Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02458:Dync2h1'

294494

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Dync2h1

Ensembl Gene

ENSMUSG00000047193

Gene Name

dynein cytoplasmic 2 heavy chain 1

Synonyms

4432416O06Rik, DHC2, D030010H02Rik, D330044F14Rik, Dnchc2, DHC1b, b2b414Clo

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL02458

Quality Score

Status

Chromosome

Chromosomal Location

6928503-7184446 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 7117422 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Glutamine at position 56 (L56Q)

Ref Sequence

ENSEMBL: ENSMUSP00000149764 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000048417] [ENSMUST00000140466] [ENSMUST00000147193] [ENSMUST00000216097]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000048417
AA Change: L2289Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000046733
Gene: ENSMUSG00000047193
AA Change: L2289Q

Domain	Start	End	E-Value	Type
Pfam:DHC_N1	187	676	1.6e-43	PFAM
Pfam:DHC_N2	1117	1523	4.1e-120	PFAM
AAA	1684	1830	3.72e-2	SMART
AAA	1971	2127	2.18e0	SMART
AAA	2283	2431	1.66e0	SMART
low complexity region	2588	2602	N/A	INTRINSIC
Pfam:AAA_8	2618	2881	6.8e-27	PFAM
Pfam:MT	2894	3230	5.4e-28	PFAM
Pfam:AAA_9	3242	3471	1.1e-50	PFAM
Pfam:Dynein_heavy	3605	4304	2.3e-136	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000140466
AA Change: L2289Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000120007
Gene: ENSMUSG00000047193
AA Change: L2289Q

Domain	Start	End	E-Value	Type
Pfam:DHC_N1	187	676	1.6e-43	PFAM
Pfam:DHC_N2	1117	1523	4.1e-120	PFAM
AAA	1684	1830	3.72e-2	SMART
AAA	1971	2127	2.18e0	SMART
AAA	2283	2431	1.66e0	SMART
low complexity region	2588	2602	N/A	INTRINSIC
Pfam:AAA_8	2618	2881	6.8e-27	PFAM
Pfam:MT	2894	3230	5.4e-28	PFAM
Pfam:AAA_9	3242	3471	1.1e-50	PFAM
Pfam:Dynein_heavy	3605	4304	2.3e-136	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000147193
AA Change: L2289Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000116679
Gene: ENSMUSG00000047193
AA Change: L2289Q

Domain	Start	End	E-Value	Type
Pfam:DHC_N1	188	674	4e-45	PFAM
Pfam:DHC_N2	1118	1521	5.5e-111	PFAM
AAA	1684	1830	3.72e-2	SMART
AAA	1971	2127	2.18e0	SMART
AAA	2283	2431	1.66e0	SMART
low complexity region	2588	2602	N/A	INTRINSIC
Pfam:AAA_8	2618	2880	4.4e-27	PFAM
Pfam:MT	2894	3230	1.3e-27	PFAM
Pfam:AAA_9	3246	3477	1e-79	PFAM
Pfam:Dynein_heavy	3618	4310	8.5e-158	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000214191

Predicted Effect

probably damaging
Transcript: ENSMUST00000216097
AA Change: L56Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a large cytoplasmic dynein protein that is involved in retrograde transport in the cilium and has a role in intraflagellar transport, a process required for ciliary/flagellar assembly. Mutations in this gene cause a heterogeneous spectrum of conditions related to altered primary cilium function and often involve polydactyly, abnormal skeletogenesis, and polycystic kidneys. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jan 2010]
PHENOTYPE: Homozygotes for a gene trap allele show complete embryonic lethality with altered heart looping and brain morphology. Chemically induced mutants show randomized heart looping and polydactyly. Holoprosencephaly or exencephaly, micrognathia, and cardiac, renal, airway and eye defects may be observed. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 68 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam25	A	T	8: 40,753,807 (GRCm38)	I37L	probably benign	Het
Alpk1	A	G	3: 127,681,319 (GRCm38)		probably null	Het
Ankrd33	T	C	15: 101,116,607 (GRCm38)	F8L	probably damaging	Het
Avil	A	G	10: 127,016,353 (GRCm38)	K669R	probably benign	Het
Bcor	G	T	X: 12,048,510 (GRCm38)	L1165I	probably damaging	Het
C7	A	G	15: 5,059,389 (GRCm38)		probably benign	Het
Cc2d2a	A	G	5: 43,718,554 (GRCm38)	I958V	probably benign	Het
Cenpe	A	T	3: 135,230,108 (GRCm38)	K435*	probably null	Het
Chrna7	G	A	7: 63,106,094 (GRCm38)	L235F	probably damaging	Het
Col6a3	C	A	1: 90,779,197 (GRCm38)	V2065L	unknown	Het
Copb1	A	T	7: 114,246,785 (GRCm38)	N183K	probably benign	Het
Cpn2	G	A	16: 30,260,835 (GRCm38)	A16V	probably benign	Het
Cul1	A	G	6: 47,525,608 (GRCm38)	K769E	possibly damaging	Het
Ddx58	A	G	4: 40,229,536 (GRCm38)	S83P	probably damaging	Het
Deup1	C	T	9: 15,592,360 (GRCm38)	V302M	probably benign	Het
Dnah17	T	C	11: 118,036,350 (GRCm38)	K3871E	probably damaging	Het
Dnah6	A	G	6: 73,027,448 (GRCm38)	V3844A	probably benign	Het
Dnah7a	A	T	1: 53,618,328 (GRCm38)	L763*	probably null	Het
Donson	A	T	16: 91,681,176 (GRCm38)	W461R	probably damaging	Het
Dpp10	T	C	1: 123,341,689 (GRCm38)	I664V	probably benign	Het
Dusp8	T	A	7: 142,082,747 (GRCm38)	T369S	probably benign	Het
Ecd	A	T	14: 20,324,477 (GRCm38)	S532T	probably benign	Het
Frg2f1	G	A	4: 119,530,957 (GRCm38)	T115I	probably damaging	Het
Gpatch2l	A	G	12: 86,288,961 (GRCm38)		probably benign	Het
Gtf3c2	T	A	5: 31,159,523 (GRCm38)		probably null	Het
Haghl	T	C	17: 25,783,496 (GRCm38)		probably benign	Het
Hoxc8	A	T	15: 102,992,749 (GRCm38)	N208I	probably damaging	Het
Igf2	T	C	7: 142,654,048 (GRCm38)	D115G	probably benign	Het
Jag2	T	A	12: 112,915,993 (GRCm38)	D385V	probably damaging	Het
Laptm4b	A	G	15: 34,258,742 (GRCm38)	H54R	probably benign	Het
Lrp2	A	G	2: 69,521,773 (GRCm38)	S640P	probably damaging	Het
Map3k8	A	C	18: 4,334,660 (GRCm38)	V328G	probably damaging	Het
Mfsd13a	A	G	19: 46,372,247 (GRCm38)	E388G	probably damaging	Het
Ms4a13	G	A	19: 11,171,928 (GRCm38)	T168I	probably benign	Het
Mtg1	C	A	7: 140,150,172 (GRCm38)	Q294K	probably benign	Het
Myh3	C	T	11: 67,096,940 (GRCm38)	A1413V	possibly damaging	Het
Neo1	A	T	9: 58,893,867 (GRCm38)		probably benign	Het
Ogfod3	T	C	11: 121,200,923 (GRCm38)	E119G	probably benign	Het
Olfr1250	A	G	2: 89,657,348 (GRCm38)	L31P	probably damaging	Het
Olfr1331	A	G	4: 118,869,300 (GRCm38)	N173S	possibly damaging	Het
Olfr331	A	T	11: 58,502,247 (GRCm38)	M109K	probably benign	Het
Olfr800	A	T	10: 129,660,606 (GRCm38)	I267F	probably benign	Het
Olfr988	G	A	2: 85,353,662 (GRCm38)	T88I	probably benign	Het
Parvb	G	T	15: 84,303,434 (GRCm38)	D248Y	probably damaging	Het
Pcdh11x	A	T	X: 120,400,618 (GRCm38)	H586L	possibly damaging	Het
Phactr2	T	C	10: 13,261,828 (GRCm38)	E120G	probably damaging	Het
Ppfibp2	A	T	7: 107,742,964 (GRCm38)	Q775L	probably damaging	Het
Rcbtb1	A	G	14: 59,229,994 (GRCm38)	Y427C	probably damaging	Het
Rftn2	A	T	1: 55,211,192 (GRCm38)	C131*	probably null	Het
Rps6ka2	A	G	17: 7,289,003 (GRCm38)	D474G	probably benign	Het
Rsbn1l	T	C	5: 20,951,736 (GRCm38)	E17G	probably damaging	Het
Ryr2	T	C	13: 11,705,699 (GRCm38)	M2688V	probably benign	Het
Slc22a18	C	A	7: 143,492,837 (GRCm38)		probably benign	Het
Smarcc1	A	G	9: 110,132,126 (GRCm38)		probably benign	Het
Soat2	T	C	15: 102,162,115 (GRCm38)	V451A	probably damaging	Het
Sptlc2	A	T	12: 87,309,893 (GRCm38)		probably benign	Het
Tada1	C	T	1: 166,392,634 (GRCm38)	L308F	probably damaging	Het
Tango2	A	T	16: 18,310,867 (GRCm38)		probably null	Het
Tbc1d15	A	T	10: 115,229,206 (GRCm38)	V158D	probably damaging	Het
Tcrg-V3	A	G	13: 19,243,253 (GRCm38)	Y102C	probably damaging	Het
Tmx2	A	T	2: 84,673,244 (GRCm38)		probably benign	Het
Tpte	T	A	8: 22,305,858 (GRCm38)	I79K	probably benign	Het
Trav6-1	A	G	14: 52,638,742 (GRCm38)	I40V	probably benign	Het
Ubash3a	T	C	17: 31,231,481 (GRCm38)	S377P	possibly damaging	Het
Vmn2r7	T	C	3: 64,693,025 (GRCm38)	D575G	probably damaging	Het
Vps41	A	G	13: 18,853,479 (GRCm38)	D704G	possibly damaging	Het
Vwa5a	T	C	9: 38,726,963 (GRCm38)	S261P	possibly damaging	Het
Zc3hav1	A	G	6: 38,340,329 (GRCm38)	V112A	probably damaging	Het

Other mutations in Dync2h1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00159:Dync2h1	APN	9	7,158,839 (GRCm38)	missense	probably benign	0.42
IGL00310:Dync2h1	APN	9	7,155,072 (GRCm38)	splice site	probably benign
IGL00499:Dync2h1	APN	9	7,168,700 (GRCm38)	missense	possibly damaging	0.95
IGL00579:Dync2h1	APN	9	7,035,728 (GRCm38)	splice site	probably benign
IGL00660:Dync2h1	APN	9	7,075,797 (GRCm38)	missense	probably damaging	0.98
IGL00964:Dync2h1	APN	9	7,174,881 (GRCm38)	splice site	probably benign
IGL01025:Dync2h1	APN	9	7,162,789 (GRCm38)	missense	probably damaging	1.00
IGL01093:Dync2h1	APN	9	7,145,611 (GRCm38)	missense	probably benign	0.01
IGL01108:Dync2h1	APN	9	7,176,771 (GRCm38)	missense	possibly damaging	0.87
IGL01126:Dync2h1	APN	9	7,116,588 (GRCm38)	missense	probably benign	0.00
IGL01474:Dync2h1	APN	9	7,102,493 (GRCm38)	missense	probably benign	0.01
IGL01531:Dync2h1	APN	9	7,071,111 (GRCm38)	missense	probably benign	0.11
IGL01548:Dync2h1	APN	9	7,071,922 (GRCm38)	missense	probably damaging	1.00
IGL01621:Dync2h1	APN	9	7,140,897 (GRCm38)	critical splice donor site	probably null
IGL01672:Dync2h1	APN	9	7,118,884 (GRCm38)	nonsense	probably null
IGL01681:Dync2h1	APN	9	7,142,196 (GRCm38)	splice site	probably null
IGL01685:Dync2h1	APN	9	7,142,297 (GRCm38)	missense	probably damaging	1.00
IGL01724:Dync2h1	APN	9	7,081,077 (GRCm38)	missense	probably benign	0.03
IGL01738:Dync2h1	APN	9	7,114,922 (GRCm38)	missense	possibly damaging	0.77
IGL01783:Dync2h1	APN	9	7,118,822 (GRCm38)	unclassified	probably benign
IGL01813:Dync2h1	APN	9	7,122,799 (GRCm38)	missense	probably damaging	1.00
IGL01931:Dync2h1	APN	9	7,114,973 (GRCm38)	missense	probably damaging	1.00
IGL01931:Dync2h1	APN	9	7,011,207 (GRCm38)	missense	probably benign	0.33
IGL02105:Dync2h1	APN	9	7,075,892 (GRCm38)	missense	probably damaging	1.00
IGL02137:Dync2h1	APN	9	7,134,349 (GRCm38)	missense	probably benign
IGL02140:Dync2h1	APN	9	7,147,791 (GRCm38)	missense	probably benign
IGL02175:Dync2h1	APN	9	7,111,548 (GRCm38)	missense	possibly damaging	0.91
IGL02283:Dync2h1	APN	9	7,125,912 (GRCm38)	missense	probably damaging	0.99
IGL02305:Dync2h1	APN	9	7,122,678 (GRCm38)	missense	probably benign
IGL02342:Dync2h1	APN	9	7,142,246 (GRCm38)	missense	probably damaging	1.00
IGL02367:Dync2h1	APN	9	7,158,926 (GRCm38)	missense	probably damaging	0.98
IGL02563:Dync2h1	APN	9	7,035,700 (GRCm38)	missense	possibly damaging	0.95
IGL02825:Dync2h1	APN	9	6,955,901 (GRCm38)	splice site	probably benign
IGL02955:Dync2h1	APN	9	7,142,864 (GRCm38)	missense	probably benign	0.00
IGL02992:Dync2h1	APN	9	7,137,074 (GRCm38)	missense	probably benign	0.01
IGL02996:Dync2h1	APN	9	6,935,279 (GRCm38)	missense	probably damaging	0.99
IGL03224:Dync2h1	APN	9	7,076,235 (GRCm38)	missense	probably benign	0.32
IGL03226:Dync2h1	APN	9	7,125,918 (GRCm38)	missense	probably benign
IGL03233:Dync2h1	APN	9	7,101,525 (GRCm38)	missense	possibly damaging	0.90
deinonychus	UTSW	9	7,159,478 (GRCm38)	splice site	probably null
R0016:Dync2h1	UTSW	9	7,144,346 (GRCm38)	splice site	probably benign
R0016:Dync2h1	UTSW	9	7,144,346 (GRCm38)	splice site	probably benign
R0043:Dync2h1	UTSW	9	7,005,574 (GRCm38)	missense	probably benign	0.05
R0109:Dync2h1	UTSW	9	7,111,487 (GRCm38)	missense	probably damaging	1.00
R0109:Dync2h1	UTSW	9	7,111,487 (GRCm38)	missense	probably damaging	1.00
R0121:Dync2h1	UTSW	9	7,001,327 (GRCm38)	splice site	probably benign
R0277:Dync2h1	UTSW	9	7,129,046 (GRCm38)	missense	probably benign
R0360:Dync2h1	UTSW	9	7,113,182 (GRCm38)	missense	possibly damaging	0.62
R0362:Dync2h1	UTSW	9	7,005,487 (GRCm38)	splice site	probably null
R0389:Dync2h1	UTSW	9	7,167,244 (GRCm38)	splice site	probably null
R0443:Dync2h1	UTSW	9	7,167,244 (GRCm38)	splice site	probably null
R0496:Dync2h1	UTSW	9	7,155,180 (GRCm38)	missense	probably benign	0.42
R0506:Dync2h1	UTSW	9	7,113,153 (GRCm38)	missense	probably benign	0.05
R0511:Dync2h1	UTSW	9	7,122,692 (GRCm38)	missense	probably benign	0.00
R0540:Dync2h1	UTSW	9	7,051,480 (GRCm38)	missense	probably benign	0.00
R0550:Dync2h1	UTSW	9	7,120,954 (GRCm38)	splice site	probably null
R0564:Dync2h1	UTSW	9	7,139,432 (GRCm38)	missense	probably damaging	1.00
R0607:Dync2h1	UTSW	9	7,051,480 (GRCm38)	missense	probably benign	0.00
R0699:Dync2h1	UTSW	9	7,103,680 (GRCm38)	missense	probably benign	0.00
R0725:Dync2h1	UTSW	9	7,015,497 (GRCm38)	missense	possibly damaging	0.93
R0835:Dync2h1	UTSW	9	7,116,642 (GRCm38)	critical splice acceptor site	probably null
R0837:Dync2h1	UTSW	9	7,077,979 (GRCm38)	missense	probably benign	0.07
R0894:Dync2h1	UTSW	9	7,041,734 (GRCm38)	splice site	probably benign
R0938:Dync2h1	UTSW	9	7,002,658 (GRCm38)	missense	probably benign	0.02
R1056:Dync2h1	UTSW	9	7,147,731 (GRCm38)	missense	probably benign	0.15
R1081:Dync2h1	UTSW	9	7,005,488 (GRCm38)	critical splice donor site	probably null
R1178:Dync2h1	UTSW	9	7,101,193 (GRCm38)	splice site	probably benign
R1243:Dync2h1	UTSW	9	7,120,882 (GRCm38)	missense	probably benign
R1295:Dync2h1	UTSW	9	7,075,752 (GRCm38)	splice site	probably benign
R1304:Dync2h1	UTSW	9	7,102,318 (GRCm38)	missense	probably damaging	1.00
R1387:Dync2h1	UTSW	9	7,125,816 (GRCm38)	missense	probably benign
R1513:Dync2h1	UTSW	9	7,103,663 (GRCm38)	missense	possibly damaging	0.74
R1557:Dync2h1	UTSW	9	7,140,911 (GRCm38)	missense	probably damaging	1.00
R1568:Dync2h1	UTSW	9	7,157,553 (GRCm38)	missense	probably null	0.02
R1570:Dync2h1	UTSW	9	7,176,926 (GRCm38)	missense	probably benign	0.12
R1670:Dync2h1	UTSW	9	6,993,942 (GRCm38)	missense	possibly damaging	0.82
R1713:Dync2h1	UTSW	9	7,131,891 (GRCm38)	missense	probably benign
R1766:Dync2h1	UTSW	9	7,015,526 (GRCm38)	critical splice acceptor site	probably null
R1773:Dync2h1	UTSW	9	7,128,256 (GRCm38)	missense	probably damaging	1.00
R1786:Dync2h1	UTSW	9	7,081,084 (GRCm38)	missense	probably damaging	1.00
R1848:Dync2h1	UTSW	9	7,049,166 (GRCm38)	missense	probably benign	0.01
R1850:Dync2h1	UTSW	9	7,001,448 (GRCm38)	missense	probably benign	0.00
R1935:Dync2h1	UTSW	9	7,139,159 (GRCm38)	critical splice donor site	probably null
R1936:Dync2h1	UTSW	9	7,139,159 (GRCm38)	critical splice donor site	probably null
R1937:Dync2h1	UTSW	9	7,139,159 (GRCm38)	critical splice donor site	probably null
R1939:Dync2h1	UTSW	9	7,139,159 (GRCm38)	critical splice donor site	probably null
R1940:Dync2h1	UTSW	9	7,139,159 (GRCm38)	critical splice donor site	probably null
R1944:Dync2h1	UTSW	9	7,001,377 (GRCm38)	missense	probably damaging	1.00
R1976:Dync2h1	UTSW	9	7,129,045 (GRCm38)	missense	probably benign
R2012:Dync2h1	UTSW	9	7,169,589 (GRCm38)	missense	probably benign	0.00
R2020:Dync2h1	UTSW	9	7,162,925 (GRCm38)	missense	probably benign	0.25
R2020:Dync2h1	UTSW	9	7,122,772 (GRCm38)	missense	probably damaging	0.99
R2024:Dync2h1	UTSW	9	7,129,062 (GRCm38)	missense	probably damaging	0.97
R2038:Dync2h1	UTSW	9	6,967,226 (GRCm38)	missense	probably damaging	0.99
R2045:Dync2h1	UTSW	9	7,160,171 (GRCm38)	missense	probably damaging	1.00
R2060:Dync2h1	UTSW	9	7,162,802 (GRCm38)	missense	possibly damaging	0.92
R2094:Dync2h1	UTSW	9	7,148,735 (GRCm38)	missense	probably benign	0.18
R2129:Dync2h1	UTSW	9	7,175,289 (GRCm38)	missense	possibly damaging	0.94
R2130:Dync2h1	UTSW	9	7,011,253 (GRCm38)	missense	probably damaging	1.00
R2136:Dync2h1	UTSW	9	7,122,772 (GRCm38)	missense	probably damaging	0.99
R2164:Dync2h1	UTSW	9	7,124,797 (GRCm38)	missense	probably damaging	1.00
R2242:Dync2h1	UTSW	9	7,037,828 (GRCm38)	splice site	probably null
R2255:Dync2h1	UTSW	9	6,955,905 (GRCm38)	critical splice donor site	probably null
R2357:Dync2h1	UTSW	9	7,081,053 (GRCm38)	missense	probably benign	0.03
R2389:Dync2h1	UTSW	9	7,122,618 (GRCm38)	missense	possibly damaging	0.82
R2412:Dync2h1	UTSW	9	7,144,246 (GRCm38)	missense	probably benign	0.01
R2885:Dync2h1	UTSW	9	7,102,329 (GRCm38)	missense	probably damaging	1.00
R2909:Dync2h1	UTSW	9	7,049,114 (GRCm38)	missense	probably damaging	1.00
R3434:Dync2h1	UTSW	9	7,011,236 (GRCm38)	missense	probably benign
R3719:Dync2h1	UTSW	9	7,006,882 (GRCm38)	splice site	probably benign
R3723:Dync2h1	UTSW	9	7,041,658 (GRCm38)	missense	probably benign	0.17
R3800:Dync2h1	UTSW	9	7,101,525 (GRCm38)	missense	possibly damaging	0.90
R3803:Dync2h1	UTSW	9	6,935,293 (GRCm38)	missense	probably benign	0.00
R3936:Dync2h1	UTSW	9	7,001,482 (GRCm38)	missense	probably damaging	1.00
R3941:Dync2h1	UTSW	9	7,124,825 (GRCm38)	missense	probably benign
R3950:Dync2h1	UTSW	9	7,112,061 (GRCm38)	nonsense	probably null
R4004:Dync2h1	UTSW	9	7,117,404 (GRCm38)	missense	probably damaging	1.00
R4091:Dync2h1	UTSW	9	7,131,881 (GRCm38)	missense	probably benign	0.01
R4233:Dync2h1	UTSW	9	7,134,360 (GRCm38)	missense	probably benign	0.02
R4302:Dync2h1	UTSW	9	7,077,880 (GRCm38)	missense	probably benign	0.02
R4451:Dync2h1	UTSW	9	6,983,477 (GRCm38)	missense	probably benign	0.02
R4512:Dync2h1	UTSW	9	7,085,009 (GRCm38)	nonsense	probably null
R4596:Dync2h1	UTSW	9	6,992,595 (GRCm38)	missense	probably benign
R4604:Dync2h1	UTSW	9	7,140,995 (GRCm38)	missense	probably benign	0.00
R4614:Dync2h1	UTSW	9	7,011,290 (GRCm38)	missense	probably benign	0.03
R4667:Dync2h1	UTSW	9	7,051,411 (GRCm38)	missense	probably benign	0.00
R4671:Dync2h1	UTSW	9	7,169,640 (GRCm38)	missense	possibly damaging	0.82
R4714:Dync2h1	UTSW	9	7,118,932 (GRCm38)	missense	possibly damaging	0.86
R4716:Dync2h1	UTSW	9	7,142,648 (GRCm38)	critical splice donor site	probably null
R4736:Dync2h1	UTSW	9	7,006,862 (GRCm38)	missense	probably benign	0.00
R4807:Dync2h1	UTSW	9	7,139,422 (GRCm38)	missense	probably benign	0.31
R4850:Dync2h1	UTSW	9	7,134,364 (GRCm38)	missense	probably benign	0.14
R4862:Dync2h1	UTSW	9	7,147,717 (GRCm38)	missense	probably benign
R4899:Dync2h1	UTSW	9	7,131,921 (GRCm38)	nonsense	probably null
R4971:Dync2h1	UTSW	9	7,131,949 (GRCm38)	missense	probably benign
R5040:Dync2h1	UTSW	9	6,992,625 (GRCm38)	missense	probably benign	0.09
R5054:Dync2h1	UTSW	9	7,085,007 (GRCm38)	missense	possibly damaging	0.63
R5274:Dync2h1	UTSW	9	7,116,540 (GRCm38)	missense	probably benign	0.00
R5307:Dync2h1	UTSW	9	7,155,099 (GRCm38)	missense	probably damaging	1.00
R5347:Dync2h1	UTSW	9	7,129,727 (GRCm38)	missense	probably damaging	1.00
R5372:Dync2h1	UTSW	9	7,176,962 (GRCm38)	unclassified	probably benign
R5384:Dync2h1	UTSW	9	7,016,791 (GRCm38)	missense	probably damaging	0.99
R5385:Dync2h1	UTSW	9	7,016,791 (GRCm38)	missense	probably damaging	0.99
R5394:Dync2h1	UTSW	9	7,120,899 (GRCm38)	nonsense	probably null
R5402:Dync2h1	UTSW	9	7,114,949 (GRCm38)	missense	probably damaging	1.00
R5446:Dync2h1	UTSW	9	7,144,217 (GRCm38)	missense	probably benign
R5538:Dync2h1	UTSW	9	7,168,630 (GRCm38)	intron	probably benign
R5551:Dync2h1	UTSW	9	7,031,718 (GRCm38)	missense	possibly damaging	0.74
R5619:Dync2h1	UTSW	9	7,118,885 (GRCm38)	missense	probably benign	0.02
R5621:Dync2h1	UTSW	9	7,120,909 (GRCm38)	missense	possibly damaging	0.86
R5652:Dync2h1	UTSW	9	7,116,638 (GRCm38)	missense	probably benign	0.45
R5655:Dync2h1	UTSW	9	7,148,659 (GRCm38)	missense	probably benign	0.01
R5689:Dync2h1	UTSW	9	7,169,689 (GRCm38)	missense	probably damaging	1.00
R5725:Dync2h1	UTSW	9	7,169,528 (GRCm38)	missense	probably benign	0.21
R5742:Dync2h1	UTSW	9	7,165,762 (GRCm38)	missense	possibly damaging	0.64
R5817:Dync2h1	UTSW	9	6,996,905 (GRCm38)	missense	probably damaging	1.00
R5852:Dync2h1	UTSW	9	7,011,290 (GRCm38)	missense	probably benign	0.03
R5898:Dync2h1	UTSW	9	7,148,717 (GRCm38)	missense	probably benign	0.00
R5916:Dync2h1	UTSW	9	7,102,309 (GRCm38)	critical splice donor site	probably null
R5939:Dync2h1	UTSW	9	7,037,801 (GRCm38)	missense	probably damaging	0.99
R5942:Dync2h1	UTSW	9	7,117,466 (GRCm38)	nonsense	probably null
R5982:Dync2h1	UTSW	9	6,955,986 (GRCm38)	missense	probably benign	0.00
R6029:Dync2h1	UTSW	9	7,157,646 (GRCm38)	missense	probably benign
R6125:Dync2h1	UTSW	9	7,168,706 (GRCm38)	missense	probably damaging	1.00
R6209:Dync2h1	UTSW	9	7,165,677 (GRCm38)	missense	probably benign	0.01
R6247:Dync2h1	UTSW	9	7,135,078 (GRCm38)	missense	probably damaging	1.00
R6294:Dync2h1	UTSW	9	7,084,986 (GRCm38)	missense	probably benign	0.01
R6328:Dync2h1	UTSW	9	7,165,717 (GRCm38)	missense	probably benign	0.00
R6376:Dync2h1	UTSW	9	7,165,703 (GRCm38)	missense	probably benign	0.21
R6394:Dync2h1	UTSW	9	7,168,331 (GRCm38)	missense	probably damaging	0.99
R6539:Dync2h1	UTSW	9	7,159,478 (GRCm38)	splice site	probably null
R6554:Dync2h1	UTSW	9	7,037,699 (GRCm38)	missense	probably benign	0.39
R6559:Dync2h1	UTSW	9	7,139,501 (GRCm38)	missense	possibly damaging	0.72
R6563:Dync2h1	UTSW	9	7,120,819 (GRCm38)	missense	probably benign	0.27
R6807:Dync2h1	UTSW	9	7,041,718 (GRCm38)	missense	probably benign	0.10
R6848:Dync2h1	UTSW	9	7,159,632 (GRCm38)	missense	probably benign	0.22
R6901:Dync2h1	UTSW	9	7,131,855 (GRCm38)	missense	probably damaging	1.00
R6921:Dync2h1	UTSW	9	7,102,549 (GRCm38)	missense	probably benign
R6997:Dync2h1	UTSW	9	7,168,743 (GRCm38)	missense	probably null	0.00
R7084:Dync2h1	UTSW	9	7,113,214 (GRCm38)	missense	possibly damaging	0.72
R7113:Dync2h1	UTSW	9	7,075,788 (GRCm38)	missense	probably benign	0.03
R7131:Dync2h1	UTSW	9	7,075,786 (GRCm38)	missense	probably damaging	1.00
R7165:Dync2h1	UTSW	9	7,050,479 (GRCm38)	missense	probably benign
R7196:Dync2h1	UTSW	9	7,147,715 (GRCm38)	nonsense	probably null
R7208:Dync2h1	UTSW	9	7,141,059 (GRCm38)	missense	probably damaging	1.00
R7225:Dync2h1	UTSW	9	7,142,756 (GRCm38)	missense	probably benign
R7237:Dync2h1	UTSW	9	6,993,966 (GRCm38)	missense	probably benign	0.00
R7243:Dync2h1	UTSW	9	7,102,405 (GRCm38)	missense	possibly damaging	0.64
R7291:Dync2h1	UTSW	9	6,929,590 (GRCm38)	missense	possibly damaging	0.69
R7293:Dync2h1	UTSW	9	7,001,454 (GRCm38)	missense	possibly damaging	0.88
R7329:Dync2h1	UTSW	9	7,011,247 (GRCm38)	missense	probably benign
R7351:Dync2h1	UTSW	9	7,167,145 (GRCm38)	missense	probably damaging	1.00
R7358:Dync2h1	UTSW	9	7,159,479 (GRCm38)	critical splice donor site	probably null
R7387:Dync2h1	UTSW	9	7,157,932 (GRCm38)	missense	possibly damaging	0.68
R7446:Dync2h1	UTSW	9	7,041,720 (GRCm38)	missense	probably benign	0.03
R7487:Dync2h1	UTSW	9	7,132,041 (GRCm38)	missense	probably benign	0.26
R7488:Dync2h1	UTSW	9	7,124,855 (GRCm38)	missense	probably benign	0.03
R7496:Dync2h1	UTSW	9	7,135,015 (GRCm38)	splice site	probably null
R7501:Dync2h1	UTSW	9	7,175,336 (GRCm38)	missense	possibly damaging	0.82
R7571:Dync2h1	UTSW	9	7,002,623 (GRCm38)	missense	probably damaging	1.00
R7627:Dync2h1	UTSW	9	7,101,111 (GRCm38)	missense	probably benign	0.00
R7639:Dync2h1	UTSW	9	7,141,254 (GRCm38)	missense	probably damaging	0.97
R7653:Dync2h1	UTSW	9	7,117,570 (GRCm38)	missense	probably benign
R7654:Dync2h1	UTSW	9	7,122,664 (GRCm38)	missense	probably damaging	1.00
R7742:Dync2h1	UTSW	9	7,076,232 (GRCm38)	missense	probably benign	0.00
R7755:Dync2h1	UTSW	9	7,015,490 (GRCm38)	missense	probably benign	0.00
R7762:Dync2h1	UTSW	9	7,129,719 (GRCm38)	missense	probably benign	0.01
R7790:Dync2h1	UTSW	9	7,114,914 (GRCm38)	missense	probably damaging	0.96
R7834:Dync2h1	UTSW	9	7,118,953 (GRCm38)	missense	probably benign	0.04
R7883:Dync2h1	UTSW	9	7,005,566 (GRCm38)	missense	possibly damaging	0.80
R7952:Dync2h1	UTSW	9	7,129,802 (GRCm38)	missense	possibly damaging	0.63
R8111:Dync2h1	UTSW	9	7,148,688 (GRCm38)	missense	probably benign	0.03
R8157:Dync2h1	UTSW	9	7,001,473 (GRCm38)	missense	possibly damaging	0.47
R8166:Dync2h1	UTSW	9	7,129,089 (GRCm38)	nonsense	probably null
R8236:Dync2h1	UTSW	9	7,080,363 (GRCm38)	intron	probably benign
R8326:Dync2h1	UTSW	9	7,147,771 (GRCm38)	missense	probably benign
R8335:Dync2h1	UTSW	9	7,084,941 (GRCm38)	missense	probably benign	0.28
R8347:Dync2h1	UTSW	9	7,116,578 (GRCm38)	missense	possibly damaging	0.81
R8372:Dync2h1	UTSW	9	7,111,514 (GRCm38)	missense	possibly damaging	0.90
R8421:Dync2h1	UTSW	9	7,102,477 (GRCm38)	missense	probably damaging	1.00
R8518:Dync2h1	UTSW	9	7,051,452 (GRCm38)	missense	probably benign	0.04
R8556:Dync2h1	UTSW	9	7,113,198 (GRCm38)	missense	probably benign	0.32
R8690:Dync2h1	UTSW	9	7,075,824 (GRCm38)	missense	probably damaging	1.00
R8713:Dync2h1	UTSW	9	7,141,008 (GRCm38)	nonsense	probably null
R8719:Dync2h1	UTSW	9	7,041,641 (GRCm38)	missense	probably benign	0.05
R8732:Dync2h1	UTSW	9	7,168,326 (GRCm38)	missense	probably damaging	1.00
R8744:Dync2h1	UTSW	9	7,011,220 (GRCm38)	nonsense	probably null
R8749:Dync2h1	UTSW	9	7,035,063 (GRCm38)	missense	probably benign	0.32
R8795:Dync2h1	UTSW	9	7,137,087 (GRCm38)	missense	probably benign	0.00
R8853:Dync2h1	UTSW	9	7,117,645 (GRCm38)	missense	possibly damaging	0.94
R8923:Dync2h1	UTSW	9	7,168,515 (GRCm38)	missense	probably benign
R8969:Dync2h1	UTSW	9	7,130,723 (GRCm38)	missense	probably damaging	1.00
R8988:Dync2h1	UTSW	9	7,037,727 (GRCm38)	missense	probably benign	0.00
R8997:Dync2h1	UTSW	9	7,129,003 (GRCm38)	missense	probably benign
R9025:Dync2h1	UTSW	9	7,139,462 (GRCm38)	nonsense	probably null
R9036:Dync2h1	UTSW	9	7,051,495 (GRCm38)	missense	probably damaging	1.00
R9055:Dync2h1	UTSW	9	6,996,641 (GRCm38)	intron	probably benign
R9165:Dync2h1	UTSW	9	7,114,883 (GRCm38)	missense	probably damaging	0.99
R9172:Dync2h1	UTSW	9	7,031,771 (GRCm38)	missense	probably damaging	1.00
R9286:Dync2h1	UTSW	9	6,941,668 (GRCm38)	missense	probably benign	0.01
R9312:Dync2h1	UTSW	9	7,050,413 (GRCm38)	missense	probably damaging	1.00
R9335:Dync2h1	UTSW	9	7,112,149 (GRCm38)	missense	possibly damaging	0.88
R9344:Dync2h1	UTSW	9	7,148,659 (GRCm38)	missense	probably benign	0.01
R9351:Dync2h1	UTSW	9	7,176,911 (GRCm38)	missense	probably damaging	0.98
R9367:Dync2h1	UTSW	9	7,125,730 (GRCm38)	critical splice donor site	probably null
R9613:Dync2h1	UTSW	9	7,075,769 (GRCm38)	missense	probably damaging	0.99
R9650:Dync2h1	UTSW	9	7,174,849 (GRCm38)	missense	possibly damaging	0.83
R9726:Dync2h1	UTSW	9	7,077,999 (GRCm38)	missense	possibly damaging	0.94
R9731:Dync2h1	UTSW	9	7,141,166 (GRCm38)	missense	probably benign
X0009:Dync2h1	UTSW	9	7,117,576 (GRCm38)	missense	possibly damaging	0.81
Z1176:Dync2h1	UTSW	9	7,168,730 (GRCm38)	frame shift	probably null
Z1176:Dync2h1	UTSW	9	7,142,361 (GRCm38)	missense	probably damaging	0.99
Z1177:Dync2h1	UTSW	9	7,102,427 (GRCm38)	missense	probably damaging	1.00

Posted On

2015-04-16