Incidental Mutation 'IGL02475:Olfr1502'
ID294903
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1502
Ensembl Gene ENSMUSG00000056858
Gene Nameolfactory receptor 1502
SynonymsGA_x6K02T2RE5P-4193992-4194942, MOR211-1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.101) question?
Stock #IGL02475
Quality Score
Status
Chromosome19
Chromosomal Location13861795-13862745 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 13862299 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Serine at position 169 (C169S)
Ref Sequence ENSEMBL: ENSMUSP00000073843 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074221]
Predicted Effect probably damaging
Transcript: ENSMUST00000074221
AA Change: C169S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000073843
Gene: ENSMUSG00000056858
AA Change: C169S

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 7.1e-43 PFAM
Pfam:7tm_1 41 290 1.6e-17 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700001J03Rik A T 5: 146,182,533 probably benign Het
5730409E04Rik A G 4: 126,611,949 E90G probably damaging Het
Abhd6 T A 14: 8,039,849 I27N probably damaging Het
Akap6 A T 12: 53,139,494 E1230D probably benign Het
Bcl2l12 A G 7: 44,996,893 V31A possibly damaging Het
Cep350 G A 1: 155,862,595 R2501W probably damaging Het
Cnga3 A G 1: 37,257,991 probably null Het
Crcp T C 5: 130,059,858 probably benign Het
Creb5 G A 6: 53,693,924 S304N probably damaging Het
Csgalnact1 C A 8: 68,401,492 G219V probably damaging Het
Dnah5 A G 15: 28,219,150 D38G probably benign Het
Fam171a1 A G 2: 3,223,490 I293V possibly damaging Het
Fbxw10 T C 11: 62,857,735 V396A possibly damaging Het
Gm10340 G A 14: 3,140,482 probably benign Het
Gm20390 A G 11: 93,955,574 V16A probably damaging Het
Grik3 A G 4: 125,650,517 T344A probably benign Het
Itga7 T C 10: 128,934,089 F34S probably damaging Het
Musk T C 4: 58,353,936 probably benign Het
Neb G T 2: 52,292,819 N1038K probably damaging Het
Nf1 T C 11: 79,535,667 Y1636H probably damaging Het
Ngef G T 1: 87,479,150 T632K possibly damaging Het
Nts A G 10: 102,490,247 probably benign Het
Olfml2b A G 1: 170,682,174 D697G probably damaging Het
Olfr1031 T C 2: 85,992,032 F72L probably benign Het
Olfr205 A T 16: 59,328,725 H261Q probably benign Het
Otof T C 5: 30,376,682 R1428G probably damaging Het
Pgghg T C 7: 140,945,720 S479P Het
Rnaseh2b T A 14: 62,346,615 F37I probably damaging Het
Rtn4 T A 11: 29,733,801 I1031N probably damaging Het
Rxfp2 A G 5: 150,063,686 E344G probably benign Het
Scel A G 14: 103,537,008 R89G possibly damaging Het
Sirt4 T C 5: 115,482,996 E39G probably benign Het
Slc6a12 T A 6: 121,354,375 probably null Het
Snapc3 C A 4: 83,450,096 H277N probably benign Het
Susd2 A G 10: 75,637,499 probably null Het
Tagap1 T C 17: 6,956,427 Q290R probably benign Het
Tenm3 A T 8: 48,279,198 probably benign Het
Tmem54 A T 4: 129,108,280 H40L probably damaging Het
Tnks1bp1 T C 2: 85,059,377 S683P probably damaging Het
Tnpo2 A G 8: 85,050,502 D547G probably benign Het
Tpd52l2 G A 2: 181,499,874 V17M probably benign Het
Trip11 T A 12: 101,895,683 T208S probably benign Het
Ttc17 C A 2: 94,364,376 D551Y probably damaging Het
Ttll12 A T 15: 83,587,101 W222R probably damaging Het
Xkr8 A T 4: 132,728,201 I287N probably damaging Het
Zdhhc2 G T 8: 40,473,025 G354C probably null Het
Zfp13 C T 17: 23,576,098 A493T probably benign Het
Other mutations in Olfr1502
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00094:Olfr1502 APN 19 13861786 unclassified probably benign
IGL01061:Olfr1502 APN 19 13862705 missense possibly damaging 0.94
IGL01534:Olfr1502 APN 19 13861919 missense probably damaging 1.00
IGL02017:Olfr1502 APN 19 13862231 missense possibly damaging 0.58
IGL02039:Olfr1502 APN 19 13862719 nonsense probably null
IGL02173:Olfr1502 APN 19 13862014 missense probably benign 0.00
IGL02219:Olfr1502 APN 19 13861823 missense probably damaging 1.00
IGL02604:Olfr1502 APN 19 13861806 missense probably benign 0.01
R0012:Olfr1502 UTSW 19 13861823 missense probably damaging 0.98
R0594:Olfr1502 UTSW 19 13862279 missense probably benign 0.04
R2184:Olfr1502 UTSW 19 13862035 missense probably benign 0.02
R2518:Olfr1502 UTSW 19 13862309 missense probably damaging 1.00
R5541:Olfr1502 UTSW 19 13861964 missense probably benign
R5587:Olfr1502 UTSW 19 13862576 missense probably damaging 1.00
R6211:Olfr1502 UTSW 19 13862574 missense probably benign 0.01
R6351:Olfr1502 UTSW 19 13861822 missense probably benign 0.04
R7575:Olfr1502 UTSW 19 13862017 missense probably damaging 1.00
Posted On2015-04-16