Incidental Mutation 'IGL02470:Mobp'
ID294697
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mobp
Ensembl Gene ENSMUSG00000032517
Gene Namemyelin-associated oligodendrocytic basic protein
SynonymsMOBP155
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.108) question?
Stock #IGL02470
Quality Score
Status
Chromosome9
Chromosomal Location120149707-120181484 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 120168006 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 68 (T68A)
Ref Sequence ENSEMBL: ENSMUSP00000149831 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068698] [ENSMUST00000093773] [ENSMUST00000111627] [ENSMUST00000174193] [ENSMUST00000214943] [ENSMUST00000215512]
Predicted Effect probably benign
Transcript: ENSMUST00000068698
AA Change: T68A

PolyPhen 2 Score 0.184 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000071084
Gene: ENSMUSG00000032517
AA Change: T68A

DomainStartEndE-ValueType
Pfam:FYVE_2 1 75 6.4e-13 PFAM
low complexity region 82 99 N/A INTRINSIC
low complexity region 102 151 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000093773
AA Change: T68A

PolyPhen 2 Score 0.184 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000091287
Gene: ENSMUSG00000032517
AA Change: T68A

DomainStartEndE-ValueType
Pfam:FYVE_2 1 77 3.8e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000111627
AA Change: T68A

PolyPhen 2 Score 0.184 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000107254
Gene: ENSMUSG00000032517
AA Change: T68A

DomainStartEndE-ValueType
Pfam:FYVE_2 1 77 3.8e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000174193
AA Change: T68A

PolyPhen 2 Score 0.184 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000134410
Gene: ENSMUSG00000032517
AA Change: T68A

DomainStartEndE-ValueType
Pfam:FYVE_2 1 77 3.8e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214943
AA Change: T68A

PolyPhen 2 Score 0.184 (Sensitivity: 0.92; Specificity: 0.87)
Predicted Effect probably benign
Transcript: ENSMUST00000215512
AA Change: T68A

PolyPhen 2 Score 0.184 (Sensitivity: 0.92; Specificity: 0.87)
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for one null allele show abnormal myelin arrangements but do not exhibit an overt behavorial phenotype. Mice homozygous for another allele have normal myelin. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610010F05Rik A T 11: 23,615,222 M255K probably damaging Het
Adcy10 A G 1: 165,567,726 Y1422C probably damaging Het
Adnp T A 2: 168,183,194 K727I probably damaging Het
Akr1c21 A T 13: 4,577,407 N167Y probably damaging Het
Arl4a T C 12: 40,036,748 probably benign Het
BB014433 A T 8: 15,042,803 F17I unknown Het
Best1 T C 19: 9,992,976 S91G probably benign Het
Ccdc148 A T 2: 59,001,899 S235T probably damaging Het
Cdc45 C T 16: 18,798,729 M200I probably benign Het
Csgalnact1 C A 8: 68,401,492 G219V probably damaging Het
Dcc A T 18: 71,955,082 probably benign Het
Dnajc13 G A 9: 104,175,747 T1672I probably benign Het
Elf3 A T 1: 135,255,012 F325Y probably damaging Het
Enpp2 A G 15: 54,839,460 L880P probably damaging Het
Fndc3b A G 3: 27,461,720 Y646H probably damaging Het
Fzd6 A T 15: 39,036,557 probably benign Het
Gnb1 T A 4: 155,527,513 probably benign Het
Mast1 C A 8: 84,921,212 G511V probably damaging Het
Mcmbp T C 7: 128,704,621 I424M possibly damaging Het
Myh11 T C 16: 14,218,046 E1006G probably damaging Het
Ncstn A G 1: 172,082,599 probably null Het
Olfr1089 A T 2: 86,733,585 V9E probably damaging Het
Olfr340 A G 2: 36,452,597 D4G probably benign Het
Phip A T 9: 82,890,454 V1075D possibly damaging Het
Serpinb1a C T 13: 32,850,393 S5N probably damaging Het
Slc15a3 A G 19: 10,853,170 N295S probably benign Het
Trmt13 A C 3: 116,590,228 probably null Het
Trp63 A C 16: 25,820,384 probably benign Het
Zfp518a G A 19: 40,914,617 G997R probably damaging Het
Other mutations in Mobp
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01155:Mobp APN 9 120168234 missense probably benign 0.08
IGL01730:Mobp APN 9 120167926 missense probably damaging 1.00
IGL02078:Mobp APN 9 120167914 missense probably damaging 1.00
P0041:Mobp UTSW 9 120168017 utr 3 prime probably benign
R3794:Mobp UTSW 9 120167967 nonsense probably null
R3890:Mobp UTSW 9 120167956 missense probably damaging 1.00
R5173:Mobp UTSW 9 120168245 missense possibly damaging 0.68
R5255:Mobp UTSW 9 120168353 unclassified probably benign
R5549:Mobp UTSW 9 120167810 missense probably damaging 1.00
R5870:Mobp UTSW 9 120167853 missense probably damaging 0.98
R6128:Mobp UTSW 9 120168326 unclassified probably benign
R7267:Mobp UTSW 9 120167848 missense probably damaging 1.00
Posted On2015-04-16