Incidental Mutation 'IGL02391:Amn1'
ID 293873
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Amn1
Ensembl Gene ENSMUSG00000068250
Gene Name antagonist of mitotic exit network 1
Synonyms C730024G19Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.087) question?
Stock # IGL02391
Quality Score
Status
Chromosome 6
Chromosomal Location 149059075-149090210 bp(-) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) A to G at 149070944 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000107160 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000095319] [ENSMUST00000111535] [ENSMUST00000141346]
AlphaFold B8JKV0
Predicted Effect probably null
Transcript: ENSMUST00000095319
SMART Domains Protein: ENSMUSP00000092957
Gene: ENSMUSG00000068250

DomainStartEndE-ValueType
LRR 17 41 2.82e0 SMART
LRR 42 70 1.52e2 SMART
LRR 71 96 1.25e-1 SMART
LRR 97 122 3.89e-3 SMART
LRR 123 147 1.44e1 SMART
LRR 150 175 1.28e1 SMART
Blast:LRR 176 204 3e-10 BLAST
Predicted Effect probably null
Transcript: ENSMUST00000111535
SMART Domains Protein: ENSMUSP00000107160
Gene: ENSMUSG00000068250

DomainStartEndE-ValueType
LRR 60 84 2.82e0 SMART
LRR 85 113 1.52e2 SMART
LRR 114 139 1.25e-1 SMART
LRR 140 165 3.89e-3 SMART
LRR 166 190 1.44e1 SMART
LRR 193 218 1.28e1 SMART
Blast:LRR 219 247 4e-10 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127743
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134181
Predicted Effect probably benign
Transcript: ENSMUST00000141346
SMART Domains Protein: ENSMUSP00000116060
Gene: ENSMUSG00000068250

DomainStartEndE-ValueType
LRR 17 41 2.82e0 SMART
LRR 42 70 1.52e2 SMART
LRR 71 96 1.25e-1 SMART
LRR 97 121 1.44e1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149149
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150610
Predicted Effect noncoding transcript
Transcript: ENSMUST00000152062
Predicted Effect probably benign
Transcript: ENSMUST00000156864
Predicted Effect noncoding transcript
Transcript: ENSMUST00000204681
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203043
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc4 T A 14: 118,790,764 (GRCm39) N748Y probably damaging Het
Actbl2 A G 13: 111,391,701 (GRCm39) D12G possibly damaging Het
Adamts10 T C 17: 33,747,785 (GRCm39) S74P probably benign Het
Adprs C T 4: 126,211,701 (GRCm39) probably benign Het
Antxr1 A T 6: 87,264,038 (GRCm39) I144N probably damaging Het
Atp2a3 C A 11: 72,866,165 (GRCm39) H262N probably benign Het
Cabp5 A T 7: 13,132,269 (GRCm39) R13* probably null Het
Cacna1e A G 1: 154,296,859 (GRCm39) Y1669H probably damaging Het
Ccdc174 A G 6: 91,875,263 (GRCm39) E364G possibly damaging Het
Ccdc18 C T 5: 108,283,918 (GRCm39) P74S probably damaging Het
Clec3a C T 8: 115,152,240 (GRCm39) S82L probably benign Het
Cnih3 A G 1: 181,234,078 (GRCm39) D43G probably damaging Het
Dpp10 G A 1: 123,578,087 (GRCm39) T128M probably damaging Het
Edar A T 10: 58,464,403 (GRCm39) F79I probably damaging Het
Eif2ak4 T A 2: 118,251,272 (GRCm39) H199Q probably benign Het
Fermt1 A G 2: 132,783,871 (GRCm39) L46P probably damaging Het
Glipr1 A G 10: 111,824,799 (GRCm39) probably benign Het
Gsdmc T C 15: 63,675,428 (GRCm39) N129S probably damaging Het
Ift88 T C 14: 57,718,871 (GRCm39) S619P possibly damaging Het
Itga9 T A 9: 118,679,873 (GRCm39) V262E probably benign Het
Med17 G A 9: 15,188,963 (GRCm39) R101* probably null Het
Mta1 T A 12: 113,100,203 (GRCm39) I688N possibly damaging Het
Muc4 A T 16: 32,570,894 (GRCm39) R651S probably benign Het
Opcml A G 9: 28,586,560 (GRCm39) I93V probably damaging Het
Or12d17 C T 17: 37,777,477 (GRCm39) P127S probably damaging Het
Or13p4 A G 4: 118,547,538 (GRCm39) L37P probably damaging Het
Or9r7 A G 10: 129,962,773 (GRCm39) V51A possibly damaging Het
Parg T G 14: 31,984,638 (GRCm39) probably null Het
Rps3a3 A G 13: 108,807,417 (GRCm39) probably benign Het
Safb T A 17: 56,907,813 (GRCm39) probably benign Het
Sat2 G T 11: 69,513,575 (GRCm39) C54F probably damaging Het
Scin T A 12: 40,127,530 (GRCm39) Y420F probably benign Het
Slc22a29 A T 19: 8,146,717 (GRCm39) S362T probably benign Het
Smchd1 T C 17: 71,738,254 (GRCm39) D537G probably null Het
Spred3 A G 7: 28,865,830 (GRCm39) S126P probably benign Het
Ssh1 C T 5: 114,080,578 (GRCm39) E951K probably damaging Het
Ssmem1 A G 6: 30,512,441 (GRCm39) E28G possibly damaging Het
Stox1 A T 10: 62,495,455 (GRCm39) probably benign Het
Syn3 T C 10: 85,900,770 (GRCm39) I373V probably benign Het
Tecrl A T 5: 83,502,674 (GRCm39) F58L probably benign Het
Trp53bp1 T C 2: 121,033,191 (GRCm39) N1655S possibly damaging Het
Usp2 G T 9: 44,002,524 (GRCm39) Q147H probably damaging Het
Usp24 T A 4: 106,264,326 (GRCm39) N1751K possibly damaging Het
Wipf1 T A 2: 73,264,487 (GRCm39) D438V probably damaging Het
Other mutations in Amn1
AlleleSourceChrCoordTypePredicted EffectPPH Score
PIT4453001:Amn1 UTSW 6 149,072,357 (GRCm39) missense probably benign 0.00
R0153:Amn1 UTSW 6 149,090,091 (GRCm39) utr 5 prime probably benign
R0494:Amn1 UTSW 6 149,086,634 (GRCm39) unclassified probably benign
R0557:Amn1 UTSW 6 149,072,503 (GRCm39) missense possibly damaging 0.50
R0717:Amn1 UTSW 6 149,084,970 (GRCm39) missense possibly damaging 0.88
R0736:Amn1 UTSW 6 149,084,970 (GRCm39) missense possibly damaging 0.88
R3420:Amn1 UTSW 6 149,070,950 (GRCm39) nonsense probably null
R3421:Amn1 UTSW 6 149,070,950 (GRCm39) nonsense probably null
R4466:Amn1 UTSW 6 149,068,343 (GRCm39) splice site probably null
R4760:Amn1 UTSW 6 149,086,611 (GRCm39) missense probably benign
R5294:Amn1 UTSW 6 149,086,622 (GRCm39) unclassified probably benign
R5356:Amn1 UTSW 6 149,068,392 (GRCm39) missense possibly damaging 0.80
R5561:Amn1 UTSW 6 149,086,522 (GRCm39) missense probably damaging 0.98
R7501:Amn1 UTSW 6 149,086,529 (GRCm39) missense probably benign 0.19
R7564:Amn1 UTSW 6 149,086,529 (GRCm39) missense probably benign 0.19
R7643:Amn1 UTSW 6 149,086,529 (GRCm39) missense probably benign 0.19
R7645:Amn1 UTSW 6 149,086,529 (GRCm39) missense probably benign 0.19
R8097:Amn1 UTSW 6 149,070,853 (GRCm39) unclassified probably benign
R9390:Amn1 UTSW 6 149,084,983 (GRCm39) missense probably damaging 1.00
R9565:Amn1 UTSW 6 149,090,103 (GRCm39) start gained probably benign
X0064:Amn1 UTSW 6 149,072,533 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16