Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02456:Zfp39'

294165

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp39

Ensembl Gene

ENSMUSG00000037001

Gene Name

zinc finger protein 39

Synonyms

Zfp-39, CTfin33

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.213) question?

Stock #

IGL02456

Quality Score

Status

Chromosome

Chromosomal Location

58888153-58904225 bp(-) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to T at 58902800 bp

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 37 (Y37*)

Ref Sequence

ENSEMBL: ENSMUSP00000099764 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000102703]

Predicted Effect

probably null
Transcript: ENSMUST00000102703
AA Change: Y37*

SMART Domains

Protein: ENSMUSP00000099764
Gene: ENSMUSG00000037001
AA Change: Y37*

Domain	Start	End	E-Value	Type
KRAB	59	119	8.23e-34	SMART
low complexity region	171	180	N/A	INTRINSIC
ZnF_C2H2	298	320	9.58e-3	SMART
ZnF_C2H2	326	347	2.2e2	SMART
ZnF_C2H2	353	373	1.18e2	SMART
ZnF_C2H2	409	431	8.34e-3	SMART
ZnF_C2H2	437	459	7.26e-3	SMART
ZnF_C2H2	465	487	1.53e-1	SMART
ZnF_C2H2	493	515	9.08e-4	SMART
ZnF_C2H2	521	543	2.61e-4	SMART
ZnF_C2H2	549	571	1.12e-3	SMART
ZnF_C2H2	577	599	4.94e-5	SMART
ZnF_C2H2	605	627	5.14e-3	SMART
ZnF_C2H2	633	655	1.38e-3	SMART
ZnF_C2H2	661	683	6.78e-3	SMART
ZnF_C2H2	689	711	5.14e-3	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000148244

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a Kruppel-associated box (KRAB) zinc-finger protein, which belongs to a large group of transcriptional regulators in mammals. These proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation and apoptosis, and in regulating viral replication and transcription. A pseudogene of this gene was identified on chromosome 1. [provided by RefSeq, May 2016]

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
0610009O20Rik	T	A	18: 38,261,124	L458Q	probably damaging	Het
4921511C20Rik	T	A	X: 127,394,961	Y174*	probably null	Het
Apc	C	A	18: 34,313,882	S1243*	probably null	Het
Atp8b5	A	G	4: 43,365,578	T731A	probably benign	Het
Bcl2a1c	T	A	9: 114,330,390	F79I	probably damaging	Het
Brip1	G	T	11: 86,065,099	L863I	possibly damaging	Het
Cbx4	T	A	11: 119,082,112	K146*	probably null	Het
Ccdc36	G	T	9: 108,406,621	T208K	probably benign	Het
Ces1a	C	T	8: 93,039,498	V163I	possibly damaging	Het
Ces5a	C	T	8: 93,528,644		probably benign	Het
Cfhr1	A	C	1: 139,556,393	N128K	possibly damaging	Het
Clcn3	T	C	8: 60,941,357	D46G	probably damaging	Het
Cntnap1	T	G	11: 101,178,129	I166S	probably benign	Het
Cntnap3	A	T	13: 64,799,058		probably benign	Het
Cntnap5c	T	A	17: 58,407,744		probably benign	Het
Ddx23	A	T	15: 98,647,549	V626E	probably damaging	Het
Gcm2	T	C	13: 41,103,001	Y424C	probably benign	Het
Gm9964	A	G	11: 79,296,370	F84L	probably damaging	Het
Grn	T	A	11: 102,436,104	D509E	probably benign	Het
Kdm5c	G	A	X: 152,246,318	D343N	probably damaging	Het
Ly75	C	T	2: 60,293,781	M1717I	probably benign	Het
Map1a	C	A	2: 121,298,653	P133T	probably damaging	Het
Mpp2	C	A	11: 102,059,373	A552S	possibly damaging	Het
Mtr	T	C	13: 12,199,094	I897M	probably damaging	Het
Npas3	A	T	12: 54,048,767	I337F	probably damaging	Het
Nup85	T	C	11: 115,581,865		probably benign	Het
Olfr118	T	A	17: 37,672,449	M142K	possibly damaging	Het
Olfr325	T	A	11: 58,581,198	L118H	possibly damaging	Het
Olfr517	A	G	7: 108,869,050	Y35H	probably benign	Het
Olfr630	T	A	7: 103,755,493	I31F	possibly damaging	Het
Olfr683	T	C	7: 105,143,759	N178S	probably damaging	Het
Pdia4	A	T	6: 47,803,495	D301E	probably benign	Het
Phf2	C	A	13: 48,828,846	G134C	unknown	Het
Polr2h	T	A	16: 20,720,602	L76H	probably damaging	Het
Rbm47	G	A	5: 66,027,021	R80C	probably damaging	Het
Sfmbt1	T	C	14: 30,785,880	S286P	probably damaging	Het
Slc5a12	T	C	2: 110,616,834		probably benign	Het
Tacc2	T	C	7: 130,626,261	S1559P	probably benign	Het
Tbc1d16	T	G	11: 119,210,546	H46P	probably damaging	Het
Tbck	A	G	3: 132,734,714		probably benign	Het
Tmtc4	A	T	14: 122,925,962		probably null	Het
Ttc13	T	C	8: 124,690,361		probably null	Het
Ttc17	T	C	2: 94,362,785		probably benign	Het
Vmn1r121	T	A	7: 21,098,513	M1L	possibly damaging	Het
Vps13c	T	C	9: 67,952,976	S2825P	probably damaging	Het
Zan	A	C	5: 137,446,844	S1718A	unknown	Het
Zfp407	T	C	18: 84,558,641	N1449S	probably damaging	Het
Zhx2	C	A	15: 57,823,639	D801E	possibly damaging	Het

Other mutations in Zfp39

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00791:Zfp39	APN	11	58893059	splice site	probably benign
IGL01597:Zfp39	APN	11	58891543	missense	probably damaging	0.96
IGL02055:Zfp39	APN	11	58891330	missense	probably benign
IGL02873:Zfp39	APN	11	58891022	missense	probably benign	0.12
H8562:Zfp39	UTSW	11	58900686	missense	probably damaging	1.00
R0462:Zfp39	UTSW	11	58890406	missense	probably benign	0.03
R0513:Zfp39	UTSW	11	58889987	missense	probably benign	0.09
R1185:Zfp39	UTSW	11	58902844	missense	possibly damaging	0.91
R1185:Zfp39	UTSW	11	58902844	missense	possibly damaging	0.91
R1185:Zfp39	UTSW	11	58902844	missense	possibly damaging	0.91
R1401:Zfp39	UTSW	11	58890323	missense	probably benign	0.01
R1797:Zfp39	UTSW	11	58900660	missense	probably damaging	0.96
R2146:Zfp39	UTSW	11	58890332	missense	probably benign	0.05
R3903:Zfp39	UTSW	11	58890175	missense	probably benign	0.44
R4303:Zfp39	UTSW	11	58890017	missense	probably damaging	1.00
R4706:Zfp39	UTSW	11	58902807	missense	probably benign	0.41
R4957:Zfp39	UTSW	11	58891231	missense	possibly damaging	0.63
R5092:Zfp39	UTSW	11	58891202	missense	possibly damaging	0.71
R5158:Zfp39	UTSW	11	58889845	missense	possibly damaging	0.81
R5292:Zfp39	UTSW	11	58900589	missense	probably damaging	0.97
R5697:Zfp39	UTSW	11	58889835	missense	probably benign	0.08
R5906:Zfp39	UTSW	11	58902891	missense	probably benign
R5925:Zfp39	UTSW	11	58891273	missense	possibly damaging	0.94
R6174:Zfp39	UTSW	11	58891387	missense	probably benign	0.01
R6177:Zfp39	UTSW	11	58891061	missense	probably benign	0.27
R6968:Zfp39	UTSW	11	58891480	missense	probably benign	0.00
R7045:Zfp39	UTSW	11	58890443	missense	unknown
R7139:Zfp39	UTSW	11	58890559	missense	probably damaging	1.00
R7421:Zfp39	UTSW	11	58890107	missense	probably damaging	1.00
R7493:Zfp39	UTSW	11	58891043	missense	possibly damaging	0.82
R7689:Zfp39	UTSW	11	58890643	missense	probably damaging	1.00
R8061:Zfp39	UTSW	11	58902747	missense	probably benign
R8136:Zfp39	UTSW	11	58891402	missense	probably damaging	0.99

Posted On

2015-04-16