Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02485:Vmn2r60'

295393

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r60

Ensembl Gene

ENSMUSG00000090619

Gene Name

vomeronasal 2, receptor 60

Synonyms

Gprc2a-rs3, Casr-rs3, EG637898

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.113) question?

Stock #

IGL02485

Quality Score

Status

Chromosome

Chromosomal Location

42116471-42195776 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 42195466 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Asparagine at position 751 (T751N)

Ref Sequence

ENSEMBL: ENSMUSP00000128493 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000166447]

AlphaFold

A0A3B2WBC8

Predicted Effect

possibly damaging
Transcript: ENSMUST00000166447
AA Change: T751N

PolyPhen 2 Score 0.543 (Sensitivity: 0.88; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000128493
Gene: ENSMUSG00000090619
AA Change: T751N

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	78	471	1.2e-44	PFAM
Pfam:NCD3G	514	567	5.1e-23	PFAM
Pfam:7tm_3	600	835	1.4e-51	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 25 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930430A15Rik	A	T	2: 111,228,325 (GRCm38)	V94E	probably damaging	Het
Agl	A	G	3: 116,779,080 (GRCm38)	S841P	probably benign	Het
BC003331	A	G	1: 150,363,489 (GRCm38)		probably null	Het
Cd59b	A	C	2: 104,081,104 (GRCm38)		probably benign	Het
Dopey2	T	C	16: 93,770,822 (GRCm38)	L1379P	probably damaging	Het
Ercc2	G	A	7: 19,394,045 (GRCm38)	A433T	possibly damaging	Het
Gm17175	T	C	14: 51,569,611 (GRCm38)		probably benign	Het
Gm5150	A	T	3: 15,990,752 (GRCm38)	I103N	probably damaging	Het
Igf1	A	G	10: 87,864,746 (GRCm38)	M11V	probably benign	Het
Incenp	T	C	19: 9,893,368 (GRCm38)	N299S	unknown	Het
Maneal	A	T	4: 124,856,770 (GRCm38)	S398T	probably damaging	Het
Map1a	A	G	2: 121,299,288 (GRCm38)	N195S	probably damaging	Het
Mars2	T	C	1: 55,237,591 (GRCm38)	F118L	possibly damaging	Het
Mast4	A	G	13: 102,735,496 (GRCm38)	S2263P	probably benign	Het
Mrgprb1	C	A	7: 48,447,717 (GRCm38)	R149L	possibly damaging	Het
Myo1d	T	C	11: 80,666,581 (GRCm38)	D511G	probably damaging	Het
Ntan1	T	C	16: 13,834,676 (GRCm38)		probably benign	Het
Nxf2	A	G	X: 134,956,467 (GRCm38)	F158L	probably damaging	Het
Olfr1513	T	A	14: 52,350,044 (GRCm38)	M1L	possibly damaging	Het
Trpm1	C	T	7: 64,269,114 (GRCm38)	A734V	possibly damaging	Het
Upf2	G	A	2: 6,027,291 (GRCm38)	E883K	unknown	Het
Ush1c	T	C	7: 46,229,250 (GRCm38)	I83V	probably damaging	Het
Zfp146	A	G	7: 30,162,590 (GRCm38)	I9T	probably benign	Het
Zfp592	G	A	7: 81,037,970 (GRCm38)		probably benign	Het
Zswim8	C	T	14: 20,711,887 (GRCm38)	L243F	probably damaging	Het

Other mutations in Vmn2r60

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01622:Vmn2r60	APN	7	42,136,486 (GRCm38)	missense	probably benign	0.09
IGL01623:Vmn2r60	APN	7	42,136,486 (GRCm38)	missense	probably benign	0.09
IGL02363:Vmn2r60	APN	7	42,195,154 (GRCm38)	missense	probably benign	0.02
IGL02651:Vmn2r60	APN	7	42,195,586 (GRCm38)	missense	probably damaging	0.99
IGL02660:Vmn2r60	APN	7	42,142,296 (GRCm38)	nonsense	probably null
IGL03135:Vmn2r60	APN	7	42,136,594 (GRCm38)	missense	probably benign	0.13
IGL03307:Vmn2r60	APN	7	42,116,547 (GRCm38)	missense	probably benign	0.14
R0310:Vmn2r60	UTSW	7	42,195,140 (GRCm38)	missense	possibly damaging	0.54
R0314:Vmn2r60	UTSW	7	42,135,561 (GRCm38)	splice site	probably benign
R0328:Vmn2r60	UTSW	7	42,142,320 (GRCm38)	splice site	probably benign
R0464:Vmn2r60	UTSW	7	42,135,831 (GRCm38)	missense	probably damaging	0.99
R0755:Vmn2r60	UTSW	7	42,195,445 (GRCm38)	missense	probably damaging	1.00
R1119:Vmn2r60	UTSW	7	42,194,941 (GRCm38)	missense	possibly damaging	0.68
R1162:Vmn2r60	UTSW	7	42,195,771 (GRCm38)	missense	probably benign	0.29
R1241:Vmn2r60	UTSW	7	42,137,052 (GRCm38)	missense	probably benign	0.01
R1404:Vmn2r60	UTSW	7	42,136,787 (GRCm38)	missense	probably damaging	0.99
R1404:Vmn2r60	UTSW	7	42,136,787 (GRCm38)	missense	probably damaging	0.99
R1488:Vmn2r60	UTSW	7	42,136,713 (GRCm38)	missense	probably benign	0.17
R1623:Vmn2r60	UTSW	7	42,135,855 (GRCm38)	nonsense	probably null
R1628:Vmn2r60	UTSW	7	42,136,406 (GRCm38)	nonsense	probably null
R1883:Vmn2r60	UTSW	7	42,136,670 (GRCm38)	missense	probably damaging	0.99
R1884:Vmn2r60	UTSW	7	42,136,670 (GRCm38)	missense	probably damaging	0.99
R2182:Vmn2r60	UTSW	7	42,195,507 (GRCm38)	missense	probably benign	0.06
R2275:Vmn2r60	UTSW	7	42,136,827 (GRCm38)	nonsense	probably null
R2847:Vmn2r60	UTSW	7	42,136,433 (GRCm38)	missense	probably benign	0.07
R2885:Vmn2r60	UTSW	7	42,140,979 (GRCm38)	missense	possibly damaging	0.91
R2894:Vmn2r60	UTSW	7	42,135,796 (GRCm38)	missense	probably benign
R2921:Vmn2r60	UTSW	7	42,141,035 (GRCm38)	missense	probably damaging	0.98
R2922:Vmn2r60	UTSW	7	42,141,035 (GRCm38)	missense	probably damaging	0.98
R3772:Vmn2r60	UTSW	7	42,116,556 (GRCm38)	missense	probably benign	0.35
R3820:Vmn2r60	UTSW	7	42,135,701 (GRCm38)	missense	probably damaging	0.98
R3822:Vmn2r60	UTSW	7	42,135,701 (GRCm38)	missense	probably damaging	0.98
R3872:Vmn2r60	UTSW	7	42,136,454 (GRCm38)	missense	probably benign	0.19
R4222:Vmn2r60	UTSW	7	42,116,528 (GRCm38)	missense	probably benign	0.08
R4223:Vmn2r60	UTSW	7	42,116,528 (GRCm38)	missense	probably benign	0.08
R4224:Vmn2r60	UTSW	7	42,116,528 (GRCm38)	missense	probably benign	0.08
R4526:Vmn2r60	UTSW	7	42,195,243 (GRCm38)	missense	probably damaging	0.96
R4547:Vmn2r60	UTSW	7	42,135,663 (GRCm38)	missense	probably null	0.54
R4840:Vmn2r60	UTSW	7	42,135,861 (GRCm38)	missense	probably damaging	1.00
R5173:Vmn2r60	UTSW	7	42,195,511 (GRCm38)	missense	probably damaging	0.97
R5231:Vmn2r60	UTSW	7	42,137,024 (GRCm38)	missense	possibly damaging	0.93
R5480:Vmn2r60	UTSW	7	42,135,730 (GRCm38)	missense	probably damaging	0.98
R5521:Vmn2r60	UTSW	7	42,195,625 (GRCm38)	missense	probably damaging	0.99
R5834:Vmn2r60	UTSW	7	42,116,508 (GRCm38)	missense	probably benign	0.17
R6038:Vmn2r60	UTSW	7	42,194,962 (GRCm38)	missense	probably benign	0.04
R6038:Vmn2r60	UTSW	7	42,194,962 (GRCm38)	missense	probably benign	0.04
R6112:Vmn2r60	UTSW	7	42,195,423 (GRCm38)	missense	probably damaging	1.00
R6149:Vmn2r60	UTSW	7	42,136,976 (GRCm38)	missense	probably damaging	1.00
R6170:Vmn2r60	UTSW	7	42,135,621 (GRCm38)	missense	possibly damaging	0.94
R6383:Vmn2r60	UTSW	7	42,116,471 (GRCm38)	start codon destroyed	probably null	0.04
R6811:Vmn2r60	UTSW	7	42,194,886 (GRCm38)	missense	probably damaging	1.00
R6876:Vmn2r60	UTSW	7	42,135,663 (GRCm38)	missense	probably null	0.54
R6997:Vmn2r60	UTSW	7	42,142,292 (GRCm38)	missense	probably benign	0.00
R7040:Vmn2r60	UTSW	7	42,142,242 (GRCm38)	missense	probably benign	0.00
R7116:Vmn2r60	UTSW	7	42,137,063 (GRCm38)	missense	probably benign	0.00
R7128:Vmn2r60	UTSW	7	42,195,112 (GRCm38)	missense	probably damaging	0.96
R7232:Vmn2r60	UTSW	7	42,136,742 (GRCm38)	missense	possibly damaging	0.83
R7296:Vmn2r60	UTSW	7	42,136,402 (GRCm38)	missense	probably benign	0.01
R7376:Vmn2r60	UTSW	7	42,195,207 (GRCm38)	missense	probably damaging	1.00
R7526:Vmn2r60	UTSW	7	42,195,734 (GRCm38)	frame shift	probably null
R7527:Vmn2r60	UTSW	7	42,195,734 (GRCm38)	frame shift	probably null
R7528:Vmn2r60	UTSW	7	42,195,734 (GRCm38)	frame shift	probably null
R7764:Vmn2r60	UTSW	7	42,195,111 (GRCm38)	missense	probably damaging	0.99
R7843:Vmn2r60	UTSW	7	42,195,087 (GRCm38)	missense	probably benign	0.00
R8080:Vmn2r60	UTSW	7	42,141,097 (GRCm38)	missense	probably benign	0.30
R8290:Vmn2r60	UTSW	7	42,142,266 (GRCm38)	missense	probably damaging	1.00
R8342:Vmn2r60	UTSW	7	42,141,070 (GRCm38)	missense	possibly damaging	0.63
R8362:Vmn2r60	UTSW	7	42,195,530 (GRCm38)	missense	probably damaging	1.00
R8418:Vmn2r60	UTSW	7	42,195,426 (GRCm38)	missense	probably damaging	0.97
R8848:Vmn2r60	UTSW	7	42,136,745 (GRCm38)	missense	probably damaging	1.00
R8860:Vmn2r60	UTSW	7	42,142,230 (GRCm38)	missense	probably damaging	0.99
R8882:Vmn2r60	UTSW	7	42,141,094 (GRCm38)	missense	probably benign	0.00
R8913:Vmn2r60	UTSW	7	42,136,354 (GRCm38)	missense	probably benign	0.27
R9190:Vmn2r60	UTSW	7	42,195,511 (GRCm38)	missense	probably damaging	0.99
R9229:Vmn2r60	UTSW	7	42,142,299 (GRCm38)	missense	possibly damaging	0.95
R9295:Vmn2r60	UTSW	7	42,136,531 (GRCm38)	missense	probably benign	0.01
R9335:Vmn2r60	UTSW	7	42,194,908 (GRCm38)	missense	probably damaging	1.00
R9796:Vmn2r60	UTSW	7	42,135,748 (GRCm38)	missense	probably benign
RF024:Vmn2r60	UTSW	7	42,140,939 (GRCm38)	missense	probably benign	0.01
X0023:Vmn2r60	UTSW	7	42,141,114 (GRCm38)	missense	probably benign	0.01

Posted On

2015-04-16