Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02479:Olfr420'

295080

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Olfr420

Ensembl Gene

ENSMUSG00000055033

Gene Name

olfactory receptor 420

Synonyms

GA_x6K02T2P20D-20995211-20994246, MOR105-10

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.092) question?

Stock #

IGL02479

Quality Score

Status

Chromosome

Chromosomal Location

174155633-174162195 bp(+) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

C to A at 174158954 bp

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 60 (Y60*)

Ref Sequence

ENSEMBL: ENSMUSP00000149052 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000068403] [ENSMUST00000213748]

Predicted Effect

probably null
Transcript: ENSMUST00000068403
AA Change: Y60*

SMART Domains

Protein: ENSMUSP00000069662
Gene: ENSMUSG00000055033
AA Change: Y60*

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	310	9.9e-60	PFAM
Pfam:7tm_1	41	292	4.1e-20	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000213748
AA Change: Y60*

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 57 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam1b	T	C	5: 121,501,398	Y528C	probably damaging	Het
Adam24	T	A	8: 40,679,532	I13N	probably benign	Het
Arsj	T	C	3: 126,438,939	S445P	possibly damaging	Het
Btf3l4	G	A	4: 108,826,176	T31I	possibly damaging	Het
Cask	A	T	X: 13,557,058	D502E	probably damaging	Het
Cenpl	T	A	1: 161,083,067	S195T	probably benign	Het
Clhc1	T	A	11: 29,578,107	I545N	probably damaging	Het
Clrn2	T	C	5: 45,463,912	I216T	probably benign	Het
Csf2rb	C	T	15: 78,341,724	Q332*	probably null	Het
Cyp3a44	T	C	5: 145,790,667	D284G	probably benign	Het
Dgka	T	C	10: 128,730,246	E345G	probably benign	Het
Dync1i2	G	A	2: 71,235,979	V128I	probably damaging	Het
Eno3	T	A	11: 70,660,888		probably benign	Het
Epc2	T	A	2: 49,532,135	I347K	probably benign	Het
F8	A	T	X: 75,288,240	N681K	probably damaging	Het
Fam207a	T	C	10: 77,514,327	S76G	probably damaging	Het
Fancm	T	A	12: 65,106,485	D1238E	probably damaging	Het
Fcna	T	A	2: 25,625,260	Q237L	probably benign	Het
Fpr2	A	T	17: 17,892,812	R23S	probably benign	Het
Frmd3	A	G	4: 74,187,515	D466G	probably benign	Het
Gen1	C	A	12: 11,241,935	V618L	probably benign	Het
Gja4	T	C	4: 127,312,424	E182G	probably benign	Het
Gsdmc	T	A	15: 63,777,975	I356F	possibly damaging	Het
Kctd19	T	C	8: 105,384,768	D102G	probably damaging	Het
Lrit2	T	C	14: 37,072,278	L433P	probably damaging	Het
Lrp2	G	A	2: 69,464,801		probably benign	Het
Luc7l3	G	A	11: 94,296,909		probably benign	Het
Map3k5	T	A	10: 20,056,484	L458Q	probably damaging	Het
Mast4	A	G	13: 102,742,037	S1038P	probably damaging	Het
Med12	A	T	X: 101,296,992		probably benign	Het
Mtor	T	A	4: 148,470,584	L888M	probably damaging	Het
Nova1	A	T	12: 46,816,918	I83N	unknown	Het
Obscn	A	G	11: 59,056,227		probably benign	Het
Olfr1309	A	C	2: 111,983,385	S230A	probably benign	Het
Olfr1320	T	C	X: 49,683,865	V121A	probably benign	Het
Olfr1426	T	A	19: 12,087,905	M296L	probably benign	Het
Pde2a	A	G	7: 101,501,083	Y243C	probably damaging	Het
Pdzd8	T	A	19: 59,299,783	K1062*	probably null	Het
Phc1	A	T	6: 122,323,717		probably benign	Het
Pik3c2g	T	A	6: 139,918,004	S764T	probably benign	Het
Pmp2	T	G	3: 10,182,202	R89S	probably benign	Het
Prdm2	A	G	4: 143,134,929	L597P	probably damaging	Het
Rfx6	T	A	10: 51,678,328	D88E	probably benign	Het
Rgs9	T	C	11: 109,225,652	S442G	possibly damaging	Het
Ror2	C	T	13: 53,131,932	R82Q	possibly damaging	Het
Sez6	C	A	11: 77,978,026	A986E	possibly damaging	Het
Slc5a5	T	A	8: 70,888,911	M325L	possibly damaging	Het
Sppl2c	G	A	11: 104,186,937	V188I	probably benign	Het
Srrm3	G	T	5: 135,835,249	C67F	probably damaging	Het
Stk31	A	G	6: 49,421,688	E341G	probably damaging	Het
Svil	A	T	18: 5,099,476	M1267L	probably damaging	Het
Tas2r135	C	T	6: 42,405,751	R75*	probably null	Het
Trav8d-1	T	C	14: 52,778,800	S48P	probably benign	Het
Vrk1	A	T	12: 106,051,002	Q95L	probably benign	Het
Wdr25	C	A	12: 108,898,601	T224K	probably benign	Het
Wdr37	A	T	13: 8,842,784	H224Q	probably damaging	Het
Zhx1	C	T	15: 58,054,371	E160K	probably damaging	Het

Other mutations in Olfr420

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01394:Olfr420	APN	1	174158857	missense	probably damaging	1.00
IGL03190:Olfr420	APN	1	174159544	missense	probably damaging	0.99
IGL03270:Olfr420	APN	1	174159553	missense	probably benign	0.04
R0645:Olfr420	UTSW	1	174159354	missense	probably benign	0.00
R0834:Olfr420	UTSW	1	174159364	missense	possibly damaging	0.55
R1432:Olfr420	UTSW	1	174158917	missense	possibly damaging	0.67
R1508:Olfr420	UTSW	1	174159364	missense	possibly damaging	0.55
R2351:Olfr420	UTSW	1	174158920	missense	probably damaging	0.99
R3440:Olfr420	UTSW	1	174159180	missense	probably benign	0.14
R3441:Olfr420	UTSW	1	174159180	missense	probably benign	0.14
R4571:Olfr420	UTSW	1	174158928	missense	possibly damaging	0.77
R5072:Olfr420	UTSW	1	174158961	missense	probably damaging	1.00
R6060:Olfr420	UTSW	1	174159341	nonsense	probably null
R6166:Olfr420	UTSW	1	174159093	missense	probably benign	0.43
R6228:Olfr420	UTSW	1	174152146	missense	probably benign	0.00
R6272:Olfr420	UTSW	1	174159175	missense	probably benign	0.02
R6298:Olfr420	UTSW	1	174152182	missense	probably benign	0.02
R6400:Olfr420	UTSW	1	174159264	missense	probably damaging	0.99
R7581:Olfr420	UTSW	1	174158771	utr 5 prime	probably null
R7677:Olfr420	UTSW	1	174159048	missense	probably damaging	1.00
R7823:Olfr420	UTSW	1	174159688	missense	probably benign	0.12
R7829:Olfr420	UTSW	1	174158859	missense	probably benign	0.00

Posted On

2015-04-16