Incidental Mutation 'IGL02391:Or13p4'
ID 293861
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or13p4
Ensembl Gene ENSMUSG00000043383
Gene Name olfactory receptor family 13 subfamily P member 4
Synonyms GA_x6K02T2QD9B-18856980-18857927, MOR258-3, Olfr1342
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # IGL02391
Quality Score
Chromosome 4
Chromosomal Location 118546349-118550231 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 118547538 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 37 (L37P)
Ref Sequence ENSEMBL: ENSMUSP00000149966 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060562] [ENSMUST00000216226]
AlphaFold Q8VFY3
Predicted Effect probably damaging
Transcript: ENSMUST00000060562
AA Change: L37P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000053925
Gene: ENSMUSG00000043383
AA Change: L37P

low complexity region 10 24 N/A INTRINSIC
Pfam:7tm_4 34 311 1.5e-55 PFAM
Pfam:7TM_GPCR_Srsx 38 243 1.6e-5 PFAM
Pfam:7tm_1 44 293 4.2e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000216226
AA Change: L37P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc4 T A 14: 118,790,764 (GRCm39) N748Y probably damaging Het
Actbl2 A G 13: 111,391,701 (GRCm39) D12G possibly damaging Het
Adamts10 T C 17: 33,747,785 (GRCm39) S74P probably benign Het
Adprs C T 4: 126,211,701 (GRCm39) probably benign Het
Amn1 A G 6: 149,070,944 (GRCm39) probably null Het
Antxr1 A T 6: 87,264,038 (GRCm39) I144N probably damaging Het
Atp2a3 C A 11: 72,866,165 (GRCm39) H262N probably benign Het
Cabp5 A T 7: 13,132,269 (GRCm39) R13* probably null Het
Cacna1e A G 1: 154,296,859 (GRCm39) Y1669H probably damaging Het
Ccdc174 A G 6: 91,875,263 (GRCm39) E364G possibly damaging Het
Ccdc18 C T 5: 108,283,918 (GRCm39) P74S probably damaging Het
Clec3a C T 8: 115,152,240 (GRCm39) S82L probably benign Het
Cnih3 A G 1: 181,234,078 (GRCm39) D43G probably damaging Het
Dpp10 G A 1: 123,578,087 (GRCm39) T128M probably damaging Het
Edar A T 10: 58,464,403 (GRCm39) F79I probably damaging Het
Eif2ak4 T A 2: 118,251,272 (GRCm39) H199Q probably benign Het
Fermt1 A G 2: 132,783,871 (GRCm39) L46P probably damaging Het
Glipr1 A G 10: 111,824,799 (GRCm39) probably benign Het
Gsdmc T C 15: 63,675,428 (GRCm39) N129S probably damaging Het
Ift88 T C 14: 57,718,871 (GRCm39) S619P possibly damaging Het
Itga9 T A 9: 118,679,873 (GRCm39) V262E probably benign Het
Med17 G A 9: 15,188,963 (GRCm39) R101* probably null Het
Mta1 T A 12: 113,100,203 (GRCm39) I688N possibly damaging Het
Muc4 A T 16: 32,570,894 (GRCm39) R651S probably benign Het
Opcml A G 9: 28,586,560 (GRCm39) I93V probably damaging Het
Or12d17 C T 17: 37,777,477 (GRCm39) P127S probably damaging Het
Or9r7 A G 10: 129,962,773 (GRCm39) V51A possibly damaging Het
Parg T G 14: 31,984,638 (GRCm39) probably null Het
Rps3a3 A G 13: 108,807,417 (GRCm39) probably benign Het
Safb T A 17: 56,907,813 (GRCm39) probably benign Het
Sat2 G T 11: 69,513,575 (GRCm39) C54F probably damaging Het
Scin T A 12: 40,127,530 (GRCm39) Y420F probably benign Het
Slc22a29 A T 19: 8,146,717 (GRCm39) S362T probably benign Het
Smchd1 T C 17: 71,738,254 (GRCm39) D537G probably null Het
Spred3 A G 7: 28,865,830 (GRCm39) S126P probably benign Het
Ssh1 C T 5: 114,080,578 (GRCm39) E951K probably damaging Het
Ssmem1 A G 6: 30,512,441 (GRCm39) E28G possibly damaging Het
Stox1 A T 10: 62,495,455 (GRCm39) probably benign Het
Syn3 T C 10: 85,900,770 (GRCm39) I373V probably benign Het
Tecrl A T 5: 83,502,674 (GRCm39) F58L probably benign Het
Trp53bp1 T C 2: 121,033,191 (GRCm39) N1655S possibly damaging Het
Usp2 G T 9: 44,002,524 (GRCm39) Q147H probably damaging Het
Usp24 T A 4: 106,264,326 (GRCm39) N1751K possibly damaging Het
Wipf1 T A 2: 73,264,487 (GRCm39) D438V probably damaging Het
Other mutations in Or13p4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01823:Or13p4 APN 4 118,546,918 (GRCm39) missense probably damaging 1.00
R0648:Or13p4 UTSW 4 118,547,269 (GRCm39) missense probably benign
R1565:Or13p4 UTSW 4 118,547,389 (GRCm39) missense probably damaging 1.00
R1675:Or13p4 UTSW 4 118,547,145 (GRCm39) missense probably benign 0.00
R1823:Or13p4 UTSW 4 118,547,389 (GRCm39) missense probably damaging 1.00
R2343:Or13p4 UTSW 4 118,547,384 (GRCm39) missense probably benign 0.30
R4618:Or13p4 UTSW 4 118,546,667 (GRCm39) utr 3 prime probably benign
R4941:Or13p4 UTSW 4 118,547,089 (GRCm39) missense possibly damaging 0.76
R5408:Or13p4 UTSW 4 118,547,641 (GRCm39) missense probably benign 0.00
R5587:Or13p4 UTSW 4 118,547,067 (GRCm39) missense probably damaging 1.00
R5895:Or13p4 UTSW 4 118,547,314 (GRCm39) missense probably damaging 0.97
R6023:Or13p4 UTSW 4 118,547,271 (GRCm39) missense probably damaging 1.00
R6307:Or13p4 UTSW 4 118,547,145 (GRCm39) missense probably benign 0.00
R6324:Or13p4 UTSW 4 118,547,728 (GRCm39) start gained probably benign
R6890:Or13p4 UTSW 4 118,546,728 (GRCm39) missense possibly damaging 0.72
R7218:Or13p4 UTSW 4 118,547,215 (GRCm39) missense probably benign
R7408:Or13p4 UTSW 4 118,546,859 (GRCm39) missense probably damaging 0.98
R7555:Or13p4 UTSW 4 118,546,839 (GRCm39) missense possibly damaging 0.94
R7749:Or13p4 UTSW 4 118,547,425 (GRCm39) missense probably damaging 1.00
R8098:Or13p4 UTSW 4 118,547,406 (GRCm39) missense possibly damaging 0.88
R8493:Or13p4 UTSW 4 118,547,229 (GRCm39) missense probably benign 0.01
R9445:Or13p4 UTSW 4 118,547,416 (GRCm39) missense probably damaging 0.98
R9500:Or13p4 UTSW 4 118,546,930 (GRCm39) missense possibly damaging 0.91
Z1176:Or13p4 UTSW 4 118,547,469 (GRCm39) missense probably benign 0.31
Posted On 2015-04-16