Incidental Mutation 'IGL02476:Ifi205'
ID294931
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ifi205
Ensembl Gene ENSMUSG00000054203
Gene Nameinterferon activated gene 205
SynonymsD3
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.074) question?
Stock #IGL02476
Quality Score
Status
Chromosome1
Chromosomal Location174011998-174031810 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to T at 174015061 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Lysine at position 356 (N356K)
Ref Sequence ENSEMBL: ENSMUSP00000062409 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059226]
Predicted Effect probably damaging
Transcript: ENSMUST00000059226
AA Change: N356K

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000062409
Gene: ENSMUSG00000054203
AA Change: N356K

DomainStartEndE-ValueType
PYRIN 6 84 9.42e-13 SMART
low complexity region 102 112 N/A INTRINSIC
low complexity region 121 134 N/A INTRINSIC
low complexity region 168 185 N/A INTRINSIC
Pfam:HIN 204 372 2e-76 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aamp T A 1: 74,281,524 probably benign Het
Birc6 A G 17: 74,696,391 E4752G possibly damaging Het
Chd1 C T 17: 15,734,273 P468S probably damaging Het
Cnot3 A G 7: 3,658,068 D556G probably benign Het
Csnk1d A G 11: 120,972,512 Y201H probably damaging Het
Dhtkd1 A G 2: 5,930,906 S132P possibly damaging Het
Dhx58 G T 11: 100,702,264 Q206K probably benign Het
Dio1 C A 4: 107,292,377 V195F probably damaging Het
Dio3 T C 12: 110,279,482 V84A probably benign Het
Extl3 T C 14: 65,077,244 K163R probably benign Het
Fat2 A T 11: 55,311,124 S375T probably damaging Het
Fbrs A G 7: 127,487,669 D73G probably damaging Het
Fnip1 A G 11: 54,499,567 probably benign Het
Frmpd4 A G X: 167,497,855 V343A probably damaging Het
Gcc1 T C 6: 28,420,469 D283G probably benign Het
Ghr T C 15: 3,320,046 D550G probably damaging Het
Glycam1 G A 15: 103,562,880 probably benign Het
Gpatch8 A G 11: 102,478,591 S1374P probably damaging Het
Grm1 A T 10: 10,689,453 M1037K probably benign Het
Gtpbp3 T C 8: 71,492,598 L438P probably damaging Het
Ifi206 A G 1: 173,481,566 L288P probably benign Het
Ift57 T C 16: 49,763,889 V291A probably benign Het
Kif13a A C 13: 46,785,296 C166G probably damaging Het
Lypd6 A G 2: 50,190,728 T143A possibly damaging Het
Mtus2 G A 5: 148,077,938 A514T probably benign Het
Neu2 T C 1: 87,596,952 W220R probably damaging Het
Notch3 T C 17: 32,158,638 S155G possibly damaging Het
Nrxn2 A G 19: 6,454,985 E286G probably damaging Het
Onecut3 A G 10: 80,513,890 E406G probably benign Het
Oog2 T A 4: 144,195,229 D236E probably benign Het
Pck1 A G 2: 173,158,282 H502R probably benign Het
Pld1 A G 3: 28,048,039 Y313C probably damaging Het
Rhox3f A T X: 37,581,539 probably benign Het
Rpl34 A G 3: 130,726,964 probably benign Het
Sema4c T C 1: 36,555,950 K31E probably damaging Het
Sept11 T C 5: 93,148,584 probably null Het
Slc4a9 T A 18: 36,535,445 probably null Het
Snrnp200 T A 2: 127,217,488 S434T probably benign Het
Snx13 A T 12: 35,086,941 I134F probably damaging Het
Syt2 T C 1: 134,747,631 S407P probably benign Het
Tbc1d19 T C 5: 53,889,413 probably null Het
Tbc1d32 G T 10: 56,198,542 Q192K possibly damaging Het
Ubr4 T A 4: 139,421,249 C1681* probably null Het
Vmn1r43 T A 6: 89,870,061 I148F possibly damaging Het
Vwa8 T C 14: 78,925,341 V187A possibly damaging Het
Wdr78 T A 4: 103,087,348 I3L possibly damaging Het
Other mutations in Ifi205
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00990:Ifi205 APN 1 174027333 splice site probably benign
IGL02419:Ifi205 APN 1 174017614 missense probably damaging 0.99
IGL03128:Ifi205 APN 1 174015086 missense probably damaging 0.99
IGL03154:Ifi205 APN 1 174017666 splice site probably benign
R0211:Ifi205 UTSW 1 174028428 missense probably benign
R1932:Ifi205 UTSW 1 174028414 missense possibly damaging 0.47
R2397:Ifi205 UTSW 1 174017575 missense possibly damaging 0.64
R3115:Ifi205 UTSW 1 174028335 missense possibly damaging 0.95
R4534:Ifi205 UTSW 1 174017641 missense probably benign 0.16
R4544:Ifi205 UTSW 1 174026573 missense possibly damaging 0.96
R4715:Ifi205 UTSW 1 174028321 missense possibly damaging 0.51
R4977:Ifi205 UTSW 1 174015008 missense probably benign 0.07
R5844:Ifi205 UTSW 1 174026692 splice site probably null
R6061:Ifi205 UTSW 1 174027264 missense possibly damaging 0.91
R6510:Ifi205 UTSW 1 174017565 missense probably damaging 1.00
R7032:Ifi205 UTSW 1 174028350 missense possibly damaging 0.80
R7196:Ifi205 UTSW 1 174026543 missense probably damaging 0.96
R7244:Ifi205 UTSW 1 174017644 nonsense probably null
R7419:Ifi205 UTSW 1 174028308 missense possibly damaging 0.71
R7431:Ifi205 UTSW 1 174028377 missense probably benign
R7660:Ifi205 UTSW 1 174028248 missense probably benign 0.27
Posted On2015-04-16