Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02471:Olfr745'

294713

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Olfr745

Ensembl Gene

ENSMUSG00000050028

Gene Name

olfactory receptor 745

Synonyms

GA_x6K02T2PMLR-6361495-6362481, MOR106-11

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.113) question?

Stock #

IGL02471

Quality Score

Status

Chromosome

Chromosomal Location

50639388-50643885 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 50642757 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 159 (I159F)

Ref Sequence

ENSEMBL: ENSMUSP00000050184 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000062534] [ENSMUST00000213127] [ENSMUST00000218546]

AlphaFold

Q7TRL9

Predicted Effect

probably benign
Transcript: ENSMUST00000062534
AA Change: I159F

PolyPhen 2 Score 0.431 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000050184
Gene: ENSMUSG00000050028
AA Change: I159F

Domain	Start	End	E-Value	Type
transmembrane domain	5	27	N/A	INTRINSIC
Pfam:7tm_4	44	324	6.3e-54	PFAM
Pfam:7TM_GPCR_Srsx	51	191	6.6e-6	PFAM
Pfam:7tm_1	57	306	1e-21	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000206749

Predicted Effect

probably benign
Transcript: ENSMUST00000213127
AA Change: I153F

PolyPhen 2 Score 0.377 (Sensitivity: 0.90; Specificity: 0.89)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000216105

Predicted Effect

probably benign
Transcript: ENSMUST00000218546

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca12	G	T	1: 71,258,198	H2378N	probably benign	Het
Btaf1	C	A	19: 37,000,192	A1470E	probably damaging	Het
Ccdc110	A	G	8: 45,941,756	D228G	probably benign	Het
Cdc45	C	T	16: 18,798,729	M200I	probably benign	Het
Cldn18	T	C	9: 99,696,075	D205G	probably benign	Het
Clip2	T	C	5: 134,518,022	T231A	probably benign	Het
Cltc	A	G	11: 86,718,034	V723A	probably damaging	Het
Cpa3	C	T	3: 20,228,807		probably null	Het
Cyfip2	T	G	11: 46,200,803	T1097P	possibly damaging	Het
Dnah9	T	A	11: 65,947,618	R667*	probably null	Het
Dock10	T	C	1: 80,515,622	E1878G	probably damaging	Het
Ermap	G	A	4: 119,179,963	H353Y	probably damaging	Het
Etfa	A	T	9: 55,486,700		probably null	Het
F5	C	T	1: 164,174,291	P188S	probably damaging	Het
Foxq1	G	A	13: 31,559,343	E143K	possibly damaging	Het
Gsr	C	T	8: 33,682,584		probably benign	Het
Hebp1	T	A	6: 135,155,276	Y31F	probably benign	Het
Ighv1-14	T	C	12: 114,646,837		noncoding transcript	Het
Lamb1	T	A	12: 31,320,908	D1319E	probably damaging	Het
Lrp5	A	T	19: 3,602,408	V1154E	probably benign	Het
Manba	G	A	3: 135,507,008		probably benign	Het
Mknk2	A	T	10: 80,668,121	F319I	probably damaging	Het
Mup6	A	T	4: 60,003,971		probably benign	Het
Nalcn	T	C	14: 123,323,314	T784A	probably benign	Het
Nt5dc1	T	C	10: 34,403,725	E107G	probably benign	Het
Olfr1497	G	A	19: 13,795,225	P129S	probably damaging	Het
Olfr688	T	A	7: 105,289,045	F317L	probably benign	Het
Phldb1	T	C	9: 44,711,233	E41G	probably damaging	Het
Ptk2	T	C	15: 73,298,187	D309G	probably benign	Het
Rab11fip5	A	G	6: 85,348,225	S367P	probably damaging	Het
Rb1cc1	T	A	1: 6,240,051	N224K	probably benign	Het
Rchy1	A	T	5: 91,957,546	C65*	probably null	Het
Rgs18	T	C	1: 144,774,621	D56G	probably benign	Het
Rtraf	A	C	14: 19,812,228	L197R	probably damaging	Het
Slc44a5	G	T	3: 154,256,576	W382L	probably damaging	Het
Snx24	C	T	18: 53,385,169		probably benign	Het
Sphkap	T	C	1: 83,276,176	D1284G	probably damaging	Het
Tmem54	A	G	4: 129,108,318	M53V	probably benign	Het
Trip6	G	A	5: 137,310,356	P414S	probably benign	Het
Vmn1r38	A	G	6: 66,776,767	Y122H	probably benign	Het
Wapl	T	A	14: 34,691,920	N246K	possibly damaging	Het
Zfp12	G	A	5: 143,244,796	G293R	probably damaging	Het
Zfp13	C	T	17: 23,576,098	A493T	probably benign	Het
Zfp446	T	G	7: 12,982,254	V209G	probably benign	Het
Zfp518a	G	A	19: 40,914,617	G997R	probably damaging	Het

Other mutations in Olfr745

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00330:Olfr745	APN	14	50643168	missense	probably benign	0.02
IGL02316:Olfr745	APN	14	50642287	missense	probably benign	0.25
IGL02377:Olfr745	APN	14	50642518	splice site	probably null
IGL02486:Olfr745	APN	14	50642632	missense	probably damaging	1.00
IGL02517:Olfr745	APN	14	50643201	missense	probably benign	0.01
R0453:Olfr745	UTSW	14	50643004	missense	possibly damaging	0.90
R0727:Olfr745	UTSW	14	50643003	missense	probably damaging	0.98
R0746:Olfr745	UTSW	14	50642775	splice site	probably null
R1638:Olfr745	UTSW	14	50643108	missense	possibly damaging	0.93
R1688:Olfr745	UTSW	14	50643248	missense	probably benign	0.04
R1991:Olfr745	UTSW	14	50642866	missense	possibly damaging	0.90
R2245:Olfr745	UTSW	14	50642605	missense	probably damaging	1.00
R3758:Olfr745	UTSW	14	50643036	missense	possibly damaging	0.96
R4084:Olfr745	UTSW	14	50642848	missense	probably damaging	0.98
R5033:Olfr745	UTSW	14	50643162	missense	probably damaging	1.00
R5211:Olfr745	UTSW	14	50643253	missense	possibly damaging	0.78
R5302:Olfr745	UTSW	14	50642319	splice site	probably null
R5645:Olfr745	UTSW	14	50643067	missense	probably benign	0.00
R5731:Olfr745	UTSW	14	50642791	missense	probably damaging	1.00
R6917:Olfr745	UTSW	14	50643223	missense	possibly damaging	0.67
R7408:Olfr745	UTSW	14	50642395	missense	probably benign	0.16
R7716:Olfr745	UTSW	14	50642358	missense	probably benign	0.17
R7728:Olfr745	UTSW	14	50642392	missense	probably benign	0.00
R8208:Olfr745	UTSW	14	50642631	missense	probably benign	0.28
R8447:Olfr745	UTSW	14	50642551	missense	probably benign	0.00
R8726:Olfr745	UTSW	14	50643246	missense	probably benign	0.00
R8748:Olfr745	UTSW	14	50642754	missense	probably benign	0.19
R9279:Olfr745	UTSW	14	50643036	missense	possibly damaging	0.96

Posted On

2015-04-16