Incidental Mutation 'IGL02477:Sema3g'
ID 294981
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Sema3g
Ensembl Gene ENSMUSG00000021904
Gene Name sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02477
Quality Score
Chromosome 14
Chromosomal Location 30939830-30952309 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 30949823 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Leucine at position 668 (R668L)
Ref Sequence ENSEMBL: ENSMUSP00000087643 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090180]
AlphaFold Q4LFA9
Predicted Effect probably damaging
Transcript: ENSMUST00000090180
AA Change: R668L

PolyPhen 2 Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000087643
Gene: ENSMUSG00000021904
AA Change: R668L

signal peptide 1 22 N/A INTRINSIC
Sema 58 503 2.96e-184 SMART
PSI 521 574 3.2e-11 SMART
IG 588 674 6.41e-2 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The transcription of this gene is activated by PPAR-gamma, and the resulting protein product plays a role in endothelial cell migration. Expression of this gene also inhibits tumor cell migration and invasion. [provided by RefSeq, Jul 2016]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased lymphatic branching complexity with decreased lymphatic width. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921539E11Rik T A 4: 103,127,943 (GRCm39) I61F probably benign Het
Abr T C 11: 76,352,186 (GRCm39) K280E probably damaging Het
Acaca T C 11: 84,197,994 (GRCm39) probably benign Het
Cep131 C T 11: 119,961,406 (GRCm39) V582I probably damaging Het
Colec12 A G 18: 9,859,858 (GRCm39) N613D unknown Het
Cyp4f39 A G 17: 32,708,619 (GRCm39) T389A probably benign Het
D630003M21Rik T C 2: 158,059,408 (GRCm39) N164S probably benign Het
Eef1akmt2 A T 7: 132,452,318 (GRCm39) probably null Het
Elp3 T C 14: 65,800,760 (GRCm39) T283A probably benign Het
Fads3 C A 19: 10,033,806 (GRCm39) P397Q probably damaging Het
Fam171a1 T C 2: 3,203,612 (GRCm39) V198A possibly damaging Het
Fam171a2 T C 11: 102,330,854 (GRCm39) I208M probably benign Het
Fbxw17 G A 13: 50,577,853 (GRCm39) V119M possibly damaging Het
Gtf2ird1 G A 5: 134,408,832 (GRCm39) T140M probably damaging Het
Hspa14 C T 2: 3,497,661 (GRCm39) S277N probably damaging Het
Hspg2 C T 4: 137,271,823 (GRCm39) probably benign Het
Ing2 G T 8: 48,122,303 (GRCm39) R82S possibly damaging Het
Kat6a A G 8: 23,419,316 (GRCm39) Y693C probably damaging Het
Kcna7 A G 7: 45,059,047 (GRCm39) M445V probably benign Het
Lifr T G 15: 7,216,404 (GRCm39) I793S probably damaging Het
Lrrd1 T A 5: 3,915,770 (GRCm39) M789K probably benign Het
Myom3 T A 4: 135,506,679 (GRCm39) L484Q probably benign Het
Nav2 T A 7: 49,232,623 (GRCm39) M1860K probably damaging Het
Nipbl C T 15: 8,353,131 (GRCm39) probably null Het
Nsun7 T A 5: 66,433,992 (GRCm39) I214K probably damaging Het
Or5k17 T C 16: 58,746,126 (GRCm39) I269M probably benign Het
Or8c20 C T 9: 38,260,421 (GRCm39) S8L probably benign Het
Osm T A 11: 4,189,604 (GRCm39) N129K probably damaging Het
Plce1 C T 19: 38,707,997 (GRCm39) probably benign Het
Plch1 A G 3: 63,660,714 (GRCm39) F302L probably damaging Het
Pld2 T C 11: 70,431,751 (GRCm39) V27A possibly damaging Het
Prex2 A G 1: 11,274,378 (GRCm39) D1350G probably benign Het
Psme4 T A 11: 30,792,083 (GRCm39) V1190D probably damaging Het
Sprr2f T A 3: 92,273,204 (GRCm39) M1K probably null Het
Sult6b2 G A 6: 142,747,447 (GRCm39) P101S probably damaging Het
Trem3 G A 17: 48,556,864 (GRCm39) V112I probably benign Het
Ttll9 T A 2: 152,842,117 (GRCm39) F324I possibly damaging Het
Ttn T A 2: 76,557,104 (GRCm39) D29967V probably damaging Het
Ubr4 A G 4: 139,163,516 (GRCm39) K2639E probably damaging Het
Vwce T C 19: 10,641,982 (GRCm39) probably null Het
Zbtb14 T A 17: 69,694,690 (GRCm39) D129E probably benign Het
Zmym6 C T 4: 126,972,295 (GRCm39) Q16* probably null Het
Other mutations in Sema3g
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01626:Sema3g APN 14 30,943,684 (GRCm39) missense probably damaging 1.00
IGL01650:Sema3g APN 14 30,943,744 (GRCm39) missense probably benign 0.00
IGL01782:Sema3g APN 14 30,949,748 (GRCm39) missense probably damaging 1.00
IGL01784:Sema3g APN 14 30,944,924 (GRCm39) missense probably damaging 1.00
IGL01869:Sema3g APN 14 30,945,624 (GRCm39) missense probably damaging 1.00
IGL01999:Sema3g APN 14 30,939,922 (GRCm39) missense probably benign
IGL02095:Sema3g APN 14 30,949,781 (GRCm39) missense probably benign 0.00
IGL02232:Sema3g APN 14 30,943,181 (GRCm39) missense probably damaging 1.00
IGL02583:Sema3g APN 14 30,943,476 (GRCm39) critical splice acceptor site probably null
R0791:Sema3g UTSW 14 30,942,861 (GRCm39) splice site probably benign
R1225:Sema3g UTSW 14 30,942,636 (GRCm39) missense probably damaging 1.00
R1471:Sema3g UTSW 14 30,950,002 (GRCm39) missense probably damaging 1.00
R2303:Sema3g UTSW 14 30,944,572 (GRCm39) missense probably damaging 1.00
R3968:Sema3g UTSW 14 30,948,478 (GRCm39) critical splice donor site probably null
R3970:Sema3g UTSW 14 30,948,478 (GRCm39) critical splice donor site probably null
R4406:Sema3g UTSW 14 30,950,116 (GRCm39) missense probably benign 0.01
R4773:Sema3g UTSW 14 30,942,666 (GRCm39) missense probably benign 0.04
R7968:Sema3g UTSW 14 30,942,605 (GRCm39) missense probably damaging 0.99
R8179:Sema3g UTSW 14 30,942,542 (GRCm39) missense probably benign 0.00
R9606:Sema3g UTSW 14 30,943,783 (GRCm39) missense probably damaging 1.00
RF021:Sema3g UTSW 14 30,949,798 (GRCm39) missense probably damaging 1.00
X0013:Sema3g UTSW 14 30,944,068 (GRCm39) missense probably benign 0.02
Z1177:Sema3g UTSW 14 30,948,354 (GRCm39) missense probably benign 0.26
Posted On 2015-04-16