Incidental Mutation 'IGL02478:Vmn2r69'
| ID |
295022 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn2r69
|
| Ensembl Gene |
ENSMUSG00000091006 |
| Gene Name |
vomeronasal 2, receptor 69 |
| Synonyms |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.088)
|
| Stock # |
IGL02478
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
85055584-85064884 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 85055889 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 750
(S750P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000132726
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000171213]
|
| AlphaFold |
G3XA45 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000171213
AA Change: S750P
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000132726
Gene: ENSMUSG00000091006
AA Change: S750P
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
465 |
1.3e-28 |
PFAM |
|
Pfam:NCD3G
|
507 |
559 |
1.8e-20 |
PFAM |
|
Pfam:7tm_3
|
592 |
827 |
3.2e-54 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000207880
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 56 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcb1b |
C |
A |
5: 8,856,018 (GRCm39) |
A42E |
probably damaging |
Het |
| Agmo |
T |
A |
12: 37,451,985 (GRCm39) |
F247L |
probably damaging |
Het |
| Arap1 |
C |
A |
7: 101,049,332 (GRCm39) |
|
probably null |
Het |
| Arid1a |
T |
C |
4: 133,408,585 (GRCm39) |
D1974G |
unknown |
Het |
| Asxl3 |
C |
T |
18: 22,656,070 (GRCm39) |
A1360V |
possibly damaging |
Het |
| Celsr1 |
T |
A |
15: 85,825,337 (GRCm39) |
T1599S |
possibly damaging |
Het |
| Chrdl2 |
T |
C |
7: 99,670,190 (GRCm39) |
|
probably null |
Het |
| Csmd3 |
T |
C |
15: 47,701,794 (GRCm39) |
|
probably benign |
Het |
| Dis3l |
C |
T |
9: 64,222,055 (GRCm39) |
E452K |
probably benign |
Het |
| Dnajc2 |
A |
T |
5: 21,981,788 (GRCm39) |
H45Q |
probably damaging |
Het |
| Eps8 |
G |
A |
6: 137,499,840 (GRCm39) |
P213L |
probably benign |
Het |
| Erbb3 |
T |
A |
10: 128,407,227 (GRCm39) |
R978* |
probably null |
Het |
| Exoc2 |
A |
T |
13: 31,111,403 (GRCm39) |
C142S |
probably benign |
Het |
| Fam184b |
T |
C |
5: 45,695,039 (GRCm39) |
E735G |
probably damaging |
Het |
| Fancm |
T |
C |
12: 65,123,864 (GRCm39) |
V174A |
probably damaging |
Het |
| Fat4 |
T |
C |
3: 38,942,364 (GRCm39) |
L419P |
probably damaging |
Het |
| Fsip2 |
G |
T |
2: 82,814,736 (GRCm39) |
V3490L |
probably benign |
Het |
| Ftcd |
A |
T |
10: 76,417,255 (GRCm39) |
R255* |
probably null |
Het |
| Galc |
T |
C |
12: 98,179,391 (GRCm39) |
N506S |
possibly damaging |
Het |
| Gm20441 |
G |
T |
10: 75,608,644 (GRCm39) |
A26E |
probably damaging |
Het |
| Gm21969 |
T |
G |
4: 139,367,999 (GRCm39) |
|
probably null |
Het |
| Ifitm3 |
T |
A |
7: 140,589,787 (GRCm39) |
M89L |
possibly damaging |
Het |
| Ift25 |
T |
A |
4: 107,132,449 (GRCm39) |
S79T |
probably benign |
Het |
| Inmt |
T |
C |
6: 55,150,355 (GRCm39) |
E94G |
probably damaging |
Het |
| Insrr |
G |
A |
3: 87,716,719 (GRCm39) |
G649D |
probably benign |
Het |
| Ivd |
T |
C |
2: 118,692,572 (GRCm39) |
L24P |
probably benign |
Het |
| Kcnc1 |
A |
G |
7: 46,084,593 (GRCm39) |
N506D |
probably benign |
Het |
| Krt39 |
T |
A |
11: 99,411,723 (GRCm39) |
D121V |
probably benign |
Het |
| Lcp1 |
A |
G |
14: 75,461,536 (GRCm39) |
I510V |
probably benign |
Het |
| Mkx |
C |
T |
18: 7,002,418 (GRCm39) |
V43M |
probably damaging |
Het |
| Mmp2 |
A |
G |
8: 93,579,235 (GRCm39) |
N108S |
possibly damaging |
Het |
| Mob1b |
T |
C |
5: 88,903,947 (GRCm39) |
|
probably benign |
Het |
| Morc3 |
A |
G |
16: 93,661,844 (GRCm39) |
|
probably benign |
Het |
| Myh13 |
T |
G |
11: 67,260,204 (GRCm39) |
S1881A |
probably benign |
Het |
| Nalcn |
T |
C |
14: 123,558,717 (GRCm39) |
E843G |
probably benign |
Het |
| Ngef |
A |
G |
1: 87,408,301 (GRCm39) |
|
probably benign |
Het |
| Or14c40 |
T |
A |
7: 86,313,344 (GRCm39) |
I158N |
probably damaging |
Het |
| Osm |
A |
G |
11: 4,189,507 (GRCm39) |
Y97C |
probably damaging |
Het |
| Pclo |
T |
A |
5: 14,816,792 (GRCm39) |
L4556Q |
unknown |
Het |
| Pcyox1l |
T |
C |
18: 61,830,780 (GRCm39) |
D364G |
probably benign |
Het |
| Plekha6 |
T |
A |
1: 133,211,031 (GRCm39) |
V467E |
probably benign |
Het |
| Qrsl1 |
A |
T |
10: 43,758,158 (GRCm39) |
S312T |
probably damaging |
Het |
| Ripk1 |
T |
A |
13: 34,194,572 (GRCm39) |
L70Q |
probably damaging |
Het |
| Rnaseh1 |
A |
T |
12: 28,705,662 (GRCm39) |
Y162F |
probably damaging |
Het |
| Ror2 |
T |
A |
13: 53,275,703 (GRCm39) |
T195S |
probably damaging |
Het |
| Sh3bp2 |
T |
C |
5: 34,709,006 (GRCm39) |
L33P |
probably damaging |
Het |
| Skil |
T |
A |
3: 31,151,968 (GRCm39) |
C163* |
probably null |
Het |
| Slc25a37 |
A |
T |
14: 69,486,883 (GRCm39) |
N133K |
probably benign |
Het |
| Slitrk3 |
A |
C |
3: 72,958,046 (GRCm39) |
V242G |
probably damaging |
Het |
| Sra1 |
A |
G |
18: 36,801,845 (GRCm39) |
S82P |
probably benign |
Het |
| Synj2 |
A |
G |
17: 6,088,199 (GRCm39) |
N1417D |
probably benign |
Het |
| Tas2r122 |
A |
G |
6: 132,688,578 (GRCm39) |
V105A |
possibly damaging |
Het |
| Tasor2 |
T |
C |
13: 3,624,661 (GRCm39) |
E1763G |
probably benign |
Het |
| Ttc21b |
T |
C |
2: 66,018,624 (GRCm39) |
N1261S |
probably benign |
Het |
| Wdr95 |
A |
G |
5: 149,519,786 (GRCm39) |
T568A |
probably benign |
Het |
| Zfp319 |
T |
A |
8: 96,055,721 (GRCm39) |
I161F |
possibly damaging |
Het |
|
| Other mutations in Vmn2r69 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01019:Vmn2r69
|
APN |
7 |
85,055,739 (GRCm39) |
missense |
probably benign |
|
|
IGL01457:Vmn2r69
|
APN |
7 |
85,055,836 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL01760:Vmn2r69
|
APN |
7 |
85,056,072 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01834:Vmn2r69
|
APN |
7 |
85,061,576 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02001:Vmn2r69
|
APN |
7 |
85,056,434 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02057:Vmn2r69
|
APN |
7 |
85,060,990 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL02289:Vmn2r69
|
APN |
7 |
85,056,054 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02472:Vmn2r69
|
APN |
7 |
85,058,960 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02554:Vmn2r69
|
APN |
7 |
85,059,014 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02723:Vmn2r69
|
APN |
7 |
85,059,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0526:Vmn2r69
|
UTSW |
7 |
85,060,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0560:Vmn2r69
|
UTSW |
7 |
85,058,922 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0909:Vmn2r69
|
UTSW |
7 |
85,055,873 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0976:Vmn2r69
|
UTSW |
7 |
85,056,108 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1158:Vmn2r69
|
UTSW |
7 |
85,059,058 (GRCm39) |
splice site |
probably benign |
|
|
R1459:Vmn2r69
|
UTSW |
7 |
85,055,908 (GRCm39) |
nonsense |
probably null |
|
|
R1482:Vmn2r69
|
UTSW |
7 |
85,056,082 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1917:Vmn2r69
|
UTSW |
7 |
85,060,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2016:Vmn2r69
|
UTSW |
7 |
85,056,493 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2108:Vmn2r69
|
UTSW |
7 |
85,059,404 (GRCm39) |
missense |
probably benign |
|
|
R2571:Vmn2r69
|
UTSW |
7 |
85,064,764 (GRCm39) |
missense |
probably benign |
|
|
R2910:Vmn2r69
|
UTSW |
7 |
85,055,918 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2920:Vmn2r69
|
UTSW |
7 |
85,060,973 (GRCm39) |
missense |
probably benign |
0.08 |
|
R3708:Vmn2r69
|
UTSW |
7 |
85,061,029 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3710:Vmn2r69
|
UTSW |
7 |
85,055,601 (GRCm39) |
missense |
probably benign |
|
|
R4757:Vmn2r69
|
UTSW |
7 |
85,061,575 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4823:Vmn2r69
|
UTSW |
7 |
85,060,508 (GRCm39) |
missense |
probably benign |
0.21 |
|
R4870:Vmn2r69
|
UTSW |
7 |
85,060,793 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4918:Vmn2r69
|
UTSW |
7 |
85,055,967 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5022:Vmn2r69
|
UTSW |
7 |
85,060,367 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R5174:Vmn2r69
|
UTSW |
7 |
85,064,739 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5200:Vmn2r69
|
UTSW |
7 |
85,055,717 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5278:Vmn2r69
|
UTSW |
7 |
85,060,991 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5643:Vmn2r69
|
UTSW |
7 |
85,056,404 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5996:Vmn2r69
|
UTSW |
7 |
85,061,117 (GRCm39) |
splice site |
probably null |
|
|
R6083:Vmn2r69
|
UTSW |
7 |
85,055,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6140:Vmn2r69
|
UTSW |
7 |
85,060,657 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6306:Vmn2r69
|
UTSW |
7 |
85,064,799 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6330:Vmn2r69
|
UTSW |
7 |
85,060,835 (GRCm39) |
missense |
probably benign |
|
|
R6380:Vmn2r69
|
UTSW |
7 |
85,061,067 (GRCm39) |
missense |
probably benign |
|
|
R6466:Vmn2r69
|
UTSW |
7 |
85,056,378 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6542:Vmn2r69
|
UTSW |
7 |
85,060,413 (GRCm39) |
nonsense |
probably null |
|
|
R6583:Vmn2r69
|
UTSW |
7 |
85,059,017 (GRCm39) |
missense |
probably benign |
|
|
R6623:Vmn2r69
|
UTSW |
7 |
85,056,309 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6709:Vmn2r69
|
UTSW |
7 |
85,061,069 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6732:Vmn2r69
|
UTSW |
7 |
85,060,351 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6741:Vmn2r69
|
UTSW |
7 |
85,061,724 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7070:Vmn2r69
|
UTSW |
7 |
85,060,688 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7234:Vmn2r69
|
UTSW |
7 |
85,056,315 (GRCm39) |
missense |
probably benign |
0.22 |
|
R7323:Vmn2r69
|
UTSW |
7 |
85,060,972 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7427:Vmn2r69
|
UTSW |
7 |
85,060,467 (GRCm39) |
missense |
probably benign |
0.28 |
|
R7428:Vmn2r69
|
UTSW |
7 |
85,060,467 (GRCm39) |
missense |
probably benign |
0.28 |
|
R7453:Vmn2r69
|
UTSW |
7 |
85,060,768 (GRCm39) |
frame shift |
probably null |
|
|
R7532:Vmn2r69
|
UTSW |
7 |
85,059,622 (GRCm39) |
missense |
probably benign |
0.36 |
|
R7556:Vmn2r69
|
UTSW |
7 |
85,060,768 (GRCm39) |
frame shift |
probably null |
|
|
R7562:Vmn2r69
|
UTSW |
7 |
85,056,420 (GRCm39) |
missense |
probably benign |
|
|
R7592:Vmn2r69
|
UTSW |
7 |
85,060,768 (GRCm39) |
frame shift |
probably null |
|
|
R7708:Vmn2r69
|
UTSW |
7 |
85,061,755 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R7803:Vmn2r69
|
UTSW |
7 |
85,056,324 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7960:Vmn2r69
|
UTSW |
7 |
85,055,973 (GRCm39) |
missense |
probably benign |
|
|
R7966:Vmn2r69
|
UTSW |
7 |
85,060,762 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R8071:Vmn2r69
|
UTSW |
7 |
85,055,713 (GRCm39) |
nonsense |
probably null |
|
|
R8237:Vmn2r69
|
UTSW |
7 |
85,060,340 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8347:Vmn2r69
|
UTSW |
7 |
85,064,838 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8737:Vmn2r69
|
UTSW |
7 |
85,055,783 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8795:Vmn2r69
|
UTSW |
7 |
85,064,883 (GRCm39) |
start codon destroyed |
probably null |
0.94 |
|
R8831:Vmn2r69
|
UTSW |
7 |
85,059,018 (GRCm39) |
nonsense |
probably null |
|
|
R8856:Vmn2r69
|
UTSW |
7 |
85,061,663 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8998:Vmn2r69
|
UTSW |
7 |
85,060,307 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8999:Vmn2r69
|
UTSW |
7 |
85,060,307 (GRCm39) |
missense |
probably benign |
0.33 |
|
R9161:Vmn2r69
|
UTSW |
7 |
85,056,177 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R9228:Vmn2r69
|
UTSW |
7 |
85,064,697 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9494:Vmn2r69
|
UTSW |
7 |
85,060,768 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9494:Vmn2r69
|
UTSW |
7 |
85,056,084 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9541:Vmn2r69
|
UTSW |
7 |
85,056,209 (GRCm39) |
missense |
probably benign |
|
|
R9620:Vmn2r69
|
UTSW |
7 |
85,061,504 (GRCm39) |
missense |
probably benign |
0.10 |
|
Z1176:Vmn2r69
|
UTSW |
7 |
85,055,696 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2015-04-16 |
Incidental Mutation