Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02441:Zfp609'

293996

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp609

Ensembl Gene

ENSMUSG00000040524

Gene Name

zinc finger protein 609

Synonyms

Accession Numbers

Essential gene?

Possibly essential (E-score: 0.620) question?

Stock #

IGL02441

Quality Score

Status

Chromosome

Chromosomal Location

65599673-65734846 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 65610611 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Serine at position 784 (L784S)

Ref Sequence

ENSEMBL: ENSMUSP00000124089 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000159109]

AlphaFold

Q8BZ47

Predicted Effect

possibly damaging
Transcript: ENSMUST00000159109
AA Change: L784S

PolyPhen 2 Score 0.915 (Sensitivity: 0.81; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000124089
Gene: ENSMUSG00000040524
AA Change: L784S

Domain	Start	End	E-Value	Type
low complexity region	83	101	N/A	INTRINSIC
low complexity region	125	139	N/A	INTRINSIC
low complexity region	155	176	N/A	INTRINSIC
low complexity region	259	269	N/A	INTRINSIC
low complexity region	365	376	N/A	INTRINSIC
low complexity region	386	405	N/A	INTRINSIC
ZnF_C2H2	495	520	2.14e0	SMART
low complexity region	629	638	N/A	INTRINSIC
low complexity region	657	667	N/A	INTRINSIC
low complexity region	724	738	N/A	INTRINSIC
low complexity region	1000	1020	N/A	INTRINSIC
low complexity region	1210	1219	N/A	INTRINSIC
low complexity region	1257	1273	N/A	INTRINSIC
low complexity region	1329	1348	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000159878

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 58 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Alg8	C	T	7: 97,029,504 (GRCm39)	R179C	probably benign	Het
Als2	A	G	1: 59,254,631 (GRCm39)	M242T	probably damaging	Het
Atad1	C	T	19: 32,684,348 (GRCm39)	V17I	probably benign	Het
Bag4	A	G	8: 26,258,136 (GRCm39)	V397A	probably damaging	Het
Brd7	A	G	8: 89,070,218 (GRCm39)	V396A	probably damaging	Het
Cdc45	C	T	16: 18,617,479 (GRCm39)	M200I	probably benign	Het
Cdhr4	T	A	9: 107,870,466 (GRCm39)	I123N	possibly damaging	Het
Cep68	A	G	11: 20,189,186 (GRCm39)	F609L	probably benign	Het
Clec3b	C	A	9: 122,980,178 (GRCm39)	P24T	possibly damaging	Het
Ctsg	T	A	14: 56,339,869 (GRCm39)	T9S	probably benign	Het
Dalrd3	A	T	9: 108,448,725 (GRCm39)		probably benign	Het
Dock6	A	T	9: 21,753,222 (GRCm39)	V286E	possibly damaging	Het
Dpep2	G	A	8: 106,711,723 (GRCm39)	A568V	probably benign	Het
Dph5	A	C	3: 115,720,390 (GRCm39)	Q192P	possibly damaging	Het
Eppin	T	A	2: 164,433,698 (GRCm39)	R37*	probably null	Het
Esyt1	A	G	10: 128,348,293 (GRCm39)	L865P	possibly damaging	Het
Exoc6b	A	G	6: 84,981,990 (GRCm39)	L102P	probably damaging	Het
Foxo6	A	G	4: 120,125,232 (GRCm39)	I521T	possibly damaging	Het
Guca1a	A	T	17: 47,705,578 (GRCm39)		probably benign	Het
Hpx	A	G	7: 105,241,430 (GRCm39)	F327S	probably damaging	Het
Hspa12b	A	G	2: 130,980,515 (GRCm39)	M145V	probably null	Het
Hspa4	A	T	11: 53,161,809 (GRCm39)	S448T	probably benign	Het
Kbtbd6	T	C	14: 79,690,759 (GRCm39)	Y422H	probably benign	Het
Lama4	A	T	10: 38,937,441 (GRCm39)	D677V	probably benign	Het
Ldb1	C	T	19: 46,024,195 (GRCm39)	E111K	probably damaging	Het
Macf1	A	G	4: 123,281,029 (GRCm39)	S3823P	probably damaging	Het
Man1a2	G	A	3: 100,499,189 (GRCm39)	T415I	probably benign	Het
Map3k2	T	C	18: 32,333,099 (GRCm39)		probably benign	Het
Morn5	T	A	2: 35,945,038 (GRCm39)	Y87*	probably null	Het
Mpp3	T	C	11: 101,900,501 (GRCm39)	D326G	probably benign	Het
Mrgprx1	T	C	7: 47,671,336 (GRCm39)	H137R	probably benign	Het
Nav2	C	A	7: 49,102,260 (GRCm39)	P292T	probably damaging	Het
Nlrp2	C	A	7: 5,338,566 (GRCm39)		probably null	Het
Noxo1	G	A	17: 24,918,030 (GRCm39)	S112N	probably damaging	Het
Nudt9	G	T	5: 104,212,885 (GRCm39)	K319N	probably benign	Het
Or8b38	A	T	9: 37,973,233 (GRCm39)	I206L	probably benign	Het
Osbpl7	C	A	11: 96,958,528 (GRCm39)	Q728K	probably damaging	Het
Pcsk1	A	T	13: 75,280,282 (GRCm39)	E702D	probably benign	Het
Piezo2	T	C	18: 63,205,933 (GRCm39)	D1492G	probably damaging	Het
Plekhg1	A	G	10: 3,908,103 (GRCm39)	K1007E	possibly damaging	Het
Ppp6r3	G	A	19: 3,514,693 (GRCm39)	P141S	probably benign	Het
Prrt3	T	C	6: 113,473,977 (GRCm39)	T354A	probably damaging	Het
Ptk2	C	A	15: 73,192,675 (GRCm39)	W181L	probably benign	Het
Rif1	T	A	2: 51,995,527 (GRCm39)	H915Q	probably benign	Het
Selenbp2	G	T	3: 94,611,371 (GRCm39)	V361L	probably benign	Het
Slamf7	A	G	1: 171,468,625 (GRCm39)	L89P	probably damaging	Het
Slc6a21	G	A	7: 44,937,505 (GRCm39)	V599M	probably damaging	Het
Sltm	G	T	9: 70,494,467 (GRCm39)	S921I	probably damaging	Het
Smc4	C	A	3: 68,913,544 (GRCm39)	A44E	probably damaging	Het
Tdrd5	A	T	1: 156,087,513 (GRCm39)		probably benign	Het
Tead2	T	A	7: 44,866,845 (GRCm39)	I68N	probably damaging	Het
Tnks1bp1	T	A	2: 84,902,143 (GRCm39)	S1680T	probably damaging	Het
Topbp1	T	C	9: 103,197,438 (GRCm39)	V386A	possibly damaging	Het
Tpx2	C	A	2: 152,724,207 (GRCm39)	P328T	possibly damaging	Het
Ttn	T	A	2: 76,576,332 (GRCm39)	I24854F	probably damaging	Het
Zbtb11	G	A	16: 55,794,552 (GRCm39)	R43H	possibly damaging	Het
Zfp703	T	C	8: 27,470,036 (GRCm39)	S567P	probably damaging	Het
Zfp750	A	G	11: 121,404,455 (GRCm39)	I140T	probably benign	Het

Other mutations in Zfp609

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00956:Zfp609	APN	9	65,610,045 (GRCm39)	missense	probably benign	0.18
IGL01688:Zfp609	APN	9	65,611,307 (GRCm39)	missense	probably benign
IGL01718:Zfp609	APN	9	65,609,682 (GRCm39)	nonsense	probably null
IGL01860:Zfp609	APN	9	65,610,116 (GRCm39)	missense	possibly damaging	0.82
IGL02490:Zfp609	APN	9	65,611,250 (GRCm39)	missense	possibly damaging	0.92
IGL02614:Zfp609	APN	9	65,610,072 (GRCm39)	missense	probably damaging	0.96
IGL02794:Zfp609	APN	9	65,611,602 (GRCm39)	missense	possibly damaging	0.83
IGL02959:Zfp609	APN	9	65,610,675 (GRCm39)	missense	probably benign
IGL02967:Zfp609	APN	9	65,604,901 (GRCm39)	missense	possibly damaging	0.83
IGL03036:Zfp609	APN	9	65,609,927 (GRCm39)	missense	possibly damaging	0.89
IGL03182:Zfp609	APN	9	65,608,287 (GRCm39)	missense	probably benign	0.02
H8441:Zfp609	UTSW	9	65,702,169 (GRCm39)	missense	possibly damaging	0.82
R0304:Zfp609	UTSW	9	65,608,470 (GRCm39)	missense	possibly damaging	0.89
R0487:Zfp609	UTSW	9	65,609,916 (GRCm39)	missense	unknown
R0505:Zfp609	UTSW	9	65,610,744 (GRCm39)	missense	possibly damaging	0.92
R0684:Zfp609	UTSW	9	65,638,483 (GRCm39)	missense	probably benign	0.01
R1480:Zfp609	UTSW	9	65,610,593 (GRCm39)	missense	possibly damaging	0.82
R1507:Zfp609	UTSW	9	65,702,059 (GRCm39)	missense	possibly damaging	0.92
R1579:Zfp609	UTSW	9	65,611,754 (GRCm39)	missense	possibly damaging	0.90
R1655:Zfp609	UTSW	9	65,610,836 (GRCm39)	missense	possibly damaging	0.46
R1692:Zfp609	UTSW	9	65,702,593 (GRCm39)	missense	probably damaging	0.98
R1701:Zfp609	UTSW	9	65,638,282 (GRCm39)	missense	probably benign	0.05
R1735:Zfp609	UTSW	9	65,610,374 (GRCm39)	nonsense	probably null
R1883:Zfp609	UTSW	9	65,702,040 (GRCm39)	missense	probably benign
R1970:Zfp609	UTSW	9	65,702,559 (GRCm39)	missense	probably damaging	0.96
R2059:Zfp609	UTSW	9	65,611,716 (GRCm39)	missense	possibly damaging	0.83
R2302:Zfp609	UTSW	9	65,702,179 (GRCm39)	missense	possibly damaging	0.66
R3404:Zfp609	UTSW	9	65,608,454 (GRCm39)	missense	possibly damaging	0.68
R3405:Zfp609	UTSW	9	65,608,454 (GRCm39)	missense	possibly damaging	0.68
R4514:Zfp609	UTSW	9	65,610,977 (GRCm39)	missense	possibly damaging	0.46
R4533:Zfp609	UTSW	9	65,610,890 (GRCm39)	missense	probably benign	0.00
R5043:Zfp609	UTSW	9	65,608,109 (GRCm39)	missense	probably damaging	0.97
R5499:Zfp609	UTSW	9	65,610,137 (GRCm39)	missense	probably benign	0.00
R7081:Zfp609	UTSW	9	65,609,723 (GRCm39)	missense	possibly damaging	0.46
R7514:Zfp609	UTSW	9	65,613,418 (GRCm39)	missense	probably benign	0.05
R7677:Zfp609	UTSW	9	65,604,456 (GRCm39)	missense	possibly damaging	0.61
R7684:Zfp609	UTSW	9	65,638,362 (GRCm39)	missense	possibly damaging	0.66
R8229:Zfp609	UTSW	9	65,610,782 (GRCm39)	missense	possibly damaging	0.66
R8266:Zfp609	UTSW	9	65,610,996 (GRCm39)	missense	possibly damaging	0.66
R8278:Zfp609	UTSW	9	65,604,804 (GRCm39)	missense	possibly damaging	0.90
R8934:Zfp609	UTSW	9	65,610,561 (GRCm39)	missense	possibly damaging	0.90
R8938:Zfp609	UTSW	9	65,610,561 (GRCm39)	missense	possibly damaging	0.90
R8940:Zfp609	UTSW	9	65,610,561 (GRCm39)	missense	possibly damaging	0.90
R8986:Zfp609	UTSW	9	65,610,561 (GRCm39)	missense	possibly damaging	0.90
R9267:Zfp609	UTSW	9	65,608,328 (GRCm39)	missense	possibly damaging	0.90
R9456:Zfp609	UTSW	9	65,611,125 (GRCm39)	missense
R9561:Zfp609	UTSW	9	65,604,512 (GRCm39)	nonsense	probably null
X0028:Zfp609	UTSW	9	65,604,362 (GRCm39)	small deletion	probably benign

Posted On

2015-04-16