Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02478:Tas2r122'

295065

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tas2r122

Ensembl Gene

ENSMUSG00000078280

Gene Name

taste receptor, type 2, member 122

Synonyms

Tas2r22, mGR22, T2R22

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.058) question?

Stock #

IGL02478

Quality Score

Status

Chromosome

Chromosomal Location

132687962-132688891 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 132688578 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 105 (V105A)

Ref Sequence

ENSEMBL: ENSMUSP00000100699 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000105077]

AlphaFold

D3YU55

Predicted Effect

possibly damaging
Transcript: ENSMUST00000105077
AA Change: V105A

PolyPhen 2 Score 0.814 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000100699
Gene: ENSMUSG00000078280
AA Change: V105A

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	302	2.3e-73	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb1b	C	A	5: 8,856,018 (GRCm39)	A42E	probably damaging	Het
Agmo	T	A	12: 37,451,985 (GRCm39)	F247L	probably damaging	Het
Arap1	C	A	7: 101,049,332 (GRCm39)		probably null	Het
Arid1a	T	C	4: 133,408,585 (GRCm39)	D1974G	unknown	Het
Asxl3	C	T	18: 22,656,070 (GRCm39)	A1360V	possibly damaging	Het
Celsr1	T	A	15: 85,825,337 (GRCm39)	T1599S	possibly damaging	Het
Chrdl2	T	C	7: 99,670,190 (GRCm39)		probably null	Het
Csmd3	T	C	15: 47,701,794 (GRCm39)		probably benign	Het
Dis3l	C	T	9: 64,222,055 (GRCm39)	E452K	probably benign	Het
Dnajc2	A	T	5: 21,981,788 (GRCm39)	H45Q	probably damaging	Het
Eps8	G	A	6: 137,499,840 (GRCm39)	P213L	probably benign	Het
Erbb3	T	A	10: 128,407,227 (GRCm39)	R978*	probably null	Het
Exoc2	A	T	13: 31,111,403 (GRCm39)	C142S	probably benign	Het
Fam184b	T	C	5: 45,695,039 (GRCm39)	E735G	probably damaging	Het
Fancm	T	C	12: 65,123,864 (GRCm39)	V174A	probably damaging	Het
Fat4	T	C	3: 38,942,364 (GRCm39)	L419P	probably damaging	Het
Fsip2	G	T	2: 82,814,736 (GRCm39)	V3490L	probably benign	Het
Ftcd	A	T	10: 76,417,255 (GRCm39)	R255*	probably null	Het
Galc	T	C	12: 98,179,391 (GRCm39)	N506S	possibly damaging	Het
Gm20441	G	T	10: 75,608,644 (GRCm39)	A26E	probably damaging	Het
Gm21969	T	G	4: 139,367,999 (GRCm39)		probably null	Het
Ifitm3	T	A	7: 140,589,787 (GRCm39)	M89L	possibly damaging	Het
Ift25	T	A	4: 107,132,449 (GRCm39)	S79T	probably benign	Het
Inmt	T	C	6: 55,150,355 (GRCm39)	E94G	probably damaging	Het
Insrr	G	A	3: 87,716,719 (GRCm39)	G649D	probably benign	Het
Ivd	T	C	2: 118,692,572 (GRCm39)	L24P	probably benign	Het
Kcnc1	A	G	7: 46,084,593 (GRCm39)	N506D	probably benign	Het
Krt39	T	A	11: 99,411,723 (GRCm39)	D121V	probably benign	Het
Lcp1	A	G	14: 75,461,536 (GRCm39)	I510V	probably benign	Het
Mkx	C	T	18: 7,002,418 (GRCm39)	V43M	probably damaging	Het
Mmp2	A	G	8: 93,579,235 (GRCm39)	N108S	possibly damaging	Het
Mob1b	T	C	5: 88,903,947 (GRCm39)		probably benign	Het
Morc3	A	G	16: 93,661,844 (GRCm39)		probably benign	Het
Myh13	T	G	11: 67,260,204 (GRCm39)	S1881A	probably benign	Het
Nalcn	T	C	14: 123,558,717 (GRCm39)	E843G	probably benign	Het
Ngef	A	G	1: 87,408,301 (GRCm39)		probably benign	Het
Or14c40	T	A	7: 86,313,344 (GRCm39)	I158N	probably damaging	Het
Osm	A	G	11: 4,189,507 (GRCm39)	Y97C	probably damaging	Het
Pclo	T	A	5: 14,816,792 (GRCm39)	L4556Q	unknown	Het
Pcyox1l	T	C	18: 61,830,780 (GRCm39)	D364G	probably benign	Het
Plekha6	T	A	1: 133,211,031 (GRCm39)	V467E	probably benign	Het
Qrsl1	A	T	10: 43,758,158 (GRCm39)	S312T	probably damaging	Het
Ripk1	T	A	13: 34,194,572 (GRCm39)	L70Q	probably damaging	Het
Rnaseh1	A	T	12: 28,705,662 (GRCm39)	Y162F	probably damaging	Het
Ror2	T	A	13: 53,275,703 (GRCm39)	T195S	probably damaging	Het
Sh3bp2	T	C	5: 34,709,006 (GRCm39)	L33P	probably damaging	Het
Skil	T	A	3: 31,151,968 (GRCm39)	C163*	probably null	Het
Slc25a37	A	T	14: 69,486,883 (GRCm39)	N133K	probably benign	Het
Slitrk3	A	C	3: 72,958,046 (GRCm39)	V242G	probably damaging	Het
Sra1	A	G	18: 36,801,845 (GRCm39)	S82P	probably benign	Het
Synj2	A	G	17: 6,088,199 (GRCm39)	N1417D	probably benign	Het
Tasor2	T	C	13: 3,624,661 (GRCm39)	E1763G	probably benign	Het
Ttc21b	T	C	2: 66,018,624 (GRCm39)	N1261S	probably benign	Het
Vmn2r69	A	G	7: 85,055,889 (GRCm39)	S750P	probably damaging	Het
Wdr95	A	G	5: 149,519,786 (GRCm39)	T568A	probably benign	Het
Zfp319	T	A	8: 96,055,721 (GRCm39)	I161F	possibly damaging	Het

Other mutations in Tas2r122

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01712:Tas2r122	APN	6	132,688,725 (GRCm39)	missense	possibly damaging	0.87
IGL02605:Tas2r122	APN	6	132,688,572 (GRCm39)	missense	probably damaging	0.99
IGL02646:Tas2r122	APN	6	132,688,753 (GRCm39)	missense	probably damaging	1.00
IGL02716:Tas2r122	APN	6	132,688,227 (GRCm39)	missense	probably damaging	1.00
R0318:Tas2r122	UTSW	6	132,688,795 (GRCm39)	missense	possibly damaging	0.90
R0462:Tas2r122	UTSW	6	132,688,141 (GRCm39)	missense	probably benign	0.06
R0532:Tas2r122	UTSW	6	132,688,791 (GRCm39)	missense	possibly damaging	0.94
R0538:Tas2r122	UTSW	6	132,688,778 (GRCm39)	missense	probably benign	0.06
R0570:Tas2r122	UTSW	6	132,688,774 (GRCm39)	missense	probably damaging	1.00
R1863:Tas2r122	UTSW	6	132,688,065 (GRCm39)	nonsense	probably null
R1966:Tas2r122	UTSW	6	132,688,157 (GRCm39)	nonsense	probably null
R2001:Tas2r122	UTSW	6	132,688,585 (GRCm39)	missense	possibly damaging	0.91
R3500:Tas2r122	UTSW	6	132,688,523 (GRCm39)	missense	probably damaging	1.00
R3871:Tas2r122	UTSW	6	132,688,543 (GRCm39)	missense	probably benign	0.00
R4174:Tas2r122	UTSW	6	132,688,839 (GRCm39)	missense	probably damaging	0.96
R5533:Tas2r122	UTSW	6	132,688,393 (GRCm39)	missense	probably damaging	1.00
R5567:Tas2r122	UTSW	6	132,688,335 (GRCm39)	missense	probably benign	0.28
R6455:Tas2r122	UTSW	6	132,688,626 (GRCm39)	nonsense	probably null
R6716:Tas2r122	UTSW	6	132,688,860 (GRCm39)	missense	probably damaging	0.98
R8812:Tas2r122	UTSW	6	132,688,702 (GRCm39)	missense	probably benign	0.09
R9139:Tas2r122	UTSW	6	132,688,779 (GRCm39)	missense	probably benign	0.33
R9720:Tas2r122	UTSW	6	132,688,634 (GRCm39)	missense	probably benign	0.01

Posted On

2015-04-16