpr158	UTSW	2	21,581,771 (GRCm39)	missense	possibly damaging	0.68
R3943:Gpr158	UTSW	2	21,373,370 (GRCm39)	missense	possibly damaging	0.65
R4238:Gpr158	UTSW	2	21,373,362 (GRCm39)	missense	probably damaging	1.00
R4379:Gpr158	UTSW	2	21,830,025 (GRCm39)	missense	probably damaging	1.00
R4381:Gpr158	UTSW	2	21,832,403 (GRCm39)	missense	probably damaging	1.00
R4464:Gpr158	UTSW	2	21,831,810 (GRCm39)	missense	probably damaging	0.99
R4467:Gpr158	UTSW	2	21,831,810 (GRCm39)	missense	probably damaging	0.99
R4496:Gpr158	UTSW	2	21,831,810 (GRCm39)	missense	probably damaging	0.99
R4506:Gpr158	UTSW	2	21,831,810 (GRCm39)	missense	probably damaging	0.99
R4530:Gpr158	UTSW	2	21,373,811 (GRCm39)	missense	probably benign	0.03
R4646:Gpr158	UTSW	2	21,831,864 (GRCm39)	missense	probably benign
R4798:Gpr158	UTSW	2	21,787,993 (GRCm39)	missense	probably damaging	1.00
R4882:Gpr158	UTSW	2	21,830,059 (GRCm39)	missense	probably damaging	0.98
R4943:Gpr158	UTSW	2	21,831,968 (GRCm39)	missense	probably damaging	1.00
R5334:Gpr158	UTSW	2	21,832,316 (GRCm39)	missense	probably benign	0.01
R5560:Gpr158	UTSW	2	21,831,101 (GRCm39)	missense	possibly damaging	0.67
R5600:Gpr158	UTSW	2	21,832,046 (GRCm39)	missense	probably benign
R5637:Gpr158	UTSW	2	21,788,083 (GRCm39)	missense	probably benign	0.00
R5701:Gpr158	UTSW	2	21,751,520 (GRCm39)	missense	probably damaging	1.00
R5744:Gpr158	UTSW	2	21,373,331 (GRCm39)	missense	probably damaging	1.00
R5911:Gpr158	UTSW	2	21,373,932 (GRCm39)	missense	possibly damaging	0.95
R5991:Gpr158	UTSW	2	21,373,319 (GRCm39)	missense	probably damaging	0.99
R6200:Gpr158	UTSW	2	21,404,227 (GRCm39)	missense	probably damaging	0.97
R6306:Gpr158	UTSW	2	21,820,422 (GRCm39)	missense	possibly damaging	0.84
R6324:Gpr158	UTSW	2	21,815,365 (GRCm39)	missense	probably damaging	1.00
R6384:Gpr158	UTSW	2	21,831,099 (GRCm39)	missense	probably damaging	1.00
R6698:Gpr158	UTSW	2	21,831,921 (GRCm39)	missense	probably damaging	1.00
R6997:Gpr158	UTSW	2	21,653,802 (GRCm39)	missense	possibly damaging	0.46
R7086:Gpr158	UTSW	2	21,831,386 (GRCm39)	missense	probably benign	0.01
R7175:Gpr158	UTSW	2	21,373,113 (GRCm39)	missense	probably benign	0.13
R7197:Gpr158	UTSW	2	21,815,412 (GRCm39)	missense	probably damaging	0.99
R7293:Gpr158	UTSW	2	21,581,750 (GRCm39)	missense	possibly damaging	0.47
R7427:Gpr158	UTSW	2	21,832,129 (GRCm39)	missense	probably benign
R7515:Gpr158	UTSW	2	21,373,092 (GRCm39)	missense	probably damaging	1.00
R7730:Gpr158	UTSW	2	21,831,158 (GRCm39)	missense	probably damaging	1.00
R8122:Gpr158	UTSW	2	21,831,674 (GRCm39)	missense	probably benign
R8311:Gpr158	UTSW	2	21,373,701 (GRCm39)	missense	probably benign	0.00
R8754:Gpr158	UTSW	2	21,581,693 (GRCm39)	missense	probably benign	0.00
R8782:Gpr158	UTSW	2	21,404,149 (GRCm39)	missense	probably damaging	1.00
R8792:Gpr158	UTSW	2	21,558,137 (GRCm39)	missense	probably damaging	1.00
R8842:Gpr158	UTSW	2	21,581,751 (GRCm39)	missense	possibly damaging	0.88
R9009:Gpr158	UTSW	2	21,581,760 (GRCm39)	missense	probably damaging	1.00
R9102:Gpr158	UTSW	2	21,830,078 (GRCm39)	missense	probably damaging	1.00
R9150:Gpr158	UTSW	2	21,831,251 (GRCm39)	missense	probably benign	0.17
R9254:Gpr158	UTSW	2	21,373,042 (GRCm39)	start gained	probably benign
R9317:Gpr158	UTSW	2	21,832,037 (GRCm39)	missense	probably benign
R9379:Gpr158	UTSW	2	21,373,042 (GRCm39)	start gained	probably benign
R9428:Gpr158	UTSW	2	21,787,972 (GRCm39)	missense	probably benign
R9497:Gpr158	UTSW	2	21,831,825 (GRCm39)	missense	probably benign	0.00
R9667:Gpr158	UTSW	2	21,830,054 (GRCm39)	missense	probably damaging	0.99
R9681:Gpr158	UTSW	2	21,831,315 (GRCm39)	missense	probably damaging	0.99
X0062:Gpr158	UTSW	2	21,831,180 (GRCm39)	missense	probably damaging	1.00
Z1176:Gpr158	UTSW	2	21,815,501 (GRCm39)	critical splice donor site	probably null
Z1177:Gpr158	UTSW	2	21,832,083 (GRCm39)	missense	possibly damaging	0.46

Posted On

2015-04-16