Incidental Mutation 'IGL02466:Tas2r117'
| ID |
294572 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Tas2r117
|
| Ensembl Gene |
ENSMUSG00000058349 |
| Gene Name |
taste receptor, type 2, member 117 |
| Synonyms |
T2R17, mGR17, Tas2r17, mt2r54 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.048)
|
| Stock # |
IGL02466
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
6 |
| Chromosomal Location |
132779864-132780856 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 132779963 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Valine
at position 34
(M34V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000069768
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000068302]
|
| AlphaFold |
Q7M715 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000068302
AA Change: M34V
PolyPhen 2
Score 0.117 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000069768
Gene: ENSMUSG00000058349
AA Change: M34V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
8 |
307 |
1.2e-85 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 36 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca13 |
T |
C |
11: 9,247,527 (GRCm39) |
F2425L |
probably benign |
Het |
| Adgre4 |
A |
T |
17: 56,121,188 (GRCm39) |
Y418F |
probably benign |
Het |
| Adra1a |
G |
T |
14: 66,875,322 (GRCm39) |
C99F |
probably damaging |
Het |
| Aox3 |
C |
A |
1: 58,197,431 (GRCm39) |
H592Q |
probably benign |
Het |
| Cacna1f |
A |
G |
X: 7,495,644 (GRCm39) |
|
probably null |
Het |
| Cacna2d2 |
T |
A |
9: 107,342,753 (GRCm39) |
I100N |
probably damaging |
Het |
| Cblif |
A |
T |
19: 11,729,596 (GRCm39) |
N185I |
probably damaging |
Het |
| Ccr9 |
T |
A |
9: 123,608,911 (GRCm39) |
C198S |
probably damaging |
Het |
| Cdc45 |
C |
T |
16: 18,617,479 (GRCm39) |
M200I |
probably benign |
Het |
| Col4a3 |
T |
A |
1: 82,647,913 (GRCm39) |
C475S |
unknown |
Het |
| Csnk2a2 |
T |
C |
8: 96,203,859 (GRCm39) |
D100G |
possibly damaging |
Het |
| Cstf2t |
G |
A |
19: 31,061,277 (GRCm39) |
G271E |
possibly damaging |
Het |
| Fbxw22 |
T |
C |
9: 109,214,160 (GRCm39) |
R219G |
probably damaging |
Het |
| Homez |
A |
G |
14: 55,095,559 (GRCm39) |
F50L |
probably damaging |
Het |
| Hspa4l |
C |
T |
3: 40,707,657 (GRCm39) |
Q81* |
probably null |
Het |
| Ifi202b |
T |
C |
1: 173,799,875 (GRCm39) |
D202G |
possibly damaging |
Het |
| Inava |
T |
C |
1: 136,144,173 (GRCm39) |
|
probably null |
Het |
| Mansc1 |
T |
A |
6: 134,587,814 (GRCm39) |
D121V |
probably damaging |
Het |
| Or13a24 |
A |
G |
7: 140,154,684 (GRCm39) |
Y206C |
probably benign |
Het |
| Or4a27 |
T |
G |
2: 88,559,739 (GRCm39) |
D68A |
probably damaging |
Het |
| Or51h5 |
T |
A |
7: 102,577,723 (GRCm39) |
V296E |
possibly damaging |
Het |
| P2rx1 |
A |
T |
11: 72,900,410 (GRCm39) |
|
probably null |
Het |
| Phactr4 |
A |
G |
4: 132,104,483 (GRCm39) |
|
probably benign |
Het |
| Pus10 |
C |
T |
11: 23,675,574 (GRCm39) |
T482I |
probably damaging |
Het |
| Scyl2 |
G |
T |
10: 89,488,871 (GRCm39) |
Y206* |
probably null |
Het |
| Sell |
G |
A |
1: 163,896,632 (GRCm39) |
|
probably null |
Het |
| Slfn10-ps |
C |
T |
11: 82,921,090 (GRCm39) |
|
noncoding transcript |
Het |
| Ssh2 |
T |
C |
11: 77,307,233 (GRCm39) |
|
probably benign |
Het |
| Vmn2r103 |
A |
T |
17: 19,993,631 (GRCm39) |
T3S |
probably benign |
Het |
| Vmn2r73 |
A |
T |
7: 85,522,084 (GRCm39) |
I85K |
probably damaging |
Het |
| Vps13b |
T |
C |
15: 35,770,887 (GRCm39) |
V2110A |
possibly damaging |
Het |
| Zfp13 |
C |
T |
17: 23,795,072 (GRCm39) |
A493T |
probably benign |
Het |
| Zfp518a |
G |
A |
19: 40,903,061 (GRCm39) |
G997R |
probably damaging |
Het |
| Zfp592 |
G |
A |
7: 80,673,746 (GRCm39) |
G237R |
probably damaging |
Het |
| Zkscan7 |
A |
G |
9: 122,717,950 (GRCm39) |
E115G |
probably damaging |
Het |
| Zranb3 |
G |
A |
1: 127,943,829 (GRCm39) |
T306M |
probably benign |
Het |
|
| Other mutations in Tas2r117 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01611:Tas2r117
|
APN |
6 |
132,780,450 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01611:Tas2r117
|
APN |
6 |
132,780,447 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02140:Tas2r117
|
APN |
6 |
132,780,558 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL02154:Tas2r117
|
APN |
6 |
132,780,678 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02942:Tas2r117
|
APN |
6 |
132,780,657 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03328:Tas2r117
|
APN |
6 |
132,780,041 (GRCm39) |
missense |
probably benign |
0.40 |
|
PIT4480001:Tas2r117
|
UTSW |
6 |
132,780,014 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R0380:Tas2r117
|
UTSW |
6 |
132,780,551 (GRCm39) |
nonsense |
probably null |
|
|
R0456:Tas2r117
|
UTSW |
6 |
132,780,354 (GRCm39) |
missense |
probably benign |
0.12 |
|
R0699:Tas2r117
|
UTSW |
6 |
132,780,161 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2118:Tas2r117
|
UTSW |
6 |
132,780,129 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2265:Tas2r117
|
UTSW |
6 |
132,780,188 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4420:Tas2r117
|
UTSW |
6 |
132,780,312 (GRCm39) |
nonsense |
probably null |
|
|
R4861:Tas2r117
|
UTSW |
6 |
132,780,092 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4861:Tas2r117
|
UTSW |
6 |
132,780,092 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5233:Tas2r117
|
UTSW |
6 |
132,780,585 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5384:Tas2r117
|
UTSW |
6 |
132,780,117 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6750:Tas2r117
|
UTSW |
6 |
132,779,817 (GRCm39) |
start gained |
probably benign |
|
|
R6852:Tas2r117
|
UTSW |
6 |
132,779,892 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6902:Tas2r117
|
UTSW |
6 |
132,780,288 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6946:Tas2r117
|
UTSW |
6 |
132,780,288 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7129:Tas2r117
|
UTSW |
6 |
132,780,350 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7412:Tas2r117
|
UTSW |
6 |
132,780,192 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7733:Tas2r117
|
UTSW |
6 |
132,780,138 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7768:Tas2r117
|
UTSW |
6 |
132,780,485 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7953:Tas2r117
|
UTSW |
6 |
132,780,281 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9629:Tas2r117
|
UTSW |
6 |
132,780,374 (GRCm39) |
missense |
probably benign |
0.41 |
|
| Posted On |
2015-04-16 |
Incidental Mutation