Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02466:Vmn2r73'

294590

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r73

Ensembl Gene

ENSMUSG00000070458

Gene Name

vomeronasal 2, receptor 73

Synonyms

EG620928

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.157) question?

Stock #

IGL02466

Quality Score

Status

Chromosome

Chromosomal Location

85857547-85875938 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 85872876 bp

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Lysine at position 85 (I85K)

Ref Sequence

ENSEMBL: ENSMUSP00000076687 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000077478]

Predicted Effect

probably damaging
Transcript: ENSMUST00000077478
AA Change: I85K

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000076687
Gene: ENSMUSG00000070458
AA Change: I85K

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	77	465	1.4e-30	PFAM
Pfam:NCD3G	508	560	5.9e-21	PFAM
Pfam:7tm_3	590	827	4.4e-51	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
5730559C18Rik	T	C	1: 136,216,435		probably null	Het
Abca13	T	C	11: 9,297,527	F2425L	probably benign	Het
Adgre4	A	T	17: 55,814,188	Y418F	probably benign	Het
Adra1a	G	T	14: 66,637,873	C99F	probably damaging	Het
Aox3	C	A	1: 58,158,272	H592Q	probably benign	Het
Cacna1f	A	G	X: 7,629,405		probably null	Het
Cacna2d2	T	A	9: 107,465,554	I100N	probably damaging	Het
Ccr9	T	A	9: 123,779,846	C198S	probably damaging	Het
Cdc45	C	T	16: 18,798,729	M200I	probably benign	Het
Col4a3	T	A	1: 82,670,192	C475S	unknown	Het
Csnk2a2	T	C	8: 95,477,231	D100G	possibly damaging	Het
Cstf2t	G	A	19: 31,083,877	G271E	possibly damaging	Het
Fbxw22	T	C	9: 109,385,092	R219G	probably damaging	Het
Gif	A	T	19: 11,752,232	N185I	probably damaging	Het
Homez	A	G	14: 54,858,102	F50L	probably damaging	Het
Hspa4l	C	T	3: 40,753,225	Q81*	probably null	Het
Ifi202b	T	C	1: 173,972,309	D202G	possibly damaging	Het
Mansc1	T	A	6: 134,610,851	D121V	probably damaging	Het
Olfr1197	T	G	2: 88,729,395	D68A	probably damaging	Het
Olfr538	A	G	7: 140,574,771	Y206C	probably benign	Het
Olfr572	T	A	7: 102,928,516	V296E	possibly damaging	Het
P2rx1	A	T	11: 73,009,584		probably null	Het
Phactr4	A	G	4: 132,377,172		probably benign	Het
Pus10	C	T	11: 23,725,574	T482I	probably damaging	Het
Scyl2	G	T	10: 89,653,009	Y206*	probably null	Het
Sell	G	A	1: 164,069,063		probably null	Het
Slfn10-ps	C	T	11: 83,030,264		noncoding transcript	Het
Ssh2	T	C	11: 77,416,407		probably benign	Het
Tas2r117	A	G	6: 132,803,000	M34V	probably benign	Het
Vmn2r103	A	T	17: 19,773,369	T3S	probably benign	Het
Vps13b	T	C	15: 35,770,741	V2110A	possibly damaging	Het
Zfp13	C	T	17: 23,576,098	A493T	probably benign	Het
Zfp518a	G	A	19: 40,914,617	G997R	probably damaging	Het
Zfp592	G	A	7: 81,023,998	G237R	probably damaging	Het
Zkscan7	A	G	9: 122,888,885	E115G	probably damaging	Het
Zranb3	G	A	1: 128,016,092	T306M	probably benign	Het

Other mutations in Vmn2r73

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00158:Vmn2r73	APN	7	85857587	missense	probably benign
IGL01151:Vmn2r73	APN	7	85857878	missense	probably damaging	0.99
IGL01408:Vmn2r73	APN	7	85872247	missense	probably benign	0.45
IGL01505:Vmn2r73	APN	7	85858059	nonsense	probably null
IGL01731:Vmn2r73	APN	7	85857549	makesense	probably null
IGL01818:Vmn2r73	APN	7	85869901	splice site	probably benign
IGL02236:Vmn2r73	APN	7	85872694	missense	probably benign	0.00
IGL02265:Vmn2r73	APN	7	85871639	missense	probably benign	0.02
IGL02266:Vmn2r73	APN	7	85875799	missense	possibly damaging	0.52
IGL02276:Vmn2r73	APN	7	85869772	critical splice donor site	probably null
IGL02284:Vmn2r73	APN	7	85857915	missense	possibly damaging	0.92
IGL02380:Vmn2r73	APN	7	85858175	missense	probably benign	0.00
IGL03172:Vmn2r73	APN	7	85858287	missense	probably benign	0.01
IGL03179:Vmn2r73	APN	7	85870260	missense	probably benign	0.04
R0077:Vmn2r73	UTSW	7	85875867	missense	probably benign	0.00
R0311:Vmn2r73	UTSW	7	85871789	missense	probably benign
R0413:Vmn2r73	UTSW	7	85871879	missense	possibly damaging	0.68
R0494:Vmn2r73	UTSW	7	85872932	missense	probably benign
R1523:Vmn2r73	UTSW	7	85870278	missense	probably benign	0.02
R1618:Vmn2r73	UTSW	7	85875912	nonsense	probably null
R1667:Vmn2r73	UTSW	7	85857681	missense	probably benign	0.00
R1728:Vmn2r73	UTSW	7	85857878	missense	probably damaging	1.00
R1729:Vmn2r73	UTSW	7	85857878	missense	probably damaging	1.00
R1747:Vmn2r73	UTSW	7	85858167	missense	probably damaging	1.00
R1784:Vmn2r73	UTSW	7	85857878	missense	probably damaging	1.00
R2152:Vmn2r73	UTSW	7	85857728	missense	probably benign	0.03
R2395:Vmn2r73	UTSW	7	85857767	missense	probably damaging	1.00
R2415:Vmn2r73	UTSW	7	85872223	missense	probably damaging	1.00
R2926:Vmn2r73	UTSW	7	85871663	missense	probably benign	0.17
R3719:Vmn2r73	UTSW	7	85870374	missense	probably damaging	1.00
R3766:Vmn2r73	UTSW	7	85871990	missense	probably benign
R3838:Vmn2r73	UTSW	7	85858050	missense	probably benign	0.00
R3890:Vmn2r73	UTSW	7	85857936	missense	probably benign
R4030:Vmn2r73	UTSW	7	85871836	missense	possibly damaging	0.92
R4247:Vmn2r73	UTSW	7	85872675	missense	probably damaging	0.99
R4409:Vmn2r73	UTSW	7	85871560	missense	probably damaging	0.97
R4427:Vmn2r73	UTSW	7	85857773	missense	probably damaging	1.00
R4430:Vmn2r73	UTSW	7	85870241	missense	probably benign
R4552:Vmn2r73	UTSW	7	85875847	missense	probably benign	0.12
R4779:Vmn2r73	UTSW	7	85871715	nonsense	probably null
R4906:Vmn2r73	UTSW	7	85857621	missense	probably damaging	0.99
R4942:Vmn2r73	UTSW	7	85870374	missense	probably damaging	1.00
R5280:Vmn2r73	UTSW	7	85857947	missense	probably damaging	0.98
R5344:Vmn2r73	UTSW	7	85875838	missense	probably benign	0.00
R5478:Vmn2r73	UTSW	7	85869788	missense	probably damaging	1.00
R5527:Vmn2r73	UTSW	7	85858367	missense	possibly damaging	0.65
R5691:Vmn2r73	UTSW	7	85858091	missense	probably damaging	1.00
R5826:Vmn2r73	UTSW	7	85875748	missense	possibly damaging	0.77
R6018:Vmn2r73	UTSW	7	85872667	missense	possibly damaging	0.48
R6082:Vmn2r73	UTSW	7	85858221	missense	probably benign	0.00
R6111:Vmn2r73	UTSW	7	85871789	missense	probably benign
R6233:Vmn2r73	UTSW	7	85869891	missense	probably benign	0.00
R6278:Vmn2r73	UTSW	7	85872932	missense	probably benign
R6283:Vmn2r73	UTSW	7	85871841	missense	probably benign	0.00
R6307:Vmn2r73	UTSW	7	85857620	missense	probably damaging	1.00
R6413:Vmn2r73	UTSW	7	85870336	nonsense	probably null
R6782:Vmn2r73	UTSW	7	85870355	missense	probably benign	0.00
R6884:Vmn2r73	UTSW	7	85858005	missense	probably benign	0.05
R6921:Vmn2r73	UTSW	7	85858238	missense	probably benign	0.27
R7169:Vmn2r73	UTSW	7	85858455	nonsense	probably null
R7206:Vmn2r73	UTSW	7	85872867	missense	probably benign	0.03
R7311:Vmn2r73	UTSW	7	85871984	missense	possibly damaging	0.80
R7650:Vmn2r73	UTSW	7	85871939	missense	probably benign
X0023:Vmn2r73	UTSW	7	85858456	missense	probably benign	0.31

Posted On

2015-04-16