Incidental Mutation 'IGL02393:Kif26a'
ID 293906
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Kif26a
Ensembl Gene ENSMUSG00000021294
Gene Name kinesin family member 26A
Synonyms N-11 kinesin
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL02393
Quality Score
Status
Chromosome 12
Chromosomal Location 112112642-112148181 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 112139098 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Methionine at position 396 (V396M)
Ref Sequence ENSEMBL: ENSMUSP00000119482 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000128402]
AlphaFold Q52KG5
Predicted Effect probably damaging
Transcript: ENSMUST00000128402
AA Change: V396M

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000119482
Gene: ENSMUSG00000021294
AA Change: V396M

DomainStartEndE-ValueType
low complexity region 238 248 N/A INTRINSIC
low complexity region 279 297 N/A INTRINSIC
KISc 362 726 9.57e-35 SMART
low complexity region 727 739 N/A INTRINSIC
low complexity region 740 754 N/A INTRINSIC
low complexity region 932 957 N/A INTRINSIC
low complexity region 1005 1012 N/A INTRINSIC
low complexity region 1044 1054 N/A INTRINSIC
low complexity region 1084 1095 N/A INTRINSIC
low complexity region 1328 1360 N/A INTRINSIC
low complexity region 1458 1471 N/A INTRINSIC
low complexity region 1477 1493 N/A INTRINSIC
low complexity region 1519 1538 N/A INTRINSIC
low complexity region 1574 1587 N/A INTRINSIC
low complexity region 1664 1675 N/A INTRINSIC
low complexity region 1699 1713 N/A INTRINSIC
coiled coil region 1780 1812 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit premature death associated with megacolon and hyperganglionosis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam32 A T 8: 25,410,069 (GRCm39) Y129N probably damaging Het
Afap1l2 T C 19: 56,902,872 (GRCm39) K695R probably damaging Het
Arhgap18 T G 10: 26,753,179 (GRCm39) S357R probably benign Het
Camsap1 T C 2: 25,828,334 (GRCm39) H1130R probably benign Het
Cdkl4 A G 17: 80,867,844 (GRCm39) F35L probably damaging Het
Crnn A G 3: 93,056,675 (GRCm39) H487R probably damaging Het
Dcaf4 C T 12: 83,576,805 (GRCm39) P95L probably damaging Het
Deaf1 A T 7: 140,893,246 (GRCm39) V382E possibly damaging Het
Dph7 T G 2: 24,856,609 (GRCm39) V187G possibly damaging Het
Fat3 G T 9: 15,899,708 (GRCm39) C3108* probably null Het
Ggt5 T C 10: 75,446,071 (GRCm39) probably benign Het
Med17 G A 9: 15,188,963 (GRCm39) R101* probably null Het
Mterf4 C T 1: 93,230,601 (GRCm39) V182I possibly damaging Het
Nsg1 T C 5: 38,316,255 (GRCm39) D32G probably damaging Het
Or5k8 A G 16: 58,644,409 (GRCm39) I221T probably damaging Het
Or6c3 T C 10: 129,309,064 (GRCm39) S168P probably damaging Het
Or6c65 T A 10: 129,603,662 (GRCm39) V99E probably benign Het
P3h2 T C 16: 25,811,575 (GRCm39) Y216C probably damaging Het
Pdzd9 A C 7: 120,262,206 (GRCm39) Y85* probably null Het
Prkdc T A 16: 15,634,622 (GRCm39) V3589D probably benign Het
Qars1 A G 9: 108,391,528 (GRCm39) T26A probably benign Het
Relch A G 1: 105,615,093 (GRCm39) I253M probably damaging Het
Rhd T C 4: 134,611,406 (GRCm39) S189P probably benign Het
Rhobtb1 A T 10: 69,124,817 (GRCm39) H555L probably damaging Het
Rogdi G A 16: 4,827,088 (GRCm39) S306F probably benign Het
Slc25a25 C T 2: 32,307,855 (GRCm39) V259I probably benign Het
Srrm1 A T 4: 135,048,725 (GRCm39) probably benign Het
Stkld1 T C 2: 26,840,154 (GRCm39) V408A probably benign Het
Thbs1 T C 2: 117,953,580 (GRCm39) V999A possibly damaging Het
Tmprss11d T A 5: 86,451,471 (GRCm39) *280L probably null Het
Trim54 A G 5: 31,289,324 (GRCm39) probably benign Het
Tspear G A 10: 77,672,407 (GRCm39) R202H probably damaging Het
Vwa8 G A 14: 79,420,417 (GRCm39) G1706D probably damaging Het
Other mutations in Kif26a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00233:Kif26a APN 12 112,124,066 (GRCm39) missense probably damaging 0.97
IGL01734:Kif26a APN 12 112,143,262 (GRCm39) missense probably benign 0.23
IGL01916:Kif26a APN 12 112,143,328 (GRCm39) missense possibly damaging 0.49
IGL02080:Kif26a APN 12 112,124,000 (GRCm39) missense probably damaging 1.00
IGL02138:Kif26a APN 12 112,141,284 (GRCm39) missense probably damaging 1.00
IGL02145:Kif26a APN 12 112,143,409 (GRCm39) missense probably benign 0.00
IGL02285:Kif26a APN 12 112,123,941 (GRCm39) missense probably damaging 1.00
IGL02445:Kif26a APN 12 112,140,177 (GRCm39) missense probably damaging 1.00
IGL02865:Kif26a APN 12 112,144,049 (GRCm39) nonsense probably null
IGL03057:Kif26a APN 12 112,142,208 (GRCm39) nonsense probably null
IGL03204:Kif26a APN 12 112,141,213 (GRCm39) missense probably damaging 1.00
R0013:Kif26a UTSW 12 112,144,314 (GRCm39) missense probably benign 0.03
R0034:Kif26a UTSW 12 112,135,397 (GRCm39) splice site probably benign
R0089:Kif26a UTSW 12 112,143,837 (GRCm39) missense probably damaging 0.98
R0111:Kif26a UTSW 12 112,129,771 (GRCm39) splice site probably benign
R0220:Kif26a UTSW 12 112,123,824 (GRCm39) missense probably damaging 0.98
R0346:Kif26a UTSW 12 112,145,782 (GRCm39) missense probably null 0.09
R0383:Kif26a UTSW 12 112,144,510 (GRCm39) missense possibly damaging 0.94
R0478:Kif26a UTSW 12 112,142,223 (GRCm39) missense probably damaging 1.00
R0494:Kif26a UTSW 12 112,145,905 (GRCm39) splice site probably null
R1163:Kif26a UTSW 12 112,146,379 (GRCm39) missense probably benign 0.08
R1450:Kif26a UTSW 12 112,140,286 (GRCm39) missense probably damaging 1.00
R1512:Kif26a UTSW 12 112,113,389 (GRCm39) missense possibly damaging 0.47
R1616:Kif26a UTSW 12 112,123,680 (GRCm39) critical splice acceptor site probably null
R1723:Kif26a UTSW 12 112,140,292 (GRCm39) missense possibly damaging 0.67
R1728:Kif26a UTSW 12 112,143,219 (GRCm39) missense possibly damaging 0.95
R1729:Kif26a UTSW 12 112,143,219 (GRCm39) missense possibly damaging 0.95
R1903:Kif26a UTSW 12 112,141,974 (GRCm39) missense probably damaging 1.00
R2283:Kif26a UTSW 12 112,143,787 (GRCm39) missense possibly damaging 0.66
R3862:Kif26a UTSW 12 112,146,323 (GRCm39) missense probably benign 0.30
R3906:Kif26a UTSW 12 112,143,324 (GRCm39) missense probably benign
R4050:Kif26a UTSW 12 112,146,350 (GRCm39) missense probably benign 0.08
R4270:Kif26a UTSW 12 112,139,848 (GRCm39) missense probably damaging 1.00
R4271:Kif26a UTSW 12 112,139,848 (GRCm39) missense probably damaging 1.00
R4731:Kif26a UTSW 12 112,142,007 (GRCm39) missense probably benign
R4732:Kif26a UTSW 12 112,142,007 (GRCm39) missense probably benign
R4733:Kif26a UTSW 12 112,142,007 (GRCm39) missense probably benign
R4908:Kif26a UTSW 12 112,123,776 (GRCm39) missense probably damaging 1.00
R4946:Kif26a UTSW 12 112,144,228 (GRCm39) missense probably damaging 0.99
R5566:Kif26a UTSW 12 112,123,788 (GRCm39) missense probably damaging 1.00
R6280:Kif26a UTSW 12 112,141,303 (GRCm39) missense probably damaging 0.99
R6422:Kif26a UTSW 12 112,135,309 (GRCm39) missense possibly damaging 0.95
R6513:Kif26a UTSW 12 112,141,926 (GRCm39) missense probably damaging 0.97
R6860:Kif26a UTSW 12 112,113,263 (GRCm39) missense probably damaging 1.00
R6879:Kif26a UTSW 12 112,144,087 (GRCm39) missense probably benign
R7127:Kif26a UTSW 12 112,144,579 (GRCm39) missense probably damaging 1.00
R7366:Kif26a UTSW 12 112,129,976 (GRCm39) critical splice donor site probably null
R7595:Kif26a UTSW 12 112,145,759 (GRCm39) missense probably benign 0.30
R7630:Kif26a UTSW 12 112,142,131 (GRCm39) missense probably damaging 1.00
R7784:Kif26a UTSW 12 112,144,581 (GRCm39) missense possibly damaging 0.66
R7992:Kif26a UTSW 12 112,142,481 (GRCm39) missense probably benign
R8170:Kif26a UTSW 12 112,141,752 (GRCm39) splice site probably null
R9206:Kif26a UTSW 12 112,144,480 (GRCm39) missense possibly damaging 0.92
R9287:Kif26a UTSW 12 112,145,719 (GRCm39) nonsense probably null
R9293:Kif26a UTSW 12 112,112,835 (GRCm39) missense probably damaging 1.00
R9524:Kif26a UTSW 12 112,140,286 (GRCm39) missense probably damaging 1.00
R9559:Kif26a UTSW 12 112,142,004 (GRCm39) missense probably damaging 1.00
R9687:Kif26a UTSW 12 112,143,625 (GRCm39) missense probably damaging 0.99
R9793:Kif26a UTSW 12 112,142,887 (GRCm39) missense probably damaging 1.00
X0027:Kif26a UTSW 12 112,142,504 (GRCm39) missense probably benign 0.26
Z1176:Kif26a UTSW 12 112,144,052 (GRCm39) missense probably damaging 0.97
Z1177:Kif26a UTSW 12 112,144,045 (GRCm39) missense probably damaging 0.98
Posted On 2015-04-16