Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02474:Vmn2r109'

294862

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r109

Ensembl Gene

ENSMUSG00000090572

Gene Name

vomeronasal 2, receptor 109

Synonyms

EG627814

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.074) question?

Stock #

IGL02474

Quality Score

Status

Chromosome

Chromosomal Location

20540517-20564756 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 20540888 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Isoleucine at position 736 (F736I)

Ref Sequence

ENSEMBL: ENSMUSP00000132641 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000167093]

AlphaFold

K7N747

Predicted Effect

probably benign
Transcript: ENSMUST00000167093
AA Change: F736I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000132641
Gene: ENSMUSG00000090572
AA Change: F736I

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	83	467	1.4e-35	PFAM
Pfam:NCD3G	510	563	3.1e-21	PFAM
Pfam:7tm_3	596	831	7.4e-52	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Afdn	A	G	17: 13,818,229 (GRCm38)	E283G	probably damaging	Het
Ahnak	A	G	19: 9,004,933 (GRCm38)	I1194V	probably benign	Het
Aqr	T	A	2: 114,112,646 (GRCm38)	N1149Y	probably damaging	Het
Bms1	T	C	6: 118,416,519 (GRCm38)	I131V	probably benign	Het
Cacna1s	A	C	1: 136,118,380 (GRCm38)	T1461P	probably benign	Het
Chrnb3	T	C	8: 27,393,369 (GRCm38)	S113P	probably damaging	Het
Col1a2	C	T	6: 4,516,398 (GRCm38)	R171C	unknown	Het
Cramp1l	A	G	17: 24,985,050 (GRCm38)	V318A	probably damaging	Het
Csf2ra	A	G	19: 61,226,537 (GRCm38)	V163A	possibly damaging	Het
Csgalnact1	C	A	8: 68,401,492 (GRCm38)	G219V	probably damaging	Het
Ctnnd2	A	G	15: 30,669,562 (GRCm38)	D439G	possibly damaging	Het
Dnah11	T	A	12: 118,027,445 (GRCm38)		probably null	Het
Dyrk4	C	A	6: 126,880,231 (GRCm38)	C495F	probably damaging	Het
Gabra6	A	G	11: 42,307,417 (GRCm38)	V402A	probably benign	Het
Gba2	T	C	4: 43,568,538 (GRCm38)	M643V	possibly damaging	Het
Gbp9	A	T	5: 105,094,567 (GRCm38)		probably benign	Het
Ginm1	A	G	10: 7,777,768 (GRCm38)		probably benign	Het
Git1	T	A	11: 77,503,391 (GRCm38)	D282E	probably damaging	Het
Gm5799	T	C	14: 43,544,629 (GRCm38)	I86T	probably damaging	Het
Gm9894	T	C	13: 67,765,094 (GRCm38)		noncoding transcript	Het
Gng12	A	G	6: 67,015,761 (GRCm38)	K4R	probably benign	Het
Hnrnpul1	A	T	7: 25,726,757 (GRCm38)	D556E	probably benign	Het
Kat6b	T	A	14: 21,669,039 (GRCm38)	L1153Q	possibly damaging	Het
Ly75	A	T	2: 60,383,182 (GRCm38)	L17Q	probably null	Het
Mc5r	T	C	18: 68,338,839 (GRCm38)	F90L	probably damaging	Het
Olfr1356	A	T	10: 78,847,063 (GRCm38)	M284K	probably damaging	Het
Olfr175-ps1	A	T	16: 58,824,656 (GRCm38)	S18T	probably benign	Het
Olfr524	T	C	7: 140,202,587 (GRCm38)	Y61C	probably damaging	Het
Olfr54	C	A	11: 51,027,365 (GRCm38)	A121D	probably damaging	Het
Olfr877	A	T	9: 37,855,360 (GRCm38)	I181L	probably benign	Het
Pi4ka	A	T	16: 17,325,429 (GRCm38)	Y6N	probably damaging	Het
Polr2g	C	A	19: 8,798,456 (GRCm38)		probably null	Het
Psme3	A	G	11: 101,317,654 (GRCm38)	Q82R	probably benign	Het
Rab11a	G	T	9: 64,726,647 (GRCm38)	T17K	possibly damaging	Het
Rbm12	A	T	2: 156,098,097 (GRCm38)	L85Q	probably damaging	Het
Skap1	A	T	11: 96,708,686 (GRCm38)	Y188F	probably damaging	Het
Tmprss6	A	T	15: 78,442,336 (GRCm38)	F34I	probably damaging	Het
Trip12	A	C	1: 84,794,133 (GRCm38)	I98S	probably benign	Het
Ttn	T	C	2: 76,878,188 (GRCm38)		probably benign	Het
Ube2t	A	T	1: 134,971,341 (GRCm38)	K21*	probably null	Het
Vmn1r216	T	C	13: 23,099,477 (GRCm38)	V110A	possibly damaging	Het
Vps13c	A	G	9: 67,937,876 (GRCm38)	T2081A	probably benign	Het
Zfp13	C	T	17: 23,576,098 (GRCm38)	A493T	probably benign	Het

Other mutations in Vmn2r109

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01313:Vmn2r109	APN	17	20,550,157 (GRCm38)	missense	probably damaging	1.00
IGL01383:Vmn2r109	APN	17	20,541,121 (GRCm38)	missense	possibly damaging	0.89
IGL01469:Vmn2r109	APN	17	20,541,409 (GRCm38)	missense	probably damaging	1.00
IGL01762:Vmn2r109	APN	17	20,554,392 (GRCm38)	missense	probably benign
IGL01864:Vmn2r109	APN	17	20,541,134 (GRCm38)	missense	probably benign	0.28
IGL02028:Vmn2r109	APN	17	20,541,080 (GRCm38)	missense	probably benign	0.28
IGL02074:Vmn2r109	APN	17	20,554,341 (GRCm38)	missense	probably benign	0.05
IGL02162:Vmn2r109	APN	17	20,554,160 (GRCm38)	missense	probably benign	0.01
IGL02490:Vmn2r109	APN	17	20,540,984 (GRCm38)	missense	possibly damaging	0.78
IGL02604:Vmn2r109	APN	17	20,540,701 (GRCm38)	missense	probably damaging	1.00
IGL02669:Vmn2r109	APN	17	20,554,256 (GRCm38)	missense	possibly damaging	0.64
IGL02705:Vmn2r109	APN	17	20,553,800 (GRCm38)	missense	probably benign
IGL02745:Vmn2r109	APN	17	20,541,250 (GRCm38)	missense	probably damaging	0.99
PIT4142001:Vmn2r109	UTSW	17	20,554,577 (GRCm38)	critical splice acceptor site	probably null
R0389:Vmn2r109	UTSW	17	20,541,074 (GRCm38)	missense	probably damaging	1.00
R0470:Vmn2r109	UTSW	17	20,552,886 (GRCm38)	missense	probably benign	0.06
R0570:Vmn2r109	UTSW	17	20,540,675 (GRCm38)	missense	probably damaging	0.99
R0855:Vmn2r109	UTSW	17	20,541,408 (GRCm38)	nonsense	probably null
R0882:Vmn2r109	UTSW	17	20,554,580 (GRCm38)	splice site	probably benign
R1241:Vmn2r109	UTSW	17	20,555,241 (GRCm38)	missense	possibly damaging	0.86
R1587:Vmn2r109	UTSW	17	20,540,740 (GRCm38)	missense	probably damaging	1.00
R1931:Vmn2r109	UTSW	17	20,553,810 (GRCm38)	nonsense	probably null
R1957:Vmn2r109	UTSW	17	20,564,707 (GRCm38)	missense	probably benign	0.11
R1962:Vmn2r109	UTSW	17	20,553,923 (GRCm38)	missense	probably damaging	0.99
R2020:Vmn2r109	UTSW	17	20,541,186 (GRCm38)	nonsense	probably null
R2073:Vmn2r109	UTSW	17	20,564,712 (GRCm38)	missense	probably benign	0.00
R2436:Vmn2r109	UTSW	17	20,554,536 (GRCm38)	missense	probably damaging	0.99
R3123:Vmn2r109	UTSW	17	20,540,986 (GRCm38)	missense	probably damaging	1.00
R3839:Vmn2r109	UTSW	17	20,554,442 (GRCm38)	missense	probably damaging	1.00
R4019:Vmn2r109	UTSW	17	20,553,812 (GRCm38)	missense	probably benign
R4428:Vmn2r109	UTSW	17	20,553,024 (GRCm38)	missense	probably benign
R4584:Vmn2r109	UTSW	17	20,554,558 (GRCm38)	nonsense	probably null
R4652:Vmn2r109	UTSW	17	20,541,394 (GRCm38)	missense	probably damaging	1.00
R4708:Vmn2r109	UTSW	17	20,541,343 (GRCm38)	missense	probably damaging	0.97
R4823:Vmn2r109	UTSW	17	20,553,891 (GRCm38)	missense	probably damaging	1.00
R4831:Vmn2r109	UTSW	17	20,541,232 (GRCm38)	missense	probably benign	0.01
R4907:Vmn2r109	UTSW	17	20,550,086 (GRCm38)	missense	probably damaging	1.00
R5011:Vmn2r109	UTSW	17	20,555,189 (GRCm38)	missense	probably damaging	1.00
R5296:Vmn2r109	UTSW	17	20,554,341 (GRCm38)	missense	possibly damaging	0.90
R5600:Vmn2r109	UTSW	17	20,540,927 (GRCm38)	missense	probably damaging	1.00
R5602:Vmn2r109	UTSW	17	20,540,671 (GRCm38)	missense	possibly damaging	0.94
R5652:Vmn2r109	UTSW	17	20,540,519 (GRCm38)	makesense	probably null
R5702:Vmn2r109	UTSW	17	20,554,145 (GRCm38)	missense	probably benign	0.42
R5706:Vmn2r109	UTSW	17	20,554,305 (GRCm38)	missense	probably benign	0.16
R5714:Vmn2r109	UTSW	17	20,552,859 (GRCm38)	missense	probably damaging	1.00
R5832:Vmn2r109	UTSW	17	20,541,056 (GRCm38)	missense	probably benign	0.10
R6008:Vmn2r109	UTSW	17	20,540,719 (GRCm38)	missense	probably damaging	1.00
R6334:Vmn2r109	UTSW	17	20,541,178 (GRCm38)	missense	probably benign	0.18
R6377:Vmn2r109	UTSW	17	20,564,534 (GRCm38)	critical splice donor site	probably null
R6738:Vmn2r109	UTSW	17	20,554,523 (GRCm38)	missense	possibly damaging	0.52
R6857:Vmn2r109	UTSW	17	20,540,670 (GRCm38)	missense	probably benign	0.45
R6953:Vmn2r109	UTSW	17	20,540,711 (GRCm38)	missense	possibly damaging	0.95
R7108:Vmn2r109	UTSW	17	20,564,744 (GRCm38)	missense	probably benign	0.03
R7229:Vmn2r109	UTSW	17	20,540,963 (GRCm38)	missense	possibly damaging	0.80
R7238:Vmn2r109	UTSW	17	20,541,074 (GRCm38)	missense	probably damaging	1.00
R7244:Vmn2r109	UTSW	17	20,540,683 (GRCm38)	missense	possibly damaging	0.70
R7292:Vmn2r109	UTSW	17	20,541,438 (GRCm38)	missense	probably benign	0.05
R7354:Vmn2r109	UTSW	17	20,540,781 (GRCm38)	missense	probably damaging	1.00
R7357:Vmn2r109	UTSW	17	20,541,274 (GRCm38)	missense	probably damaging	1.00
R7522:Vmn2r109	UTSW	17	20,554,403 (GRCm38)	missense	probably benign	0.11
R7596:Vmn2r109	UTSW	17	20,540,680 (GRCm38)	missense	probably damaging	0.98
R7728:Vmn2r109	UTSW	17	20,552,855 (GRCm38)	missense	probably damaging	0.99
R7859:Vmn2r109	UTSW	17	20,541,174 (GRCm38)	missense	probably damaging	1.00
R7871:Vmn2r109	UTSW	17	20,540,520 (GRCm38)	missense	probably benign	0.08
R8113:Vmn2r109	UTSW	17	20,554,467 (GRCm38)	missense	probably benign	0.01
R8153:Vmn2r109	UTSW	17	20,564,707 (GRCm38)	missense	probably benign	0.11
R8977:Vmn2r109	UTSW	17	20,554,269 (GRCm38)	missense	possibly damaging	0.96
R9687:Vmn2r109	UTSW	17	20,555,070 (GRCm38)	missense
Z1176:Vmn2r109	UTSW	17	20,552,994 (GRCm38)	missense	probably benign	0.00

Posted On

2015-04-16