Incidental Mutation 'IGL02468:Zfp13'
| ID |
294614 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp13
|
| Ensembl Gene |
ENSMUSG00000062012 |
| Gene Name |
zinc finger protein 13 |
| Synonyms |
Krox-8, Zfp-13 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.124)
|
| Stock # |
IGL02468
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
17 |
| Chromosomal Location |
23794818-23818461 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 23795072 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Alanine to Threonine
at position 493
(A493T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000054595
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000057029]
[ENSMUST00000115516]
[ENSMUST00000227952]
|
| AlphaFold |
P10754 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000057029
AA Change: A493T
PolyPhen 2
Score 0.053 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000054595
Gene: ENSMUSG00000062012
AA Change: A493T
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
117 |
179 |
7.54e-10 |
SMART |
|
ZnF_C2H2
|
259 |
281 |
7.37e-4 |
SMART |
|
ZnF_C2H2
|
287 |
309 |
1.2e-3 |
SMART |
|
ZnF_C2H2
|
315 |
337 |
5.9e-3 |
SMART |
|
ZnF_C2H2
|
343 |
365 |
1.26e-2 |
SMART |
|
ZnF_C2H2
|
371 |
393 |
9.73e-4 |
SMART |
|
ZnF_C2H2
|
399 |
421 |
2.12e-4 |
SMART |
|
ZnF_C2H2
|
427 |
449 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
455 |
477 |
6.52e-5 |
SMART |
|
low complexity region
|
480 |
503 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000115516
AA Change: A500T
|
| SMART Domains |
Protein: ENSMUSP00000111178
Gene: ENSMUSG00000062012
AA Change: A500T
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
124 |
186 |
7.54e-10 |
SMART |
|
ZnF_C2H2
|
266 |
288 |
7.37e-4 |
SMART |
|
ZnF_C2H2
|
294 |
316 |
1.2e-3 |
SMART |
|
ZnF_C2H2
|
322 |
344 |
5.9e-3 |
SMART |
|
ZnF_C2H2
|
350 |
372 |
1.26e-2 |
SMART |
|
ZnF_C2H2
|
378 |
400 |
9.73e-4 |
SMART |
|
ZnF_C2H2
|
406 |
428 |
2.12e-4 |
SMART |
|
ZnF_C2H2
|
434 |
456 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
462 |
484 |
6.52e-5 |
SMART |
|
low complexity region
|
487 |
510 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000226550
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000227952
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000228942
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 36 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adgrl2 |
A |
T |
3: 148,596,116 (GRCm39) |
D73E |
probably damaging |
Het |
| Aspm |
A |
G |
1: 139,408,688 (GRCm39) |
Y2525C |
probably damaging |
Het |
| Cdc45 |
C |
T |
16: 18,617,479 (GRCm39) |
M200I |
probably benign |
Het |
| Cep89 |
T |
G |
7: 35,102,577 (GRCm39) |
S97A |
probably benign |
Het |
| Clec16a |
T |
A |
16: 10,559,742 (GRCm39) |
I1005N |
probably benign |
Het |
| Cog5 |
T |
C |
12: 31,887,357 (GRCm39) |
|
probably null |
Het |
| Crybg2 |
T |
C |
4: 133,809,898 (GRCm39) |
S1217P |
probably damaging |
Het |
| Csgalnact1 |
C |
A |
8: 68,854,144 (GRCm39) |
G219V |
probably damaging |
Het |
| Cytip |
A |
T |
2: 58,024,025 (GRCm39) |
M265K |
probably benign |
Het |
| Ddx60 |
T |
G |
8: 62,411,676 (GRCm39) |
S509R |
probably damaging |
Het |
| Fat4 |
T |
C |
3: 39,037,195 (GRCm39) |
S3616P |
probably benign |
Het |
| Galnt9 |
T |
C |
5: 110,762,089 (GRCm39) |
F409S |
possibly damaging |
Het |
| Hrh2 |
T |
C |
13: 54,368,828 (GRCm39) |
V268A |
probably benign |
Het |
| Ifi47 |
T |
A |
11: 48,986,810 (GRCm39) |
S192R |
probably damaging |
Het |
| Igdcc4 |
T |
C |
9: 65,034,114 (GRCm39) |
Y596H |
probably damaging |
Het |
| Lamb2 |
T |
C |
9: 108,364,348 (GRCm39) |
C1096R |
probably damaging |
Het |
| Marchf1 |
A |
G |
8: 66,871,563 (GRCm39) |
Q109R |
probably damaging |
Het |
| Or2y1d |
A |
T |
11: 49,321,941 (GRCm39) |
I213F |
probably damaging |
Het |
| Or7d9 |
T |
C |
9: 20,197,574 (GRCm39) |
L201P |
probably damaging |
Het |
| Or7g32 |
G |
T |
9: 19,408,473 (GRCm39) |
C143F |
probably benign |
Het |
| Patl1 |
T |
A |
19: 11,909,574 (GRCm39) |
V500D |
probably damaging |
Het |
| Pbx3 |
A |
T |
2: 34,114,589 (GRCm39) |
L57H |
probably damaging |
Het |
| Pcdhb1 |
T |
C |
18: 37,399,231 (GRCm39) |
V394A |
probably benign |
Het |
| Pogz |
A |
G |
3: 94,786,394 (GRCm39) |
N994S |
probably damaging |
Het |
| Prom1 |
T |
A |
5: 44,187,040 (GRCm39) |
M406L |
probably benign |
Het |
| Psg26 |
T |
C |
7: 18,212,387 (GRCm39) |
S323G |
probably damaging |
Het |
| Ptprm |
T |
C |
17: 67,121,504 (GRCm39) |
T854A |
probably benign |
Het |
| Puf60 |
A |
C |
15: 75,947,685 (GRCm39) |
|
probably benign |
Het |
| Six2 |
C |
T |
17: 85,992,931 (GRCm39) |
E191K |
possibly damaging |
Het |
| Tbc1d17 |
A |
G |
7: 44,497,753 (GRCm39) |
F40L |
probably benign |
Het |
| Tektip1 |
G |
T |
10: 81,201,563 (GRCm39) |
L20I |
possibly damaging |
Het |
| Thsd7a |
A |
G |
6: 12,318,170 (GRCm39) |
V1600A |
probably damaging |
Het |
| Tm4sf19 |
C |
A |
16: 32,226,533 (GRCm39) |
|
probably benign |
Het |
| Tnfrsf1a |
A |
G |
6: 125,334,824 (GRCm39) |
T33A |
probably benign |
Het |
| Troap |
A |
T |
15: 98,973,242 (GRCm39) |
T3S |
possibly damaging |
Het |
| Wdfy4 |
T |
A |
14: 32,688,389 (GRCm39) |
I3074L |
probably benign |
Het |
|
| Other mutations in Zfp13 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02236:Zfp13
|
APN |
17 |
23,799,739 (GRCm39) |
splice site |
probably benign |
|
|
IGL02447:Zfp13
|
APN |
17 |
23,795,072 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02449:Zfp13
|
APN |
17 |
23,795,072 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02450:Zfp13
|
APN |
17 |
23,795,072 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02466:Zfp13
|
APN |
17 |
23,795,072 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02471:Zfp13
|
APN |
17 |
23,795,072 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02473:Zfp13
|
APN |
17 |
23,795,072 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02474:Zfp13
|
APN |
17 |
23,795,072 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02475:Zfp13
|
APN |
17 |
23,795,072 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02491:Zfp13
|
APN |
17 |
23,795,072 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02511:Zfp13
|
APN |
17 |
23,795,072 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02558:Zfp13
|
APN |
17 |
23,795,072 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL03030:Zfp13
|
APN |
17 |
23,799,819 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03388:Zfp13
|
APN |
17 |
23,795,888 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0053:Zfp13
|
UTSW |
17 |
23,795,122 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0053:Zfp13
|
UTSW |
17 |
23,795,122 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1514:Zfp13
|
UTSW |
17 |
23,795,386 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2420:Zfp13
|
UTSW |
17 |
23,795,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3433:Zfp13
|
UTSW |
17 |
23,795,602 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4458:Zfp13
|
UTSW |
17 |
23,800,150 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4650:Zfp13
|
UTSW |
17 |
23,799,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4824:Zfp13
|
UTSW |
17 |
23,795,797 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5088:Zfp13
|
UTSW |
17 |
23,796,035 (GRCm39) |
nonsense |
probably null |
|
|
R5110:Zfp13
|
UTSW |
17 |
23,799,834 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5384:Zfp13
|
UTSW |
17 |
23,800,156 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7302:Zfp13
|
UTSW |
17 |
23,800,036 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8443:Zfp13
|
UTSW |
17 |
23,795,866 (GRCm39) |
missense |
probably benign |
|
|
R9728:Zfp13
|
UTSW |
17 |
23,799,788 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
| Posted On |
2015-04-16 |
Incidental Mutation