Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02456:Olfr325'

294153

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Olfr325

Ensembl Gene

ENSMUSG00000060765

Gene Name

olfactory receptor 325

Synonyms

MOR275-5, MOR275-11_p, GA_x6K02T2NKPP-844642-843680

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.052) question?

Stock #

IGL02456

Quality Score

Status

Chromosome

Chromosomal Location

58577730-58582365 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 58581198 bp

Zygosity

Heterozygous

Amino Acid Change

Leucine to Histidine at position 118 (L118H)

Ref Sequence

ENSEMBL: ENSMUSP00000145386 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000169428] [ENSMUST00000203418]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000169428
AA Change: L118H

PolyPhen 2 Score 0.482 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000131257
Gene: ENSMUSG00000060765
AA Change: L118H

Domain	Start	End	E-Value	Type
Pfam:7tm_4	35	312	2.3e-46	PFAM
Pfam:7TM_GPCR_Srsx	39	290	1.4e-6	PFAM
Pfam:7tm_1	45	294	1.6e-27	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000203418
AA Change: L118H

PolyPhen 2 Score 0.482 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000145386
Gene: ENSMUSG00000060765
AA Change: L118H

Domain	Start	End	E-Value	Type
Pfam:7tm_4	35	130	7.6e-14	PFAM
Pfam:7TM_GPCR_Srsx	36	130	1.1e-4	PFAM
Pfam:7tm_1	45	130	2.6e-16	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
0610009O20Rik	T	A	18: 38,261,124	L458Q	probably damaging	Het
4921511C20Rik	T	A	X: 127,394,961	Y174*	probably null	Het
Apc	C	A	18: 34,313,882	S1243*	probably null	Het
Atp8b5	A	G	4: 43,365,578	T731A	probably benign	Het
Bcl2a1c	T	A	9: 114,330,390	F79I	probably damaging	Het
Brip1	G	T	11: 86,065,099	L863I	possibly damaging	Het
Cbx4	T	A	11: 119,082,112	K146*	probably null	Het
Ccdc36	G	T	9: 108,406,621	T208K	probably benign	Het
Ces1a	C	T	8: 93,039,498	V163I	possibly damaging	Het
Ces5a	C	T	8: 93,528,644		probably benign	Het
Cfhr1	A	C	1: 139,556,393	N128K	possibly damaging	Het
Clcn3	T	C	8: 60,941,357	D46G	probably damaging	Het
Cntnap1	T	G	11: 101,178,129	I166S	probably benign	Het
Cntnap3	A	T	13: 64,799,058		probably benign	Het
Cntnap5c	T	A	17: 58,407,744		probably benign	Het
Ddx23	A	T	15: 98,647,549	V626E	probably damaging	Het
Gcm2	T	C	13: 41,103,001	Y424C	probably benign	Het
Gm9964	A	G	11: 79,296,370	F84L	probably damaging	Het
Grn	T	A	11: 102,436,104	D509E	probably benign	Het
Kdm5c	G	A	X: 152,246,318	D343N	probably damaging	Het
Ly75	C	T	2: 60,293,781	M1717I	probably benign	Het
Map1a	C	A	2: 121,298,653	P133T	probably damaging	Het
Mpp2	C	A	11: 102,059,373	A552S	possibly damaging	Het
Mtr	T	C	13: 12,199,094	I897M	probably damaging	Het
Npas3	A	T	12: 54,048,767	I337F	probably damaging	Het
Nup85	T	C	11: 115,581,865		probably benign	Het
Olfr118	T	A	17: 37,672,449	M142K	possibly damaging	Het
Olfr517	A	G	7: 108,869,050	Y35H	probably benign	Het
Olfr630	T	A	7: 103,755,493	I31F	possibly damaging	Het
Olfr683	T	C	7: 105,143,759	N178S	probably damaging	Het
Pdia4	A	T	6: 47,803,495	D301E	probably benign	Het
Phf2	C	A	13: 48,828,846	G134C	unknown	Het
Polr2h	T	A	16: 20,720,602	L76H	probably damaging	Het
Rbm47	G	A	5: 66,027,021	R80C	probably damaging	Het
Sfmbt1	T	C	14: 30,785,880	S286P	probably damaging	Het
Slc5a12	T	C	2: 110,616,834		probably benign	Het
Tacc2	T	C	7: 130,626,261	S1559P	probably benign	Het
Tbc1d16	T	G	11: 119,210,546	H46P	probably damaging	Het
Tbck	A	G	3: 132,734,714		probably benign	Het
Tmtc4	A	T	14: 122,925,962		probably null	Het
Ttc13	T	C	8: 124,690,361		probably null	Het
Ttc17	T	C	2: 94,362,785		probably benign	Het
Vmn1r121	T	A	7: 21,098,513	M1L	possibly damaging	Het
Vps13c	T	C	9: 67,952,976	S2825P	probably damaging	Het
Zan	A	C	5: 137,446,844	S1718A	unknown	Het
Zfp39	G	T	11: 58,902,800	Y37*	probably null	Het
Zfp407	T	C	18: 84,558,641	N1449S	probably damaging	Het
Zhx2	C	A	15: 57,823,639	D801E	possibly damaging	Het

Other mutations in Olfr325

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00953:Olfr325	APN	11	58581810	missense	probably benign
IGL01922:Olfr325	APN	11	58581073	missense	probably benign	0.01
IGL02440:Olfr325	APN	11	58581209	missense	probably damaging	1.00
IGL03088:Olfr325	APN	11	58581827	utr 3 prime	probably benign
IGL03328:Olfr325	APN	11	58581713	missense	probably damaging	1.00
R0604:Olfr325	UTSW	11	58581348	missense	probably damaging	0.99
R1698:Olfr325	UTSW	11	58581251	missense	probably damaging	1.00
R2473:Olfr325	UTSW	11	58581575	missense	probably damaging	1.00
R2888:Olfr325	UTSW	11	58581162	missense	possibly damaging	0.96
R4133:Olfr325	UTSW	11	58581075	missense	probably damaging	0.97
R4710:Olfr325	UTSW	11	58581722	missense	probably damaging	1.00
R4715:Olfr325	UTSW	11	58581429	missense	probably damaging	1.00
R4898:Olfr325	UTSW	11	58581720	missense	probably damaging	1.00
R4939:Olfr325	UTSW	11	58581211	missense	probably damaging	1.00
R4977:Olfr325	UTSW	11	58581629	missense	possibly damaging	0.57
R5389:Olfr325	UTSW	11	58580999	missense	possibly damaging	0.78
R5393:Olfr325	UTSW	11	58580999	missense	possibly damaging	0.78
R6137:Olfr325	UTSW	11	58581068	missense	probably benign
R6302:Olfr325	UTSW	11	58581638	missense	probably benign
R6655:Olfr325	UTSW	11	58581210	missense	probably damaging	1.00
R6927:Olfr325	UTSW	11	58581665	missense	possibly damaging	0.81
R7451:Olfr325	UTSW	11	58581690	missense	probably damaging	1.00
R7494:Olfr325	UTSW	11	58581212	missense	probably damaging	0.97
R7626:Olfr325	UTSW	11	58581173	missense	probably damaging	0.97
R7724:Olfr325	UTSW	11	58581382	missense	probably benign	0.01
R7874:Olfr325	UTSW	11	58581747	missense	possibly damaging	0.93
R8217:Olfr325	UTSW	11	58580966	missense	probably benign	0.00
R8252:Olfr325	UTSW	11	58581132	missense	probably damaging	1.00
Z1177:Olfr325	UTSW	11	58581311	missense	probably damaging	1.00

Posted On

2015-04-16