Incidental Mutation 'IGL02455:Oprm1'
ID 293827
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Oprm1
Ensembl Gene ENSMUSG00000000766
Gene Name opioid receptor, mu 1
Synonyms MOP-R, MOR-1, MOP receptor, mor, Oprm, muOR
Accession Numbers
Essential gene? Probably non essential (E-score: 0.110) question?
Stock # IGL02455
Quality Score
Status
Chromosome 10
Chromosomal Location 6708593-6988209 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 6780219 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 294 (T294A)
Ref Sequence ENSEMBL: ENSMUSP00000101229 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000000783] [ENSMUST00000052751] [ENSMUST00000056385] [ENSMUST00000063036] [ENSMUST00000078634] [ENSMUST00000092729] [ENSMUST00000092731] [ENSMUST00000092734] [ENSMUST00000105601] [ENSMUST00000105611] [ENSMUST00000105607] [ENSMUST00000105605] [ENSMUST00000105602] [ENSMUST00000105604] [ENSMUST00000105603] [ENSMUST00000123861] [ENSMUST00000105615] [ENSMUST00000105597] [ENSMUST00000144264] [ENSMUST00000135502] [ENSMUST00000129954] [ENSMUST00000154941] [ENSMUST00000129221] [ENSMUST00000147171] [ENSMUST00000154906] [ENSMUST00000152674] [ENSMUST00000150374] [ENSMUST00000143875]
AlphaFold P42866
Predicted Effect possibly damaging
Transcript: ENSMUST00000000783
AA Change: T294A

PolyPhen 2 Score 0.901 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000000783
Gene: ENSMUSG00000000766
AA Change: T294A

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 76 339 1.6e-7 PFAM
Pfam:7TM_GPCR_Srsx 79 351 1.3e-10 PFAM
Pfam:7tm_1 85 336 4e-67 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000052751
AA Change: T294A

PolyPhen 2 Score 0.901 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000060329
Gene: ENSMUSG00000000766
AA Change: T294A

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 76 325 1.1e-7 PFAM
Pfam:7TM_GPCR_Srsx 79 351 1e-10 PFAM
Pfam:7tm_1 85 336 3.2e-67 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000056385
AA Change: T294A

PolyPhen 2 Score 0.901 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000060590
Gene: ENSMUSG00000000766
AA Change: T294A

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 76 325 1.7e-7 PFAM
Pfam:7TM_GPCR_Srsx 79 351 1e-10 PFAM
Pfam:7tm_1 85 336 3.3e-67 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000063036
AA Change: T226A

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000053498
Gene: ENSMUSG00000000766
AA Change: T226A

DomainStartEndE-ValueType
Pfam:7tm_1 24 268 8.7e-64 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000078634
AA Change: T294A

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000077704
Gene: ENSMUSG00000000766
AA Change: T294A

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 76 339 2.1e-7 PFAM
Pfam:7TM_GPCR_Srsx 79 351 2.4e-10 PFAM
Pfam:7tm_1 85 336 9e-60 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000092729
AA Change: T294A

PolyPhen 2 Score 0.901 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000090405
Gene: ENSMUSG00000000766
AA Change: T294A

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 76 325 1.7e-7 PFAM
Pfam:7TM_GPCR_Srsx 79 351 9.6e-11 PFAM
Pfam:7tm_1 85 336 3.1e-67 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000092731
AA Change: T294A

PolyPhen 2 Score 0.901 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000090407
Gene: ENSMUSG00000000766
AA Change: T294A

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 76 325 1e-7 PFAM
Pfam:7TM_GPCR_Srsx 79 351 9.9e-11 PFAM
Pfam:7tm_1 85 336 3.2e-67 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000092734
AA Change: T294A

PolyPhen 2 Score 0.901 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000090410
Gene: ENSMUSG00000000766
AA Change: T294A

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 76 325 1.7e-7 PFAM
Pfam:7TM_GPCR_Srsx 79 351 1e-10 PFAM
Pfam:7tm_1 85 336 3.3e-67 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000105601
AA Change: D176G

PolyPhen 2 Score 0.904 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000101226
Gene: ENSMUSG00000000766
AA Change: D176G

DomainStartEndE-ValueType
SCOP:d1l9ha_ 46 100 3e-9 SMART
PDB:4DKL|A 52 100 3e-21 PDB
low complexity region 119 131 N/A INTRINSIC
low complexity region 173 184 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000105611
AA Change: T294A

PolyPhen 2 Score 0.901 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000101236
Gene: ENSMUSG00000000766
AA Change: T294A

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 76 338 1.7e-7 PFAM
Pfam:7TM_GPCR_Srsx 79 351 1.4e-10 PFAM
Pfam:7tm_1 85 336 4.4e-67 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000105607
AA Change: T294A

PolyPhen 2 Score 0.901 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000101232
Gene: ENSMUSG00000000766
AA Change: T294A

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 76 325 1.7e-7 PFAM
Pfam:7TM_GPCR_Srsx 79 351 1e-10 PFAM
Pfam:7tm_1 85 336 3.3e-67 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000105605
AA Change: T294A

PolyPhen 2 Score 0.901 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000101230
Gene: ENSMUSG00000000766
AA Change: T294A

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 76 325 1e-7 PFAM
Pfam:7TM_GPCR_Srsx 79 351 9.8e-11 PFAM
Pfam:7tm_1 85 336 3.2e-67 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000105602
AA Change: T294A

PolyPhen 2 Score 0.901 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000101227
Gene: ENSMUSG00000000766
AA Change: T294A

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 76 325 1.8e-7 PFAM
Pfam:7TM_GPCR_Srsx 79 351 9.8e-11 PFAM
Pfam:7tm_1 85 336 3.1e-67 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000105604
AA Change: T294A

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000101229
Gene: ENSMUSG00000000766
AA Change: T294A

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 76 332 5.1e-8 PFAM
Pfam:7TM_GPCR_Srsx 79 351 9.9e-11 PFAM
Pfam:7tm_1 85 336 3.8e-67 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000105603
AA Change: T294A

PolyPhen 2 Score 0.091 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000101228
Gene: ENSMUSG00000000766
AA Change: T294A

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 76 325 6.7e-8 PFAM
Pfam:7TM_GPCR_Srsx 79 351 9.6e-11 PFAM
Pfam:7tm_1 85 336 3.6e-67 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000123861
AA Change: D176G

PolyPhen 2 Score 0.904 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000120187
Gene: ENSMUSG00000000766
AA Change: D176G

DomainStartEndE-ValueType
SCOP:d1l9ha_ 46 100 3e-9 SMART
PDB:4DKL|A 52 100 3e-21 PDB
low complexity region 119 131 N/A INTRINSIC
low complexity region 173 184 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000105615
AA Change: T226A

PolyPhen 2 Score 0.125 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000101240
Gene: ENSMUSG00000000766
AA Change: T226A

DomainStartEndE-ValueType
Pfam:7tm_1 24 268 1.3e-63 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000105597
Predicted Effect possibly damaging
Transcript: ENSMUST00000144264
AA Change: T294A

PolyPhen 2 Score 0.901 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000115836
Gene: ENSMUSG00000000766
AA Change: T294A

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 76 325 1.7e-7 PFAM
Pfam:7TM_GPCR_Srsx 79 351 1e-10 PFAM
Pfam:7tm_1 85 336 3.4e-67 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000135502
AA Change: T294A

PolyPhen 2 Score 0.901 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000135143
Gene: ENSMUSG00000000766
AA Change: T294A

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 76 339 2.2e-7 PFAM
Pfam:7TM_GPCR_Srsx 79 351 1.9e-10 PFAM
Pfam:7tm_1 85 336 7.5e-67 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000129954
AA Change: T294A

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000122385
Gene: ENSMUSG00000000766
AA Change: T294A

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 76 338 6.9e-8 PFAM
Pfam:7TM_GPCR_Srsx 79 351 1.5e-10 PFAM
Pfam:7tm_1 85 336 5.4e-67 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000154941
AA Change: T230A

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000115413
Gene: ENSMUSG00000000766
AA Change: T230A

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 12 261 9.6e-8 PFAM
Pfam:7TM_GPCR_Srsx 15 287 6.1e-11 PFAM
Pfam:7tm_1 21 272 2e-67 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000129221
AA Change: T230A

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000123117
Gene: ENSMUSG00000000766
AA Change: T230A

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 12 261 1.1e-7 PFAM
Pfam:7TM_GPCR_Srsx 15 287 7.3e-11 PFAM
Pfam:7tm_1 21 272 2.4e-67 PFAM
low complexity region 340 351 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000147171
AA Change: T226A

PolyPhen 2 Score 0.955 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000117950
Gene: ENSMUSG00000000766
AA Change: T226A

DomainStartEndE-ValueType
Pfam:7tm_1 24 268 9.2e-64 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000154906
AA Change: T294A

PolyPhen 2 Score 0.901 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000114342
Gene: ENSMUSG00000000766
AA Change: T294A

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 76 332 1.5e-7 PFAM
Pfam:7TM_GPCR_Srsx 79 351 1.1e-10 PFAM
Pfam:7tm_1 85 336 3.6e-67 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133486
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141897
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148625
Predicted Effect probably benign
Transcript: ENSMUST00000152674
SMART Domains Protein: ENSMUSP00000115552
Gene: ENSMUSG00000000766

DomainStartEndE-ValueType
SCOP:d1l9ha_ 46 94 8e-8 SMART
PDB:4DKL|A 52 94 7e-23 PDB
Predicted Effect probably benign
Transcript: ENSMUST00000150374
Predicted Effect probably benign
Transcript: ENSMUST00000143875
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes the mu opioid receptor which is where drugs such as morphine and other opioids have pharmacological effects. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
PHENOTYPE: Homozygotes for null mutations exhibit isoform dependent loss of behavioral and gastrointestinal opioid responses and may also show impaired spatial memory, heightened nociception, reduced locomotor activity, increased hematopoietic proliferation, and decreased male fertility. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcf1 A G 17: 36,271,021 (GRCm39) V479A probably damaging Het
Adam18 T C 8: 25,141,864 (GRCm39) D235G probably damaging Het
Cdh22 T C 2: 164,984,175 (GRCm39) N359S possibly damaging Het
Cebpz G T 17: 79,242,465 (GRCm39) N396K probably benign Het
Celsr3 T A 9: 108,720,092 (GRCm39) W2493R probably benign Het
Clca3a2 C T 3: 144,787,172 (GRCm39) V500M probably benign Het
Clec4a4 A C 6: 122,990,739 (GRCm39) N160H possibly damaging Het
Crb2 T C 2: 37,684,576 (GRCm39) S1139P possibly damaging Het
Dnah8 T C 17: 30,891,308 (GRCm39) I771T probably damaging Het
Etfbkmt C T 6: 149,048,724 (GRCm39) A121V probably damaging Het
Fat4 T A 3: 39,005,280 (GRCm39) L1893Q possibly damaging Het
Fbxw13 A T 9: 109,012,255 (GRCm39) S188T probably benign Het
Fign T C 2: 63,810,841 (GRCm39) D143G probably benign Het
Foxj3 C A 4: 119,477,434 (GRCm39) H381N unknown Het
Gpr158 A T 2: 21,373,511 (GRCm39) T149S probably benign Het
Ift74 C T 4: 94,524,068 (GRCm39) Q195* probably null Het
Kif2c C A 4: 117,029,551 (GRCm39) M143I probably benign Het
Kmt2b A G 7: 30,278,303 (GRCm39) probably null Het
Krt84 C T 15: 101,434,170 (GRCm39) R599H unknown Het
Ly6g6f C T 17: 35,301,866 (GRCm39) R196H possibly damaging Het
Map4 C A 9: 109,828,901 (GRCm39) N95K probably benign Het
Mrgprx3-ps T A 7: 46,959,263 (GRCm39) noncoding transcript Het
Mroh9 T C 1: 162,903,149 (GRCm39) M85V probably benign Het
Npffr2 T C 5: 89,715,994 (GRCm39) I107T probably damaging Het
Nrcam T C 12: 44,617,313 (GRCm39) V737A probably damaging Het
Or10d5j T C 9: 39,868,198 (GRCm39) E11G probably damaging Het
Or5w17 A T 2: 87,583,927 (GRCm39) S137T possibly damaging Het
Or7g32 C T 9: 19,408,559 (GRCm39) Q172* probably null Het
Parvg A G 15: 84,214,283 (GRCm39) R156G possibly damaging Het
Pclo T C 5: 14,590,189 (GRCm39) S830P unknown Het
Pde11a T C 2: 75,988,737 (GRCm39) D468G possibly damaging Het
Peak1 A T 9: 56,134,757 (GRCm39) S195T possibly damaging Het
Pkhd1 A G 1: 20,434,425 (GRCm39) Y2338H probably damaging Het
Ppp1r1b A T 11: 98,241,395 (GRCm39) I28F probably damaging Het
Prpf8 A G 11: 75,400,084 (GRCm39) Y2326C probably benign Het
Psmd1 T A 1: 86,006,302 (GRCm39) L223I probably damaging Het
Runx3 T A 4: 134,902,841 (GRCm39) Y310N probably damaging Het
Secisbp2l C T 2: 125,615,398 (GRCm39) D76N possibly damaging Het
Slfn4 A T 11: 83,077,584 (GRCm39) N124I probably damaging Het
Spata13 G A 14: 60,944,163 (GRCm39) V519I probably benign Het
Ssh3 C T 19: 4,314,460 (GRCm39) E365K probably damaging Het
Strc A G 2: 121,206,272 (GRCm39) probably benign Het
Tdp2 T A 13: 25,025,245 (GRCm39) I338N probably damaging Het
Vmn1r13 A T 6: 57,187,457 (GRCm39) R205S probably damaging Het
Wdr19 G T 5: 65,382,102 (GRCm39) A441S probably benign Het
Ylpm1 A G 12: 85,077,037 (GRCm39) D796G probably damaging Het
Zbtb11 T C 16: 55,821,038 (GRCm39) S712P probably damaging Het
Zcchc14 A G 8: 122,333,009 (GRCm39) probably benign Het
Zfp608 T G 18: 55,032,405 (GRCm39) S512R probably damaging Het
Other mutations in Oprm1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01018:Oprm1 APN 10 6,987,170 (GRCm39) utr 3 prime probably benign
IGL01768:Oprm1 APN 10 6,779,186 (GRCm39) missense probably damaging 1.00
IGL03391:Oprm1 APN 10 6,964,077 (GRCm39) intron probably benign
IGL03410:Oprm1 APN 10 6,780,051 (GRCm39) missense probably damaging 1.00
IGL03048:Oprm1 UTSW 10 6,779,064 (GRCm39) missense probably damaging 1.00
R0189:Oprm1 UTSW 10 6,739,071 (GRCm39) missense possibly damaging 0.94
R0321:Oprm1 UTSW 10 6,779,183 (GRCm39) missense probably damaging 1.00
R0629:Oprm1 UTSW 10 6,782,604 (GRCm39) splice site probably null
R0730:Oprm1 UTSW 10 6,782,652 (GRCm39) intron probably benign
R1542:Oprm1 UTSW 10 6,738,960 (GRCm39) missense probably damaging 1.00
R1743:Oprm1 UTSW 10 6,780,105 (GRCm39) missense probably damaging 0.99
R1874:Oprm1 UTSW 10 6,739,035 (GRCm39) missense probably benign 0.17
R2864:Oprm1 UTSW 10 6,744,226 (GRCm39) splice site probably null
R2964:Oprm1 UTSW 10 6,738,914 (GRCm39) missense probably damaging 0.98
R3792:Oprm1 UTSW 10 6,789,544 (GRCm39) missense probably benign 0.00
R4008:Oprm1 UTSW 10 6,782,520 (GRCm39) missense probably benign
R4049:Oprm1 UTSW 10 6,779,087 (GRCm39) missense probably benign 0.36
R4088:Oprm1 UTSW 10 6,780,234 (GRCm39) missense probably damaging 1.00
R4724:Oprm1 UTSW 10 6,708,656 (GRCm39) nonsense probably null
R4812:Oprm1 UTSW 10 6,782,698 (GRCm39) intron probably benign
R4822:Oprm1 UTSW 10 6,779,036 (GRCm39) missense probably damaging 0.99
R4855:Oprm1 UTSW 10 6,788,468 (GRCm39) missense probably benign 0.01
R5072:Oprm1 UTSW 10 6,782,550 (GRCm39) missense probably benign 0.15
R5768:Oprm1 UTSW 10 6,739,026 (GRCm39) missense probably damaging 1.00
R5770:Oprm1 UTSW 10 6,739,026 (GRCm39) missense probably damaging 1.00
R5995:Oprm1 UTSW 10 6,782,520 (GRCm39) missense probably benign
R6327:Oprm1 UTSW 10 6,780,063 (GRCm39) missense probably damaging 0.99
R7135:Oprm1 UTSW 10 6,780,203 (GRCm39) missense possibly damaging 0.77
R7413:Oprm1 UTSW 10 6,778,919 (GRCm39) missense probably damaging 1.00
R7455:Oprm1 UTSW 10 6,780,204 (GRCm39) missense probably damaging 1.00
R8192:Oprm1 UTSW 10 6,788,417 (GRCm39) missense probably benign 0.04
R8210:Oprm1 UTSW 10 6,780,442 (GRCm39) missense probably benign 0.02
R8945:Oprm1 UTSW 10 6,782,644 (GRCm39) intron probably benign
R9054:Oprm1 UTSW 10 6,773,914 (GRCm39) intron probably benign
R9723:Oprm1 UTSW 10 6,788,514 (GRCm39) missense possibly damaging 0.66
R9726:Oprm1 UTSW 10 6,929,694 (GRCm39) missense probably benign 0.00
X0066:Oprm1 UTSW 10 6,780,462 (GRCm39) missense probably damaging 0.99
Posted On 2015-04-16