Incidental Mutation 'IGL02485:Zfp146'
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ID295392
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp146
Ensembl Gene ENSMUSG00000037029
Gene Namezinc finger protein 146
SynonymsOZF
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.156) question?
Stock #IGL02485
Quality Score
Status
Chromosome7
Chromosomal Location30161269-30169750 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 30162590 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Threonine at position 9 (I9T)
Ref Sequence ENSEMBL: ENSMUSP00000058588 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062181]
Predicted Effect probably benign
Transcript: ENSMUST00000062181
AA Change: I9T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000058588
Gene: ENSMUSG00000037029
AA Change: I9T

DomainStartEndE-ValueType
ZnF_C2H2 16 38 1.01e-1 SMART
ZnF_C2H2 44 66 5.5e-3 SMART
ZnF_C2H2 72 94 3.44e-4 SMART
ZnF_C2H2 100 122 2.27e-4 SMART
ZnF_C2H2 128 150 1.98e-4 SMART
ZnF_C2H2 156 178 3.89e-3 SMART
ZnF_C2H2 184 206 6.99e-5 SMART
ZnF_C2H2 212 234 1.6e-4 SMART
ZnF_C2H2 240 262 5.5e-3 SMART
ZnF_C2H2 268 290 1.82e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136508
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930430A15Rik A T 2: 111,228,325 V94E probably damaging Het
Agl A G 3: 116,779,080 S841P probably benign Het
BC003331 A G 1: 150,363,489 probably null Het
Cd59b A C 2: 104,081,104 probably benign Het
Dopey2 T C 16: 93,770,822 L1379P probably damaging Het
Ercc2 G A 7: 19,394,045 A433T possibly damaging Het
Gm17175 T C 14: 51,569,611 probably benign Het
Gm5150 A T 3: 15,990,752 I103N probably damaging Het
Igf1 A G 10: 87,864,746 M11V probably benign Het
Incenp T C 19: 9,893,368 N299S unknown Het
Maneal A T 4: 124,856,770 S398T probably damaging Het
Map1a A G 2: 121,299,288 N195S probably damaging Het
Mars2 T C 1: 55,237,591 F118L possibly damaging Het
Mast4 A G 13: 102,735,496 S2263P probably benign Het
Mrgprb1 C A 7: 48,447,717 R149L possibly damaging Het
Myo1d T C 11: 80,666,581 D511G probably damaging Het
Ntan1 T C 16: 13,834,676 probably benign Het
Nxf2 A G X: 134,956,467 F158L probably damaging Het
Olfr1513 T A 14: 52,350,044 M1L possibly damaging Het
Trpm1 C T 7: 64,269,114 A734V possibly damaging Het
Upf2 G A 2: 6,027,291 E883K unknown Het
Ush1c T C 7: 46,229,250 I83V probably damaging Het
Vmn2r60 C A 7: 42,195,466 T751N possibly damaging Het
Zfp592 G A 7: 81,037,970 probably benign Het
Zswim8 C T 14: 20,711,887 L243F probably damaging Het
Other mutations in Zfp146
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02170:Zfp146 APN 7 30162480 missense possibly damaging 0.51
IGL02796:Zfp146 UTSW 7 30162558 missense probably benign 0.01
R2043:Zfp146 UTSW 7 30162239 missense possibly damaging 0.92
R4166:Zfp146 UTSW 7 30162440 missense possibly damaging 0.50
R4385:Zfp146 UTSW 7 30162422 missense probably benign
R5270:Zfp146 UTSW 7 30162475 missense probably benign 0.03
R5271:Zfp146 UTSW 7 30162475 missense probably benign 0.03
R5746:Zfp146 UTSW 7 30162393 missense probably benign 0.00
Posted On2015-04-16