Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02475:Zfp13'

294891

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp13

Ensembl Gene

ENSMUSG00000062012

Gene Name

zinc finger protein 13

Synonyms

Zfp-13, Krox-8

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.129) question?

Stock #

IGL02475

Quality Score

Status

Chromosome

Chromosomal Location

23575844-23599487 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 23576098 bp

Zygosity

Heterozygous

Amino Acid Change

Alanine to Threonine at position 493 (A493T)

Ref Sequence

ENSEMBL: ENSMUSP00000054595 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000057029] [ENSMUST00000115516] [ENSMUST00000227952]

Predicted Effect

probably benign
Transcript: ENSMUST00000057029
AA Change: A493T

PolyPhen 2 Score 0.053 (Sensitivity: 0.94; Specificity: 0.84)

SMART Domains

Protein: ENSMUSP00000054595
Gene: ENSMUSG00000062012
AA Change: A493T

Domain	Start	End	E-Value	Type
KRAB	117	179	7.54e-10	SMART
ZnF_C2H2	259	281	7.37e-4	SMART
ZnF_C2H2	287	309	1.2e-3	SMART
ZnF_C2H2	315	337	5.9e-3	SMART
ZnF_C2H2	343	365	1.26e-2	SMART
ZnF_C2H2	371	393	9.73e-4	SMART
ZnF_C2H2	399	421	2.12e-4	SMART
ZnF_C2H2	427	449	1.18e-2	SMART
ZnF_C2H2	455	477	6.52e-5	SMART
low complexity region	480	503	N/A	INTRINSIC

Predicted Effect

unknown
Transcript: ENSMUST00000115516
AA Change: A500T

SMART Domains

Protein: ENSMUSP00000111178
Gene: ENSMUSG00000062012
AA Change: A500T

Domain	Start	End	E-Value	Type
KRAB	124	186	7.54e-10	SMART
ZnF_C2H2	266	288	7.37e-4	SMART
ZnF_C2H2	294	316	1.2e-3	SMART
ZnF_C2H2	322	344	5.9e-3	SMART
ZnF_C2H2	350	372	1.26e-2	SMART
ZnF_C2H2	378	400	9.73e-4	SMART
ZnF_C2H2	406	428	2.12e-4	SMART
ZnF_C2H2	434	456	1.18e-2	SMART
ZnF_C2H2	462	484	6.52e-5	SMART
low complexity region	487	510	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000226550

Predicted Effect

probably benign
Transcript: ENSMUST00000227952

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000228942

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700001J03Rik	A	T	5: 146,182,533		probably benign	Het
5730409E04Rik	A	G	4: 126,611,949	E90G	probably damaging	Het
Abhd6	T	A	14: 8,039,849	I27N	probably damaging	Het
Akap6	A	T	12: 53,139,494	E1230D	probably benign	Het
Bcl2l12	A	G	7: 44,996,893	V31A	possibly damaging	Het
Cep350	G	A	1: 155,862,595	R2501W	probably damaging	Het
Cnga3	A	G	1: 37,257,991		probably null	Het
Crcp	T	C	5: 130,059,858		probably benign	Het
Creb5	G	A	6: 53,693,924	S304N	probably damaging	Het
Csgalnact1	C	A	8: 68,401,492	G219V	probably damaging	Het
Dnah5	A	G	15: 28,219,150	D38G	probably benign	Het
Fam171a1	A	G	2: 3,223,490	I293V	possibly damaging	Het
Fbxw10	T	C	11: 62,857,735	V396A	possibly damaging	Het
Gm10340	G	A	14: 3,140,482		probably benign	Het
Gm20390	A	G	11: 93,955,574	V16A	probably damaging	Het
Grik3	A	G	4: 125,650,517	T344A	probably benign	Het
Itga7	T	C	10: 128,934,089	F34S	probably damaging	Het
Musk	T	C	4: 58,353,936		probably benign	Het
Neb	G	T	2: 52,292,819	N1038K	probably damaging	Het
Nf1	T	C	11: 79,535,667	Y1636H	probably damaging	Het
Ngef	G	T	1: 87,479,150	T632K	possibly damaging	Het
Nts	A	G	10: 102,490,247		probably benign	Het
Olfml2b	A	G	1: 170,682,174	D697G	probably damaging	Het
Olfr1031	T	C	2: 85,992,032	F72L	probably benign	Het
Olfr1502	T	A	19: 13,862,299	C169S	probably damaging	Het
Olfr205	A	T	16: 59,328,725	H261Q	probably benign	Het
Otof	T	C	5: 30,376,682	R1428G	probably damaging	Het
Pgghg	T	C	7: 140,945,720	S479P		Het
Rnaseh2b	T	A	14: 62,346,615	F37I	probably damaging	Het
Rtn4	T	A	11: 29,733,801	I1031N	probably damaging	Het
Rxfp2	A	G	5: 150,063,686	E344G	probably benign	Het
Scel	A	G	14: 103,537,008	R89G	possibly damaging	Het
Sirt4	T	C	5: 115,482,996	E39G	probably benign	Het
Slc6a12	T	A	6: 121,354,375		probably null	Het
Snapc3	C	A	4: 83,450,096	H277N	probably benign	Het
Susd2	A	G	10: 75,637,499		probably null	Het
Tagap1	T	C	17: 6,956,427	Q290R	probably benign	Het
Tenm3	A	T	8: 48,279,198		probably benign	Het
Tmem54	A	T	4: 129,108,280	H40L	probably damaging	Het
Tnks1bp1	T	C	2: 85,059,377	S683P	probably damaging	Het
Tnpo2	A	G	8: 85,050,502	D547G	probably benign	Het
Tpd52l2	G	A	2: 181,499,874	V17M	probably benign	Het
Trip11	T	A	12: 101,895,683	T208S	probably benign	Het
Ttc17	C	A	2: 94,364,376	D551Y	probably damaging	Het
Ttll12	A	T	15: 83,587,101	W222R	probably damaging	Het
Xkr8	A	T	4: 132,728,201	I287N	probably damaging	Het
Zdhhc2	G	T	8: 40,473,025	G354C	probably null	Het

Other mutations in Zfp13

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02236:Zfp13	APN	17	23580765	splice site	probably benign
IGL02447:Zfp13	APN	17	23576098	missense	probably benign	0.05
IGL02449:Zfp13	APN	17	23576098	missense	probably benign	0.05
IGL02450:Zfp13	APN	17	23576098	missense	probably benign	0.05
IGL02466:Zfp13	APN	17	23576098	missense	probably benign	0.05
IGL02468:Zfp13	APN	17	23576098	missense	probably benign	0.05
IGL02471:Zfp13	APN	17	23576098	missense	probably benign	0.05
IGL02473:Zfp13	APN	17	23576098	missense	probably benign	0.05
IGL02474:Zfp13	APN	17	23576098	missense	probably benign	0.05
IGL02491:Zfp13	APN	17	23576098	missense	probably benign	0.05
IGL02511:Zfp13	APN	17	23576098	missense	probably benign	0.05
IGL02558:Zfp13	APN	17	23576098	missense	probably benign	0.05
IGL03030:Zfp13	APN	17	23580845	missense	probably benign	0.01
IGL03388:Zfp13	APN	17	23576914	missense	probably benign	0.00
R0053:Zfp13	UTSW	17	23576148	missense	probably damaging	1.00
R0053:Zfp13	UTSW	17	23576148	missense	probably damaging	1.00
R1514:Zfp13	UTSW	17	23576412	missense	probably damaging	1.00
R2420:Zfp13	UTSW	17	23576212	missense	probably damaging	1.00
R3433:Zfp13	UTSW	17	23576628	missense	probably damaging	0.99
R4458:Zfp13	UTSW	17	23581176	missense	probably benign	0.01
R4650:Zfp13	UTSW	17	23580138	missense	probably damaging	1.00
R4824:Zfp13	UTSW	17	23576823	missense	possibly damaging	0.95
R5088:Zfp13	UTSW	17	23577061	nonsense	probably null
R5110:Zfp13	UTSW	17	23580860	missense	probably benign	0.02
R5384:Zfp13	UTSW	17	23581182	missense	probably damaging	1.00
R7302:Zfp13	UTSW	17	23581062	missense	probably damaging	1.00
R8443:Zfp13	UTSW	17	23576892	missense	probably benign

Posted On

2015-04-16