Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02391:Amn1'

293873

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Amn1

Ensembl Gene

ENSMUSG00000068250

Gene Name

antagonist of mitotic exit network 1

Synonyms

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.146) question?

Stock #

IGL02391

Quality Score

Status

Chromosome

Chromosomal Location

149157147-149188712 bp(-) (GRCm38)

Type of Mutation

critical splice donor site (2 bp from exon)

DNA Base Change (assembly)

A to G at 149169446 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000107160 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095319] [ENSMUST00000111535] [ENSMUST00000141346]

AlphaFold

B8JKV0

Predicted Effect

probably null
Transcript: ENSMUST00000095319

SMART Domains

Protein: ENSMUSP00000092957
Gene: ENSMUSG00000068250

Domain	Start	End	E-Value	Type
LRR	17	41	2.82e0	SMART
LRR	42	70	1.52e2	SMART
LRR	71	96	1.25e-1	SMART
LRR	97	122	3.89e-3	SMART
LRR	123	147	1.44e1	SMART
LRR	150	175	1.28e1	SMART
Blast:LRR	176	204	3e-10	BLAST

Predicted Effect

probably null
Transcript: ENSMUST00000111535

SMART Domains

Protein: ENSMUSP00000107160
Gene: ENSMUSG00000068250

Domain	Start	End	E-Value	Type
LRR	60	84	2.82e0	SMART
LRR	85	113	1.52e2	SMART
LRR	114	139	1.25e-1	SMART
LRR	140	165	3.89e-3	SMART
LRR	166	190	1.44e1	SMART
LRR	193	218	1.28e1	SMART
Blast:LRR	219	247	4e-10	BLAST

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000127743

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000134181

Predicted Effect

probably benign
Transcript: ENSMUST00000141346

SMART Domains

Protein: ENSMUSP00000116060
Gene: ENSMUSG00000068250

Domain	Start	End	E-Value	Type
LRR	17	41	2.82e0	SMART
LRR	42	70	1.52e2	SMART
LRR	71	96	1.25e-1	SMART
LRR	97	121	1.44e1	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000149149

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000150610

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000152062

Predicted Effect

probably benign
Transcript: ENSMUST00000156864

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000203043

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000204681

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc4	T	A	14: 118,553,352	N748Y	probably damaging	Het
Actbl2	A	G	13: 111,255,167	D12G	possibly damaging	Het
Adamts10	T	C	17: 33,528,811	S74P	probably benign	Het
Adprhl2	C	T	4: 126,317,908		probably benign	Het
Antxr1	A	T	6: 87,287,056	I144N	probably damaging	Het
Atp2a3	C	A	11: 72,975,339	H262N	probably benign	Het
Cabp5	A	T	7: 13,398,344	R13*	probably null	Het
Cacna1e	A	G	1: 154,421,113	Y1669H	probably damaging	Het
Ccdc174	A	G	6: 91,898,282	E364G	possibly damaging	Het
Ccdc18	C	T	5: 108,136,052	P74S	probably damaging	Het
Clec3a	C	T	8: 114,425,500	S82L	probably benign	Het
Cnih3	A	G	1: 181,406,513	D43G	probably damaging	Het
Dpp10	G	A	1: 123,650,358	T128M	probably damaging	Het
Edar	A	T	10: 58,628,581	F79I	probably damaging	Het
Eif2ak4	T	A	2: 118,420,791	H199Q	probably benign	Het
Fermt1	A	G	2: 132,941,951	L46P	probably damaging	Het
Glipr1	A	G	10: 111,988,894		probably benign	Het
Gsdmc	T	C	15: 63,803,579	N129S	probably damaging	Het
Ift88	T	C	14: 57,481,414	S619P	possibly damaging	Het
Itga9	T	A	9: 118,850,805	V262E	probably benign	Het
Med17	G	A	9: 15,277,667	R101*	probably null	Het
Mta1	T	A	12: 113,136,583	I688N	possibly damaging	Het
Muc4	A	T	16: 32,752,076	R651S	probably benign	Het
Olfr109	C	T	17: 37,466,586	P127S	probably damaging	Het
Olfr1342	A	G	4: 118,690,341	L37P	probably damaging	Het
Olfr824	A	G	10: 130,126,904	V51A	possibly damaging	Het
Opcml	A	G	9: 28,675,264	I93V	probably damaging	Het
Parg	T	G	14: 32,262,681		probably null	Het
Rps3a3	A	G	13: 108,670,883		probably benign	Het
Safb	T	A	17: 56,600,813		probably benign	Het
Sat2	G	T	11: 69,622,749	C54F	probably damaging	Het
Scin	T	A	12: 40,077,531	Y420F	probably benign	Het
Slc22a29	A	T	19: 8,169,353	S362T	probably benign	Het
Smchd1	T	C	17: 71,431,259	D537G	probably null	Het
Spred3	A	G	7: 29,166,405	S126P	probably benign	Het
Ssh1	C	T	5: 113,942,517	E951K	probably damaging	Het
Ssmem1	A	G	6: 30,512,442	E28G	possibly damaging	Het
Stox1	A	T	10: 62,659,676		probably benign	Het
Syn3	T	C	10: 86,064,906	I373V	probably benign	Het
Tecrl	A	T	5: 83,354,827	F58L	probably benign	Het
Trp53bp1	T	C	2: 121,202,710	N1655S	possibly damaging	Het
Usp2	G	T	9: 44,091,227	Q147H	probably damaging	Het
Usp24	T	A	4: 106,407,129	N1751K	possibly damaging	Het
Wipf1	T	A	2: 73,434,143	D438V	probably damaging	Het

Other mutations in Amn1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
PIT4453001:Amn1	UTSW	6	149170859	missense	probably benign	0.00
R0153:Amn1	UTSW	6	149188593	utr 5 prime	probably benign
R0494:Amn1	UTSW	6	149185136	unclassified	probably benign
R0557:Amn1	UTSW	6	149171005	missense	possibly damaging	0.50
R0717:Amn1	UTSW	6	149183472	missense	possibly damaging	0.88
R0736:Amn1	UTSW	6	149183472	missense	possibly damaging	0.88
R3420:Amn1	UTSW	6	149169452	nonsense	probably null
R3421:Amn1	UTSW	6	149169452	nonsense	probably null
R4466:Amn1	UTSW	6	149166845	splice site	probably null
R4760:Amn1	UTSW	6	149185113	missense	probably benign
R5294:Amn1	UTSW	6	149185124	unclassified	probably benign
R5356:Amn1	UTSW	6	149166894	missense	possibly damaging	0.80
R5561:Amn1	UTSW	6	149185024	missense	probably damaging	0.98
R7501:Amn1	UTSW	6	149185031	missense	probably benign	0.19
R7564:Amn1	UTSW	6	149185031	missense	probably benign	0.19
R7643:Amn1	UTSW	6	149185031	missense	probably benign	0.19
R7645:Amn1	UTSW	6	149185031	missense	probably benign	0.19
R8097:Amn1	UTSW	6	149169355	unclassified	probably benign
R9390:Amn1	UTSW	6	149183485	missense	probably damaging	1.00
X0064:Amn1	UTSW	6	149171035	missense	probably damaging	1.00

Posted On

2015-04-16