Incidental Mutation 'IGL02456:Or10al2'
ID 294151
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or10al2
Ensembl Gene ENSMUSG00000080990
Gene Name olfactory receptor family 10 subfamily AL member 2
Synonyms GA_x6K02T2PSCP-2131124-2132089, MOR263-13, Olfr118
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # IGL02456
Quality Score
Status
Chromosome 17
Chromosomal Location 37982916-37983888 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 37983340 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 142 (M142K)
Ref Sequence ENSEMBL: ENSMUSP00000151212 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000122036] [ENSMUST00000215811] [ENSMUST00000216551]
AlphaFold Q7TRJ6
Predicted Effect possibly damaging
Transcript: ENSMUST00000122036
AA Change: M142K

PolyPhen 2 Score 0.903 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000113988
Gene: ENSMUSG00000080990
AA Change: M142K

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srv 32 173 2e-6 PFAM
Pfam:7tm_4 37 314 2.1e-57 PFAM
Pfam:7TM_GPCR_Srsx 41 311 5.8e-6 PFAM
Pfam:7tm_1 47 296 1.4e-24 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000215811
AA Change: M142K

PolyPhen 2 Score 0.903 (Sensitivity: 0.82; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000216551
AA Change: M142K

PolyPhen 2 Score 0.903 (Sensitivity: 0.82; Specificity: 0.94)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921511C20Rik T A X: 126,302,584 (GRCm39) Y174* probably null Het
Apc C A 18: 34,446,935 (GRCm39) S1243* probably null Het
Atp8b5 A G 4: 43,365,578 (GRCm39) T731A probably benign Het
Bcl2a1c T A 9: 114,159,458 (GRCm39) F79I probably damaging Het
Brip1 G T 11: 85,955,925 (GRCm39) L863I possibly damaging Het
Cbx4 T A 11: 118,972,938 (GRCm39) K146* probably null Het
Ces1a C T 8: 93,766,126 (GRCm39) V163I possibly damaging Het
Ces5a C T 8: 94,255,272 (GRCm39) probably benign Het
Cfhr1 A C 1: 139,484,131 (GRCm39) N128K possibly damaging Het
Clcn3 T C 8: 61,394,391 (GRCm39) D46G probably damaging Het
Cntnap1 T G 11: 101,068,955 (GRCm39) I166S probably benign Het
Cntnap3 A T 13: 64,946,872 (GRCm39) probably benign Het
Cntnap5c T A 17: 58,714,739 (GRCm39) probably benign Het
Ddx23 A T 15: 98,545,430 (GRCm39) V626E probably damaging Het
Dele1 T A 18: 38,394,177 (GRCm39) L458Q probably damaging Het
Gcm2 T C 13: 41,256,477 (GRCm39) Y424C probably benign Het
Gm9964 A G 11: 79,187,196 (GRCm39) F84L probably damaging Het
Grn T A 11: 102,326,930 (GRCm39) D509E probably benign Het
Iho1 G T 9: 108,283,820 (GRCm39) T208K probably benign Het
Kdm5c G A X: 151,029,314 (GRCm39) D343N probably damaging Het
Ly75 C T 2: 60,124,125 (GRCm39) M1717I probably benign Het
Map1a C A 2: 121,129,134 (GRCm39) P133T probably damaging Het
Mpp2 C A 11: 101,950,199 (GRCm39) A552S possibly damaging Het
Mtr T C 13: 12,213,980 (GRCm39) I897M probably damaging Het
Npas3 A T 12: 54,095,550 (GRCm39) I337F probably damaging Het
Nup85 T C 11: 115,472,691 (GRCm39) probably benign Het
Or10a49 A G 7: 108,468,257 (GRCm39) Y35H probably benign Het
Or2t46 T A 11: 58,472,024 (GRCm39) L118H possibly damaging Het
Or51l4 T A 7: 103,404,700 (GRCm39) I31F possibly damaging Het
Or56a5 T C 7: 104,792,966 (GRCm39) N178S probably damaging Het
Pdia4 A T 6: 47,780,429 (GRCm39) D301E probably benign Het
Phf2 C A 13: 48,982,322 (GRCm39) G134C unknown Het
Polr2h T A 16: 20,539,352 (GRCm39) L76H probably damaging Het
Rbm47 G A 5: 66,184,364 (GRCm39) R80C probably damaging Het
Sfmbt1 T C 14: 30,507,837 (GRCm39) S286P probably damaging Het
Slc5a12 T C 2: 110,447,179 (GRCm39) probably benign Het
Tacc2 T C 7: 130,227,991 (GRCm39) S1559P probably benign Het
Tbc1d16 T G 11: 119,101,372 (GRCm39) H46P probably damaging Het
Tbck A G 3: 132,440,475 (GRCm39) probably benign Het
Tmtc4 A T 14: 123,163,374 (GRCm39) probably null Het
Ttc13 T C 8: 125,417,100 (GRCm39) probably null Het
Ttc17 T C 2: 94,193,130 (GRCm39) probably benign Het
Vmn1r121 T A 7: 20,832,438 (GRCm39) M1L possibly damaging Het
Vps13c T C 9: 67,860,258 (GRCm39) S2825P probably damaging Het
Zan A C 5: 137,445,106 (GRCm39) S1718A unknown Het
Zfp39 G T 11: 58,793,626 (GRCm39) Y37* probably null Het
Zfp407 T C 18: 84,576,766 (GRCm39) N1449S probably damaging Het
Zhx2 C A 15: 57,687,035 (GRCm39) D801E possibly damaging Het
Other mutations in Or10al2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01300:Or10al2 APN 17 37,983,778 (GRCm39) missense probably damaging 1.00
IGL02750:Or10al2 APN 17 37,983,500 (GRCm39) nonsense probably null
IGL03083:Or10al2 APN 17 37,983,551 (GRCm39) nonsense probably null
IGL03339:Or10al2 APN 17 37,983,448 (GRCm39) missense possibly damaging 0.87
R0032:Or10al2 UTSW 17 37,983,378 (GRCm39) missense probably damaging 1.00
R1457:Or10al2 UTSW 17 37,983,816 (GRCm39) nonsense probably null
R1542:Or10al2 UTSW 17 37,983,142 (GRCm39) missense probably damaging 1.00
R1771:Or10al2 UTSW 17 37,983,554 (GRCm39) missense probably damaging 1.00
R1893:Or10al2 UTSW 17 37,983,747 (GRCm39) nonsense probably null
R2395:Or10al2 UTSW 17 37,983,587 (GRCm39) nonsense probably null
R3619:Or10al2 UTSW 17 37,983,531 (GRCm39) missense probably benign 0.05
R3917:Or10al2 UTSW 17 37,983,684 (GRCm39) missense probably damaging 1.00
R3937:Or10al2 UTSW 17 37,983,858 (GRCm39) missense probably benign 0.01
R5600:Or10al2 UTSW 17 37,983,176 (GRCm39) missense possibly damaging 0.91
R6415:Or10al2 UTSW 17 37,983,448 (GRCm39) missense possibly damaging 0.87
R6462:Or10al2 UTSW 17 37,983,111 (GRCm39) missense probably damaging 1.00
R7355:Or10al2 UTSW 17 37,983,301 (GRCm39) missense probably benign 0.02
R7861:Or10al2 UTSW 17 37,983,408 (GRCm39) missense possibly damaging 0.91
R7913:Or10al2 UTSW 17 37,982,999 (GRCm39) missense probably benign
R7952:Or10al2 UTSW 17 37,983,708 (GRCm39) missense probably damaging 1.00
R7969:Or10al2 UTSW 17 37,983,547 (GRCm39) missense probably damaging 1.00
R8879:Or10al2 UTSW 17 37,983,302 (GRCm39) nonsense probably null
R8923:Or10al2 UTSW 17 37,983,702 (GRCm39) missense probably benign 0.00
R9253:Or10al2 UTSW 17 37,983,637 (GRCm39) missense probably benign 0.00
R9778:Or10al2 UTSW 17 37,983,145 (GRCm39) missense probably damaging 0.97
R9789:Or10al2 UTSW 17 37,983,059 (GRCm39) missense probably damaging 1.00
RF003:Or10al2 UTSW 17 37,983,749 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16