Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02391:Tecrl'

293837

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tecrl

Ensembl Gene

ENSMUSG00000049537

Gene Name

trans-2,3-enoyl-CoA reductase-like

Synonyms

Srd5a2l2, D330017N19Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.060) question?

Stock #

IGL02391

Quality Score

Status

Chromosome

Chromosomal Location

83425992-83503042 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 83502674 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 58 (F58L)

Ref Sequence

ENSEMBL: ENSMUSP00000062122 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000053543]

AlphaFold

Q8BFZ1

Predicted Effect

probably benign
Transcript: ENSMUST00000053543
AA Change: F58L

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000062122
Gene: ENSMUSG00000049537
AA Change: F58L

Domain	Start	End	E-Value	Type
PDB:2DZJ\|A	53	135	1e-17	PDB
Blast:UBQ	59	135	2e-7	BLAST
transmembrane domain	139	161	N/A	INTRINSIC
Pfam:Steroid_dh	208	361	3.8e-22	PFAM

Predicted Effect

unknown
Transcript: ENSMUST00000146669
AA Change: F43L

SMART Domains

Protein: ENSMUSP00000115144
Gene: ENSMUSG00000049537
AA Change: F43L

Domain	Start	End	E-Value	Type
PDB:2DZJ\|A	39	93	1e-11	PDB
transmembrane domain	100	122	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc4	T	A	14: 118,790,764 (GRCm39)	N748Y	probably damaging	Het
Actbl2	A	G	13: 111,391,701 (GRCm39)	D12G	possibly damaging	Het
Adamts10	T	C	17: 33,747,785 (GRCm39)	S74P	probably benign	Het
Adprs	C	T	4: 126,211,701 (GRCm39)		probably benign	Het
Amn1	A	G	6: 149,070,944 (GRCm39)		probably null	Het
Antxr1	A	T	6: 87,264,038 (GRCm39)	I144N	probably damaging	Het
Atp2a3	C	A	11: 72,866,165 (GRCm39)	H262N	probably benign	Het
Cabp5	A	T	7: 13,132,269 (GRCm39)	R13*	probably null	Het
Cacna1e	A	G	1: 154,296,859 (GRCm39)	Y1669H	probably damaging	Het
Ccdc174	A	G	6: 91,875,263 (GRCm39)	E364G	possibly damaging	Het
Ccdc18	C	T	5: 108,283,918 (GRCm39)	P74S	probably damaging	Het
Clec3a	C	T	8: 115,152,240 (GRCm39)	S82L	probably benign	Het
Cnih3	A	G	1: 181,234,078 (GRCm39)	D43G	probably damaging	Het
Dpp10	G	A	1: 123,578,087 (GRCm39)	T128M	probably damaging	Het
Edar	A	T	10: 58,464,403 (GRCm39)	F79I	probably damaging	Het
Eif2ak4	T	A	2: 118,251,272 (GRCm39)	H199Q	probably benign	Het
Fermt1	A	G	2: 132,783,871 (GRCm39)	L46P	probably damaging	Het
Glipr1	A	G	10: 111,824,799 (GRCm39)		probably benign	Het
Gsdmc	T	C	15: 63,675,428 (GRCm39)	N129S	probably damaging	Het
Ift88	T	C	14: 57,718,871 (GRCm39)	S619P	possibly damaging	Het
Itga9	T	A	9: 118,679,873 (GRCm39)	V262E	probably benign	Het
Med17	G	A	9: 15,188,963 (GRCm39)	R101*	probably null	Het
Mta1	T	A	12: 113,100,203 (GRCm39)	I688N	possibly damaging	Het
Muc4	A	T	16: 32,570,894 (GRCm39)	R651S	probably benign	Het
Opcml	A	G	9: 28,586,560 (GRCm39)	I93V	probably damaging	Het
Or12d17	C	T	17: 37,777,477 (GRCm39)	P127S	probably damaging	Het
Or13p4	A	G	4: 118,547,538 (GRCm39)	L37P	probably damaging	Het
Or9r7	A	G	10: 129,962,773 (GRCm39)	V51A	possibly damaging	Het
Parg	T	G	14: 31,984,638 (GRCm39)		probably null	Het
Rps3a3	A	G	13: 108,807,417 (GRCm39)		probably benign	Het
Safb	T	A	17: 56,907,813 (GRCm39)		probably benign	Het
Sat2	G	T	11: 69,513,575 (GRCm39)	C54F	probably damaging	Het
Scin	T	A	12: 40,127,530 (GRCm39)	Y420F	probably benign	Het
Slc22a29	A	T	19: 8,146,717 (GRCm39)	S362T	probably benign	Het
Smchd1	T	C	17: 71,738,254 (GRCm39)	D537G	probably null	Het
Spred3	A	G	7: 28,865,830 (GRCm39)	S126P	probably benign	Het
Ssh1	C	T	5: 114,080,578 (GRCm39)	E951K	probably damaging	Het
Ssmem1	A	G	6: 30,512,441 (GRCm39)	E28G	possibly damaging	Het
Stox1	A	T	10: 62,495,455 (GRCm39)		probably benign	Het
Syn3	T	C	10: 85,900,770 (GRCm39)	I373V	probably benign	Het
Trp53bp1	T	C	2: 121,033,191 (GRCm39)	N1655S	possibly damaging	Het
Usp2	G	T	9: 44,002,524 (GRCm39)	Q147H	probably damaging	Het
Usp24	T	A	4: 106,264,326 (GRCm39)	N1751K	possibly damaging	Het
Wipf1	T	A	2: 73,264,487 (GRCm39)	D438V	probably damaging	Het

Other mutations in Tecrl

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01981:Tecrl	APN	5	83,442,453 (GRCm39)	missense	probably benign
IGL02067:Tecrl	APN	5	83,432,122 (GRCm39)	missense	probably benign	0.05
IGL02111:Tecrl	APN	5	83,502,639 (GRCm39)	missense	probably damaging	1.00
IGL02860:Tecrl	APN	5	83,502,844 (GRCm39)	missense	probably benign	0.01
IGL03079:Tecrl	APN	5	83,442,447 (GRCm39)	missense	probably damaging	0.96
IGL03109:Tecrl	APN	5	83,457,156 (GRCm39)	intron	probably benign
gaudenz	UTSW	5	83,457,049 (GRCm39)	critical splice donor site	probably null
Whoopie	UTSW	5	83,442,453 (GRCm39)	missense	probably damaging	1.00
BB004:Tecrl	UTSW	5	83,502,666 (GRCm39)	missense	probably damaging	1.00
BB014:Tecrl	UTSW	5	83,502,666 (GRCm39)	missense	probably damaging	1.00
R0095:Tecrl	UTSW	5	83,442,417 (GRCm39)	splice site	probably benign
R0347:Tecrl	UTSW	5	83,442,479 (GRCm39)	missense	probably damaging	1.00
R0372:Tecrl	UTSW	5	83,442,506 (GRCm39)	missense	probably damaging	1.00
R0403:Tecrl	UTSW	5	83,502,605 (GRCm39)	splice site	probably benign
R0426:Tecrl	UTSW	5	83,502,610 (GRCm39)	splice site	probably benign
R0597:Tecrl	UTSW	5	83,502,775 (GRCm39)	nonsense	probably null
R1607:Tecrl	UTSW	5	83,428,355 (GRCm39)	splice site	probably null
R1771:Tecrl	UTSW	5	83,439,134 (GRCm39)	missense	probably damaging	1.00
R1800:Tecrl	UTSW	5	83,427,077 (GRCm39)	missense	probably damaging	1.00
R1815:Tecrl	UTSW	5	83,427,081 (GRCm39)	missense	probably benign	0.01
R1869:Tecrl	UTSW	5	83,502,706 (GRCm39)	missense	probably benign	0.00
R1870:Tecrl	UTSW	5	83,502,706 (GRCm39)	missense	probably benign	0.00
R4296:Tecrl	UTSW	5	83,461,174 (GRCm39)	nonsense	probably null
R4471:Tecrl	UTSW	5	83,461,134 (GRCm39)	missense	probably benign
R6281:Tecrl	UTSW	5	83,442,453 (GRCm39)	missense	probably damaging	1.00
R6343:Tecrl	UTSW	5	83,442,447 (GRCm39)	missense	probably damaging	0.96
R6866:Tecrl	UTSW	5	83,461,161 (GRCm39)	missense	probably damaging	1.00
R6948:Tecrl	UTSW	5	83,457,097 (GRCm39)	missense	probably benign
R6971:Tecrl	UTSW	5	83,502,649 (GRCm39)	missense	possibly damaging	0.58
R6981:Tecrl	UTSW	5	83,502,768 (GRCm39)	missense	possibly damaging	0.83
R7246:Tecrl	UTSW	5	83,427,182 (GRCm39)	missense	probably damaging	0.99
R7282:Tecrl	UTSW	5	83,502,754 (GRCm39)	missense	probably benign	0.26
R7444:Tecrl	UTSW	5	83,502,915 (GRCm39)	unclassified	probably benign
R7900:Tecrl	UTSW	5	83,427,188 (GRCm39)	missense	probably benign	0.04
R7927:Tecrl	UTSW	5	83,502,666 (GRCm39)	missense	probably damaging	1.00
R8246:Tecrl	UTSW	5	83,427,156 (GRCm39)	missense	probably damaging	0.99
R8360:Tecrl	UTSW	5	83,448,764 (GRCm39)	missense	probably damaging	1.00
R8466:Tecrl	UTSW	5	83,428,367 (GRCm39)	nonsense	probably null
R8947:Tecrl	UTSW	5	83,461,154 (GRCm39)	missense	probably benign	0.10
R8949:Tecrl	UTSW	5	83,461,154 (GRCm39)	missense	probably benign	0.10
R9009:Tecrl	UTSW	5	83,432,121 (GRCm39)	missense	probably damaging	0.96
R9115:Tecrl	UTSW	5	83,427,906 (GRCm39)	missense	possibly damaging	0.93
R9182:Tecrl	UTSW	5	83,457,049 (GRCm39)	critical splice donor site	probably null
R9320:Tecrl	UTSW	5	83,428,422 (GRCm39)	missense	possibly damaging	0.67
X0019:Tecrl	UTSW	5	83,486,099 (GRCm39)	missense	probably benign	0.32
X0024:Tecrl	UTSW	5	83,486,099 (GRCm39)	missense	probably benign	0.32
X0034:Tecrl	UTSW	5	83,486,099 (GRCm39)	missense	probably benign	0.32
X0035:Tecrl	UTSW	5	83,486,099 (GRCm39)	missense	probably benign	0.32
X0036:Tecrl	UTSW	5	83,486,099 (GRCm39)	missense	probably benign	0.32
X0037:Tecrl	UTSW	5	83,486,099 (GRCm39)	missense	probably benign	0.32
X0038:Tecrl	UTSW	5	83,486,099 (GRCm39)	missense	probably benign	0.32
X0039:Tecrl	UTSW	5	83,486,099 (GRCm39)	missense	probably benign	0.32
X0040:Tecrl	UTSW	5	83,486,099 (GRCm39)	missense	probably benign	0.32
X0052:Tecrl	UTSW	5	83,486,099 (GRCm39)	missense	probably benign	0.32
X0053:Tecrl	UTSW	5	83,486,099 (GRCm39)	missense	probably benign	0.32
X0054:Tecrl	UTSW	5	83,486,099 (GRCm39)	missense	probably benign	0.32
X0058:Tecrl	UTSW	5	83,486,099 (GRCm39)	missense	probably benign	0.32
X0060:Tecrl	UTSW	5	83,486,099 (GRCm39)	missense	probably benign	0.32
X0061:Tecrl	UTSW	5	83,486,099 (GRCm39)	missense	probably benign	0.32
X0062:Tecrl	UTSW	5	83,486,099 (GRCm39)	missense	probably benign	0.32
X0063:Tecrl	UTSW	5	83,486,099 (GRCm39)	missense	probably benign	0.32

Posted On

2015-04-16