Incidental Mutation 'IGL02466:Adgre4'
ID 294591
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Adgre4
Ensembl Gene ENSMUSG00000032915
Gene Name adhesion G protein-coupled receptor E4
Synonyms EGF-TM7, Gpr127, FIRE, Emr4, D17Ertd479e
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02466
Quality Score
Status
Chromosome 17
Chromosomal Location 56056984-56160662 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 56121188 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 418 (Y418F)
Ref Sequence ENSEMBL: ENSMUSP00000025004 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025004]
AlphaFold Q91ZE5
Predicted Effect probably benign
Transcript: ENSMUST00000025004
AA Change: Y418F

PolyPhen 2 Score 0.421 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000025004
Gene: ENSMUSG00000032915
AA Change: Y418F

DomainStartEndE-ValueType
signal peptide 1 36 N/A INTRINSIC
Blast:EGF_like 38 76 2e-10 BLAST
Pfam:EGF_CA 77 117 3.6e-9 PFAM
GPS 288 338 4.03e-12 SMART
Pfam:7tm_2 343 588 5.7e-57 PFAM
low complexity region 613 628 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 T C 11: 9,247,527 (GRCm39) F2425L probably benign Het
Adra1a G T 14: 66,875,322 (GRCm39) C99F probably damaging Het
Aox3 C A 1: 58,197,431 (GRCm39) H592Q probably benign Het
Cacna1f A G X: 7,495,644 (GRCm39) probably null Het
Cacna2d2 T A 9: 107,342,753 (GRCm39) I100N probably damaging Het
Cblif A T 19: 11,729,596 (GRCm39) N185I probably damaging Het
Ccr9 T A 9: 123,608,911 (GRCm39) C198S probably damaging Het
Cdc45 C T 16: 18,617,479 (GRCm39) M200I probably benign Het
Col4a3 T A 1: 82,647,913 (GRCm39) C475S unknown Het
Csnk2a2 T C 8: 96,203,859 (GRCm39) D100G possibly damaging Het
Cstf2t G A 19: 31,061,277 (GRCm39) G271E possibly damaging Het
Fbxw22 T C 9: 109,214,160 (GRCm39) R219G probably damaging Het
Homez A G 14: 55,095,559 (GRCm39) F50L probably damaging Het
Hspa4l C T 3: 40,707,657 (GRCm39) Q81* probably null Het
Ifi202b T C 1: 173,799,875 (GRCm39) D202G possibly damaging Het
Inava T C 1: 136,144,173 (GRCm39) probably null Het
Mansc1 T A 6: 134,587,814 (GRCm39) D121V probably damaging Het
Or13a24 A G 7: 140,154,684 (GRCm39) Y206C probably benign Het
Or4a27 T G 2: 88,559,739 (GRCm39) D68A probably damaging Het
Or51h5 T A 7: 102,577,723 (GRCm39) V296E possibly damaging Het
P2rx1 A T 11: 72,900,410 (GRCm39) probably null Het
Phactr4 A G 4: 132,104,483 (GRCm39) probably benign Het
Pus10 C T 11: 23,675,574 (GRCm39) T482I probably damaging Het
Scyl2 G T 10: 89,488,871 (GRCm39) Y206* probably null Het
Sell G A 1: 163,896,632 (GRCm39) probably null Het
Slfn10-ps C T 11: 82,921,090 (GRCm39) noncoding transcript Het
Ssh2 T C 11: 77,307,233 (GRCm39) probably benign Het
Tas2r117 A G 6: 132,779,963 (GRCm39) M34V probably benign Het
Vmn2r103 A T 17: 19,993,631 (GRCm39) T3S probably benign Het
Vmn2r73 A T 7: 85,522,084 (GRCm39) I85K probably damaging Het
Vps13b T C 15: 35,770,887 (GRCm39) V2110A possibly damaging Het
Zfp13 C T 17: 23,795,072 (GRCm39) A493T probably benign Het
Zfp518a G A 19: 40,903,061 (GRCm39) G997R probably damaging Het
Zfp592 G A 7: 80,673,746 (GRCm39) G237R probably damaging Het
Zkscan7 A G 9: 122,717,950 (GRCm39) E115G probably damaging Het
Zranb3 G A 1: 127,943,829 (GRCm39) T306M probably benign Het
Other mutations in Adgre4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00089:Adgre4 APN 17 56,098,915 (GRCm39) splice site probably benign
IGL00228:Adgre4 APN 17 56,109,135 (GRCm39) missense probably damaging 1.00
IGL00572:Adgre4 APN 17 56,127,648 (GRCm39) missense probably benign 0.00
IGL01404:Adgre4 APN 17 56,104,639 (GRCm39) missense possibly damaging 0.63
IGL01420:Adgre4 APN 17 56,106,785 (GRCm39) splice site probably benign
IGL01501:Adgre4 APN 17 56,109,002 (GRCm39) splice site probably benign
IGL01510:Adgre4 APN 17 56,125,760 (GRCm39) critical splice donor site probably null
IGL01554:Adgre4 APN 17 56,124,090 (GRCm39) missense probably damaging 1.00
IGL01607:Adgre4 APN 17 56,101,748 (GRCm39) splice site probably benign
IGL01767:Adgre4 APN 17 56,104,740 (GRCm39) missense probably benign 0.19
IGL02253:Adgre4 APN 17 56,067,573 (GRCm39) missense probably benign 0.01
IGL02358:Adgre4 APN 17 56,150,209 (GRCm39) missense probably benign 0.15
IGL03057:Adgre4 APN 17 56,106,602 (GRCm39) splice site probably benign
R0070:Adgre4 UTSW 17 56,109,154 (GRCm39) missense probably damaging 0.98
R0070:Adgre4 UTSW 17 56,109,154 (GRCm39) missense probably damaging 0.98
R0111:Adgre4 UTSW 17 56,124,073 (GRCm39) missense possibly damaging 0.92
R0311:Adgre4 UTSW 17 56,109,010 (GRCm39) missense probably benign 0.36
R0366:Adgre4 UTSW 17 56,099,001 (GRCm39) nonsense probably null
R0415:Adgre4 UTSW 17 56,159,288 (GRCm39) missense probably benign 0.03
R0465:Adgre4 UTSW 17 56,092,137 (GRCm39) splice site probably benign
R0619:Adgre4 UTSW 17 56,127,679 (GRCm39) missense possibly damaging 0.52
R0685:Adgre4 UTSW 17 56,099,035 (GRCm39) missense probably benign 0.05
R0724:Adgre4 UTSW 17 56,159,281 (GRCm39) missense probably benign 0.00
R0835:Adgre4 UTSW 17 56,106,637 (GRCm39) missense probably damaging 1.00
R1330:Adgre4 UTSW 17 56,085,814 (GRCm39) missense probably benign 0.36
R1452:Adgre4 UTSW 17 56,091,996 (GRCm39) missense probably benign 0.35
R1960:Adgre4 UTSW 17 56,098,497 (GRCm39) missense probably benign
R1961:Adgre4 UTSW 17 56,098,497 (GRCm39) missense probably benign
R2046:Adgre4 UTSW 17 56,085,847 (GRCm39) missense possibly damaging 0.82
R2421:Adgre4 UTSW 17 56,085,872 (GRCm39) missense probably benign 0.10
R2570:Adgre4 UTSW 17 56,085,878 (GRCm39) missense possibly damaging 0.54
R3162:Adgre4 UTSW 17 56,109,218 (GRCm39) splice site probably benign
R4222:Adgre4 UTSW 17 56,092,121 (GRCm39) missense probably damaging 1.00
R4526:Adgre4 UTSW 17 56,092,016 (GRCm39) nonsense probably null
R4631:Adgre4 UTSW 17 56,121,305 (GRCm39) missense probably null 1.00
R4689:Adgre4 UTSW 17 56,109,096 (GRCm39) missense probably damaging 1.00
R4701:Adgre4 UTSW 17 56,091,971 (GRCm39) missense probably damaging 1.00
R4792:Adgre4 UTSW 17 56,098,491 (GRCm39) missense probably benign 0.00
R5205:Adgre4 UTSW 17 56,101,727 (GRCm39) nonsense probably null
R5210:Adgre4 UTSW 17 56,092,029 (GRCm39) missense probably damaging 0.97
R5358:Adgre4 UTSW 17 56,125,758 (GRCm39) missense probably benign 0.00
R5873:Adgre4 UTSW 17 56,159,282 (GRCm39) missense probably benign 0.13
R6025:Adgre4 UTSW 17 56,099,013 (GRCm39) missense probably benign 0.00
R6257:Adgre4 UTSW 17 56,109,133 (GRCm39) missense possibly damaging 0.87
R6426:Adgre4 UTSW 17 56,109,196 (GRCm39) missense probably benign 0.18
R6440:Adgre4 UTSW 17 56,101,744 (GRCm39) critical splice donor site probably null
R6484:Adgre4 UTSW 17 56,109,036 (GRCm39) missense possibly damaging 0.52
R6680:Adgre4 UTSW 17 56,098,959 (GRCm39) missense probably benign 0.09
R7086:Adgre4 UTSW 17 56,127,649 (GRCm39) missense probably benign 0.00
R7442:Adgre4 UTSW 17 56,159,340 (GRCm39) missense probably benign 0.04
R7467:Adgre4 UTSW 17 56,098,952 (GRCm39) missense probably benign 0.00
R7875:Adgre4 UTSW 17 56,099,016 (GRCm39) missense probably benign 0.00
R8007:Adgre4 UTSW 17 56,121,233 (GRCm39) missense probably damaging 0.99
R8096:Adgre4 UTSW 17 56,127,700 (GRCm39) missense probably damaging 1.00
R8172:Adgre4 UTSW 17 56,104,769 (GRCm39) missense probably benign 0.00
R8512:Adgre4 UTSW 17 56,125,760 (GRCm39) critical splice donor site probably null
R8972:Adgre4 UTSW 17 56,109,189 (GRCm39) missense probably damaging 1.00
R9018:Adgre4 UTSW 17 56,098,993 (GRCm39) missense probably benign 0.00
R9049:Adgre4 UTSW 17 56,092,094 (GRCm39) missense probably benign 0.05
S24628:Adgre4 UTSW 17 56,159,288 (GRCm39) missense probably benign 0.03
X0010:Adgre4 UTSW 17 56,121,308 (GRCm39) missense probably damaging 1.00
Z1177:Adgre4 UTSW 17 56,121,152 (GRCm39) critical splice acceptor site probably null
Posted On 2015-04-16