Incidental Mutation 'IGL00956:Gm4951'
ID29435
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm4951
Ensembl Gene ENSMUSG00000073555
Gene Namepredicted gene 4951
Synonyms
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL00956
Quality Score
Status
Chromosome18
Chromosomal Location60212080-60247820 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to C at 60246190 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Proline at position 266 (T266P)
Ref Sequence ENSEMBL: ENSMUSP00000031549 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031549]
Predicted Effect probably damaging
Transcript: ENSMUST00000031549
AA Change: T266P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000031549
Gene: ENSMUSG00000073555
AA Change: T266P

DomainStartEndE-ValueType
Pfam:IIGP 34 402 4.8e-157 PFAM
Pfam:MMR_HSR1 70 198 2.8e-8 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 20 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Cdhr2 G T 13: 54,718,343 V319F probably damaging Het
Chac2 A G 11: 30,986,225 S8P probably damaging Het
Clec4b2 T A 6: 123,202,151 Y137* probably null Het
Dbt G A 3: 116,546,114 G384S probably benign Het
Duox1 G T 2: 122,323,306 R370L probably benign Het
Gm21949 C A 3: 68,625,851 A255E probably damaging Het
Hnrnpm C A 17: 33,649,902 R517L probably damaging Het
Kcnh7 G A 2: 62,777,639 R533C probably damaging Het
Nckap5 A C 1: 126,025,018 L1266V probably damaging Het
Opcml A G 9: 28,675,328 N121S possibly damaging Het
Rad54b T A 4: 11,597,833 N239K probably damaging Het
Rp1 T C 1: 4,352,212 D215G probably damaging Het
Scaf8 T C 17: 3,171,147 I303T unknown Het
Slc35f3 G A 8: 126,382,224 A171T probably damaging Het
Tlk2 T A 11: 105,247,592 I322N probably benign Het
Tubb4a A G 17: 57,086,072 V66A probably benign Het
Ubxn2a C T 12: 4,883,956 A152T probably benign Het
Ush2a A T 1: 188,753,522 D2943V probably damaging Het
Wdr62 A G 7: 30,261,339 V55A probably damaging Het
Zfp609 A G 9: 65,702,763 Y973H probably benign Het
Other mutations in Gm4951
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00717:Gm4951 APN 18 60246293 missense probably damaging 1.00
IGL00807:Gm4951 APN 18 60245411 missense probably damaging 1.00
IGL01017:Gm4951 APN 18 60245436 missense possibly damaging 0.87
IGL01929:Gm4951 APN 18 60246482 missense probably benign 0.02
IGL02267:Gm4951 APN 18 60246398 missense probably damaging 0.97
IGL02276:Gm4951 APN 18 60246079 missense probably damaging 0.99
IGL02499:Gm4951 APN 18 60245638 missense probably damaging 1.00
IGL02538:Gm4951 APN 18 60245872 nonsense probably null
IGL03139:Gm4951 APN 18 60246149 missense probably benign 0.01
IGL03209:Gm4951 APN 18 60246071 missense probably damaging 1.00
IGL03270:Gm4951 APN 18 60245476 missense probably benign 0.01
IGL03325:Gm4951 APN 18 60245811 nonsense probably null
Carboniferous UTSW 18 60245768 missense probably damaging 1.00
Oily UTSW 18 60245652 missense probably damaging 1.00
R0554:Gm4951 UTSW 18 60245417 missense probably benign 0.15
R2046:Gm4951 UTSW 18 60245499 missense probably benign 0.00
R2296:Gm4951 UTSW 18 60245470 missense probably benign 0.00
R4583:Gm4951 UTSW 18 60246080 missense possibly damaging 0.93
R5500:Gm4951 UTSW 18 60246020 missense probably damaging 0.99
R5532:Gm4951 UTSW 18 60246070 missense probably benign 0.23
R5938:Gm4951 UTSW 18 60245652 missense probably damaging 1.00
R6446:Gm4951 UTSW 18 60245768 missense probably damaging 1.00
R7191:Gm4951 UTSW 18 60246257 missense probably benign 0.01
R7238:Gm4951 UTSW 18 60246283 missense possibly damaging 0.64
R7443:Gm4951 UTSW 18 60246050 missense probably benign 0.11
Z1177:Gm4951 UTSW 18 60246296 missense probably benign 0.23
Posted On2013-04-17