Incidental Mutation 'IGL02450:Kif23'
ID 294139
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Kif23
Ensembl Gene ENSMUSG00000032254
Gene Name kinesin family member 23
Synonyms Knsl5, CHO1, C87313, MKLP-1, 3110001D19Rik, MKLP1
Accession Numbers
Essential gene? Probably essential (E-score: 0.972) question?
Stock # IGL02450
Quality Score
Status
Chromosome 9
Chromosomal Location 61824559-61854078 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 61831239 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Threonine at position 777 (M777T)
Ref Sequence ENSEMBL: ENSMUSP00000034815 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034815] [ENSMUST00000214295]
AlphaFold E9Q5G3
Predicted Effect probably benign
Transcript: ENSMUST00000034815
AA Change: M777T

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000034815
Gene: ENSMUSG00000032254
AA Change: M777T

DomainStartEndE-ValueType
KISc 23 444 6.56e-147 SMART
Blast:KISc 524 607 8e-20 BLAST
low complexity region 661 678 N/A INTRINSIC
low complexity region 681 693 N/A INTRINSIC
low complexity region 715 728 N/A INTRINSIC
Pfam:MKLP1_Arf_bdg 796 899 9.2e-47 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213159
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213595
Predicted Effect probably benign
Transcript: ENSMUST00000214295
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214940
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215319
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216812
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216717
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216746
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215965
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215743
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aco2 A G 15: 81,798,963 (GRCm39) *781W probably null Het
Adamts16 C A 13: 70,984,419 (GRCm39) R81S probably damaging Het
Aldh1l1 A G 6: 90,546,855 (GRCm39) D386G probably benign Het
Anxa6 G A 11: 54,885,767 (GRCm39) R393W probably damaging Het
Bdnf G A 2: 109,553,949 (GRCm39) V108I possibly damaging Het
Bpgm C T 6: 34,464,399 (GRCm39) R39W probably damaging Het
Cd101 T C 3: 100,901,054 (GRCm39) E1006G probably damaging Het
Cd109 A T 9: 78,603,132 (GRCm39) E972V possibly damaging Het
Cdhr3 T A 12: 33,132,224 (GRCm39) Q133L probably benign Het
Cdk5r1 C T 11: 80,368,666 (GRCm39) A111V probably benign Het
Cnga4 A T 7: 105,054,955 (GRCm39) I77F probably damaging Het
Egfem1 G A 3: 29,711,417 (GRCm39) probably null Het
Fbxl21 T A 13: 56,674,766 (GRCm39) V39D possibly damaging Het
Gimap6 T C 6: 48,681,351 (GRCm39) I94M probably benign Het
Glis1 T C 4: 107,484,726 (GRCm39) V407A probably benign Het
Gm5784 C T 12: 19,437,970 (GRCm39) noncoding transcript Het
Gm9839 A T 1: 32,559,964 (GRCm39) probably benign Het
Heatr5a T A 12: 51,992,213 (GRCm39) M566L probably benign Het
Jph1 G A 1: 17,074,201 (GRCm39) P606S possibly damaging Het
Jup C T 11: 100,269,183 (GRCm39) C410Y probably damaging Het
Lifr G T 15: 7,220,246 (GRCm39) D959Y probably damaging Het
Lsm1 C A 8: 26,283,806 (GRCm39) L73I possibly damaging Het
Maneal G A 4: 124,750,928 (GRCm39) A276V probably benign Het
Myh4 A G 11: 67,142,635 (GRCm39) D932G probably damaging Het
Nipbl C T 15: 8,373,058 (GRCm39) V1063M probably damaging Het
Nlrx1 A G 9: 44,164,798 (GRCm39) V882A probably benign Het
Obox6 A G 7: 15,567,638 (GRCm39) C270R probably damaging Het
Or13a19 A G 7: 139,903,140 (GRCm39) H176R possibly damaging Het
Pard3b A G 1: 62,571,835 (GRCm39) I925V possibly damaging Het
Pdhx A G 2: 102,872,594 (GRCm39) S163P probably benign Het
Pdzrn3 T C 6: 101,331,461 (GRCm39) D271G probably damaging Het
Plec A G 15: 76,075,515 (GRCm39) I399T probably damaging Het
Pthlh T G 6: 147,158,666 (GRCm39) D98A possibly damaging Het
Spata31f3 A G 4: 42,874,127 (GRCm39) S14P probably benign Het
Spock3 T A 8: 63,698,249 (GRCm39) probably null Het
Tgtp2 C T 11: 48,950,317 (GRCm39) G85D probably benign Het
Tmem94 A G 11: 115,683,897 (GRCm39) D739G probably damaging Het
Washc5 G A 15: 59,204,166 (GRCm39) R706* probably null Het
Zfp13 C T 17: 23,795,072 (GRCm39) A493T probably benign Het
Zscan20 G T 4: 128,480,450 (GRCm39) D680E probably damaging Het
Other mutations in Kif23
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00428:Kif23 APN 9 61,833,750 (GRCm39) missense probably benign 0.19
IGL00814:Kif23 APN 9 61,844,389 (GRCm39) missense possibly damaging 0.95
IGL01295:Kif23 APN 9 61,839,411 (GRCm39) missense possibly damaging 0.89
IGL01521:Kif23 APN 9 61,827,182 (GRCm39) missense probably damaging 0.99
IGL01583:Kif23 APN 9 61,842,750 (GRCm39) missense probably damaging 1.00
IGL01680:Kif23 APN 9 61,839,096 (GRCm39) missense probably benign 0.17
IGL02698:Kif23 APN 9 61,832,283 (GRCm39) missense possibly damaging 0.49
IGL03152:Kif23 APN 9 61,837,058 (GRCm39) splice site probably benign
IGL03233:Kif23 APN 9 61,833,735 (GRCm39) missense probably benign 0.05
H8562:Kif23 UTSW 9 61,831,347 (GRCm39) missense probably benign
R0225:Kif23 UTSW 9 61,832,976 (GRCm39) splice site probably benign
R0419:Kif23 UTSW 9 61,833,687 (GRCm39) nonsense probably null
R0512:Kif23 UTSW 9 61,826,257 (GRCm39) splice site probably benign
R0731:Kif23 UTSW 9 61,832,314 (GRCm39) missense possibly damaging 0.67
R0980:Kif23 UTSW 9 61,844,046 (GRCm39) missense possibly damaging 0.93
R1315:Kif23 UTSW 9 61,831,270 (GRCm39) splice site probably null
R1347:Kif23 UTSW 9 61,834,438 (GRCm39) missense probably damaging 0.99
R1347:Kif23 UTSW 9 61,834,438 (GRCm39) missense probably damaging 0.99
R1451:Kif23 UTSW 9 61,832,084 (GRCm39) missense probably damaging 1.00
R1624:Kif23 UTSW 9 61,832,982 (GRCm39) splice site probably null
R1820:Kif23 UTSW 9 61,833,720 (GRCm39) missense possibly damaging 0.67
R1867:Kif23 UTSW 9 61,826,243 (GRCm39) missense possibly damaging 0.87
R1937:Kif23 UTSW 9 61,853,892 (GRCm39) critical splice donor site probably null
R2001:Kif23 UTSW 9 61,834,666 (GRCm39) nonsense probably null
R2002:Kif23 UTSW 9 61,834,666 (GRCm39) nonsense probably null
R2310:Kif23 UTSW 9 61,831,426 (GRCm39) missense probably damaging 1.00
R2680:Kif23 UTSW 9 61,844,758 (GRCm39) missense probably benign 0.25
R3196:Kif23 UTSW 9 61,839,193 (GRCm39) nonsense probably null
R3774:Kif23 UTSW 9 61,832,274 (GRCm39) missense probably benign 0.00
R3775:Kif23 UTSW 9 61,832,274 (GRCm39) missense probably benign 0.00
R3776:Kif23 UTSW 9 61,832,274 (GRCm39) missense probably benign 0.00
R4349:Kif23 UTSW 9 61,839,396 (GRCm39) missense probably damaging 1.00
R4671:Kif23 UTSW 9 61,852,641 (GRCm39) missense probably benign 0.04
R4981:Kif23 UTSW 9 61,839,153 (GRCm39) missense probably damaging 1.00
R4983:Kif23 UTSW 9 61,843,985 (GRCm39) missense probably benign 0.01
R5685:Kif23 UTSW 9 61,852,691 (GRCm39) missense probably benign 0.12
R5721:Kif23 UTSW 9 61,851,498 (GRCm39) missense probably benign 0.45
R6903:Kif23 UTSW 9 61,834,436 (GRCm39) missense possibly damaging 0.77
R7067:Kif23 UTSW 9 61,832,271 (GRCm39) missense probably benign 0.01
R7103:Kif23 UTSW 9 61,827,174 (GRCm39) missense probably damaging 0.99
R7456:Kif23 UTSW 9 61,844,402 (GRCm39) missense probably benign 0.09
R7468:Kif23 UTSW 9 61,844,457 (GRCm39) nonsense probably null
R8357:Kif23 UTSW 9 61,834,317 (GRCm39) critical splice donor site probably null
R8457:Kif23 UTSW 9 61,834,317 (GRCm39) critical splice donor site probably null
R8716:Kif23 UTSW 9 61,844,477 (GRCm39) missense probably damaging 1.00
R8783:Kif23 UTSW 9 61,834,853 (GRCm39) missense probably benign 0.00
R9028:Kif23 UTSW 9 61,828,341 (GRCm39) missense probably damaging 0.99
R9137:Kif23 UTSW 9 61,834,713 (GRCm39) missense probably damaging 0.97
R9283:Kif23 UTSW 9 61,852,651 (GRCm39) missense probably benign
R9430:Kif23 UTSW 9 61,834,722 (GRCm39) missense probably damaging 1.00
R9457:Kif23 UTSW 9 61,851,507 (GRCm39) missense probably benign 0.02
R9533:Kif23 UTSW 9 61,832,924 (GRCm39) missense probably benign
Z1177:Kif23 UTSW 9 61,831,445 (GRCm39) missense possibly damaging 0.93
Posted On 2015-04-16