Incidental Mutation 'IGL02441:Zfp703'
ID293997
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp703
Ensembl Gene ENSMUSG00000085795
Gene Namezinc finger protein 703
SynonymsZeppo1, End2, 1110032O19Rik, Csmn1
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.295) question?
Stock #IGL02441
Quality Score
Status
Chromosome8
Chromosomal Location26977325-26981461 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 26980008 bp
ZygosityHeterozygous
Amino Acid Change Serine to Proline at position 567 (S567P)
Ref Sequence ENSEMBL: ENSMUSP00000128757 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000127097] [ENSMUST00000154256] [ENSMUST00000209411] [ENSMUST00000209610]
Predicted Effect probably benign
Transcript: ENSMUST00000127097
SMART Domains Protein: ENSMUSP00000132801
Gene: ENSMUSG00000085795

DomainStartEndE-ValueType
low complexity region 15 29 N/A INTRINSIC
low complexity region 32 47 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000154256
AA Change: S567P

PolyPhen 2 Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000128757
Gene: ENSMUSG00000085795
AA Change: S567P

DomainStartEndE-ValueType
low complexity region 15 29 N/A INTRINSIC
low complexity region 32 47 N/A INTRINSIC
low complexity region 133 145 N/A INTRINSIC
low complexity region 164 191 N/A INTRINSIC
low complexity region 212 231 N/A INTRINSIC
low complexity region 261 275 N/A INTRINSIC
Pfam:nlz1 315 369 3.6e-24 PFAM
low complexity region 426 442 N/A INTRINSIC
ZnF_C2H2 460 488 1.16e1 SMART
low complexity region 497 541 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000209411
Predicted Effect probably benign
Transcript: ENSMUST00000209610
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210723
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alg8 C T 7: 97,380,297 R179C probably benign Het
Als2 A G 1: 59,215,472 M242T probably damaging Het
Atad1 C T 19: 32,706,948 V17I probably benign Het
Bag4 A G 8: 25,768,108 V397A probably damaging Het
Brd7 A G 8: 88,343,590 V396A probably damaging Het
Cdc45 C T 16: 18,798,729 M200I probably benign Het
Cdhr4 T A 9: 107,993,267 I123N possibly damaging Het
Cep68 A G 11: 20,239,186 F609L probably benign Het
Clec3b C A 9: 123,151,113 P24T possibly damaging Het
Ctsg T A 14: 56,102,412 T9S probably benign Het
Dalrd3 A T 9: 108,571,526 probably benign Het
Dock6 A T 9: 21,841,926 V286E possibly damaging Het
Dpep2 G A 8: 105,985,091 A568V probably benign Het
Dph5 A C 3: 115,926,741 Q192P possibly damaging Het
Eppin T A 2: 164,591,778 R37* probably null Het
Esyt1 A G 10: 128,512,424 L865P possibly damaging Het
Exoc6b A G 6: 85,005,008 L102P probably damaging Het
Foxo6 A G 4: 120,268,035 I521T possibly damaging Het
Guca1a A T 17: 47,394,653 probably benign Het
Hpx A G 7: 105,592,223 F327S probably damaging Het
Hspa12b A G 2: 131,138,595 M145V probably null Het
Hspa4 A T 11: 53,270,982 S448T probably benign Het
Kbtbd6 T C 14: 79,453,319 Y422H probably benign Het
Lama4 A T 10: 39,061,445 D677V probably benign Het
Ldb1 C T 19: 46,035,756 E111K probably damaging Het
Macf1 A G 4: 123,387,236 S3823P probably damaging Het
Man1a2 G A 3: 100,591,873 T415I probably benign Het
Map3k2 T C 18: 32,200,046 probably benign Het
Morn5 T A 2: 36,055,026 Y87* probably null Het
Mpp3 T C 11: 102,009,675 D326G probably benign Het
Mrgprx1 T C 7: 48,021,588 H137R probably benign Het
Nav2 C A 7: 49,452,512 P292T probably damaging Het
Nlrp2 C A 7: 5,335,567 probably null Het
Noxo1 G A 17: 24,699,056 S112N probably damaging Het
Nudt9 G T 5: 104,065,019 K319N probably benign Het
Olfr885 A T 9: 38,061,937 I206L probably benign Het
Osbpl7 C A 11: 97,067,702 Q728K probably damaging Het
Pcsk1 A T 13: 75,132,163 E702D probably benign Het
Piezo2 T C 18: 63,072,862 D1492G probably damaging Het
Plekhg1 A G 10: 3,958,103 K1007E possibly damaging Het
Ppp6r3 G A 19: 3,464,693 P141S probably benign Het
Prrt3 T C 6: 113,497,016 T354A probably damaging Het
Ptk2 C A 15: 73,320,826 W181L probably benign Het
Rif1 T A 2: 52,105,515 H915Q probably benign Het
Selenbp2 G T 3: 94,704,064 V361L probably benign Het
Slamf7 A G 1: 171,641,057 L89P probably damaging Het
Slc6a21 G A 7: 45,288,081 V599M probably damaging Het
Sltm G T 9: 70,587,185 S921I probably damaging Het
Smc4 C A 3: 69,006,211 A44E probably damaging Het
Tdrd5 A T 1: 156,259,943 probably benign Het
Tead2 T A 7: 45,217,421 I68N probably damaging Het
Tnks1bp1 T A 2: 85,071,799 S1680T probably damaging Het
Topbp1 T C 9: 103,320,239 V386A possibly damaging Het
Tpx2 C A 2: 152,882,287 P328T possibly damaging Het
Ttn T A 2: 76,745,988 I24854F probably damaging Het
Zbtb11 G A 16: 55,974,189 R43H possibly damaging Het
Zfp609 A G 9: 65,703,329 L784S possibly damaging Het
Zfp750 A G 11: 121,513,629 I140T probably benign Het
Other mutations in Zfp703
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1524:Zfp703 UTSW 8 26979373 missense probably damaging 1.00
R2082:Zfp703 UTSW 8 26978988 missense probably benign 0.01
R4049:Zfp703 UTSW 8 26979085 missense possibly damaging 0.70
R4570:Zfp703 UTSW 8 26978953 missense probably benign 0.10
R4884:Zfp703 UTSW 8 26978701 missense probably benign 0.03
R4929:Zfp703 UTSW 8 26978851 missense possibly damaging 0.66
R4938:Zfp703 UTSW 8 26979773 missense probably damaging 1.00
R4943:Zfp703 UTSW 8 26979591 missense probably benign 0.35
R5117:Zfp703 UTSW 8 26979205 missense probably damaging 1.00
R5118:Zfp703 UTSW 8 26979205 missense probably damaging 1.00
R5297:Zfp703 UTSW 8 26979205 missense probably damaging 1.00
R5465:Zfp703 UTSW 8 26979205 missense probably damaging 1.00
R5466:Zfp703 UTSW 8 26979205 missense probably damaging 1.00
R5467:Zfp703 UTSW 8 26979205 missense probably damaging 1.00
R5492:Zfp703 UTSW 8 26979205 missense probably damaging 1.00
R5493:Zfp703 UTSW 8 26979205 missense probably damaging 1.00
R5494:Zfp703 UTSW 8 26979205 missense probably damaging 1.00
R5757:Zfp703 UTSW 8 26979205 missense probably damaging 1.00
R5758:Zfp703 UTSW 8 26979205 missense probably damaging 1.00
R5802:Zfp703 UTSW 8 26979205 missense probably damaging 1.00
R5828:Zfp703 UTSW 8 26979205 missense probably damaging 1.00
R5850:Zfp703 UTSW 8 26979205 missense probably damaging 1.00
R5854:Zfp703 UTSW 8 26979205 missense probably damaging 1.00
R5856:Zfp703 UTSW 8 26979205 missense probably damaging 1.00
R5959:Zfp703 UTSW 8 26979205 missense probably damaging 1.00
R6464:Zfp703 UTSW 8 26979327 missense probably damaging 1.00
R6867:Zfp703 UTSW 8 26978640 missense probably damaging 0.97
R7067:Zfp703 UTSW 8 26979016 missense probably damaging 0.96
R7812:Zfp703 UTSW 8 26979878 missense probably damaging 1.00
R7880:Zfp703 UTSW 8 26978690 missense unknown
R8167:Zfp703 UTSW 8 26979754 missense probably damaging 1.00
Posted On2015-04-16