Incidental Mutation 'IGL02485:Gm5150'
ID295387
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm5150
Ensembl Gene ENSMUSG00000078780
Gene Namepredicted gene 5150
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.055) question?
Stock #IGL02485
Quality Score
Status
Chromosome3
Chromosomal Location15946870-16006437 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 15990752 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Asparagine at position 103 (I103N)
Ref Sequence ENSEMBL: ENSMUSP00000141397 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108347] [ENSMUST00000194367]
Predicted Effect probably damaging
Transcript: ENSMUST00000108347
AA Change: I103N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000103984
Gene: ENSMUSG00000078780
AA Change: I103N

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
IG 37 143 8.78e-9 SMART
IG 156 262 7.52e-8 SMART
transmembrane domain 272 294 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000194367
AA Change: I103N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000141397
Gene: ENSMUSG00000078780
AA Change: I103N

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
IG 37 143 8.78e-9 SMART
IG 156 262 7.52e-8 SMART
transmembrane domain 272 294 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930430A15Rik A T 2: 111,228,325 V94E probably damaging Het
Agl A G 3: 116,779,080 S841P probably benign Het
BC003331 A G 1: 150,363,489 probably null Het
Cd59b A C 2: 104,081,104 probably benign Het
Dopey2 T C 16: 93,770,822 L1379P probably damaging Het
Ercc2 G A 7: 19,394,045 A433T possibly damaging Het
Gm17175 T C 14: 51,569,611 probably benign Het
Igf1 A G 10: 87,864,746 M11V probably benign Het
Incenp T C 19: 9,893,368 N299S unknown Het
Maneal A T 4: 124,856,770 S398T probably damaging Het
Map1a A G 2: 121,299,288 N195S probably damaging Het
Mars2 T C 1: 55,237,591 F118L possibly damaging Het
Mast4 A G 13: 102,735,496 S2263P probably benign Het
Mrgprb1 C A 7: 48,447,717 R149L possibly damaging Het
Myo1d T C 11: 80,666,581 D511G probably damaging Het
Ntan1 T C 16: 13,834,676 probably benign Het
Nxf2 A G X: 134,956,467 F158L probably damaging Het
Olfr1513 T A 14: 52,350,044 M1L possibly damaging Het
Trpm1 C T 7: 64,269,114 A734V possibly damaging Het
Upf2 G A 2: 6,027,291 E883K unknown Het
Ush1c T C 7: 46,229,250 I83V probably damaging Het
Vmn2r60 C A 7: 42,195,466 T751N possibly damaging Het
Zfp146 A G 7: 30,162,590 I9T probably benign Het
Zfp592 G A 7: 81,037,970 probably benign Het
Zswim8 C T 14: 20,711,887 L243F probably damaging Het
Other mutations in Gm5150
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02188:Gm5150 APN 3 15963662 missense possibly damaging 0.95
IGL02507:Gm5150 APN 3 15963321 missense probably damaging 0.97
R1760:Gm5150 UTSW 3 16006304 missense probably benign 0.00
R2081:Gm5150 UTSW 3 15990945 missense probably benign 0.29
R3080:Gm5150 UTSW 3 15990921 missense possibly damaging 0.93
R3149:Gm5150 UTSW 3 16006315 missense probably damaging 0.99
R5329:Gm5150 UTSW 3 15963424 missense probably benign 0.35
R5627:Gm5150 UTSW 3 15963400 missense probably damaging 1.00
R6052:Gm5150 UTSW 3 15990753 missense probably damaging 1.00
R6455:Gm5150 UTSW 3 15990651 missense probably damaging 1.00
R6963:Gm5150 UTSW 3 16006391 start gained probably benign
R7688:Gm5150 UTSW 3 15963583 missense probably benign 0.07
R7872:Gm5150 UTSW 3 16006321 start codon destroyed probably null 0.37
R8368:Gm5150 UTSW 3 15990738 missense probably damaging 1.00
Posted On2015-04-16