Incidental Mutation 'IGL02466:Zfp13'
ID294592
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp13
Ensembl Gene ENSMUSG00000062012
Gene Namezinc finger protein 13
SynonymsZfp-13, Krox-8
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.122) question?
Stock #IGL02466
Quality Score
Status
Chromosome17
Chromosomal Location23575844-23599487 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 23576098 bp
ZygosityHeterozygous
Amino Acid Change Alanine to Threonine at position 493 (A493T)
Ref Sequence ENSEMBL: ENSMUSP00000054595 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057029] [ENSMUST00000115516] [ENSMUST00000227952]
Predicted Effect probably benign
Transcript: ENSMUST00000057029
AA Change: A493T

PolyPhen 2 Score 0.053 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000054595
Gene: ENSMUSG00000062012
AA Change: A493T

DomainStartEndE-ValueType
KRAB 117 179 7.54e-10 SMART
ZnF_C2H2 259 281 7.37e-4 SMART
ZnF_C2H2 287 309 1.2e-3 SMART
ZnF_C2H2 315 337 5.9e-3 SMART
ZnF_C2H2 343 365 1.26e-2 SMART
ZnF_C2H2 371 393 9.73e-4 SMART
ZnF_C2H2 399 421 2.12e-4 SMART
ZnF_C2H2 427 449 1.18e-2 SMART
ZnF_C2H2 455 477 6.52e-5 SMART
low complexity region 480 503 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000115516
AA Change: A500T
SMART Domains Protein: ENSMUSP00000111178
Gene: ENSMUSG00000062012
AA Change: A500T

DomainStartEndE-ValueType
KRAB 124 186 7.54e-10 SMART
ZnF_C2H2 266 288 7.37e-4 SMART
ZnF_C2H2 294 316 1.2e-3 SMART
ZnF_C2H2 322 344 5.9e-3 SMART
ZnF_C2H2 350 372 1.26e-2 SMART
ZnF_C2H2 378 400 9.73e-4 SMART
ZnF_C2H2 406 428 2.12e-4 SMART
ZnF_C2H2 434 456 1.18e-2 SMART
ZnF_C2H2 462 484 6.52e-5 SMART
low complexity region 487 510 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000226550
Predicted Effect probably benign
Transcript: ENSMUST00000227952
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228942
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5730559C18Rik T C 1: 136,216,435 probably null Het
Abca13 T C 11: 9,297,527 F2425L probably benign Het
Adgre4 A T 17: 55,814,188 Y418F probably benign Het
Adra1a G T 14: 66,637,873 C99F probably damaging Het
Aox3 C A 1: 58,158,272 H592Q probably benign Het
Cacna1f A G X: 7,629,405 probably null Het
Cacna2d2 T A 9: 107,465,554 I100N probably damaging Het
Ccr9 T A 9: 123,779,846 C198S probably damaging Het
Cdc45 C T 16: 18,798,729 M200I probably benign Het
Col4a3 T A 1: 82,670,192 C475S unknown Het
Csnk2a2 T C 8: 95,477,231 D100G possibly damaging Het
Cstf2t G A 19: 31,083,877 G271E possibly damaging Het
Fbxw22 T C 9: 109,385,092 R219G probably damaging Het
Gif A T 19: 11,752,232 N185I probably damaging Het
Homez A G 14: 54,858,102 F50L probably damaging Het
Hspa4l C T 3: 40,753,225 Q81* probably null Het
Ifi202b T C 1: 173,972,309 D202G possibly damaging Het
Mansc1 T A 6: 134,610,851 D121V probably damaging Het
Olfr1197 T G 2: 88,729,395 D68A probably damaging Het
Olfr538 A G 7: 140,574,771 Y206C probably benign Het
Olfr572 T A 7: 102,928,516 V296E possibly damaging Het
P2rx1 A T 11: 73,009,584 probably null Het
Phactr4 A G 4: 132,377,172 probably benign Het
Pus10 C T 11: 23,725,574 T482I probably damaging Het
Scyl2 G T 10: 89,653,009 Y206* probably null Het
Sell G A 1: 164,069,063 probably null Het
Slfn10-ps C T 11: 83,030,264 noncoding transcript Het
Ssh2 T C 11: 77,416,407 probably benign Het
Tas2r117 A G 6: 132,803,000 M34V probably benign Het
Vmn2r103 A T 17: 19,773,369 T3S probably benign Het
Vmn2r73 A T 7: 85,872,876 I85K probably damaging Het
Vps13b T C 15: 35,770,741 V2110A possibly damaging Het
Zfp518a G A 19: 40,914,617 G997R probably damaging Het
Zfp592 G A 7: 81,023,998 G237R probably damaging Het
Zkscan7 A G 9: 122,888,885 E115G probably damaging Het
Zranb3 G A 1: 128,016,092 T306M probably benign Het
Other mutations in Zfp13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02236:Zfp13 APN 17 23580765 splice site probably benign
IGL02447:Zfp13 APN 17 23576098 missense probably benign 0.05
IGL02449:Zfp13 APN 17 23576098 missense probably benign 0.05
IGL02450:Zfp13 APN 17 23576098 missense probably benign 0.05
IGL02468:Zfp13 APN 17 23576098 missense probably benign 0.05
IGL02471:Zfp13 APN 17 23576098 missense probably benign 0.05
IGL02473:Zfp13 APN 17 23576098 missense probably benign 0.05
IGL02474:Zfp13 APN 17 23576098 missense probably benign 0.05
IGL02475:Zfp13 APN 17 23576098 missense probably benign 0.05
IGL02491:Zfp13 APN 17 23576098 missense probably benign 0.05
IGL02511:Zfp13 APN 17 23576098 missense probably benign 0.05
IGL02558:Zfp13 APN 17 23576098 missense probably benign 0.05
IGL03030:Zfp13 APN 17 23580845 missense probably benign 0.01
IGL03388:Zfp13 APN 17 23576914 missense probably benign 0.00
R0053:Zfp13 UTSW 17 23576148 missense probably damaging 1.00
R0053:Zfp13 UTSW 17 23576148 missense probably damaging 1.00
R1514:Zfp13 UTSW 17 23576412 missense probably damaging 1.00
R2420:Zfp13 UTSW 17 23576212 missense probably damaging 1.00
R3433:Zfp13 UTSW 17 23576628 missense probably damaging 0.99
R4458:Zfp13 UTSW 17 23581176 missense probably benign 0.01
R4650:Zfp13 UTSW 17 23580138 missense probably damaging 1.00
R4824:Zfp13 UTSW 17 23576823 missense possibly damaging 0.95
R5088:Zfp13 UTSW 17 23577061 nonsense probably null
R5110:Zfp13 UTSW 17 23580860 missense probably benign 0.02
R5384:Zfp13 UTSW 17 23581182 missense probably damaging 1.00
R7302:Zfp13 UTSW 17 23581062 missense probably damaging 1.00
Posted On2015-04-16