Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02474:Vmn2r109'

294862

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r109

Ensembl Gene

ENSMUSG00000090572

Gene Name

vomeronasal 2, receptor 109

Synonyms

EG627814

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.057) question?

Stock #

IGL02474

Quality Score

Status

Chromosome

Chromosomal Location

20540517-20564756 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 20540888 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Isoleucine at position 736 (F736I)

Ref Sequence

ENSEMBL: ENSMUSP00000132641 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000167093]

AlphaFold

K7N747

Predicted Effect

probably benign
Transcript: ENSMUST00000167093
AA Change: F736I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000132641
Gene: ENSMUSG00000090572
AA Change: F736I

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	83	467	1.4e-35	PFAM
Pfam:NCD3G	510	563	3.1e-21	PFAM
Pfam:7tm_3	596	831	7.4e-52	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Afdn	A	G	17: 13,818,229	E283G	probably damaging	Het
Ahnak	A	G	19: 9,004,933	I1194V	probably benign	Het
Aqr	T	A	2: 114,112,646	N1149Y	probably damaging	Het
Bms1	T	C	6: 118,416,519	I131V	probably benign	Het
Cacna1s	A	C	1: 136,118,380	T1461P	probably benign	Het
Chrnb3	T	C	8: 27,393,369	S113P	probably damaging	Het
Col1a2	C	T	6: 4,516,398	R171C	unknown	Het
Cramp1l	A	G	17: 24,985,050	V318A	probably damaging	Het
Csf2ra	A	G	19: 61,226,537	V163A	possibly damaging	Het
Csgalnact1	C	A	8: 68,401,492	G219V	probably damaging	Het
Ctnnd2	A	G	15: 30,669,562	D439G	possibly damaging	Het
Dnah11	T	A	12: 118,027,445		probably null	Het
Dyrk4	C	A	6: 126,880,231	C495F	probably damaging	Het
Gabra6	A	G	11: 42,307,417	V402A	probably benign	Het
Gba2	T	C	4: 43,568,538	M643V	possibly damaging	Het
Gbp9	A	T	5: 105,094,567		probably benign	Het
Ginm1	A	G	10: 7,777,768		probably benign	Het
Git1	T	A	11: 77,503,391	D282E	probably damaging	Het
Gm5799	T	C	14: 43,544,629	I86T	probably damaging	Het
Gm9894	T	C	13: 67,765,094		noncoding transcript	Het
Gng12	A	G	6: 67,015,761	K4R	probably benign	Het
Hnrnpul1	A	T	7: 25,726,757	D556E	probably benign	Het
Kat6b	T	A	14: 21,669,039	L1153Q	possibly damaging	Het
Ly75	A	T	2: 60,383,182	L17Q	probably null	Het
Mc5r	T	C	18: 68,338,839	F90L	probably damaging	Het
Olfr1356	A	T	10: 78,847,063	M284K	probably damaging	Het
Olfr175-ps1	A	T	16: 58,824,656	S18T	probably benign	Het
Olfr524	T	C	7: 140,202,587	Y61C	probably damaging	Het
Olfr54	C	A	11: 51,027,365	A121D	probably damaging	Het
Olfr877	A	T	9: 37,855,360	I181L	probably benign	Het
Pi4ka	A	T	16: 17,325,429	Y6N	probably damaging	Het
Polr2g	C	A	19: 8,798,456		probably null	Het
Psme3	A	G	11: 101,317,654	Q82R	probably benign	Het
Rab11a	G	T	9: 64,726,647	T17K	possibly damaging	Het
Rbm12	A	T	2: 156,098,097	L85Q	probably damaging	Het
Skap1	A	T	11: 96,708,686	Y188F	probably damaging	Het
Tmprss6	A	T	15: 78,442,336	F34I	probably damaging	Het
Trip12	A	C	1: 84,794,133	I98S	probably benign	Het
Ttn	T	C	2: 76,878,188		probably benign	Het
Ube2t	A	T	1: 134,971,341	K21*	probably null	Het
Vmn1r216	T	C	13: 23,099,477	V110A	possibly damaging	Het
Vps13c	A	G	9: 67,937,876	T2081A	probably benign	Het
Zfp13	C	T	17: 23,576,098	A493T	probably benign	Het

Other mutations in Vmn2r109

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01313:Vmn2r109	APN	17	20550157	missense	probably damaging	1.00
IGL01383:Vmn2r109	APN	17	20541121	missense	possibly damaging	0.89
IGL01469:Vmn2r109	APN	17	20541409	missense	probably damaging	1.00
IGL01762:Vmn2r109	APN	17	20554392	missense	probably benign
IGL01864:Vmn2r109	APN	17	20541134	missense	probably benign	0.28
IGL02028:Vmn2r109	APN	17	20541080	missense	probably benign	0.28
IGL02074:Vmn2r109	APN	17	20554341	missense	probably benign	0.05
IGL02162:Vmn2r109	APN	17	20554160	missense	probably benign	0.01
IGL02490:Vmn2r109	APN	17	20540984	missense	possibly damaging	0.78
IGL02604:Vmn2r109	APN	17	20540701	missense	probably damaging	1.00
IGL02669:Vmn2r109	APN	17	20554256	missense	possibly damaging	0.64
IGL02705:Vmn2r109	APN	17	20553800	missense	probably benign
IGL02745:Vmn2r109	APN	17	20541250	missense	probably damaging	0.99
PIT4142001:Vmn2r109	UTSW	17	20554577	critical splice acceptor site	probably null
R0389:Vmn2r109	UTSW	17	20541074	missense	probably damaging	1.00
R0470:Vmn2r109	UTSW	17	20552886	missense	probably benign	0.06
R0570:Vmn2r109	UTSW	17	20540675	missense	probably damaging	0.99
R0855:Vmn2r109	UTSW	17	20541408	nonsense	probably null
R0882:Vmn2r109	UTSW	17	20554580	splice site	probably benign
R1241:Vmn2r109	UTSW	17	20555241	missense	possibly damaging	0.86
R1587:Vmn2r109	UTSW	17	20540740	missense	probably damaging	1.00
R1931:Vmn2r109	UTSW	17	20553810	nonsense	probably null
R1957:Vmn2r109	UTSW	17	20564707	missense	probably benign	0.11
R1962:Vmn2r109	UTSW	17	20553923	missense	probably damaging	0.99
R2020:Vmn2r109	UTSW	17	20541186	nonsense	probably null
R2073:Vmn2r109	UTSW	17	20564712	missense	probably benign	0.00
R2436:Vmn2r109	UTSW	17	20554536	missense	probably damaging	0.99
R3123:Vmn2r109	UTSW	17	20540986	missense	probably damaging	1.00
R3839:Vmn2r109	UTSW	17	20554442	missense	probably damaging	1.00
R4019:Vmn2r109	UTSW	17	20553812	missense	probably benign
R4428:Vmn2r109	UTSW	17	20553024	missense	probably benign
R4584:Vmn2r109	UTSW	17	20554558	nonsense	probably null
R4652:Vmn2r109	UTSW	17	20541394	missense	probably damaging	1.00
R4708:Vmn2r109	UTSW	17	20541343	missense	probably damaging	0.97
R4823:Vmn2r109	UTSW	17	20553891	missense	probably damaging	1.00
R4831:Vmn2r109	UTSW	17	20541232	missense	probably benign	0.01
R4907:Vmn2r109	UTSW	17	20550086	missense	probably damaging	1.00
R5011:Vmn2r109	UTSW	17	20555189	missense	probably damaging	1.00
R5296:Vmn2r109	UTSW	17	20554341	missense	possibly damaging	0.90
R5600:Vmn2r109	UTSW	17	20540927	missense	probably damaging	1.00
R5602:Vmn2r109	UTSW	17	20540671	missense	possibly damaging	0.94
R5652:Vmn2r109	UTSW	17	20540519	makesense	probably null
R5702:Vmn2r109	UTSW	17	20554145	missense	probably benign	0.42
R5706:Vmn2r109	UTSW	17	20554305	missense	probably benign	0.16
R5714:Vmn2r109	UTSW	17	20552859	missense	probably damaging	1.00
R5832:Vmn2r109	UTSW	17	20541056	missense	probably benign	0.10
R6008:Vmn2r109	UTSW	17	20540719	missense	probably damaging	1.00
R6334:Vmn2r109	UTSW	17	20541178	missense	probably benign	0.18
R6377:Vmn2r109	UTSW	17	20564534	critical splice donor site	probably null
R6738:Vmn2r109	UTSW	17	20554523	missense	possibly damaging	0.52
R6857:Vmn2r109	UTSW	17	20540670	missense	probably benign	0.45
R6953:Vmn2r109	UTSW	17	20540711	missense	possibly damaging	0.95
R7108:Vmn2r109	UTSW	17	20564744	missense	probably benign	0.03
R7229:Vmn2r109	UTSW	17	20540963	missense	possibly damaging	0.80
R7238:Vmn2r109	UTSW	17	20541074	missense	probably damaging	1.00
R7244:Vmn2r109	UTSW	17	20540683	missense	possibly damaging	0.70
R7292:Vmn2r109	UTSW	17	20541438	missense	probably benign	0.05
R7354:Vmn2r109	UTSW	17	20540781	missense	probably damaging	1.00
R7357:Vmn2r109	UTSW	17	20541274	missense	probably damaging	1.00
R7522:Vmn2r109	UTSW	17	20554403	missense	probably benign	0.11
R7596:Vmn2r109	UTSW	17	20540680	missense	probably damaging	0.98
R7728:Vmn2r109	UTSW	17	20552855	missense	probably damaging	0.99
R7859:Vmn2r109	UTSW	17	20541174	missense	probably damaging	1.00
R7871:Vmn2r109	UTSW	17	20540520	missense	probably benign	0.08
R8113:Vmn2r109	UTSW	17	20554467	missense	probably benign	0.01
R8153:Vmn2r109	UTSW	17	20564707	missense	probably benign	0.11
R8977:Vmn2r109	UTSW	17	20554269	missense	possibly damaging	0.96
Z1176:Vmn2r109	UTSW	17	20552994	missense	probably benign	0.00

Posted On

2015-04-16