Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02395:Mapk15'

294318

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mapk15

Ensembl Gene

ENSMUSG00000063704

Gene Name

mitogen-activated protein kinase 15

Synonyms

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02395

Quality Score

Status

Chromosome

Chromosomal Location

75865618-75871003 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 75870019 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 380 (S380P)

Ref Sequence

ENSEMBL: ENSMUSP00000087098 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000060807] [ENSMUST00000089669] [ENSMUST00000170153]

AlphaFold

Q80Y86

Predicted Effect

probably benign
Transcript: ENSMUST00000060807

SMART Domains

Protein: ENSMUSP00000059839
Gene: ENSMUSG00000046761

Domain	Start	End	E-Value	Type
Pfam:DUF1669	12	283	3.4e-105	PFAM
low complexity region	304	317	N/A	INTRINSIC
low complexity region	562	578	N/A	INTRINSIC
low complexity region	629	652	N/A	INTRINSIC
low complexity region	671	679	N/A	INTRINSIC
low complexity region	685	697	N/A	INTRINSIC
low complexity region	736	747	N/A	INTRINSIC
internal_repeat_1	836	877	9.35e-9	PROSPERO
internal_repeat_1	877	921	9.35e-9	PROSPERO

Predicted Effect

probably benign
Transcript: ENSMUST00000089669
AA Change: S380P

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000087098
Gene: ENSMUSG00000063704
AA Change: S380P

Domain	Start	End	E-Value	Type
S_TKc	14	305	7.08e-97	SMART
low complexity region	391	404	N/A	INTRINSIC
low complexity region	424	434	N/A	INTRINSIC
low complexity region	475	505	N/A	INTRINSIC
low complexity region	513	525	N/A	INTRINSIC
low complexity region	538	548	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000160092

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000160637

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000161961

Predicted Effect

probably benign
Transcript: ENSMUST00000170153

SMART Domains

Protein: ENSMUSP00000126453
Gene: ENSMUSG00000046761

Domain	Start	End	E-Value	Type
Pfam:DUF1669	4	284	2.1e-110	PFAM
low complexity region	304	317	N/A	INTRINSIC
low complexity region	562	578	N/A	INTRINSIC
low complexity region	629	652	N/A	INTRINSIC
low complexity region	671	679	N/A	INTRINSIC
low complexity region	685	697	N/A	INTRINSIC
low complexity region	736	747	N/A	INTRINSIC
internal_repeat_1	836	877	9.35e-9	PROSPERO
internal_repeat_1	877	921	9.35e-9	PROSPERO

Predicted Effect

probably benign
Transcript: ENSMUST00000230929

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 29 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4833420G17Rik	T	A	13: 119,617,496 (GRCm39)	C540S	probably damaging	Het
Cdk5	A	G	5: 24,624,635 (GRCm39)	V252A	possibly damaging	Het
Ddi2	C	T	4: 141,422,725 (GRCm39)	R329Q	possibly damaging	Het
Dennd2c	T	A	3: 103,065,081 (GRCm39)	F678I	probably benign	Het
Ect2	T	C	3: 27,204,255 (GRCm39)	D18G	probably damaging	Het
Efcab11	C	A	12: 99,820,868 (GRCm39)		probably null	Het
Eri2	T	C	7: 119,387,033 (GRCm39)	E162G	probably damaging	Het
Fam120b	T	C	17: 15,622,777 (GRCm39)	S252P	probably damaging	Het
Filip1	G	A	9: 79,805,692 (GRCm39)	P21S	probably benign	Het
Kmt5b	T	A	19: 3,864,887 (GRCm39)	D627E	probably benign	Het
Krt87	T	C	15: 101,385,833 (GRCm39)	D254G	probably benign	Het
Man1a2	T	C	3: 100,551,853 (GRCm39)		probably null	Het
Mrpl48	G	T	7: 100,195,551 (GRCm39)		probably benign	Het
Nme8	T	A	13: 19,862,078 (GRCm39)	I184L	possibly damaging	Het
Nrk	A	G	X: 137,876,935 (GRCm39)	E712G	probably damaging	Het
Or4c110	T	A	2: 88,832,507 (GRCm39)	T42S	probably benign	Het
Or4k6	C	A	14: 50,475,886 (GRCm39)	G152V	probably damaging	Het
Or5m5	A	G	2: 85,814,426 (GRCm39)	T81A	possibly damaging	Het
Or6z6	C	T	7: 6,491,802 (GRCm39)	V17M	possibly damaging	Het
Plekho1	A	T	3: 95,902,876 (GRCm39)	Y36*	probably null	Het
Slco1a5	T	A	6: 142,221,213 (GRCm39)	H11L	probably damaging	Het
Tiam2	T	A	17: 3,471,756 (GRCm39)	M466K	possibly damaging	Het
Tmem214	G	A	5: 31,030,090 (GRCm39)	A296T	probably benign	Het
Tnfrsf22	A	T	7: 143,197,053 (GRCm39)	N95K	probably damaging	Het
Vmn1r90	T	C	7: 14,295,822 (GRCm39)	Y92C	probably damaging	Het
Zc2hc1a	T	A	3: 7,593,684 (GRCm39)	L214*	probably null	Het
Zcchc17	C	A	4: 130,230,920 (GRCm39)	V90F	probably damaging	Het
Zcchc7	T	C	4: 44,761,868 (GRCm39)		probably benign	Het
Zmiz1	T	C	14: 25,657,187 (GRCm39)	V821A	probably damaging	Het

Other mutations in Mapk15

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01595:Mapk15	APN	15	75,867,129 (GRCm39)	missense	probably benign	0.04
IGL02075:Mapk15	APN	15	75,866,737 (GRCm39)	missense	probably benign	0.35
IGL03052:Mapk15	UTSW	15	75,865,731 (GRCm39)	missense	probably benign	0.01
R0008:Mapk15	UTSW	15	75,870,103 (GRCm39)	missense	probably benign	0.08
R0109:Mapk15	UTSW	15	75,867,926 (GRCm39)	nonsense	probably null
R0109:Mapk15	UTSW	15	75,867,926 (GRCm39)	nonsense	probably null
R1148:Mapk15	UTSW	15	75,870,004 (GRCm39)	missense	probably benign
R1148:Mapk15	UTSW	15	75,870,004 (GRCm39)	missense	probably benign
R2406:Mapk15	UTSW	15	75,870,697 (GRCm39)	missense	possibly damaging	0.75
R4526:Mapk15	UTSW	15	75,867,104 (GRCm39)	missense	possibly damaging	0.83
R4572:Mapk15	UTSW	15	75,870,599 (GRCm39)	splice site	probably benign
R4613:Mapk15	UTSW	15	75,867,759 (GRCm39)	missense	probably damaging	0.98
R5861:Mapk15	UTSW	15	75,868,208 (GRCm39)	unclassified	probably benign
R6912:Mapk15	UTSW	15	75,865,747 (GRCm39)	missense	probably damaging	0.99
R7554:Mapk15	UTSW	15	75,867,745 (GRCm39)	missense	possibly damaging	0.63
R7620:Mapk15	UTSW	15	75,870,697 (GRCm39)	missense	probably benign	0.00
R7923:Mapk15	UTSW	15	75,868,295 (GRCm39)	missense	probably damaging	1.00
R9308:Mapk15	UTSW	15	75,865,714 (GRCm39)	nonsense	probably null
R9744:Mapk15	UTSW	15	75,869,912 (GRCm39)	missense	possibly damaging	0.78
Z1177:Mapk15	UTSW	15	75,870,310 (GRCm39)	nonsense	probably null

Posted On

2015-04-16