Incidental Mutation 'IGL02471:Olfr1497'
ID294739
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1497
Ensembl Gene ENSMUSG00000044040
Gene Nameolfactory receptor 1497
SynonymsGA_x6K02T2RE5P-4127765-4126821, MOR212-1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.141) question?
Stock #IGL02471
Quality Score
Status
Chromosome19
Chromosomal Location13794324-13798202 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 13795225 bp
ZygosityHeterozygous
Amino Acid Change Proline to Serine at position 129 (P129S)
Ref Sequence ENSEMBL: ENSMUSP00000149151 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061993] [ENSMUST00000217384]
Predicted Effect probably damaging
Transcript: ENSMUST00000061993
AA Change: P129S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000053465
Gene: ENSMUSG00000044040
AA Change: P129S

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.3e-46 PFAM
Pfam:7TM_GPCR_Srsx 35 302 7e-7 PFAM
Pfam:7tm_1 41 290 5.5e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000217384
AA Change: P129S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 G T 1: 71,258,198 H2378N probably benign Het
Btaf1 C A 19: 37,000,192 A1470E probably damaging Het
Ccdc110 A G 8: 45,941,756 D228G probably benign Het
Cdc45 C T 16: 18,798,729 M200I probably benign Het
Cldn18 T C 9: 99,696,075 D205G probably benign Het
Clip2 T C 5: 134,518,022 T231A probably benign Het
Cltc A G 11: 86,718,034 V723A probably damaging Het
Cpa3 C T 3: 20,228,807 probably null Het
Cyfip2 T G 11: 46,200,803 T1097P possibly damaging Het
Dnah9 T A 11: 65,947,618 R667* probably null Het
Dock10 T C 1: 80,515,622 E1878G probably damaging Het
Ermap G A 4: 119,179,963 H353Y probably damaging Het
Etfa A T 9: 55,486,700 probably null Het
F5 C T 1: 164,174,291 P188S probably damaging Het
Foxq1 G A 13: 31,559,343 E143K possibly damaging Het
Gsr C T 8: 33,682,584 probably benign Het
Hebp1 T A 6: 135,155,276 Y31F probably benign Het
Ighv1-14 T C 12: 114,646,837 noncoding transcript Het
Lamb1 T A 12: 31,320,908 D1319E probably damaging Het
Lrp5 A T 19: 3,602,408 V1154E probably benign Het
Manba G A 3: 135,507,008 probably benign Het
Mknk2 A T 10: 80,668,121 F319I probably damaging Het
Mup6 A T 4: 60,003,971 probably benign Het
Nalcn T C 14: 123,323,314 T784A probably benign Het
Nt5dc1 T C 10: 34,403,725 E107G probably benign Het
Olfr688 T A 7: 105,289,045 F317L probably benign Het
Olfr745 A T 14: 50,642,757 I159F probably benign Het
Phldb1 T C 9: 44,711,233 E41G probably damaging Het
Ptk2 T C 15: 73,298,187 D309G probably benign Het
Rab11fip5 A G 6: 85,348,225 S367P probably damaging Het
Rb1cc1 T A 1: 6,240,051 N224K probably benign Het
Rchy1 A T 5: 91,957,546 C65* probably null Het
Rgs18 T C 1: 144,774,621 D56G probably benign Het
Rtraf A C 14: 19,812,228 L197R probably damaging Het
Slc44a5 G T 3: 154,256,576 W382L probably damaging Het
Snx24 C T 18: 53,385,169 probably benign Het
Sphkap T C 1: 83,276,176 D1284G probably damaging Het
Tmem54 A G 4: 129,108,318 M53V probably benign Het
Trip6 G A 5: 137,310,356 P414S probably benign Het
Vmn1r38 A G 6: 66,776,767 Y122H probably benign Het
Wapl T A 14: 34,691,920 N246K possibly damaging Het
Zfp12 G A 5: 143,244,796 G293R probably damaging Het
Zfp13 C T 17: 23,576,098 A493T probably benign Het
Zfp446 T G 7: 12,982,254 V209G probably benign Het
Zfp518a G A 19: 40,914,617 G997R probably damaging Het
Other mutations in Olfr1497
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02377:Olfr1497 APN 19 13795329 missense possibly damaging 0.69
R0167:Olfr1497 UTSW 19 13795567 missense probably benign 0.03
R0602:Olfr1497 UTSW 19 13794662 splice site probably null
R1448:Olfr1497 UTSW 19 13794776 nonsense probably null
R2211:Olfr1497 UTSW 19 13795369 missense probably benign
R2295:Olfr1497 UTSW 19 13794744 missense probably damaging 1.00
R2340:Olfr1497 UTSW 19 13794771 missense probably benign 0.00
R3773:Olfr1497 UTSW 19 13795204 missense probably benign 0.00
R4596:Olfr1497 UTSW 19 13794900 missense probably damaging 1.00
R4676:Olfr1497 UTSW 19 13795474 missense possibly damaging 0.91
R4767:Olfr1497 UTSW 19 13795045 missense probably damaging 1.00
R4921:Olfr1497 UTSW 19 13795465 missense probably benign 0.03
R4930:Olfr1497 UTSW 19 13795551 missense probably benign 0.00
R5784:Olfr1497 UTSW 19 13795346 missense probably benign 0.00
R7402:Olfr1497 UTSW 19 13794994 missense probably damaging 1.00
R7473:Olfr1497 UTSW 19 13795162 missense probably benign 0.11
R8140:Olfr1497 UTSW 19 13795239 missense possibly damaging 0.91
Posted On2015-04-16