Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02466:Ifi202b'

294595

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ifi202b

Ensembl Gene

ENSMUSG00000026535

Gene Name

interferon activated gene 202B

Synonyms

p202

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.055) question?

Stock #

IGL02466

Quality Score

Status

Chromosome

Chromosomal Location

173790134-173810310 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 173799875 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 202 (D202G)

Ref Sequence

ENSEMBL: ENSMUSP00000000266 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000000266]

AlphaFold

Q9R002

PDB Structure

Structural mimicry for functional antagonism [X-RAY DIFFRACTION]
Molecular basis for abrogation of activation of pro-inflammatory cytokines [X-RAY DIFFRACTION]
Crystal structure of p202 HIN1 [X-RAY DIFFRACTION]
Crystal structure of p202 HIN1 in complex with 20-mer dsDNA [X-RAY DIFFRACTION]
p202 HIN1 in complex with 12-mer dsDNA [X-RAY DIFFRACTION]
Crystal structure of the tetrameric p202 HIN2 [X-RAY DIFFRACTION]
Crystal structure of Ifi202 HINa domain in complex with 20bp dsDNA [X-RAY DIFFRACTION]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000000266
AA Change: D202G

PolyPhen 2 Score 0.715 (Sensitivity: 0.86; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000000266
Gene: ENSMUSG00000026535
AA Change: D202G

Domain	Start	End	E-Value	Type
Pfam:HIN	58	223	4.1e-68	PFAM
Pfam:HIN	256	421	1.5e-61	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	T	C	11: 9,247,527 (GRCm39)	F2425L	probably benign	Het
Adgre4	A	T	17: 56,121,188 (GRCm39)	Y418F	probably benign	Het
Adra1a	G	T	14: 66,875,322 (GRCm39)	C99F	probably damaging	Het
Aox3	C	A	1: 58,197,431 (GRCm39)	H592Q	probably benign	Het
Cacna1f	A	G	X: 7,495,644 (GRCm39)		probably null	Het
Cacna2d2	T	A	9: 107,342,753 (GRCm39)	I100N	probably damaging	Het
Cblif	A	T	19: 11,729,596 (GRCm39)	N185I	probably damaging	Het
Ccr9	T	A	9: 123,608,911 (GRCm39)	C198S	probably damaging	Het
Cdc45	C	T	16: 18,617,479 (GRCm39)	M200I	probably benign	Het
Col4a3	T	A	1: 82,647,913 (GRCm39)	C475S	unknown	Het
Csnk2a2	T	C	8: 96,203,859 (GRCm39)	D100G	possibly damaging	Het
Cstf2t	G	A	19: 31,061,277 (GRCm39)	G271E	possibly damaging	Het
Fbxw22	T	C	9: 109,214,160 (GRCm39)	R219G	probably damaging	Het
Homez	A	G	14: 55,095,559 (GRCm39)	F50L	probably damaging	Het
Hspa4l	C	T	3: 40,707,657 (GRCm39)	Q81*	probably null	Het
Inava	T	C	1: 136,144,173 (GRCm39)		probably null	Het
Mansc1	T	A	6: 134,587,814 (GRCm39)	D121V	probably damaging	Het
Or13a24	A	G	7: 140,154,684 (GRCm39)	Y206C	probably benign	Het
Or4a27	T	G	2: 88,559,739 (GRCm39)	D68A	probably damaging	Het
Or51h5	T	A	7: 102,577,723 (GRCm39)	V296E	possibly damaging	Het
P2rx1	A	T	11: 72,900,410 (GRCm39)		probably null	Het
Phactr4	A	G	4: 132,104,483 (GRCm39)		probably benign	Het
Pus10	C	T	11: 23,675,574 (GRCm39)	T482I	probably damaging	Het
Scyl2	G	T	10: 89,488,871 (GRCm39)	Y206*	probably null	Het
Sell	G	A	1: 163,896,632 (GRCm39)		probably null	Het
Slfn10-ps	C	T	11: 82,921,090 (GRCm39)		noncoding transcript	Het
Ssh2	T	C	11: 77,307,233 (GRCm39)		probably benign	Het
Tas2r117	A	G	6: 132,779,963 (GRCm39)	M34V	probably benign	Het
Vmn2r103	A	T	17: 19,993,631 (GRCm39)	T3S	probably benign	Het
Vmn2r73	A	T	7: 85,522,084 (GRCm39)	I85K	probably damaging	Het
Vps13b	T	C	15: 35,770,887 (GRCm39)	V2110A	possibly damaging	Het
Zfp13	C	T	17: 23,795,072 (GRCm39)	A493T	probably benign	Het
Zfp518a	G	A	19: 40,903,061 (GRCm39)	G997R	probably damaging	Het
Zfp592	G	A	7: 80,673,746 (GRCm39)	G237R	probably damaging	Het
Zkscan7	A	G	9: 122,717,950 (GRCm39)	E115G	probably damaging	Het
Zranb3	G	A	1: 127,943,829 (GRCm39)	T306M	probably benign	Het

Other mutations in Ifi202b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01551:Ifi202b	APN	1	173,798,928 (GRCm39)	missense	probably benign	0.00
IGL02019:Ifi202b	APN	1	173,802,550 (GRCm39)	missense	possibly damaging	0.95
IGL02508:Ifi202b	APN	1	173,802,338 (GRCm39)	missense	probably benign	0.18
IGL02567:Ifi202b	APN	1	173,791,370 (GRCm39)	missense	possibly damaging	0.84
IGL02644:Ifi202b	APN	1	173,799,280 (GRCm39)	missense	probably benign	0.00
R0282:Ifi202b	UTSW	1	173,804,926 (GRCm39)	missense	probably benign	0.00
R1178:Ifi202b	UTSW	1	173,799,788 (GRCm39)	missense	probably benign	0.02
R3414:Ifi202b	UTSW	1	173,791,479 (GRCm39)	missense	probably benign	0.19
R5739:Ifi202b	UTSW	1	173,798,918 (GRCm39)	critical splice donor site	probably null
R5944:Ifi202b	UTSW	1	173,791,365 (GRCm39)	missense	probably benign	0.00
R6805:Ifi202b	UTSW	1	173,802,555 (GRCm39)	missense	probably damaging	1.00
R7019:Ifi202b	UTSW	1	173,791,524 (GRCm39)	missense	probably benign	0.00
R7291:Ifi202b	UTSW	1	173,802,381 (GRCm39)	missense	probably benign	0.02
R7555:Ifi202b	UTSW	1	173,799,787 (GRCm39)	missense	probably damaging	0.99
R7825:Ifi202b	UTSW	1	173,802,616 (GRCm39)	missense	probably damaging	1.00
R8151:Ifi202b	UTSW	1	173,804,923 (GRCm39)	missense	probably benign	0.00
R8379:Ifi202b	UTSW	1	173,802,298 (GRCm39)	critical splice donor site	probably null
R8887:Ifi202b	UTSW	1	173,802,480 (GRCm39)	missense	probably damaging	1.00
R9177:Ifi202b	UTSW	1	173,804,949 (GRCm39)	start codon destroyed	probably null	0.01
R9642:Ifi202b	UTSW	1	173,799,850 (GRCm39)	nonsense	probably null

Posted On

2015-04-16