Incidental Mutation 'IGL02466:Fbxw22'
ID 294586
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fbxw22
Ensembl Gene ENSMUSG00000070324
Gene Name F-box and WD-40 domain protein 22
Synonyms Gm5164
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # IGL02466
Quality Score
Status
Chromosome 9
Chromosomal Location 109207468-109233362 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 109214160 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glycine at position 219 (R219G)
Ref Sequence ENSEMBL: ENSMUSP00000079460 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080626] [ENSMUST00000197213]
AlphaFold Q5XG67
Predicted Effect probably damaging
Transcript: ENSMUST00000080626
AA Change: R219G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000079460
Gene: ENSMUSG00000070324
AA Change: R219G

DomainStartEndE-ValueType
FBOX 5 45 1.02e-5 SMART
SCOP:d1gxra_ 128 220 1e-5 SMART
Blast:WD40 137 176 6e-9 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000197213
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 T C 11: 9,247,527 (GRCm39) F2425L probably benign Het
Adgre4 A T 17: 56,121,188 (GRCm39) Y418F probably benign Het
Adra1a G T 14: 66,875,322 (GRCm39) C99F probably damaging Het
Aox3 C A 1: 58,197,431 (GRCm39) H592Q probably benign Het
Cacna1f A G X: 7,495,644 (GRCm39) probably null Het
Cacna2d2 T A 9: 107,342,753 (GRCm39) I100N probably damaging Het
Cblif A T 19: 11,729,596 (GRCm39) N185I probably damaging Het
Ccr9 T A 9: 123,608,911 (GRCm39) C198S probably damaging Het
Cdc45 C T 16: 18,617,479 (GRCm39) M200I probably benign Het
Col4a3 T A 1: 82,647,913 (GRCm39) C475S unknown Het
Csnk2a2 T C 8: 96,203,859 (GRCm39) D100G possibly damaging Het
Cstf2t G A 19: 31,061,277 (GRCm39) G271E possibly damaging Het
Homez A G 14: 55,095,559 (GRCm39) F50L probably damaging Het
Hspa4l C T 3: 40,707,657 (GRCm39) Q81* probably null Het
Ifi202b T C 1: 173,799,875 (GRCm39) D202G possibly damaging Het
Inava T C 1: 136,144,173 (GRCm39) probably null Het
Mansc1 T A 6: 134,587,814 (GRCm39) D121V probably damaging Het
Or13a24 A G 7: 140,154,684 (GRCm39) Y206C probably benign Het
Or4a27 T G 2: 88,559,739 (GRCm39) D68A probably damaging Het
Or51h5 T A 7: 102,577,723 (GRCm39) V296E possibly damaging Het
P2rx1 A T 11: 72,900,410 (GRCm39) probably null Het
Phactr4 A G 4: 132,104,483 (GRCm39) probably benign Het
Pus10 C T 11: 23,675,574 (GRCm39) T482I probably damaging Het
Scyl2 G T 10: 89,488,871 (GRCm39) Y206* probably null Het
Sell G A 1: 163,896,632 (GRCm39) probably null Het
Slfn10-ps C T 11: 82,921,090 (GRCm39) noncoding transcript Het
Ssh2 T C 11: 77,307,233 (GRCm39) probably benign Het
Tas2r117 A G 6: 132,779,963 (GRCm39) M34V probably benign Het
Vmn2r103 A T 17: 19,993,631 (GRCm39) T3S probably benign Het
Vmn2r73 A T 7: 85,522,084 (GRCm39) I85K probably damaging Het
Vps13b T C 15: 35,770,887 (GRCm39) V2110A possibly damaging Het
Zfp13 C T 17: 23,795,072 (GRCm39) A493T probably benign Het
Zfp518a G A 19: 40,903,061 (GRCm39) G997R probably damaging Het
Zfp592 G A 7: 80,673,746 (GRCm39) G237R probably damaging Het
Zkscan7 A G 9: 122,717,950 (GRCm39) E115G probably damaging Het
Zranb3 G A 1: 127,943,829 (GRCm39) T306M probably benign Het
Other mutations in Fbxw22
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00592:Fbxw22 APN 9 109,213,108 (GRCm39) missense possibly damaging 0.68
IGL00655:Fbxw22 APN 9 109,211,312 (GRCm39) splice site probably benign
IGL01122:Fbxw22 APN 9 109,215,739 (GRCm39) missense probably damaging 0.99
IGL01419:Fbxw22 APN 9 109,210,790 (GRCm39) missense probably benign 0.03
IGL01455:Fbxw22 APN 9 109,214,062 (GRCm39) missense probably benign
IGL01486:Fbxw22 APN 9 109,207,941 (GRCm39) missense probably damaging 1.00
IGL01734:Fbxw22 APN 9 109,212,993 (GRCm39) missense probably damaging 0.98
IGL02106:Fbxw22 APN 9 109,231,087 (GRCm39) missense possibly damaging 0.86
IGL02255:Fbxw22 APN 9 109,215,619 (GRCm39) splice site probably benign
IGL02820:Fbxw22 APN 9 109,215,732 (GRCm39) missense probably damaging 1.00
R0395:Fbxw22 UTSW 9 109,210,753 (GRCm39) missense probably damaging 1.00
R0705:Fbxw22 UTSW 9 109,232,164 (GRCm39) missense possibly damaging 0.92
R0741:Fbxw22 UTSW 9 109,211,287 (GRCm39) missense probably benign 0.01
R1603:Fbxw22 UTSW 9 109,207,915 (GRCm39) missense probably benign 0.00
R1673:Fbxw22 UTSW 9 109,211,196 (GRCm39) missense possibly damaging 0.93
R1874:Fbxw22 UTSW 9 109,214,179 (GRCm39) nonsense probably null
R2265:Fbxw22 UTSW 9 109,213,062 (GRCm39) missense probably benign 0.02
R2269:Fbxw22 UTSW 9 109,213,062 (GRCm39) missense probably benign 0.02
R2385:Fbxw22 UTSW 9 109,211,210 (GRCm39) missense probably damaging 1.00
R4329:Fbxw22 UTSW 9 109,213,111 (GRCm39) missense probably damaging 1.00
R4695:Fbxw22 UTSW 9 109,207,939 (GRCm39) missense probably damaging 1.00
R4731:Fbxw22 UTSW 9 109,207,937 (GRCm39) missense probably benign 0.02
R4915:Fbxw22 UTSW 9 109,213,009 (GRCm39) missense probably damaging 1.00
R5010:Fbxw22 UTSW 9 109,232,492 (GRCm39) missense probably benign 0.40
R5070:Fbxw22 UTSW 9 109,214,183 (GRCm39) missense probably benign
R5319:Fbxw22 UTSW 9 109,213,015 (GRCm39) missense possibly damaging 0.52
R5571:Fbxw22 UTSW 9 109,232,156 (GRCm39) missense probably damaging 1.00
R5765:Fbxw22 UTSW 9 109,214,064 (GRCm39) missense probably benign 0.00
R5846:Fbxw22 UTSW 9 109,215,829 (GRCm39) missense probably benign
R6002:Fbxw22 UTSW 9 109,210,750 (GRCm39) nonsense probably null
R6180:Fbxw22 UTSW 9 109,215,747 (GRCm39) missense probably damaging 1.00
R6313:Fbxw22 UTSW 9 109,232,465 (GRCm39) missense probably damaging 0.99
R6860:Fbxw22 UTSW 9 109,213,030 (GRCm39) missense probably benign 0.01
R6949:Fbxw22 UTSW 9 109,211,144 (GRCm39) missense probably benign 0.06
R7084:Fbxw22 UTSW 9 109,233,291 (GRCm39) missense probably damaging 1.00
R7296:Fbxw22 UTSW 9 109,211,143 (GRCm39) missense probably benign
R8499:Fbxw22 UTSW 9 109,214,068 (GRCm39) missense probably benign 0.00
R9088:Fbxw22 UTSW 9 109,207,952 (GRCm39) missense probably damaging 1.00
R9301:Fbxw22 UTSW 9 109,215,653 (GRCm39) missense possibly damaging 0.60
R9501:Fbxw22 UTSW 9 109,207,920 (GRCm39) missense probably benign 0.01
R9600:Fbxw22 UTSW 9 109,212,986 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16