Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL00920:Zfp608'

29408

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp608

Ensembl Gene

ENSMUSG00000052713

Gene Name

zinc finger protein 608

Synonyms

4932417D18Rik

Accession Numbers

Is this an essential gene?

Probably essential (E-score: 0.877) question?

Stock #

IGL00920

Quality Score

Status

Chromosome

Chromosomal Location

54888045-54990180 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 54889831 bp

Zygosity

Heterozygous

Amino Acid Change

Methionine to Isoleucine at position 1504 (M1504I)

Ref Sequence

ENSEMBL: ENSMUSP00000068192 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000064763]

Predicted Effect

probably benign
Transcript: ENSMUST00000064763
AA Change: M1504I

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000068192
Gene: ENSMUSG00000052713
AA Change: M1504I

Domain	Start	End	E-Value	Type
low complexity region	51	61	N/A	INTRINSIC
low complexity region	150	184	N/A	INTRINSIC
low complexity region	214	234	N/A	INTRINSIC
low complexity region	252	266	N/A	INTRINSIC
low complexity region	309	326	N/A	INTRINSIC
low complexity region	428	445	N/A	INTRINSIC
low complexity region	459	471	N/A	INTRINSIC
ZnF_C2H2	552	577	1.86e0	SMART
low complexity region	624	636	N/A	INTRINSIC
low complexity region	706	718	N/A	INTRINSIC
low complexity region	734	773	N/A	INTRINSIC
low complexity region	807	822	N/A	INTRINSIC
low complexity region	833	846	N/A	INTRINSIC
low complexity region	934	956	N/A	INTRINSIC
coiled coil region	1028	1054	N/A	INTRINSIC
low complexity region	1182	1193	N/A	INTRINSIC
low complexity region	1255	1268	N/A	INTRINSIC
low complexity region	1439	1450	N/A	INTRINSIC
low complexity region	1458	1466	N/A	INTRINSIC
low complexity region	1486	1502	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 25 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Cd209e	T	C	8: 3,849,187	D175G	probably damaging	Het
Cep78	T	C	19: 15,981,486	I165V	probably benign	Het
Coa7	G	T	4: 108,338,308	G145C	possibly damaging	Het
Dpp9	T	C	17: 56,200,599	T357A	probably benign	Het
Gm42416	T	A	18: 36,952,767	M1K	probably null	Het
Gm428	T	A	4: 73,687,442		probably benign	Het
Hnrnpm	C	A	17: 33,649,902	R517L	probably damaging	Het
Kcnh5	A	T	12: 74,976,493	D600E	probably damaging	Het
Ndst4	A	G	3: 125,438,211	D143G	probably damaging	Het
Nrros	A	G	16: 32,147,620	F14S	probably benign	Het
Olfr1009	A	T	2: 85,722,239	Y278F	probably damaging	Het
Olfr971	T	C	9: 39,839,934	F167L	probably benign	Het
Pcdh7	A	T	5: 57,720,131	I343F	probably damaging	Het
Piwil4	C	T	9: 14,727,437	R264H	probably damaging	Het
Pnpt1	A	G	11: 29,157,087		probably benign	Het
Pycr2	T	A	1: 180,906,393		probably benign	Het
Rfx7	T	A	9: 72,593,356	Y133N	probably damaging	Het
Slc17a3	A	G	13: 23,856,481	I263V	probably benign	Het
Spink5	A	T	18: 44,003,209	E562D	probably damaging	Het
Spty2d1	T	C	7: 46,998,987	R65G	probably damaging	Het
Thbs1	C	T	2: 118,113,201	T100I	probably damaging	Het
Triml1	T	C	8: 43,138,682	N213S	probably damaging	Het
Trp53bp2	T	C	1: 182,444,654		probably benign	Het
Vmn2r9	T	C	5: 108,848,024	I253V	possibly damaging	Het
Zan	C	T	5: 137,464,524	V798I	unknown	Het

Other mutations in Zfp608

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00500:Zfp608	APN	18	54988333	missense	probably benign
IGL01088:Zfp608	APN	18	54898087	missense	probably benign	0.03
IGL01447:Zfp608	APN	18	54899011	missense	possibly damaging	0.75
IGL01534:Zfp608	APN	18	54898932	missense	probably damaging	0.99
IGL01547:Zfp608	APN	18	54894449	critical splice donor site	probably null
IGL01933:Zfp608	APN	18	54987799	missense	probably benign
IGL01998:Zfp608	APN	18	54891818	missense	probably damaging	0.99
IGL02167:Zfp608	APN	18	54988224	missense	probably damaging	1.00
IGL02266:Zfp608	APN	18	54897581	missense	probably benign	0.08
IGL02335:Zfp608	APN	18	54897437	nonsense	probably null
IGL02455:Zfp608	APN	18	54899333	missense	probably damaging	1.00
IGL02612:Zfp608	APN	18	54898201	missense	probably damaging	1.00
IGL02900:Zfp608	APN	18	54946793	missense	probably damaging	1.00
PIT4243001:Zfp608	UTSW	18	54898024	missense	probably damaging	1.00
PIT4519001:Zfp608	UTSW	18	54946711	missense	possibly damaging	0.71
R0005:Zfp608	UTSW	18	54895520	missense	possibly damaging	0.88
R0010:Zfp608	UTSW	18	54895214	splice site	probably benign
R0010:Zfp608	UTSW	18	54895214	splice site	probably benign
R0064:Zfp608	UTSW	18	54898816	missense	probably benign
R0401:Zfp608	UTSW	18	54898994	missense	probably benign
R0722:Zfp608	UTSW	18	54900234	missense	probably damaging	1.00
R1351:Zfp608	UTSW	18	54898391	missense	probably benign	0.00
R1512:Zfp608	UTSW	18	54946666	missense	probably damaging	1.00
R1554:Zfp608	UTSW	18	54898054	missense	probably damaging	1.00
R1622:Zfp608	UTSW	18	54988294	missense	probably benign	0.07
R1669:Zfp608	UTSW	18	54987739	missense	probably benign	0.09
R1690:Zfp608	UTSW	18	54987634	missense	possibly damaging	0.62
R1721:Zfp608	UTSW	18	54899249	missense	probably benign
R1826:Zfp608	UTSW	18	54898576	missense	probably benign	0.03
R1864:Zfp608	UTSW	18	54897911	missense	probably benign	0.00
R1952:Zfp608	UTSW	18	54897779	nonsense	probably null
R2049:Zfp608	UTSW	18	54895565	missense	probably damaging	1.00
R2051:Zfp608	UTSW	18	54988314	missense	probably benign
R2168:Zfp608	UTSW	18	54898053	nonsense	probably null
R2218:Zfp608	UTSW	18	54987684	missense	probably benign	0.14
R2283:Zfp608	UTSW	18	54988374	missense	probably damaging	1.00
R2399:Zfp608	UTSW	18	54897902	missense	probably damaging	1.00
R2520:Zfp608	UTSW	18	54988506	missense	possibly damaging	0.92
R2961:Zfp608	UTSW	18	54898472	missense	possibly damaging	0.60
R4074:Zfp608	UTSW	18	54898108	missense	probably damaging	1.00
R4076:Zfp608	UTSW	18	54898108	missense	probably damaging	1.00
R4206:Zfp608	UTSW	18	54988195	missense	probably damaging	1.00
R4756:Zfp608	UTSW	18	54894472	missense	probably damaging	1.00
R4771:Zfp608	UTSW	18	54988300	missense	probably benign
R4820:Zfp608	UTSW	18	54987684	missense	probably benign	0.14
R4825:Zfp608	UTSW	18	54897969	missense	probably benign	0.01
R4912:Zfp608	UTSW	18	54946591	missense	probably damaging	1.00
R4975:Zfp608	UTSW	18	54889890	missense	probably damaging	1.00
R5138:Zfp608	UTSW	18	54891799	missense	probably damaging	1.00
R5192:Zfp608	UTSW	18	54898497	missense	probably damaging	1.00
R5557:Zfp608	UTSW	18	54987870	missense	possibly damaging	0.81
R5624:Zfp608	UTSW	18	54898272	missense	probably damaging	1.00
R5818:Zfp608	UTSW	18	54895396	missense	probably benign	0.02
R5840:Zfp608	UTSW	18	54898906	missense	probably damaging	1.00
R5992:Zfp608	UTSW	18	54899248	missense	probably benign	0.15
R6106:Zfp608	UTSW	18	54987872	missense	possibly damaging	0.54
R6174:Zfp608	UTSW	18	54988544	start gained	probably benign
R6181:Zfp608	UTSW	18	54895628	missense	possibly damaging	0.56
R6517:Zfp608	UTSW	18	54899078	missense	possibly damaging	0.94
R6567:Zfp608	UTSW	18	54897556	missense	probably damaging	1.00
R6668:Zfp608	UTSW	18	54898019	missense	probably damaging	1.00
R6920:Zfp608	UTSW	18	54988265	missense	probably damaging	1.00
R7061:Zfp608	UTSW	18	54987997	missense	probably benign
R7074:Zfp608	UTSW	18	54897382	missense	possibly damaging	0.69
R7087:Zfp608	UTSW	18	54899397	missense	probably damaging	1.00
R7391:Zfp608	UTSW	18	54897547	missense	possibly damaging	0.49
R7600:Zfp608	UTSW	18	54988020	missense	probably damaging	1.00
R7723:Zfp608	UTSW	18	54897601	missense	probably damaging	1.00
R8054:Zfp608	UTSW	18	54899546	missense	probably benign	0.28
R8236:Zfp608	UTSW	18	54899209	missense	probably damaging	1.00
R8260:Zfp608	UTSW	18	54897749	missense	possibly damaging	0.60

Posted On

2013-04-17